The studies of asymmetric vortices flow over slender body and its active control at high angles of attack have significant importance for both academic field and engineering area.This paper attempts to provide an upda...The studies of asymmetric vortices flow over slender body and its active control at high angles of attack have significant importance for both academic field and engineering area.This paper attempts to provide an update state of art to the investigations on the fields of forebody asymmetric vortices.This review emphasizes the correlation between micro-perturbation on the model nose and its response and evolution behaviors of the asymmetric vortices.The critical issues are discussed, which include the formation and evolution mechanism of asymmetric multi-vortices;main behaviors of asymmetric vortices flow including its deterministic feature and vortices flow structure;the evolution and development of asymmetric vortices under the perturbation on the model nose;forebody vortex active control especially discussed micro-perturbation active control concept and technique in more detail.However present understanding in this area is still very limited and this paper tries to identify the key unknown problems in the concluding remarks.展开更多
AIM: To explore the pathogenesis of asymmetric primary open angle glaucoma(POAG) in both eyes by comparing the intraocular pressure(IOP) of patients who sleep in different positions and to investigate the relatio...AIM: To explore the pathogenesis of asymmetric primary open angle glaucoma(POAG) in both eyes by comparing the intraocular pressure(IOP) of patients who sleep in different positions and to investigate the relationship between IOP variations and sleep positions.METHODS: One hundred and thirty-one patients with asymmetric POAG and forty-six healthy volunteers were enrolled. All participants completed a questionnaire that provided information about their sleep laterality. The cup disc ratio(C/D) and visual field defect established binocular asymmetry. The IOP of both eyes was measured using i Care parameters after the patients were asked to change body position. The "worse" and "better" eyes were identified according to the diagnosis, whereas the "dependent" and "independent" eyes were defined according to the lateral position. RESULTS: No significant difference in sleep laterality was observed between healthy people and patients with POAG(F=3.195, P=0.362). Among the enrolled patients, the IOP of the dependent eye was always greater than that of the independent eye in the lateral position(P〈0.05). In the patients with binocular asymmetric POAG, the questionnaire clearly showed that 85.7% of left side preferences were found their left eyes to be the worse eyes and the right eyes of 71.4% patients with a right side preference were the more serious. When the asymmetric C/D ratio was greater than or equal to 0.2, the worse eye of patients with POAG and a preferred sleeping position was the dependent eye(χ~2=16.762, P=0.001).CONCLUSION: A higher IOP was measured in the dependent eye in the lateral position. The long-term tendency to choose a lateral sleeping position might lead the dependent eye to manifest more severe symptoms than the independent eye. Thus, the lateral sleeping position might be one cause of asymmetric POAG.展开更多
·AIM:To compare the ciliary body thickness between eyes with primary angle closure(PAC)and primary angle-closure glaucoma(PACG)with the normal eyes,and to investigate the association between ciliary body thicknes...·AIM:To compare the ciliary body thickness between eyes with primary angle closure(PAC)and primary angle-closure glaucoma(PACG)with the normal eyes,and to investigate the association between ciliary body thickness and ciliary processes situation.·METHODS:In this cross-sectional study,57 patients with PAC/PACG were matched to 57 normal subjects after propensity score matching(PSM)adjusting for age and gender.All subjects underwent conventional ocular examinations and ultrasound biomicroscopy(UBM)examination,among which the patients with PAC/PACG performed the examinations one month after laser peripheral iridotomy(LPI).Quantitative parameters were measured,which included ciliary body thickness at the position of 1 mm posterior to the scleral spur(CBT1),trabecular-ciliary process distance(TCPD)and trabecularciliary process angle(TCA).·RESULTS:Eyes with PAC/PACG presented significantly thinner CBT1,shorter TCPD and smaller TCA(P<0.001)than the normal eyes,both in comparison of the means of four quadrants and in comparisons of each quadrant.After removing images with peripheral anterior synechia(PAS),the same results were also found in comparisons between the two groups.Significant correlations were found between TCPD(R~2=0.537,P<0.001)and TCA(R~2=0.517,P<0.001)with CBT1.·CONCLUSION:Eyes with PAC/PACG have thinner ciliary body thickness and more anteriorly situated ciliary processes.Thinner ciliary body thickness is associated with anterior situation of the ciliary processes.展开更多
