The following article has been retracted due to the investigation of complaints received against it. Title: A New Method of Construction of Robust Second Order Rotatable Designs Using Balanced Incomplete Block Designs...The following article has been retracted due to the investigation of complaints received against it. Title: A New Method of Construction of Robust Second Order Rotatable Designs Using Balanced Incomplete Block Designs Authors: Bejjam Re. Victorbabu, Kottapalli Rajyalakshmi. The above paper is a copy of Dr. Rabindra Nath Das’s former article, entitled '“Robust second order rotatable designs (Part I)”. The scientific community takes a very strong view on this matter and we solemnly withdrawn?the paper from the journal OJS. This paper published in OJS Vol.2 No.1, 39-47, 2012, has been retracted.展开更多
Purpose: Based on our experience of designing and testing a computer-based game for teaching undergraduate students information literacy (IL) concepts and skills, this paper summarizes the basic strategies for stri...Purpose: Based on our experience of designing and testing a computer-based game for teaching undergraduate students information literacy (IL) concepts and skills, this paper summarizes the basic strategies for striking a balance between education and entertainment for the designers of quality IL games. Design/methodology/approach: The project team recruited 10 college students to play the game and post-game group interviews revealed problems and optimization priorities. The optimized game was tested among 50 college students. Based on a comparison of testing results of the two versions of the game, basic strategies for designing quality 1L games were summarized. Findings: The following 5 basic strategies can effectively promote combination of education and entertainment: l) using adventure games to enhance gaming experience, 2) plotting an intriguing story to attract players, 3) motivating players to engage in game play with game components such as challenge, curiosity, fantasy and control, 4) presenting learning materials through game props, and 5) assigning players tasks to be completed with subject knowledge. Research limitations: The 5 basic strategies have been tested only in the development process of one game, and the book classification knowledge in the mini-game is limited to the 22 major categories of the Chinese Library Classification. Practical implications: University libraries may refer to our experience to design and utilize educational games to promote the IL education for college students. Originality value: Few empirical studies tested and summarized strategies for combining learning and fun in the design of IL games for university students. The 5 strategies, which are summarized in the process of design and optimization of the mini-game book classification, are valuable for other designers of IL games.展开更多
Dear Editor,We read with interest the article "Comparison of 45-degree Kelman and 45-degree balanced phaco tip designs in torsional microcoaxial phacoemulsification" by Demircan et al. The authors describe the intra...Dear Editor,We read with interest the article "Comparison of 45-degree Kelman and 45-degree balanced phaco tip designs in torsional microcoaxial phacoemulsification" by Demircan et al. The authors describe the intraoperative and post-operative outcomes of phacoemulsification in terms of cumulative dissipated energy (CDE), total ultrasound (US) time, torsional US time, total fluid use, percentage change in central corneal thickness and endothelial cell count in the two groups. A comparative evaluation has been made between the two groups involving the Kelman mini-flared tip and the Intrepid balanced phaco tip using the Infiniti Ozil IP Vision system (Alton Laboratories Inc., Fort Worth, TX, USA) as hasbeen explicitly mentioned in the article under the "Methods" section. However,展开更多
If the draught of each mill stand is limited by forced bite condition for compact continuous mill,the rolling load difference between one mill stand and another is very big.If deforming regulation of relative load for...If the draught of each mill stand is limited by forced bite condition for compact continuous mill,the rolling load difference between one mill stand and another is very big.If deforming regulation of relative load for each mill stand is approximate to the same,the productive capacity of compact continuous mill can be brought into full play,and also the safety running and the smooth rolling of mill can be ensured.展开更多
