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Numerical and Experimental Investigation of High-efficiency Axial-flow Pump 被引量:50
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作者 SHI Weidong ZHANGDesheng GUAN Xingfan LENG Hongfei 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2010年第1期38-44,共7页
The experimental investigation of axial-flow pump has been rapidly developed to meet the needs of South-to-North Water Diversion Project of China. Owing to the boundary conditions of hub, blade tip clearance, much of ... The experimental investigation of axial-flow pump has been rapidly developed to meet the needs of South-to-North Water Diversion Project of China. Owing to the boundary conditions of hub, blade tip clearance, much of the physical phenomena and laws involved in this complex flow field can't be fully determined. The flow characteristics of the high efficiency axial-flow pump have been simulated by RNG k-e turbulence model and SIMPLEC arithmetic based on FLUENT software. Numerical results indicate that the data from the prediction show agreement with the experimental results, static pressure on pressure side of blades increases slightly at circumferential direction with radius increasing, and keep almost constant at the same radial while increasing gradually from inlet to exit on the suction side along flow direction at design conditions. The static pressure, total pressure and velocity at inlet, impeller outlet and vane outlet were measured by a five-hole probe, and a contrastive experiment was done to investigate the influence of hub leakage. The experimental results show that inlet flow is almost axial and the prerotation is very small at various conditions. The meridional velocity and circulation distribution are almost identical at impeller outlet at design conditions due to steady flow and high efficiency. The residual circulation exits at downstream of the guide vane, and the circumferential velocity component increases linearly from hub to tip at small flow rate conditions. Hub leakage in adjustable blades results in the decrease of the meridional velocity and circulation at blade exit near hub. The results of numerical simulation and experiments supply important flow structure information for the high-efficiency axial-flow pump. 展开更多
关键词 axial-flow pump flow field multi-conditions high efficiency PROBE hub leakage
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The Effects of Axial-Flow Pump in Supporting of Regional Ischemic Left Ventricle: A Simulation Study
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作者 Bing Zhao and Jing Bai(Department of Electrical Engineering, The School of Life Science and Engineering,Tsinghua University, Beijing 100084, China) 《Chinese Journal of Biomedical Engineering(English Edition)》 1999年第3期46-47,共2页
关键词 Simulation A Simulation Study The Effects of axial-flow pump in Supporting of Regional Ischemic Left Ventricle FLOW
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Effects of proton pump inhibitors on inflammatory bowel disease:An updated review 被引量:2
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作者 Yu Liang Zhen Meng +1 位作者 Xue-Li Ding Man Jiang 《World Journal of Gastroenterology》 SCIE CAS 2024年第21期2751-2762,共12页
Inflammatory bowel disease(IBD)is believed to be caused by various factors,including abnormalities in disease susceptibility genes,environmental factors,immune factors,and intestinal bacteria.Proton pump inhibitors(PP... Inflammatory bowel disease(IBD)is believed to be caused by various factors,including abnormalities in disease susceptibility genes,environmental factors,immune factors,and intestinal bacteria.Proton pump inhibitors(PPIs)are the primary drugs used to treat acid-related diseases.They are also commonly prescribed to patients with IBD.Recent studies have suggested a potential association between the use of certain medications,such as PPIs,and the occurrence and progression of IBD.In this review,we summarize the potential impact of PPIs on IBD and analyze the underlying mechanisms.Our findings may provide insights for conducting further investigations into the effects of PPIs on IBD and serve as an important reminder for physicians to exercise caution when prescribing PPIs to patients with IBD. 展开更多
关键词 Drug safety Proton pump inhibitor Inflammatory bowel disease Ulcerative colitis Crohn’s disease
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Ultra-Robust and High-Performance Rotational Triboelectric Nanogenerator by Bearing Charge Pumping 被引量:1
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作者 Xianpeng Fu Yuhan Qin +6 位作者 Zhi Zhang Guoxu Liu Jie Cao Beibei Fan Zhaozheng Wang Zheng Wang Chi Zhang 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第2期343-349,共7页