AIM:To introduce a novel approach in removal of anterior chamber angle foreign body(ACFB) using a prism contact lens and 23-gauge foreign body forceps.METHODS:Data of 42 eyes of 42 patients who had undergone remov...AIM:To introduce a novel approach in removal of anterior chamber angle foreign body(ACFB) using a prism contact lens and 23-gauge foreign body forceps.METHODS:Data of 42 eyes of 42 patients who had undergone removal of ACFB using a prism contact lens and 23-gauge foreign body forceps from January 2008 to October 2013 were collected and analyzed. Twenty eyes in group A received the conventional approach by using toothed forceps through corneal limbus incision, and 22 eyes in group B underwent the novel method through the opposite corneal limbus incision. RESULTS:The success rate of ACFB once removal was 75%(15/20) in group A, and 100%(22/22) in group B. The average operation time of group A was significantly longer compared with group B(34.9±9.88 min vs 22.13±8.85min; P〈0.05). The average size of corneal limbus incision in group A was significantly larger than that of group B(4.85±1.89 mm vs 3.95±1.17 mm; P〈0.05). The corneal limbus incision suturing were conducted in all eyes in group A, and only 5 eyes in group B. CONCLUSION:Removal of ACFB using a prism contact lens and 23-gauge foreign body forceps is a safer, more effective, and convenient technique compared with the conventional approach.展开更多
AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospec...AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis.展开更多
Background The phase angle(PA)is an indicator of nutritional status derived from bioelectrical impedance analysis(BIA).Studies have shown that the PA is one of several factors related to the survival of cancer patient...Background The phase angle(PA)is an indicator of nutritional status derived from bioelectrical impedance analysis(BIA).Studies have shown that the PA is one of several factors related to the survival of cancer patients.However,the correlation between the PA and prognosis in patients with hepatocellular carcinoma(HCC)has not been reported.This study aimed to explore the relationship between the PA,nutrition-related indicators,and patient prognosis.Methods The data from 248 HCC patients who underwent BIA between January 2015 and December 2019 at the First Hospital of Jilin University were retrospectively analyzed.Patients were divided into two groups according to the median PA value,then the nutrition-related indicators and overall survival(OS)were compared between the two groups.The correlations between the PA and laboratory test nutrition-related indicators and the results of a body composition analysis were determined using Pearson correlation analysis.Independent predictors of the patient prognosis were identified using univariate and multivariate analyses.Results The median OS in the high and low PA groups were 70 and 54.6 months,respectively(P=0.004).The Pearson correlation analysis revealed that the PA was associated with both laboratory test nutrition-related indicators and the results of a body composition analysis.The multivariable Cox regression analysis identified the PA as an independent risk factor affecting the prognosis of patients with Barcelona Clinic Liver Cancer stage A or B.Conclusion The PA is a good biomarker for the nutritional status.We found that the PA was associated with the prognosis in patients with HCC,with a low PA indicating a poor nutritional status and worse prognosis.展开更多
BACKGROUND Obesity is a global health problem that is continuing to increase in the young population.In Brazil,the frequency of obesity in 2018 was 19.8%.Several comorbidities are directly associated with obesity,such...BACKGROUND Obesity is a global health problem that is continuing to increase in the young population.In Brazil,the frequency of obesity in 2018 was 19.8%.Several comorbidities are directly associated with obesity,such as non-alcoholic fatty liver disease(NAFLD),which is considered the most common liver disorder in Western countries and affects up to 46%of adults.Bariatric surgery is effective in treating obesity and can improve NAFLD;however,the effect of bariatric surgery on body composition,phase angle(PA),and improving NAFLD needs to be further studied.AIM To analyze the PA in the postoperative period of bariatric surgery and to correlate it with changes in body composition and liver disease.METHODS This study is a retrospective cohort study of the analysis of the medical records of patients undergoing bariatric surgery in a reference center of a teaching hospital in Porto Alegre over a 2-year period.Patients older than 18 years whose record contained all information relevant to the study were included.The