Some new construction methods of the optimum chemical balance weighing designs and pairwise efficiency and variance balanced designs are proposed, which are based on the incidence matrices of the known symmetric balan...Some new construction methods of the optimum chemical balance weighing designs and pairwise efficiency and variance balanced designs are proposed, which are based on the incidence matrices of the known symmetric balanced incomplete block designs. Also the conditions under which the constructed chemical balance weighing designs become A-optimal are also been given.展开更多
A strong partially balanced design SPBD(v, b, k; λ,0) whose b is the maximum number of blocks in all SPBD(v, b, k; λ, 0), as an optimal strong partially balanced design, briefly OSPBD(v, k, λ) is studied. In ...A strong partially balanced design SPBD(v, b, k; λ,0) whose b is the maximum number of blocks in all SPBD(v, b, k; λ, 0), as an optimal strong partially balanced design, briefly OSPBD(v, k, λ) is studied. In investigation of authentication codes it has been found that the strong partially balanced design can be used to construct authentication codes. This note investigates the existence of optimal strong partially balanced design OSPBD(v, k, 1) for k = 3 and 4, and shows that there exists an OSPBD(v, k, 1) for any v ≥ k.展开更多
The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical ind...The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical industry, etc. In this paper, a new series of generalized partially balanced incomplete blocks PBIB designs with m associated classes (m = 4, 5 and 7) based on new generalized association schemes with number of treatments v arranged in w arrays of n rows and l columns (w ≥ 2, n ≥ 2, l ≥ 2) is defined. Some construction methods of these new PBIB are given and their parameters are specified using the Combinatory Method (s). For n or l even and s divisor of n or l, the obtained PBIB designs are resolvable PBIB designs. So the Fang RBIBD method is applied to obtain a series of particular U-type designs U (wnl;) (r is the repetition number of each treatment in our resolvable PBIB design).展开更多
Methods of constructing the optimum chemical balance weighing designs from symmetric balanced incomplete block designs are proposed with illustration. As a by-product pairwise efficiency and variance balanced designs ...Methods of constructing the optimum chemical balance weighing designs from symmetric balanced incomplete block designs are proposed with illustration. As a by-product pairwise efficiency and variance balanced designs are also obtained.展开更多
This paper investigated the existence of splitting balanced incomplete block designs with blck size 2× k .The necessary conditions for such a design are λ(v-1) ≡0(mod k ),and λv(v- 1)≡0(mod 2 k 2).It will sho...This paper investigated the existence of splitting balanced incomplete block designs with blck size 2× k .The necessary conditions for such a design are λ(v-1) ≡0(mod k ),and λv(v- 1)≡0(mod 2 k 2).It will show that the above necessary conditions are also sufficient for k =3 with the definite exception( v,λ )=(10,1) and with several possible exceptions.展开更多
This paper studies the nonsystematic Low-Density Parity-Check(LDPC)codes based onSymmetric Balanced Incomplete Block Design(SBIBD).First,it is concluded that the performancedegradation of nonsystematic linear block co...This paper studies the nonsystematic Low-Density Parity-Check(LDPC)codes based onSymmetric Balanced Incomplete Block Design(SBIBD).First,it is concluded that the performancedegradation of nonsystematic linear block codes is bounded by the average row weight of generalizedinverses of their generator matrices and code rate.Then a class of nonsystematic LDPC codes con-structed based on SBIBD is presented.Their characteristics include:both generator matrices andparity-check matrices are sparse and cyclic,which are simple to encode and decode;and almost arbi-trary rate codes can be easily constructed,so they are rate-compatible codes.Because there aresparse generalized inverses of generator matrices,the performance of the proposed codes is only0.15dB away from that of the traditional systematic LDPC codes.展开更多
A t-(v,k,λ)design(X,B)is a set X of points,of cardinality v,and a collection B of k-subsets of X called blocks,with the property that every t-subset of X is contained in precisely λ blocks.A t-design is a t-(v,k,λ)...A t-(v,k,λ)design(X,B)is a set X of points,of cardinality v,and a collection B of k-subsets of X called blocks,with the property that every t-subset of X is contained in precisely λ blocks.A t-design is a t-(v,k,λ) design for some v,k,γ.In this paper,we give a generalization of t-design called balanced n-ary t-design,and obtain some properties of the new combinatorial structure.展开更多