As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in pra... As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in practical applications.Here,an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG)by bearing charge pumping is proposed.The R-TENG composes of a pumping TENG(P-TENG),an output TENG(O-TENG),a voltage-multiplying circuit(VMC),and a buffer capacitor.The P-TENG is designed with freestanding mode based on a rolling ball bearing,which can also act as the rotating mechanical energy harvester.The output low charge from the P-TENG is accumulated and pumped to the non-contact O-TENG,which can simultaneously realize ultralow mechanical wear and high output performance.The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min.Furthermore,the transferring charge of R-TENG can remain 95%during 15 days(6.4×10^(6)cycles)continuous operation.This work presents a realizable method to further enhance the durability of TENG,which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy. 展开更多
关键词 bearing charge pumping triboelectric nanogenerators ultralow mechanical wear ultra-robust voltage-multiplying circuit
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An NMOS output-capacitorless low-dropout regulator with dynamic-strength event-driven charge pump 被引量:1
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作者 Yiling Xie Baochuang Wang +1 位作者 Dihu Chen Jianping Guo 《Journal of Semiconductors》 EI CAS CSCD 2024年第6期23-34,共12页
In this paper,an NMOS output-capacitorless low-dropout regulator(OCL-LDO)featuring dual-loop regulation has been proposed,achieving fast transient response with low power consumption.An event-driven charge pump(CP)loo... In this paper,an NMOS output-capacitorless low-dropout regulator(OCL-LDO)featuring dual-loop regulation has been proposed,achieving fast transient response with low power consumption.An event-driven charge pump(CP)loop with the dynamic strength control(DSC),is proposed in this paper,which overcomes trade-offs inherent in conventional structures.The presented design addresses and resolves the large signal stability issue,which has been previously overlooked in the event-driven charge pump structure.This breakthrough allows for the full exploitation of the charge-pump structure's poten-tial,particularly in enhancing transient recovery.Moreover,a dynamic error amplifier is utilized to attain precise regulation of the steady-state output voltage,leading to favorable static characteristics.A prototype chip has been fabricated in 65 nm CMOS technology.The measurement results show that the proposed OCL-LDO achieves a 410 nA low quiescent current(IQ)and can recover within 30 ns under 200 mA/10 ns loading change. 展开更多
关键词 output-capacitorless low-dropout regulator fast transient low quiescent current event-driven charge pump
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Preface:Development and utilization of pumped storage in closed/abandoned mines
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作者 WEN Zhi-jie JIANG Yu-jing +3 位作者 ZHAO Guang-ming LI Li-ping PU Hai YANG Sheng-li 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2545-2548,共4页
China has embarked on an extensive and sustained endeavor to harness its coal resources for a substantial period.However,the depletion of coal reserves in mining regions has necessitated the closure or abandonment of ... China has embarked on an extensive and sustained endeavor to harness its coal resources for a substantial period.However,the depletion of coal reserves in mining regions has necessitated the closure or abandonment of numerous mines,resulting in a marked increase in the number of such facilities.Parallel to this,China is vigorously advancing the development of a novel energy power system,aimed at transitioning the power sector from a high-carbon,fossil fuel-dependent paradigm to a low-carbon,clean energy footing. 展开更多
关键词 pumpED SUSTAINED CLOSURE
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An LED-Side-Pumped Intracavity Frequency-Doubled Nd,Ce:YAG Laser Producing a 2W Q-Switched Red Beam
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作者 沈建平 徐少聪 +6 位作者 芦鹏 江容容 王巍 张四维 邢凤阳 陈阳 陈亮 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第3期44-47,共4页
We report a high-average-power acousto-optic(AO)Q-switched intracavity frequency-doubled red laser based on a high-efficiency light-emitting-diode(LED)pumped two-rod Nd,Ce:YAG laser module.Under quasi-continuous wave ... We report a high-average-power acousto-optic(AO)Q-switched intracavity frequency-doubled red laser based on a high-efficiency light-emitting-diode(LED)pumped two-rod Nd,Ce:YAG laser module.Under quasi-continuous wave operation conditions,a maximum output power of 1319.08 nm wavelength was achieved at 11.26 W at a repetition rate of 100 Hz. 展开更多
关键词 pumpED SWITCHED LASER
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Wear dependent virtual flow rate sensor for progressing cavity pumps with deformable stator
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作者 Jens Müller Sebastian Leonow +2 位作者 Johannes Schulz Christian Hansen Martin Monnigmann 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1346-1353,共8页
