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Axoplasmic Transport in the Rats From Growing to Senility
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作者 范明 甘思德 《Chinese Science Bulletin》 SCIE 1993年第9期753-756,共4页
One of the outstanding features of neuron is that axon lacks the ability to synthesize proteins. The structural and functional materials needed for axonal growing and regeneration have to be prepared in its cell body,... One of the outstanding features of neuron is that axon lacks the ability to synthesize proteins. The structural and functional materials needed for axonal growing and regeneration have to be prepared in its cell body, and then supplied by axoplasmic transport. In our previous work, we have found that the transport rate of some slow-transported proteins is accelerated during regeneration. Because some changes 展开更多
关键词 GROWING SENILE axoplasmic TRANSPORT
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Potential physiological and pathological roles for axonal ryanodine receptors
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作者 David P.Stirling 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第4期756-759,共4页
Clinical disability following trauma or disease to the spinal cord often involves the loss of vital white matter elements including axons and glia.Although excessive Cais an established driver of axonal degeneration,t... Clinical disability following trauma or disease to the spinal cord often involves the loss of vital white matter elements including axons and glia.Although excessive Cais an established driver of axonal degeneration,therapeutically targeting externally sourced Cato date has had limited success in both basic and clinical studies.Contributing factors that may underlie this limited success include the complexity of the many potential sources of Caentry and the discovery that axons also contain substantial amounts of stored Cathat if inappropriately released could contribute to axonal demise.Axonal Castorage is largely accomplished by the axoplasmic reticulum that is part of a continuous network of the endoplasmic reticulum that provides a major sink and source of intracellular Cafrom the tips of dendrites to axonal terminals.This“neuron-within-a-neuron”is positioned to rapidly respond to diverse external and internal stimuli by amplifying cytosolic Calevels and generating short and long distance regenerative Cawaves through Cainduced Carelease.This review provides a glimpse into the molecular machinery that has been implicated in regulating ryanodine receptor mediated Carelease in axons and how dysregulation and/or overstimulation of these internodal axonal signaling nanocomplexes may directly contribute to Ca-dependent axonal demise.Neuronal ryanodine receptors expressed in dendrites,soma,and axonal terminals have been implicated in synaptic transmission and synaptic plasticity,but a physiological role for internodal localized ryanodine receptors remains largely obscure.Plausible physiological roles for internodal ryanodine receptors and such an elaborate internodal binary membrane signaling network in axons will also be discussed. 展开更多
关键词 axomyelinic synapse AXON axoplasmic reticulum calcium ryanodine receptor secondary axonal degeneration spinal cord injury voltage-gated calcium channel white matter injury
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