In on-line role-playing games (RPG), each race holds some attributes and skills. Each skill contains several abilities such as physical damage, hit rate, etc. Parts of the attributes and all the abilities are a functi...In on-line role-playing games (RPG), each race holds some attributes and skills. Each skill contains several abilities such as physical damage, hit rate, etc. Parts of the attributes and all the abilities are a function of the character’s level, which are called Ability-Increasing Functions (AIFs). A well-balanced on-line RPG is characterized by having a set of well-balanced AIFs. In this paper, we propose an evolutionary design method, including integration with an improved Probabilistic Incremental Program Evolution (PIPE) and a Cooperative Coevolutionary Algorithm (CCEA), for on-line RPGs to maintain the game balance. Moreover, we construct a simplest turn-based game model and perform a series of experiments based on it. The results indicate that the proposed method is able to obtain a set of well-balanced AIFs efficiently. They also show that in this case the CCEA outperforms the simple genetic algorithm, and that the capability of PIPE has been significantly improved through the improvement work.展开更多
Rotating arc sensor is a key device for automation welding. The vibration has a big influence on signal's correct collection and reliable automatic welding. In order to solve the vibration problem and the dynamic ...Rotating arc sensor is a key device for automation welding. The vibration has a big influence on signal's correct collection and reliable automatic welding. In order to solve the vibration problem and the dynamic balancing design with the restricted space,a bearing force analysis based dynamic balancing structure optimal design is proposed and implemented with the help of Pro/Engineer( PROE) and automatic dynamic analysis of mechanical systems( ADAMS) virtual prototype technology, in which three parameters of the counterbalance are considered. The method is suitable for the practical online adjustment. The simulation result shows that optimal design based counterbalance structure and parameters can satisfy the space requirement with lower vibration. The methodology provides a new idea for dynamic balancing design and adjustment of rotating arc sensor with adjustable rotation radius.展开更多
Metabolic modeling and machine learning(ML)are crucial components of the evolving next-generation tools in systems and synthetic biology,aiming to unravel the intricate relationship between genotype,phenotype,and the ...Metabolic modeling and machine learning(ML)are crucial components of the evolving next-generation tools in systems and synthetic biology,aiming to unravel the intricate relationship between genotype,phenotype,and the environment.Nonetheless,the comprehensive exploration of integrating these two frameworks,and fully harnessing the potential of fluxomic data,remains an unexplored territory.In this study,we present,rigorously evaluate,and compare ML-based techniques for data integration.The hybrid model revealed that the overexpression of six target genes and the knockout of seven target genes contribute to enhanced ethanol production.Specifically,we investigated the influence of succinate dehydrogenase(SDH)on ethanol biosynthesis in Saccharomyces cerevisiae through shake flask experiments.The findings indicate a noticeable increase in ethanol yield,ranging from 6%to 10%,in SDH subunit gene knockout strains compared to the wild-type strain.Moreover,in pursuit of a high-yielding strain for ethanol production,dual-gene deletion experiments were conducted targeting glycerol-3-phosphate dehydrogenase(GPD)and SDH.The results unequivocally demonstrate significant enhancements in ethanol production for the engineered strains Δsdh4Δgpd1,Δsdh5Δgpd1,Δsdh6Δgpd1,Δsdh4Δgpd2,Δsdh5Δgpd2,and Δsdh6Δgpd2,with improvements of 21.6%,27.9%,and 22.7%,respectively.Overall,the results highlighted that integrating mechanistic flux features substantially improves the prediction of gene knockout strains not accounted for in metabolic reconstructions.In addition,the finding in this study delivers valuable tools for comprehending and manipulating intricate phenotypes,thereby enhancing prediction accuracy and facilitating deeper insights into mechanistic aspects within the field of synthetic biology.展开更多