This contribution presents a novel wear dependent virtual flow rate sensor for single stage single lobe progressing cavity pumps. We study the wear-induced material loss of the pump components and the impact of this m... This contribution presents a novel wear dependent virtual flow rate sensor for single stage single lobe progressing cavity pumps. We study the wear-induced material loss of the pump components and the impact of this material loss on the volumetric efficiency. The results are combined with an established backflow model to implement a backflow calculation procedure that is adaptive to wear. We use a laboratory test setup with a highly abrasive fluid and operate a pump from new to worn condition to validate our approach. The obtained measurement data show that the presented virtual sensor is capable of calculating the flow rate of a pump being subject to wear during its regular operation. 展开更多
关键词 BACKFLOW Progressing cavity pump Virtual sensor WEAR
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Dual-wavelength pumped latticed Fermi-Pasta-Ulam recurrences in nonlinear Schrödinger equation
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作者 张倩 姚献坤 董恒 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期277-280,共4页
We show that the nonlinear stage of the dual-wavelength pumped modulation instability(MI)in nonlinear Schrödinger equation(NLSE)can be effectively analyzed by mode truncation methods.The resulting complicated het... We show that the nonlinear stage of the dual-wavelength pumped modulation instability(MI)in nonlinear Schrödinger equation(NLSE)can be effectively analyzed by mode truncation methods.The resulting complicated heteroclinic structure of instability unveils all possible dynamic trajectories of nonlinear waves.Significantly,the latticed-Fermi-Pasta-Ulam recurrences on the modulated-wave background in NLSE are also investigated and their dynamic trajectories run along the Hamiltonian contours of the heteroclinic structure.It is demonstrated that there has much richer dynamic behavior,in contrast to the nonlinear waves reported before.This novel nonlinear wave promises to inject new vitality into the study of MI. 展开更多
关键词 modulation instability dual-wavelength pumps latticed-Fermi-Pasta-Ulam recurrences
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In-phase and out-of-phase spin pumping effects in Py/Ru/Pysynthetic antiferromagnetic structures
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作者 Zhaocong Huang Xuejian Tang +5 位作者 Qian Chen Wei Jiang Qingjie Guo Milad Jalali Jun Du Ya Zhai 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第9期541-545,共5页
The spin pumping effect in magnetic heterostructures and multilayers is a highly effective method for the generationand transmission of spin currents. In the increasingly prominent synthetic antiferromagnetic structur... The spin pumping effect in magnetic heterostructures and multilayers is a highly effective method for the generationand transmission of spin currents. In the increasingly prominent synthetic antiferromagnetic structures, the two ferromagneticlayers demonstrate in-phase and out-of-phase states, corresponding to acoustic and optical precession modes. Withinthis context, our study explores the spin pumping effect in Py/Ru/Py synthetic antiferromagnetic structures across differentmodes. The heightened magnetic damping resulting from the spin pumping effect in the in-phase state initially decreaseswith increasing Py thickness before stabilizing. Conversely, in the out-of-phase state, the amplified damping exceeds thatof the in-phase state, suggesting a greater spin relaxation within this configuration, which demonstrates sensitivity to alterationsin static exchange interactions. These findings contribute to advancing the application of synthetic antiferromagneticstructures in magnonic devices. 展开更多
关键词 SPIN pumpING SPIN transmission synthetic ANTIFERROMAGNETIC STRUCTURES SPIN dynamics
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Dynamic response characteristics of muddy sandstone in pumped storage mine under action of high-stress dynamic disturbance
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作者 LIANG Bin WANG Dong +3 位作者 LUAN Heng-jie DONG Ling LIU Jian-kang WANG Chang-sheng 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2736-2747,共12页
During the construction and operation of the abandoned mine pumped storage power station,the underground space surrounding rock body faces the complex stress environment under the action of mining disturbance,frequent... During the construction and operation of the abandoned mine pumped storage power station,the underground space surrounding rock body faces the complex stress environment under the action of mining disturbance,frequent pumping,water storage and other dynamic disturbances.The stability of the abandoned mine surrounding rock body is the basis for guaranteeing the safety and effectiveness of water storage in the underground space of the abandoned mine.By considering the two main factors of different stress levels and disturbance amplitudes,the mechanical properties,damage characteristics and acoustic emission characteristics of the abandoned mine perimeter rock body under dynamic disturbance were investigated using a creep-disturbed dynamic impact loading system.The experimental results show that:1)The stress level is considered to be the major contributing factor of the failure of muddy sandstone,followed by the amplitude of the disturbances;2)The time required for the