data analyzed were body composition and PA through electrical bioimpedance and NAFLD through liver biopsy in the pre-and postoperative period.The level of significance adopted for the statistical analyses was 5%.RESULTS We evaluated 379 patients with preoperative data.Regarding PA,169 patients were analyzed,and 33 patients had liver biopsy pre-and postoperatively with NAFLD information.In total,79.4%were female,with a mean age of 39.1±10.6 years.The average body mass index(BMI)was 45.9±7.5 kg/m².The PA showed a mean of 5.8±0.62°in the preoperative period and a significant reduction in the postoperative period.A postoperative reduction in body composition data(skeletal muscle mass,fat percentage,fat mass,body cell mass,BMI and visceral fat area)was shown as well.Regarding liver disease,all patients presented a reduction in the degrees and stages of liver disease in the postoperative period,and some had no degree of liver disease at all.CONCLUSION PA decreased after bariatric surgery,with a direct correlation with weight loss and changes in body composition.The decrease in PA was not correlated with the improvement in NAFLD.展开更多
为了研究浪向角、入射波频率和连接器刚度耦合变化对连接器载荷的影响,以刚模块柔性连接器(rigid module and flexible connector,简称RMFC)模型计算理论为基础,建立8模块海上机场超大浮体水动力模型进行数值模拟水槽实验,分别对连接器...为了研究浪向角、入射波频率和连接器刚度耦合变化对连接器载荷的影响,以刚模块柔性连接器(rigid module and flexible connector,简称RMFC)模型计算理论为基础,建立8模块海上机场超大浮体水动力模型进行数值模拟水槽实验,分别对连接器在规则波和不规则波下的载荷响应进行频域计算。选取6个连接器刚度条件,研究不同连接器刚度下连接器的载荷响应,在不同海况和连接器刚度条件下考虑0°,30°,45°,60°及90°浪向角的作用,连接器载荷响应幅值主要从纵向、横向及垂向3个方向进行比对。结果表明,同一方向上的载荷在浪向角45°和60°较为敏感,极端风浪耦合环境下,垂向载荷明显比其他两个方向载荷值大,连接器载荷值随刚度值增大而增大,在K5~K6之间呈大幅递增趋势。展开更多
基金The project supported by the National Natural Science Foundation of China(10172017)Aeronautical Science Foundation of China(02A51048)Foundation of National Key Laboratory of Aerodynamic Design and Research(51462020504HK0101)
文摘The studies of asymmetric vortices flow over slender body and its active control at high angles of attack have significant importance for both academic field and engineering area.This paper attempts to provide an update state of art to the investigations on the fields of forebody asymmetric vortices.This review emphasizes the correlation between micro-perturbation on the model nose and its response and evolution behaviors of the asymmetric vortices.The critical issues are discussed, which include the formation and evolution mechanism of asymmetric multi-vortices;main behaviors of asymmetric vortices flow including its deterministic feature and vortices flow structure;the evolution and development of asymmetric vortices under the perturbation on the model nose;forebody vortex active control especially discussed micro-perturbation active control concept and technique in more detail.However present understanding in this area is still very limited and this paper tries to identify the key unknown problems in the concluding remarks.
基金Supported by the National Major Scientific Equipment Program (NO.2012YQ12008005)the Health Research Funding of Sichuan Province in 2017 (No.17PJ539)
文摘AIM: To explore the pathogenesis of asymmetric primary open angle glaucoma(POAG) in both eyes by comparing the intraocular pressure(IOP) of patients who sleep in different positions and to investigate the relationship between IOP variations and sleep positions.METHODS: One hundred and thirty-one patients with asymmetric POAG and forty-six healthy volunteers were enrolled. All participants completed a questionnaire that provided information about their sleep laterality. The cup disc ratio(C/D) and visual field defect established binocular asymmetry. The IOP of both eyes was measured using i Care parameters after the patients were asked to change body position. The "worse" and "better" eyes were identified according to the diagnosis, whereas the "dependent" and "independent" eyes were defined according to the lateral position. RESULTS: No significant difference in sleep laterality was observed between healthy people and patients with POAG(F=3.195, P=0.362). Among the enrolled patients, the IOP of the dependent eye was always greater than that of the independent eye in the lateral position(P〈0.05). In the patients with binocular asymmetric POAG, the questionnaire clearly showed that 85.7% of left side preferences were found their left eyes to be the worse eyes and the right eyes of 71.4% patients with a right side preference were the more serious. When the asymmetric C/D ratio was greater than or equal to 0.2, the worse eye of patients with POAG and a preferred sleeping position was the dependent eye(χ~2=16.762, P=0.001).CONCLUSION: A higher IOP was measured in the dependent eye in the lateral position. The long-term tendency to choose a lateral sleeping position might lead the dependent eye to manifest more severe symptoms than the independent eye. Thus, the lateral sleeping position might be one cause of asymmetric POAG.