To improve the robustness of the Low Earth Orbit(LEO) satellites networks and realise load balancing, a Cross-layer design and Ant-colony optimization based Load-balancing routing algorithm for LEO Satellite Networks(...To improve the robustness of the Low Earth Orbit(LEO) satellites networks and realise load balancing, a Cross-layer design and Ant-colony optimization based Load-balancing routing algorithm for LEO Satellite Networks(CAL-LSN) is proposed in this paper. In CALLSN, mobile agents are used to gather routing information actively. CAL-LSN can utilise the information of the physical layer to make routing decision during the route construction phase. In order to achieve load balancing, CALLSN makes use of a multi-objective optimization model. Meanwhile, how to take the value of some key parameters is discussed while designing the algorithm so as to improve the reliability. The performance is measured by the packet delivery rate, the end-to-end delay, the link utilization and delay jitter. Simulation results show that CAL-LSN performs well in balancing traffic load and increasing the packet delivery rate. Meanwhile, the end-to-end delay and delay jitter performance can meet the requirement of video transmission.展开更多
An asymptotic existence of balanced incomplete block (BIB) designs and pairwise balanced designs (PBD) has been discussed in [1]-[3]. On the other hand, the existence of additive BIB designs and pairwise additive BIB ...An asymptotic existence of balanced incomplete block (BIB) designs and pairwise balanced designs (PBD) has been discussed in [1]-[3]. On the other hand, the existence of additive BIB designs and pairwise additive BIB designs with k = 2?and?λ = 1?has been discussed with direct and recursive constructions in [4]-[8]. In this paper, an asymptotic existence of pairwise additive BIB designs is proved by use of Wilson’s theorem on PBD, and?also for some l?and k the exact existence of l?pairwise additive BIB designs with block size k and?λ = 1?is discussed.展开更多
The necessary conditions for the existence of weak designs are given in the form of two inequalities in this paper. The relations among weak block designs (WBDs) , Balanced incomplete block designs ( BIBDs) and differ...The necessary conditions for the existence of weak designs are given in the form of two inequalities in this paper. The relations among weak block designs (WBDs) , Balanced incomplete block designs ( BIBDs) and differential balanced block designs (DBBDs) are researched.展开更多
An innovative use of spatial sampling designs is here presented. Sampling methods which consider spatial locations of statistical units are already used in agricultural and environmental contexts, while they have neve...An innovative use of spatial sampling designs is here presented. Sampling methods which consider spatial locations of statistical units are already used in agricultural and environmental contexts, while they have never been exploited for establishment surveys. However, the rapidly increasing availability of geo- referenced information about business units makes that possible. In business studies, it may indeed be important to take into account the presence of spatial autocorrelation or spatial trends in the variables of interest, in order to have more precise and efficient estimates. The opportunity of using the most innovative spatial sampling designs in business surveys, in order to produce samples that are well spread in space, is here tested by means of Monte Carlo experiments. For all designs, the Horvitz-Thompson estimator of the population total is used both with equal and unequal inclusion probabilities. The efficiency of sampling designs is evaluated in terms of relative RMSE and efficiency gain compared with designs ignoring the spatial information. Furthermore, an evaluation of spatially balancing samples is also conducted.展开更多
A method for balancing thermal and electrical packaging requirements for gallium nitride (GaN) high power amplifier (HPA) modules is presented. The goal is to find a design approach that minimizes the junction tempera...A method for balancing thermal and electrical packaging requirements for gallium nitride (GaN) high power amplifier (HPA) modules is presented. The goal is to find a design approach that minimizes the junction temperature of the GaN so that it is reliable and has interconnects that meet electrical performance requirements. One benefit of GaN is that it can simultaneously achieve high power density and operate at microwave and millimeter-wave frequencies. However, the power density can be so high that the necessary thermal solutions can have negative impact on electrical performance. This is especially a concern for the electrical interconnects required for the input/ output ports on high power amplifier devices. This is because the signal interconnects must operate at GHz frequencies, which means that special care must be taken to avoid problems such as undesired signal coupling and ground path inductance. Therefore, this work focuses on GaN packaging and its integration into a module. The results show that an optimum thickness for the GaN heat spreader exits for thermal performance but the electrical design is impacted negatively if the optimum thermal design is chosen. Therefore, a balanced design is chosen which meets overall system level requirements.展开更多