destruction of muddy sandstone decreases with the increase of amplitude.When the stress level is 80%,the sandstone specimens have a decreasing number of cycles as the disturbance amplitude increases.The disturbance amplitude is sequentially increased from 4 MPa to 5,6,7,and 8 MPa,the number of cycles required for specimen destruction decreases significantly by 96.71%,99.13%,99.60%,and 99.93%,respectively;3)Disturbance amplitude and stress level have a significant effect on muddy sandstone damage and damage occurs only after a certain threshold is reached.With the increase of stress level and disturbance amplitude,the macroscopic damage of muddy sandstone is mainly conical,with obvious flake spalling and poor damage integrity;4)According to the time-dependent changes in AE energy and ringing counts,the acoustic emission activity during the failure process could be divided into three phases,namely,weakening period,smooth period,and surge period,corresponding to the compaction phase,elastic rise phase and post-peak damage phase.The research results are of reference significance for the damage evolution analysis of muddy sandstone under dynamic disturbance and the safety and stability of abandoned mine perimeter rock body. 展开更多
关键词 abandoned mine pumped storage dynamic disturbance muddy sandstone acoustic emission
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Numerical Simulation and Entropy Production Analysis of Centrifugal Pump with Various Viscosity
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作者 Zhenjiang Zhao Lei Jiang +2 位作者 Ling Bai Bo Pan Ling Zhou 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第11期1111-1136,共26页
The fluid’s viscosity significantly affects the performance of a centrifugal pump.The entropy production method and leakage are employed to analyze the performance changes under various viscosities by numerical simul... The fluid’s viscosity significantly affects the performance of a centrifugal pump.The entropy production method and leakage are employed to analyze the performance changes under various viscosities by numerical simulation and validated by experiments.The results showed that increasing viscosity reduces both the pump head and efficiency.In addition,the optimal operating point shifts to the left.Leakage is influenced by vortex distribution in the front chamber and boundary layer thickness in wear-ring clearance,leading to an initial increase and subsequent decrease in leakage with increasing viscosity.The total entropy production Spro,Total inside the pump rises with increasing viscosity.The different mechanisms dominate under varying conditions:Turbulent dissipation dominates at low viscosity.Under high-viscosity conditions,energy loss is primarily caused by direct dissipation Spro,D and wall entropy production Spro,W.This study provides a deeper and more objective understanding of the energy characteristics of centrifugal pumps handling fluids of various viscosity,potentially aiding in optimizing pump design and improving energy conversion efficiency. 展开更多
关键词 Centrifugal pump numerical simulation VISCOSITY LEAKAGE entropy production
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Research on pumped storage and complementary energy development models for abandoned mines in China
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作者 YANG Ke LYU Xin +3 位作者 XU Chao-shui FANG Jue-jing DUAN Min-ke ZHANG Zhai-nan 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2860-2871,共12页
Within the framework of achieving carbon neutrality,various industries are confronted with fresh challenges.The ongoing process of downsizing coal industry operations has evolved into a new phase,with the burgeoning p... Within the framework of achieving carbon neutrality,various industries are confronted with fresh challenges.The ongoing process of downsizing coal industry operations has evolved into a new phase,with the burgeoning proliferation of abandoned mines posing a persistent issue.Addressing the challenges and opportunities presented by these abandoned mines,this paper advocates for a scientific approach centered on the advancement of pumped storage energy alongside gas-oil complementary energy.Leveraging abandoned mine tunnels to establish pumped storage power stations holds significant ecological and economic importance for repurposing these sites.This initiative not only serves as an effective means to restore the ecological balance in mining regions but also provides an environmentally friendly approach to repurposing abandoned mine tunnels,offering a blueprint for economically viable pumped storage power stations.This article delineates five crucial scientific considerations and outlines seven primary models for the utilization of abandoned mine sites,delineating a novel,comprehensive pathway for energy and power development that emphasizes multi-energy complementarity and synergistic optimization within abandoned mines. 展开更多
关键词 abandoned mines pumped storage underground reservoir energy systems carbon neutrality
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Transient Experiments on a Prototype Pump with an Atypical Open Impeller for Different Discharge Valve Openings