文摘·AIM:To compare the ciliary body thickness between eyes with primary angle closure(PAC)and primary angle-closure glaucoma(PACG)with the normal eyes,and to investigate the association between ciliary body thickness and ciliary processes situation.·METHODS:In this cross-sectional study,57 patients with PAC/PACG were matched to 57 normal subjects after propensity score matching(PSM)adjusting for age and gender.All subjects underwent conventional ocular examinations and ultrasound biomicroscopy(UBM)examination,among which the patients with PAC/PACG performed the examinations one month after laser peripheral iridotomy(LPI).Quantitative parameters were measured,which included ciliary body thickness at the position of 1 mm posterior to the scleral spur(CBT1),trabecular-ciliary process distance(TCPD)and trabecularciliary process angle(TCA).·RESULTS:Eyes with PAC/PACG presented significantly thinner CBT1,shorter TCPD and smaller TCA(P<0.001)than the normal eyes,both in comparison of the means of four quadrants and in comparisons of each quadrant.After removing images with peripheral anterior synechia(PAS),the same results were also found in comparisons between the two groups.Significant correlations were found between TCPD(R~2=0.537,P<0.001)and TCA(R~2=0.517,P<0.001)with CBT1.·CONCLUSION:Eyes with PAC/PACG have thinner ciliary body thickness and more anteriorly situated ciliary processes.Thinner ciliary body thickness is associated with anterior situation of the ciliary processes.
文摘AIM:To introduce a novel approach in removal of anterior chamber angle foreign body(ACFB) using a prism contact lens and 23-gauge foreign body forceps.METHODS:Data of 42 eyes of 42 patients who had undergone removal of ACFB using a prism contact lens and 23-gauge foreign body forceps from January 2008 to October 2013 were collected and analyzed. Twenty eyes in group A received the conventional approach by using toothed forceps through corneal limbus incision, and 22 eyes in group B underwent the novel method through the opposite corneal limbus incision. RESULTS:The success rate of ACFB once removal was 75%(15/20) in group A, and 100%(22/22) in group B. The average operation time of group A was significantly longer compared with group B(34.9±9.88 min vs 22.13±8.85min; P〈0.05). The average size of corneal limbus incision in group A was significantly larger than that of group B(4.85±1.89 mm vs 3.95±1.17 mm; P〈0.05). The corneal limbus incision suturing were conducted in all eyes in group A, and only 5 eyes in group B. CONCLUSION:Removal of ACFB using a prism contact lens and 23-gauge foreign body forceps is a safer, more effective, and convenient technique compared with the conventional approach.
基金Supported by The Fundacao de Amparo a Pesquisa do Estado de Sao Paulo,Nos.2011/13243-3,2012/15677-3[GB]
文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis.
基金Science and Technology Department of Jilin Provincial(No.3D5204167428 for Dr.Nan Ya Wang).
文摘Background The phase angle(PA)is an indicator of nutritional status derived from bioelectrical impedance analysis(BIA).Studies have shown that the PA is one of several factors related to the survival of cancer patients.However,the correlation between the PA and prognosis in patients with hepatocellular carcinoma(HCC)has not been reported.This study aimed to explore the relationship between the PA,nutrition-related indicators,and patient prognosis.Methods The data from 248 HCC patients who underwent BIA between January 2015 and December 2019 at the First Hospital of Jilin University were retrospectively analyzed.Patients were divided into two groups according to the median PA value,then the nutrition-related indicators and overall survival(OS)were compared between the two groups.The correlations between the PA and laboratory test nutrition-related indicators and the results of a body composition analysis were determined using Pearson correlation analysis.Independent predictors of the patient prognosis were identified using univariate and multivariate analyses.Results The median OS in the high and low PA groups were 70 and 54.6 months,respectively(P=0.004).The Pearson correlation analysis revealed that the PA was associated with both laboratory test nutrition-related indicators and the results of a body composition analysis.The multivariable Cox regression analysis identified the PA as an independent risk factor affecting the prognosis of patients with Barcelona Clinic Liver Cancer stage A or B.Conclusion The PA is a good biomarker for the nutritional status.We found that the PA was associated with the prognosis in patients with HCC,with a low PA indicating a poor nutritional status and worse prognosis.