Reconfigurable products and manufacturing systems have enabled manufacturers to provide "cost effective" variety to the market. In spite of these new technologies, the expense of manufacturing makes it infeasible to...Reconfigurable products and manufacturing systems have enabled manufacturers to provide "cost effective" variety to the market. In spite of these new technologies, the expense of manufacturing makes it infeasible to supply all the possible variants to the market for some industries. Therefore, the determination of the right number of product variantsto offer in the product portfolios becomes an important consideration. The product portfolio planning problem had been independently well studied from marketing and engineering perspectives. However, advantages can be gained from using a concurrent marketing and engineering approach. Concurrent product development strategies specifically for reconfigurable products and manufacturing systems can allow manufacturers to select best product portfolios from marketing, product design and manufacturing perspectives. A methodology for the concurrent design of a product portfolio and assembly system is presented. The objective of the concurrent product portfolio planning and assembly system design problem is to obtain the product variants that will make up the product portfolio such that oversupply of optional modules is minimized and the assembly line efficiency is maximized. Explicit design of the assembly system is obtained during the solution of the problem. It is assumed that the demand for optional modules and the assembly times for these modules are known a priori. A genetic algorithm is used in the solution of the problem. The basic premise of this methodology is that the selected product portfolio has a significant impact on the solution of the assembly line balancing problem. An example is used to validate this hypothesis. The example is then further developed to demonstrate how the methodology can be used to obtain the optimal product portfolio. This approach is intended for use by manufacturers during the early design stages of product family design.展开更多
文摘The following article has been retracted due to the investigation of complaints received against it. Title: A New Method of Construction of Robust Second Order Rotatable Designs Using Balanced Incomplete Block Designs Authors: Bejjam Re. Victorbabu, Kottapalli Rajyalakshmi. The above paper is a copy of Dr. Rabindra Nath Das’s former article, entitled '“Robust second order rotatable designs (Part I)”. The scientific community takes a very strong view on this matter and we solemnly withdrawn?the paper from the journal OJS. This paper published in OJS Vol.2 No.1, 39-47, 2012, has been retracted.
基金supported by the National Social Science Foundation of China (Grant No.: 13BTQ024) the Foundation for Humanities and Social Sciences of the Chinese Ministry of Education (Grant No.: 12YJAZH155)
文摘Purpose: Based on our experience of designing and testing a computer-based game for teaching undergraduate students information literacy (IL) concepts and skills, this paper summarizes the basic strategies for striking a balance between education and entertainment for the designers of quality IL games. Design/methodology/approach: The project team recruited 10 college students to play the game and post-game group interviews revealed problems and optimization priorities. The optimized game was tested among 50 college students. Based on a comparison of testing results of the two versions of the game, basic strategies for designing quality 1L games were summarized. Findings: The following 5 basic strategies can effectively promote combination of education and entertainment: l) using adventure games to enhance gaming experience, 2) plotting an intriguing story to attract players, 3) motivating players to engage in game play with game components such as challenge, curiosity, fantasy and control, 4) presenting learning materials through game props, and 5) assigning players tasks to be completed with subject knowledge. Research limitations: The 5 basic strategies have been tested only in the development process of one game, and the book classification knowledge in the mini-game is limited to the 22 major categories of the Chinese Library Classification. Practical implications: University libraries may refer to our experience to design and utilize educational games to promote the IL education for college students. Originality value: Few empirical studies tested and summarized strategies for combining learning and fun in the design of IL games for university students. The 5 strategies, which are summarized in the process of design and optimization of the mini-game book classification, are valuable for other designers of IL games.