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作者 Xiao Sun Huifan Huang +4 位作者 Yuliang Zhang Lianghuai Tong Xiaowei Xu Xiaoqi Jia Litao Ou 《Fluid Dynamics & Materials Processing》 EI 2024年第10期2251-2264,共14页
In order to obtain the transient characteristics of a low-speed centrifugal pump during the start-up and shutdown stages,dedicated experimental tests were conducted with eight different valve opening conditions.The Pe... In order to obtain the transient characteristics of a low-speed centrifugal pump during the start-up and shutdown stages,dedicated experimental tests were conducted with eight different valve opening conditions.The Pearson correlation coefficient was used to reveal the linear correlation between variables.According to the results,the stable rotational speed decreases with increasing valve opening(rotational speed decreases from approximately 1472 to 1453 r/min),while the stable shaft power exhibits an increasing trend(shaft power increases from approximately 0.242 to 0.390 kW).The stable time and zeroing time of each parameter during start-up and shutdown processes vary,with the flow zeroing time significantly increasing with the relative flow,reaching up to 10.468 s,while the shaft power zeroing time is roughly between 1.219 and 1.375 s.The results demonstrate that with increasing valve opening,the stable and zeroing time of flow significantly increase(|r|greater than 0.95),while the stable and zeroing time of rotational speed,power,and head display a smaller sensitivity on the valve opening(|r|less than 0.6). 展开更多
关键词 Centrifugal pump STARTUP SHUTDOWN external characteristics zeroing time
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Research on Cavitation Characteristics and Influencing Factors of Herringbone Gear Pump
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作者 Jinlong Yang Kwang-Hee Lee Chul-Hee Lee 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期2917-2946,共30页
Cavitation is a common issue in pumps,causing a decrease in pump head,a fall in volumetric efficiency,and an intensification of outlet flow pulsation.It is one of the main hazards that affect the regular operation of ... Cavitation is a common issue in pumps,causing a decrease in pump head,a fall in volumetric efficiency,and an intensification of outlet flow pulsation.It is one of the main hazards that affect the regular operation of the pump.Research on pump cavitation mainly focuses on mixed flow pumps,jet pumps,external spur gear pumps,etc.However,there are few cavitation studies on external herringbone gear pumps.In addition,pumps with different working principles significantly differ in the flow and complexity of the internal flow field.Therefore,it is urgent to study the cavitation characteristics of external herringbone gear pumps.Compared with experimentalmethods,visual research and cavitation area identification are achieved through computation fluid dynamic(CFD),and changing the boundary conditions and shape of the gear rotor is easier.The simulation yields a head error of only 0.003%under different grid numbers,and the deviation between experimental and simulation results is less than 5%.The study revealed that cavitation causes flow pulsation at the outlet,and the cavitation serious area is mainly distributed in the meshing gap and meshing area.Cavitation can be inhibited by reducing the speed,increasing the inlet pressure,and changing the helix angle can be achieved.For example,when the inlet pressure is 5 bar,the maximumgas volume fraction in themeshing area is less than 50%.These results provide a reference for optimizing the design and finding the optimal design parameters to reduce or eliminate cavitation. 展开更多
关键词 Herringbone gear pump CAVITATION rotating speed inlet pressure helix angle TwinMesh
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Evaluation of development potential of pumped hydroelectric storage and geothermal utilization system in abandoned coal mine
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作者 WANG Meng GUO Ping-ye +3 位作者 JIN Xin DANG Guan-jie GUO Yi-chen LI Yi 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2872-2890,共19页
Every year in China,a significant number of mines are closed or abandoned.The pumped hydroelectric storage(PHS)and geothermal utilization are vital means to efficiently repurpose resources in abandoned mine.In this wo... Every year in China,a significant number of mines are closed or abandoned.The pumped hydroelectric storage(PHS)and geothermal utilization are vital means to efficiently repurpose resources in abandoned mine.In this work,the development potentials of the PHS and geothermal utilization systems were evaluated.Considering the geological conditions and meteorological data available of Jiahe abandoned mine,a simple evaluation model for PHS and geothermal utilization was established.The average efficiency of the PHS system exceeds 70%and the regulatable energy of a unit volume is over 1.53 kW·h/m^(3).The PHS system achieves optimal performance when the wind/solar power ratio reaches 0.6 and 0.3 in daily and year scale,respectively.In the geothermal utilization system,the outlet temperature and heat production are significantly affected by the injection flow rate.The heat production performance is more stable at lower rate flow,and the proportion of heat production is higher in the initial stage at greater flow rate.As the operating time increases,the proportion of heat production gradually decreases.The cyclic heat storage status has obvious advantages in heat generation and cooling.Furthermore,the energy-saving and emission reduction benefits of PHS and geothermal utilization systems were calculated. 展开更多
