A crucial feature of nanoparticles,such as liposomes,magnetic nanoparticles,quantum dots,metallic nanoparticles,silica nanoparticles,polymersomes and dendrimers etc.,is their higher accumulation in the tumor than in n...A crucial feature of nanoparticles,such as liposomes,magnetic nanoparticles,quantum dots,metallic nanoparticles,silica nanoparticles,polymersomes and dendrimers etc.,is their higher accumulation in the tumor than in normal tissues1-3.Various nanoparticles have been intensively used as vehicles to deliver展开更多
The field of vascular medicine has undergone a profound transformation in the 21st century,transforming our approach to assessment and treatment.Athero-sclerosis,a complex inflammatory disease that affects medium and ...The field of vascular medicine has undergone a profound transformation in the 21st century,transforming our approach to assessment and treatment.Athero-sclerosis,a complex inflammatory disease that affects medium and large arteries,presents a major challenge for researchers and healthcare professionals.This condition,characterized by arterial plaque formation and narrowing,poses sub-stantial challenges to vascular health at individual,national,and global scales.Its repercussions are far-reaching,with clinical outcomes including ischemic heart disease,ischemic stroke,and peripheral arterial disease—conditions with esca-lating global prevalence.Early detection of vascular changes caused by athero-sclerosis is crucial in preventing these conditions,reducing morbidity,and averting mortality.This article underscored the imperative of adopting a holistic approach to grappling with the intricacies,trajectories,and ramifications of atherosclerosis.It stresses the need for a thorough evaluation of the vasculature and the implementation of a multidisciplinary treatment approach.By consi-dering the entire vascular system,healthcare providers can explore avenues for prevention,early detection,and effective management of this condition,ultima-tely leading to improved patient outcomes.We discussed current practices and proposed new directions made possible by emerging diagnostic modalities and treatment strategies.Additionally,we considered healthcare expenditure,resour-ce allocation,and the transformative potential of new innovative treatments and technologies.展开更多
Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in redu...Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in reduced blood flow and oxygen to the brain, leading to progressive symptoms and potential complications. The underlying pathophysiological mechanism remains elucidated. However, recent studies have highlighted numerous etiologic factors: abnormal immune complex responses, susceptibility genes, branched-chain amino acids, antibodies, heritable diseases, and acquired diseases, which may be the great potential triggers for the development of moyamoya disease. Its clinical presentation has varying degrees from transient asymptomatic events to significant neurological deficits. Moyamoya disease (MMD) shows different patterns in children and adults. Children with MMD are more susceptible to ischemic events due to decreased blood flow to the brain. Conversely, adults with MMD are more prone to hemorrhagic events involving brain bleeding. Children with MMD may experience a range of symptoms including motor impairments, sensory issues, seizures, headaches, dizziness, cognitive delays, or ongoing neurological problems. Although adults may present with similar clinical symptoms as children, they are more prone to experiencing sudden onset intraventricular, subarachnoid, or intracerebral hemorrhages. One of the challenges in moyamoya disease is the potential for misdiagnosis or delayed diagnosis, particularly when physicians fail to consider MMD as a possible cause in stroke patients. This review aims to provide a comprehensive overview of recent global studies on the pathophysiology of MMD, along with advancements in its management. Additionally, the review will delve into various surgical treatment options for MMD, as well as its rare occurrence alongside atrioventricular malformations. Exciting prospects include the use of autologous bone marrow transplant and the potential role of Connexin 43 protein treatment in the development of moyamoya disease.展开更多
Beijing’s iconic Tian’anmen Square joined in the celebrations for the 75th birth anniversary of the People’s Republic of China with some spectacular flowerscapes.The huge flower basket on a red raised platform is i...Beijing’s iconic Tian’anmen Square joined in the celebrations for the 75th birth anniversary of the People’s Republic of China with some spectacular flowerscapes.The huge flower basket on a red raised platform is inscribed“Blessing the Motherland”and overflows with flowers and fruits to symbolize the prosperity of the mature republic.There are dazzling displays in other parts of the capital as well.The Chang’an Avenue in downtown Beijing has themed flower beds,ideal for taking selfies or just to admire.展开更多