文摘Dear Editor,We read with interest the article "Comparison of 45-degree Kelman and 45-degree balanced phaco tip designs in torsional microcoaxial phacoemulsification" by Demircan et al. The authors describe the intraoperative and post-operative outcomes of phacoemulsification in terms of cumulative dissipated energy (CDE), total ultrasound (US) time, torsional US time, total fluid use, percentage change in central corneal thickness and endothelial cell count in the two groups. A comparative evaluation has been made between the two groups involving the Kelman mini-flared tip and the Intrepid balanced phaco tip using the Infiniti Ozil IP Vision system (Alton Laboratories Inc., Fort Worth, TX, USA) as hasbeen explicitly mentioned in the article under the "Methods" section. However,
文摘If the draught of each mill stand is limited by forced bite condition for compact continuous mill,the rolling load difference between one mill stand and another is very big.If deforming regulation of relative load for each mill stand is approximate to the same,the productive capacity of compact continuous mill can be brought into full play,and also the safety running and the smooth rolling of mill can be ensured.
文摘Some new construction methods of the optimum chemical balance weighing designs and pairwise efficiency and variance balanced designs are proposed, which are based on the incidence matrices of the known symmetric balanced incomplete block designs. Also the conditions under which the constructed chemical balance weighing designs become A-optimal are also been given.
文摘A strong partially balanced design SPBD(v, b, k; λ,0) whose b is the maximum number of blocks in all SPBD(v, b, k; λ, 0), as an optimal strong partially balanced design, briefly OSPBD(v, k, λ) is studied. In investigation of authentication codes it has been found that the strong partially balanced design can be used to construct authentication codes. This note investigates the existence of optimal strong partially balanced design OSPBD(v, k, 1) for k = 3 and 4, and shows that there exists an OSPBD(v, k, 1) for any v ≥ k.
文摘The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical industry, etc. In this paper, a new series of generalized partially balanced incomplete blocks PBIB designs with m associated classes (m = 4, 5 and 7) based on new generalized association schemes with number of treatments v arranged in w arrays of n rows and l columns (w ≥ 2, n ≥ 2, l ≥ 2) is defined. Some construction methods of these new PBIB are given and their parameters are specified using the Combinatory Method (s). For n or l even and s divisor of n or l, the obtained PBIB designs are resolvable PBIB designs. So the Fang RBIBD method is applied to obtain a series of particular U-type designs U (wnl;) (r is the repetition number of each treatment in our resolvable PBIB design).
文摘Methods of constructing the optimum chemical balance weighing designs from symmetric balanced incomplete block designs are proposed with illustration. As a by-product pairwise efficiency and variance balanced designs are also obtained.
基金National Natural Science Foundation ofChina(No.10 4710 93)
文摘This paper investigated the existence of splitting balanced incomplete block designs with blck size 2× k .The necessary conditions for such a design are λ(v-1) ≡0(mod k ),and λv(v- 1)≡0(mod 2 k 2).It will show that the above necessary conditions are also sufficient for k =3 with the definite exception( v,λ )=(10,1) and with several possible exceptions.
基金the National Natural Science Foundation of China(No.60272009,No.60472045,and No.60496313).
文摘This paper studies the nonsystematic Low-Density Parity-Check(LDPC)codes based onSymmetric Balanced Incomplete Block Design(SBIBD).First,it is concluded that the performancedegradation of nonsystematic linear block codes is bounded by the average row weight of generalizedinverses of their generator matrices and code rate.Then a class of nonsystematic LDPC codes con-structed based on SBIBD is presented.Their characteristics include:both generator matrices andparity-check matrices are sparse and cyclic,which are simple to encode and decode;and almost arbi-trary rate codes can be easily constructed,so they are rate-compatible codes.Because there aresparse generalized inverses of generator matrices,the performance of the proposed codes is only0.15dB away from that of the traditional systematic LDPC codes.