关键词 abandoned mine underground reservoir wind/solar energy pumped hydroelectric storage GEOTHERMAL
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A Numerical Study on the Effect of the Backflow Hole Position on the Performances of a Self-Priming Pump
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作者 Dongwei Wang Lijian Cao +1 位作者 Weidong Wang Jiajun Hu 《Fluid Dynamics & Materials Processing》 EI 2024年第5期1103-1122,共20页
A self-priming pump is a centrifugal pump that has the ability to prime itself. Typically, its performance dependson the configuration of its reflux hole. In this study, the ANSYS FLUENT software is used to investigat... A self-priming pump is a centrifugal pump that has the ability to prime itself. Typically, its performance dependson the configuration of its reflux hole. In this study, the ANSYS FLUENT software is used to investigate the effectsof three different radial positions of the reflux hole on gas-liquid two-phase distribution, pressure pulsation, andimp during self-priming. The research results indicate that: (1) The effective channel size for the reflux liquid toenter the volute varies depending on the location of the reflux hole. The effect of the impeller rotation on thereflux liquid becomes more obvious as the setting distance of the reflux aperture decreases. (2) The position ofthe reflux hole significantly affects the gas phase mass fraction inside the impeller, resulting in a significant reductionin the time it takes for the mass fraction to exceed 80%. (3) The position of the reflux hole significantly affectsthe average pressure on each monitoring surface. (4) Placing the reflux hole at a excessively distant radial distancecan result in an excessive vertical component. (5) The self-priming performance of the pump can be improved tosome extent by placing the return hole at a small radial distance. 展开更多
关键词 Self-priming pump self-priming time numerical calculation gas-liquid two-phase flow
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Overlapping approach Proton Pump Inhibitors/Nux vomica-Heel as new intervention for gastro-esophageal reflux management:Delphi consensus study
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作者 Edda Battaglia Luciano Bertolusso +2 位作者 Marco Del Prete Marco Monzani Marco Astegiano 《World Journal of Gastroenterology》 SCIE CAS 2024年第18期2467-2478,共12页
BACKGROUND Gastro-esophageal reflux disease(GERD)may affect the upper digestive tract;up to 20%of population in Western nations are affected by GERD.Antacids,histamine H2-receptor antagonists,and Proton Pump Inhibitor... BACKGROUND Gastro-esophageal reflux disease(GERD)may affect the upper digestive tract;up to 20%of population in Western nations are affected by GERD.Antacids,histamine H2-receptor antagonists,and Proton Pump Inhibitors(PPIs)are considered the referring medications for GERD.Nevertheless,PPIs must be managed carefully because their use,especially chronic,could be linked with some adverse effects.An effective and safe alternative pharmacological tool for GERD is needed.After the identification of potentially new medications to flank PPIs,it is mandatory to revise and improve good clinical practices even through a consensus process.AIM To optimize diagnosis and treatment guidelines for GERD through a consensus based on Delphi method.METHODS The availability of clinical studies describing the action of the multicomponent/multitarget medication Nux vomica-Heel,subject of the consensus,is the basic prerequisite for the consensus itself.A modified Delphi process was used to reach a consensus among a panel of Italian GERD specialists on the overlapping approach PPIs/Nux vomica-Heel as a new intervention model for the management of GERD.The Voting Consensus group was composed of 49 Italian Medical Doctors with different specializations:Gastroenterology,otolaryngology,geriatrics,and general medicine.A scientific committee analyzed the literature,determined areas that required investigation(in agreement with the multiple-choice questionnaire results),and identified two topics of interest:(1)GERD disease;and(2)GERD treatment.Statements for each of these topics were then formulated and validated.The Delphi process involved two rounds of questioning submitted to the panel experts using an online platform.RESULTS According to their routinary GERD practice and current clinical evidence,the panel members provided feedback to each questionnaire statement.The experts evaluated 15 statements and reached consensus on all 15.The statements regarding the GERD disease showed high levels