NO one can precisely describe Beijing with a single word or sentence due to its extreme complexity.Every passenger who arrives in Beijing by plane is welcomed by an ocean of light.The light resembles boiling magma,flo...NO one can precisely describe Beijing with a single word or sentence due to its extreme complexity.Every passenger who arrives in Beijing by plane is welcomed by an ocean of light.The light resembles boiling magma,flowing along a layout of the city in an orderly manner.If Chang’an Avenue,Sanlitun,China World Trade Center,and National Olympic Sports Center are highlights of Beijing,the hutong s(lanes)distributed along the Central Axis represent the other side of the capital city.They tell the stories of this city and its citizens with a subtler voice.In these places where the city’s neon lights cannot reach,the essence of the city’s daily life exists in a small restaurant,a tanghulu(a traditional Chinese snack of candied fruit),or even a bowl of fermented soybean drink.展开更多
Heilongjiang is a paradise of ice and snow in winter,with the Ice and Snow World,Saint Sophia Cathedral,the Central Avenue,Snow Town,the Aurora...thousands of wonders waiting to greet every visitor.The iceand snow her...Heilongjiang is a paradise of ice and snow in winter,with the Ice and Snow World,Saint Sophia Cathedral,the Central Avenue,Snow Town,the Aurora...thousands of wonders waiting to greet every visitor.The iceand snow here are extremely romantic,with rich cultural diversityand warmhearted and hospitable people.From December 21 to 27,2023,"Nihao!China"2024 Chinalce&SnowTourism OverseasPromotionSeason demonstrated"Heilongjiang Overseas Promotion Week".展开更多
Sinohydro and Senegal join forces to provide drinking water in Dakar.Sinohydro,a subsidiary of PowerChina,is currently engaged in efforts to substantially enhance the potable water supply in Dakar,Senegal.A diligent g...Sinohydro and Senegal join forces to provide drinking water in Dakar.Sinohydro,a subsidiary of PowerChina,is currently engaged in efforts to substantially enhance the potable water supply in Dakar,Senegal.A diligent group of Chinese and Senegalese workers is engaged in roundthe-clock efforts along the Avenue du Front de Terre prolongée,which marks the starting point of the Route des Pères Maristes,with the objective of improving the distribution network for potable water in the Dakar Department.With a population density of 7,277 inhabitants per square km and an estimated 1.18 million inhabitants in 2023,there is an evident and increasing need for potable water.This need is further compounded by significant water loss caused by the advanced age of the pipelines,with some pipes dating back to the colonial era.展开更多
The year 2024 will be an important one for China-Africa relations,as the summit of the Forum on China-Africa Cooperation(FOCAC)will be held on 4-6 September in Beijing.This summit will not only demonstrate the determi...The year 2024 will be an important one for China-Africa relations,as the summit of the Forum on China-Africa Cooperation(FOCAC)will be held on 4-6 September in Beijing.This summit will not only demonstrate the determination of China and African countries to strengthen bilateral cooperation,but also outline the roadmap for future common development.展开更多
China remains a key source of growth and profits for many multinationals In March,Apple opened its largest retail store on the Chinese mainland in Shanghai-the company’s second-largest flagship store after its Fifth ...China remains a key source of growth and profits for many multinationals In March,Apple opened its largest retail store on the Chinese mainland in Shanghai-the company’s second-largest flagship store after its Fifth Avenue outlet in New York.The new addition brings Apple’s store tally in Shanghai and the Chinese market to eight and 57,respectively,a significant milestone for the company,which opened its first store in China in 2008.展开更多
Comparison of Doses from Disposals of Technologically Enhanced Naturally Occurring Radioactive Materials in Kentucky and Oregon Emily A.Caffrey1,Arthur S.Rood2,Helen A.Grogan3,Colby Mangini4,John E.Till5(1.Radian Scie...Comparison of Doses from Disposals of Technologically Enhanced Naturally Occurring Radioactive Materials in Kentucky and Oregon Emily A.Caffrey1,Arthur S.Rood2,Helen A.Grogan3,Colby Mangini4,John E.Till5(1.Radian Scientific,LLC,806 Wells Ave SE,Huntsville,AL 35801;2.K-Spar,Inc.,4835 W Foxtrail Lane,Idaho Falls,ID 83402;3.Cascade Scientific,Inc.,1678 NWAlbany Avenue,Bend,OR 97703;4.Paragon Scientific,LLC,725 Rucker Avenue,Everett,WA 98201;5.Risk Assessment Corporation,417 Till Road,Neeses,SC 29107)Abstract:Oil and natural gas fracking waste contains technologically enhanced naturally occurring radioactive material(TENORM)and has increasingly been disposed of in unpermitted landfills,causing concern among regulators and the public about potential exposures.There are numerous issues with TENORM waste,including the lack of Federal regulations on its disposal and the lack of permitted landfills capable of accepting these waste streams.This paper examines two situations in which TENORM was placed in unpermitted landfills,one in Kentucky and one in Oregon.The same modeling and dose calculation methods were used in both cases,allowing for a comparison between the two sites.展开更多