文摘A t-(v,k,λ)design(X,B)is a set X of points,of cardinality v,and a collection B of k-subsets of X called blocks,with the property that every t-subset of X is contained in precisely λ blocks.A t-design is a t-(v,k,λ) design for some v,k,γ.In this paper,we give a generalization of t-design called balanced n-ary t-design,and obtain some properties of the new combinatorial structure.
文摘In on-line role-playing games (RPG), each race holds some attributes and skills. Each skill contains several abilities such as physical damage, hit rate, etc. Parts of the attributes and all the abilities are a function of the character’s level, which are called Ability-Increasing Functions (AIFs). A well-balanced on-line RPG is characterized by having a set of well-balanced AIFs. In this paper, we propose an evolutionary design method, including integration with an improved Probabilistic Incremental Program Evolution (PIPE) and a Cooperative Coevolutionary Algorithm (CCEA), for on-line RPGs to maintain the game balance. Moreover, we construct a simplest turn-based game model and perform a series of experiments based on it. The results indicate that the proposed method is able to obtain a set of well-balanced AIFs efficiently. They also show that in this case the CCEA outperforms the simple genetic algorithm, and that the capability of PIPE has been significantly improved through the improvement work.
基金Foundations of Jiangxi Provincial Department of Science and Technology,China(Nos.20132BAB206028,20132BAB206030)
文摘Rotating arc sensor is a key device for automation welding. The vibration has a big influence on signal's correct collection and reliable automatic welding. In order to solve the vibration problem and the dynamic balancing design with the restricted space,a bearing force analysis based dynamic balancing structure optimal design is proposed and implemented with the help of Pro/Engineer( PROE) and automatic dynamic analysis of mechanical systems( ADAMS) virtual prototype technology, in which three parameters of the counterbalance are considered. The method is suitable for the practical online adjustment. The simulation result shows that optimal design based counterbalance structure and parameters can satisfy the space requirement with lower vibration. The methodology provides a new idea for dynamic balancing design and adjustment of rotating arc sensor with adjustable rotation radius.
基金financially supported by the National Natural Science Foundation of China(Grant NO.32071461)the National Key Research and Development Program of China(Grant NO.2019YFA0904300).
文摘Metabolic modeling and machine learning(ML)are crucial components of the evolving next-generation tools in systems and synthetic biology,aiming to unravel the intricate relationship between genotype,phenotype,and the environment.Nonetheless,the comprehensive exploration of integrating these two frameworks,and fully harnessing the potential of fluxomic data,remains an unexplored territory.In this study,we present,rigorously evaluate,and compare ML-based techniques for data integration.The hybrid model revealed that the overexpression of six target genes and the knockout of seven target genes contribute to enhanced ethanol production.Specifically,we investigated the influence of succinate dehydrogenase(SDH)on ethanol biosynthesis in Saccharomyces cerevisiae through shake flask experiments.The findings indicate a noticeable increase in ethanol yield,ranging from 6%to 10%,in SDH subunit gene knockout strains compared to the wild-type strain.Moreover,in pursuit of a high-yielding strain for ethanol production,dual-gene deletion experiments were conducted targeting glycerol-3-phosphate dehydrogenase(GPD)and SDH.The results unequivocally demonstrate significant enhancements in ethanol production for the engineered strains Δsdh4Δgpd1,Δsdh5Δgpd1,Δsdh6Δgpd1,Δsdh4Δgpd2,Δsdh5Δgpd2,and Δsdh6Δgpd2,with improvements of 21.6%,27.9%,and 22.7%,respectively.Overall,the results highlighted that integrating mechanistic flux features substantially improves the prediction of gene knockout strains not accounted for in metabolic reconstructions.In addition,the finding in this study delivers valuable tools for comprehending and manipulating intricate phenotypes,thereby enhancing prediction accuracy and facilitating deeper insights into mechanistic aspects within the field of synthetic biology.