文摘BACKGROUND Obesity is a global health problem that is continuing to increase in the young population.In Brazil,the frequency of obesity in 2018 was 19.8%.Several comorbidities are directly associated with obesity,such as non-alcoholic fatty liver disease(NAFLD),which is considered the most common liver disorder in Western countries and affects up to 46%of adults.Bariatric surgery is effective in treating obesity and can improve NAFLD;however,the effect of bariatric surgery on body composition,phase angle(PA),and improving NAFLD needs to be further studied.AIM To analyze the PA in the postoperative period of bariatric surgery and to correlate it with changes in body composition and liver disease.METHODS This study is a retrospective cohort study of the analysis of the medical records of patients undergoing bariatric surgery in a reference center of a teaching hospital in Porto Alegre over a 2-year period.Patients older than 18 years whose record contained all information relevant to the study were included.The data analyzed were body composition and PA through electrical bioimpedance and NAFLD through liver biopsy in the pre-and postoperative period.The level of significance adopted for the statistical analyses was 5%.RESULTS We evaluated 379 patients with preoperative data.Regarding PA,169 patients were analyzed,and 33 patients had liver biopsy pre-and postoperatively with NAFLD information.In total,79.4%were female,with a mean age of 39.1±10.6 years.The average body mass index(BMI)was 45.9±7.5 kg/m².The PA showed a mean of 5.8±0.62°in the preoperative period and a significant reduction in the postoperative period.A postoperative reduction in body composition data(skeletal muscle mass,fat percentage,fat mass,body cell mass,BMI and visceral fat area)was shown as well.Regarding liver disease,all patients presented a reduction in the degrees and stages of liver disease in the postoperative period,and some had no degree of liver disease at all.CONCLUSION PA decreased after bariatric surgery,with a direct correlation with weight loss and changes in body composition.The decrease in PA was not correlated with the improvement in NAFLD.
文摘为了研究浪向角、入射波频率和连接器刚度耦合变化对连接器载荷的影响,以刚模块柔性连接器(rigid module and flexible connector,简称RMFC)模型计算理论为基础,建立8模块海上机场超大浮体水动力模型进行数值模拟水槽实验,分别对连接器在规则波和不规则波下的载荷响应进行频域计算。选取6个连接器刚度条件,研究不同连接器刚度下连接器的载荷响应,在不同海况和连接器刚度条件下考虑0°,30°,45°,60°及90°浪向角的作用,连接器载荷响应幅值主要从纵向、横向及垂向3个方向进行比对。结果表明,同一方向上的载荷在浪向角45°和60°较为敏感,极端风浪耦合环境下,垂向载荷明显比其他两个方向载荷值大,连接器载荷值随刚度值增大而增大,在K5~K6之间呈大幅递增趋势。
文摘为了探索高频段室内无线体域网通信的可行性,对11 GHz室内无线体域网的传播特性进行了测量与研究。基于大量的测量数据,给出了11 GHz频段室内无线体域网的路径损耗、阴影效应与均方根时延扩展的统计特性。针对体对体通信时人体相对角度变化的场景,提出了一种具有相对角度影响的路径损耗模型,该模型利用了与身体角度相关的路径损耗指数、浮动截距以及身体角度因子修正相对角度变化引入的路径损耗。为了验证模型的适用性,对比分析了在小型空教室和大型会议室两种不同场景下相对角度变化对信道传播特性的影响。研究结果表明:在收发端距离固定的情况下,路径损耗指数、浮动截距和由相对角度引起的路径损耗(Path Loss caused by Relative Angle,PLRA)均与相对角度具有三角函数关系;在收发端相对角度固定时,PLRA与收发端距离无关,仅与相对角度有关。上述研究结果可以为11 GHz频段在未来室内无线体域网的使用提供理论基础与实践依据。