Since 2018,the China International Import Expo(CIIE),held annually in Shanghai,has been serving as an important platform for China to advance its high-quality opening up to the outside world.More and more countries,es...Since 2018,the China International Import Expo(CIIE),held annually in Shanghai,has been serving as an important platform for China to advance its high-quality opening up to the outside world.More and more countries,especially African countries,are using this platform to showcase what they have to offer to the Chinese market and expand their exports to China,which helps to reduce trade imbalances.展开更多
Do you know anything about Chengdu Research Base of Giant Panda Breeding?Do you have any idea of how to get there?Now let me be your guide to introduce it to you.First of all,let’s talk about the transportation.Take ...Do you know anything about Chengdu Research Base of Giant Panda Breeding?Do you have any idea of how to get there?Now let me be your guide to introduce it to you.First of all,let’s talk about the transportation.Take subway line 3 to Panda Avenue Station,exit from Exit A,and then wait for a direct bus which takes you to the base at the station.展开更多
文摘A crucial feature of nanoparticles,such as liposomes,magnetic nanoparticles,quantum dots,metallic nanoparticles,silica nanoparticles,polymersomes and dendrimers etc.,is their higher accumulation in the tumor than in normal tissues1-3.Various nanoparticles have been intensively used as vehicles to deliver
文摘The field of vascular medicine has undergone a profound transformation in the 21st century,transforming our approach to assessment and treatment.Athero-sclerosis,a complex inflammatory disease that affects medium and large arteries,presents a major challenge for researchers and healthcare professionals.This condition,characterized by arterial plaque formation and narrowing,poses sub-stantial challenges to vascular health at individual,national,and global scales.Its repercussions are far-reaching,with clinical outcomes including ischemic heart disease,ischemic stroke,and peripheral arterial disease—conditions with esca-lating global prevalence.Early detection of vascular changes caused by athero-sclerosis is crucial in preventing these conditions,reducing morbidity,and averting mortality.This article underscored the imperative of adopting a holistic approach to grappling with the intricacies,trajectories,and ramifications of atherosclerosis.It stresses the need for a thorough evaluation of the vasculature and the implementation of a multidisciplinary treatment approach.By consi-dering the entire vascular system,healthcare providers can explore avenues for prevention,early detection,and effective management of this condition,ultima-tely leading to improved patient outcomes.We discussed current practices and proposed new directions made possible by emerging diagnostic modalities and treatment strategies.Additionally,we considered healthcare expenditure,resour-ce allocation,and the transformative potential of new innovative treatments and technologies.
文摘Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in reduced blood flow and oxygen to the brain, leading to progressive symptoms and potential complications. The underlying pathophysiological mechanism remains elucidated. However, recent studies have highlighted numerous etiologic factors: abnormal immune complex responses, susceptibility genes, branched-chain amino acids, antibodies, heritable diseases, and acquired diseases, which may be the great potential triggers for the development of moyamoya disease. Its clinical presentation has varying degrees from transient asymptomatic events to significant neurological deficits. Moyamoya disease (MMD) shows different patterns in children and adults. Children with MMD are more susceptible to ischemic events due to decreased blood flow to the brain. Conversely, adults with MMD are more prone to hemorrhagic events involving brain bleeding. Children with MMD may experience a range of symptoms including motor impairments, sensory issues, seizures, headaches, dizziness, cognitive delays, or ongoing neurological problems. Although adults may present with similar clinical symptoms as children, they are more prone to experiencing sudden onset intraventricular, subarachnoid, or intracerebral hemorrhages. One of the challenges in moyamoya disease is the potential for misdiagnosis or delayed diagnosis, particularly when physicians fail to consider MMD as a possible cause in stroke patients. This review aims to provide a comprehensive overview of recent global studies on the pathophysiology of MMD, along with advancements in its management. Additionally, the review will delve into various surgical treatment options for MMD, as well as its rare occurrence alongside atrioventricular malformations. Exciting prospects include the use of autologous bone marrow transplant and the potential role of Connexin 43 protein treatment in the development of moyamoya disease.
文摘Beijing’s iconic Tian’anmen Square joined in the celebrations for the 75th birth anniversary of the People’s Republic of China with some spectacular flowerscapes.The huge flower basket on a red raised platform is inscribed“Blessing the Motherland”and overflows with flowers and fruits to symbolize the prosperity of the mature republic.There are dazzling displays in other parts of the capital as well.The Chang’an Avenue in downtown Beijing has themed flower beds,ideal for taking selfies or just to admire.
