Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and ...Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and celiac disease,and is a key player in the onset of sepsis and multiple organ failure in situations of intestinal hypoperfusion,including trauma and major surgery.Insight into gut barrier integrity and function loss is important to improve our knowledge on disease etiology and pathophysiology and contributes to early detection and/or secondary prevention of disease.A variety of tests have been developed to assess intestinal epithelial cell damage,intestinal tight junction status and consequences of intestinal barrier integrity loss,i.e.increased intestinal permeability.This review discusses currently available methods for evaluating loss of human intestinal barrier integrity and function.展开更多
A multiple targets detection method based on spatial smoothing （MTDSS） is proposed to solve the problem of the source number estimation under the colored noise background. The forward and backward smoothing based on...A multiple targets detection method based on spatial smoothing （MTDSS） is proposed to solve the problem of the source number estimation under the colored noise background. The forward and backward smoothing based on auxiliary vectors which are received data on some specific elements is computed. By the spatial smoothing with auxiliary vectors, the correlated signals are decorrelated, and the colored noise is partially alleviated. The correlation matrix formed from the cross correlations between subarray data and auxiliary vectors is computed. By exploring the second-order statistics property of the covariance matrix, a threshold based on Gerschgorin radii of the smoothing correlation matrix is set to estimate the number of sources. Simulations and experimental results validate that MTDSS has an effective performance under the condition of the colored noise background and coherent sources, and MTDSS is robust with the correlated factor of signals and noise.展开更多
Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction...Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction. Methods 64 patients with initial Q - wave anterior myocardial infarction and the infarct - related arteries were total occluded conformed by angiogram at 2 to 14 days after onset were divided into successful PCI group and control group ( not re- ceiving PCI or the IRA not re - opened). 2 - DE was performed at early phase ( about 3 weeks) , 2 and 6 months after onset of AMI respectively to detect the left ventricular function and left ventricular wall motion ab- normality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up. Re- sults VWMA scores, left ventricular ejection frac- tion (LVEF) , left ventricular end - diastolic and end - systolic volume indices ( LVEDVI and LVDSVI) were similar in 2 groups at early phase and 2 months. There were no differences between early phase and 2 months in each group too. VWMA scores and LVEF did not changed at 6 months in each group compared with the early phase and 2 months ( P > 0. 05 ). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than in the control group (P < 0.01, P < 0. 05). The congestive heart failure events were taken place in 19% of patients in control group com- pared with 2% in successful PCI group ( P > 0. 05 ). Conclusions Although the infarct size does not changed, delayed opening the IRA has beneficial effect to the late phase left ventricular dilatation after acuteanterior myocardial infarction.展开更多
The recently invented artificial bee colony （ABC） al- gorithm is an optimization algorithm based on swarm intelligence that has been used to solve many kinds of numerical function optimization problems. It performs ...The recently invented artificial bee colony （ABC） al- gorithm is an optimization algorithm based on swarm intelligence that has been used to solve many kinds of numerical function optimization problems. It performs well in most cases, however, there still exists an insufficiency in the ABC algorithm that ignores the fitness of related pairs of individuals in the mechanism of find- ing a neighboring food source. This paper presents an improved ABC algorithm with mutual learning （MutualABC） that adjusts the produced candidate food source with the higher fitness between two individuals selected by a mutual learning factor. The perfor- mance of the improved MutualABC algorithm is tested on a set of benchmark functions and compared with the basic ABC algo- rithm and some classical versions of improved ABC algorithms. The experimental results show that the MutualABC algorithm with appropriate parameters outperforms other ABC algorithms in most experiments.展开更多
文摘Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and celiac disease,and is a key player in the onset of sepsis and multiple organ failure in situations of intestinal hypoperfusion,including trauma and major surgery.Insight into gut barrier integrity and function loss is important to improve our knowledge on disease etiology and pathophysiology and contributes to early detection and/or secondary prevention of disease.A variety of tests have been developed to assess intestinal epithelial cell damage,intestinal tight junction status and consequences of intestinal barrier integrity loss,i.e.increased intestinal permeability.This review discusses currently available methods for evaluating loss of human intestinal barrier integrity and function.
基金supported by the National Natural Science Foundation of China (61001153)the Fundamental Research Program of Northwestern Polytechnical University (JC20100223)
文摘A multiple targets detection method based on spatial smoothing （MTDSS） is proposed to solve the problem of the source number estimation under the colored noise background. The forward and backward smoothing based on auxiliary vectors which are received data on some specific elements is computed. By the spatial smoothing with auxiliary vectors, the correlated signals are decorrelated, and the colored noise is partially alleviated. The correlation matrix formed from the cross correlations between subarray data and auxiliary vectors is computed. By exploring the second-order statistics property of the covariance matrix, a threshold based on Gerschgorin radii of the smoothing correlation matrix is set to estimate the number of sources. Simulations and experimental results validate that MTDSS has an effective performance under the condition of the colored noise background and coherent sources, and MTDSS is robust with the correlated factor of signals and noise.
文摘Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction. Methods 64 patients with initial Q - wave anterior myocardial infarction and the infarct - related arteries were total occluded conformed by angiogram at 2 to 14 days after onset were divided into successful PCI group and control group ( not re- ceiving PCI or the IRA not re - opened). 2 - DE was performed at early phase ( about 3 weeks) , 2 and 6 months after onset of AMI respectively to detect the left ventricular function and left ventricular wall motion ab- normality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up. Re- sults VWMA scores, left ventricular ejection frac- tion (LVEF) , left ventricular end - diastolic and end - systolic volume indices ( LVEDVI and LVDSVI) were similar in 2 groups at early phase and 2 months. There were no differences between early phase and 2 months in each group too. VWMA scores and LVEF did not changed at 6 months in each group compared with the early phase and 2 months ( P > 0. 05 ). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than in the control group (P < 0.01, P < 0. 05). The congestive heart failure events were taken place in 19% of patients in control group com- pared with 2% in successful PCI group ( P > 0. 05 ). Conclusions Although the infarct size does not changed, delayed opening the IRA has beneficial effect to the late phase left ventricular dilatation after acuteanterior myocardial infarction.
基金supported by the National Natural Science Foundation of China (60803074)the Fundamental Research Funds for the Central Universities (DUT10JR06)
文摘The recently invented artificial bee colony （ABC） al- gorithm is an optimization algorithm based on swarm intelligence that has been used to solve many kinds of numerical function optimization problems. It performs well in most cases, however, there still exists an insufficiency in the ABC algorithm that ignores the fitness of related pairs of individuals in the mechanism of find- ing a neighboring food source. This paper presents an improved ABC algorithm with mutual learning （MutualABC） that adjusts the produced candidate food source with the higher fitness between two individuals selected by a mutual learning factor. The perfor- mance of the improved MutualABC algorithm is tested on a set of benchmark functions and compared with the basic ABC algo- rithm and some classical versions of improved ABC algorithms. The experimental results show that the MutualABC algorithm with appropriate parameters outperforms other ABC algorithms in most experiments.
基金This work was supported by the National Natural Science Foundation of China(Grant No.60172033)Excellent Ph.D Paper Author Foundation of China(Grant No.200036).