of agreement,with consensus ranging from 70%to 92%.The statements regarding the GERD treatment also showed very high levels of agreement,with consensus ranging from 90%to 100%.This Delphi process was able to reach consensus among physicians in relevant aspects of GERD management,such as the adoption of a new approach to treat patients with GERD based on the overlapping between PPIs and Nux vomica-Heel.The consensus was unanimous among the physicians with different specializations,underlying the uniqueness of the agreement reached to identify in the overlapping approach between PPIs and Nux vomica-Heel a new intervention model for GERD management.The results support that an effective approach to deprescribe PPIs through a progressive decalage timetable(reducing PPIs administration to as-needed use),should be considered.CONCLUSION Nux vomica-Heel appears to be a valid opportunity for GERD treatment to favor the deprescription of PPIs and to maintain low disease activity together with the symptomatology remission. 展开更多
关键词 Gastro-esophageal reflux disease Proton pump Inhibitors CONSENSUS Nux vomica-Heel OVERLAPPING Decalage
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Optimal Design of High-Speed Partial Flow Pumps using Orthogonal Tests and Numerical Simulations
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作者 Jiaqiong Wang Tao Yang +2 位作者 Chen Hu Yu Zhang Ling Zhou 《Fluid Dynamics & Materials Processing》 EI 2024年第6期1203-1218,共16页
To investigate the influence of structural parameters on the performances and internal flow characteristics of partial flow pumps at a low specific speed of 10000 rpm,special attention was paid to the first and second... To investigate the influence of structural parameters on the performances and internal flow characteristics of partial flow pumps at a low specific speed of 10000 rpm,special attention was paid to the first and second stage impeller guide vanes.Moreover,the impeller blade outlet width,impeller inlet diameter,blade inclination angle,and number of blades were considered for orthogonal tests.Accordingly,nine groups of design solutions were formed,and then used as a basis for the execution of numerical simulations(CFD)aimed at obtaining the efficiency values and heads for each design solution group.The influence of impeller geometric parameters on the efficiency and head was explored,and the“weight”of each factor was obtained via a range analysis.Optimal structural parameters were finally chosen on the basis of the numerical simulation results,and the performances of the optimized model were verified accordingly(yet by means of CFD).Evidence is provided that the increase in the efficiency and head of the optimized model was 12.11%and 23.5 m,respectively,compared with those of the original model. 展开更多
关键词 HIGH-SPEED partial flow pump orthogonal test optimal design numerical calculation
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Clogging caused by coupled grain migration and compaction effect during groundwater recharge for unconsolidated sandstone reservoir in groundwater-source heat pump
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作者 Fujian Yang Jing Luo +3 位作者 Guiling Wang Hejuan Liu Dawei Hu Hui Zhou 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第8期2947-2959,共13页
In unconsolidated sandstone reservoirs,presence of numerous movable grains and a complex grain size composition necessitates a clear understanding of the physical clogging process for effective groundwater recharge in... In unconsolidated sandstone reservoirs,presence of numerous movable grains and a complex grain size composition necessitates a clear understanding of the physical clogging process for effective groundwater recharge in groundwater-source heat pump systems.To investigate this,a series of seepage experiments was conducted under in situ stress conditions using unconsolidated sandstone samples with varying grain compositions.The clogging phenomenon arises from the combined effects of grain migration and compaction,wherein the migration of both original and secondary crushed fine-grain particles blocks the seepage channels.Notably,grain composition influences the migration and transport properties of the grains.For samples composed of smaller grains,the apparent permeability demonstrates a transition from stability to decrease.In contrast,samples with larger grains experience a skip at the stability stage and directly enter the decrease stage,with a minor exception of a slight increase observed.Furthermore,a unique failure mode characterized by diameter shrinkage in the upper part of the sample is observed due to the combined effects of grain migration and in situ stress-induced compaction.These testing results contribute to a better understanding of the clogging mechanism caused by the coupled effects of grain migration and compaction during groundwater recharge in unconsolidated sandstone reservoirs used in groundwater-source heat pump systems. 展开更多
关键词 Groundwater-source heat pump CLOGGING Grain migration Compaction effect Groundwater recharge Unconsolidated sandstone
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