文摘NO one can precisely describe Beijing with a single word or sentence due to its extreme complexity.Every passenger who arrives in Beijing by plane is welcomed by an ocean of light.The light resembles boiling magma,flowing along a layout of the city in an orderly manner.If Chang’an Avenue,Sanlitun,China World Trade Center,and National Olympic Sports Center are highlights of Beijing,the hutong s(lanes)distributed along the Central Axis represent the other side of the capital city.They tell the stories of this city and its citizens with a subtler voice.In these places where the city’s neon lights cannot reach,the essence of the city’s daily life exists in a small restaurant,a tanghulu(a traditional Chinese snack of candied fruit),or even a bowl of fermented soybean drink.
文摘Heilongjiang is a paradise of ice and snow in winter,with the Ice and Snow World,Saint Sophia Cathedral,the Central Avenue,Snow Town,the Aurora...thousands of wonders waiting to greet every visitor.The iceand snow here are extremely romantic,with rich cultural diversityand warmhearted and hospitable people.From December 21 to 27,2023,"Nihao!China"2024 Chinalce&SnowTourism OverseasPromotionSeason demonstrated"Heilongjiang Overseas Promotion Week".
文摘Sinohydro and Senegal join forces to provide drinking water in Dakar.Sinohydro,a subsidiary of PowerChina,is currently engaged in efforts to substantially enhance the potable water supply in Dakar,Senegal.A diligent group of Chinese and Senegalese workers is engaged in roundthe-clock efforts along the Avenue du Front de Terre prolongée,which marks the starting point of the Route des Pères Maristes,with the objective of improving the distribution network for potable water in the Dakar Department.With a population density of 7,277 inhabitants per square km and an estimated 1.18 million inhabitants in 2023,there is an evident and increasing need for potable water.This need is further compounded by significant water loss caused by the advanced age of the pipelines,with some pipes dating back to the colonial era.
文摘The year 2024 will be an important one for China-Africa relations,as the summit of the Forum on China-Africa Cooperation(FOCAC)will be held on 4-6 September in Beijing.This summit will not only demonstrate the determination of China and African countries to strengthen bilateral cooperation,but also outline the roadmap for future common development.
文摘China remains a key source of growth and profits for many multinationals In March,Apple opened its largest retail store on the Chinese mainland in Shanghai-the company’s second-largest flagship store after its Fifth Avenue outlet in New York.The new addition brings Apple’s store tally in Shanghai and the Chinese market to eight and 57,respectively,a significant milestone for the company,which opened its first store in China in 2008.
文摘Comparison of Doses from Disposals of Technologically Enhanced Naturally Occurring Radioactive Materials in Kentucky and Oregon Emily A.Caffrey1,Arthur S.Rood2,Helen A.Grogan3,Colby Mangini4,John E.Till5(1.Radian Scientific,LLC,806 Wells Ave SE,Huntsville,AL 35801;2.K-Spar,Inc.,4835 W Foxtrail Lane,Idaho Falls,ID 83402;3.Cascade Scientific,Inc.,1678 NWAlbany Avenue,Bend,OR 97703;4.Paragon Scientific,LLC,725 Rucker Avenue,Everett,WA 98201;5.Risk Assessment Corporation,417 Till Road,Neeses,SC 29107)Abstract:Oil and natural gas fracking waste contains technologically enhanced naturally occurring radioactive material(TENORM)and has increasingly been disposed of in unpermitted landfills,causing concern among regulators and the public about potential exposures.There are numerous issues with TENORM waste,including the lack of Federal regulations on its disposal and the lack of permitted landfills capable of accepting these waste streams.This paper examines two situations in which TENORM was placed in unpermitted landfills,one in Kentucky and one in Oregon.The same modeling and dose calculation methods were used in both cases,allowing for a comparison between the two sites.
文摘Since 2018,the China International Import Expo(CIIE),held annually in Shanghai,has been serving as an important platform for China to advance its high-quality opening up to the outside world.More and more countries,especially African countries,are using this platform to showcase what they have to offer to the Chinese market and expand their exports to China,which helps to reduce trade imbalances.
文摘Do you know anything about Chengdu Research Base of Giant Panda Breeding?Do you have any idea of how to get there?Now let me be your guide to introduce it to you.First of all,let’s talk about the transportation.Take subway line 3 to Panda Avenue Station,exit from Exit A,and then wait for a direct bus which takes you to the base at the station.