基金supported by the National Natural Science Foundation of China under Grant No.61271281the National High Technology Research and Development Program of China (863 Program) under Grant No.SS2013AA010503
文摘To improve the robustness of the Low Earth Orbit(LEO) satellites networks and realise load balancing, a Cross-layer design and Ant-colony optimization based Load-balancing routing algorithm for LEO Satellite Networks(CAL-LSN) is proposed in this paper. In CALLSN, mobile agents are used to gather routing information actively. CAL-LSN can utilise the information of the physical layer to make routing decision during the route construction phase. In order to achieve load balancing, CALLSN makes use of a multi-objective optimization model. Meanwhile, how to take the value of some key parameters is discussed while designing the algorithm so as to improve the reliability. The performance is measured by the packet delivery rate, the end-to-end delay, the link utilization and delay jitter. Simulation results show that CAL-LSN performs well in balancing traffic load and increasing the packet delivery rate. Meanwhile, the end-to-end delay and delay jitter performance can meet the requirement of video transmission.
文摘An asymptotic existence of balanced incomplete block (BIB) designs and pairwise balanced designs (PBD) has been discussed in [1]-[3]. On the other hand, the existence of additive BIB designs and pairwise additive BIB designs with k = 2?and?λ = 1?has been discussed with direct and recursive constructions in [4]-[8]. In this paper, an asymptotic existence of pairwise additive BIB designs is proved by use of Wilson’s theorem on PBD, and?also for some l?and k the exact existence of l?pairwise additive BIB designs with block size k and?λ = 1?is discussed.
文摘The necessary conditions for the existence of weak designs are given in the form of two inequalities in this paper. The relations among weak block designs (WBDs) , Balanced incomplete block designs ( BIBDs) and differential balanced block designs (DBBDs) are researched.
文摘An innovative use of spatial sampling designs is here presented. Sampling methods which consider spatial locations of statistical units are already used in agricultural and environmental contexts, while they have never been exploited for establishment surveys. However, the rapidly increasing availability of geo- referenced information about business units makes that possible. In business studies, it may indeed be important to take into account the presence of spatial autocorrelation or spatial trends in the variables of interest, in order to have more precise and efficient estimates. The opportunity of using the most innovative spatial sampling designs in business surveys, in order to produce samples that are well spread in space, is here tested by means of Monte Carlo experiments. For all designs, the Horvitz-Thompson estimator of the population total is used both with equal and unequal inclusion probabilities. The efficiency of sampling designs is evaluated in terms of relative RMSE and efficiency gain compared with designs ignoring the spatial information. Furthermore, an evaluation of spatially balancing samples is also conducted.
文摘A method for balancing thermal and electrical packaging requirements for gallium nitride (GaN) high power amplifier (HPA) modules is presented. The goal is to find a design approach that minimizes the junction temperature of the GaN so that it is reliable and has interconnects that meet electrical performance requirements. One benefit of GaN is that it can simultaneously achieve high power density and operate at microwave and millimeter-wave frequencies. However, the power density can be so high that the necessary thermal solutions can have negative impact on electrical performance. This is especially a concern for the electrical interconnects required for the input/ output ports on high power amplifier devices. This is because the signal interconnects must operate at GHz frequencies, which means that special care must be taken to avoid problems such as undesired signal coupling and ground path inductance. Therefore, this work focuses on GaN packaging and its integration into a module. The results show that an optimum thickness for the GaN heat spreader exits for thermal performance but the electrical design is impacted negatively if the optimum thermal design is chosen. Therefore, a balanced design is chosen which meets overall system level requirements.
文摘Reconfigurable products and manufacturing systems have enabled manufacturers to provide "cost effective" variety to the market. In spite of these new technologies, the expense of manufacturing makes it infeasible to supply all the possible variants to the market for some industries. Therefore, the determination of the right number of product variantsto offer in the product portfolios becomes an important consideration. The product portfolio planning problem had been independently well studied from marketing and engineering perspectives. However, advantages can be gained from using a concurrent marketing and engineering approach. Concurrent product development strategies specifically for reconfigurable products and manufacturing systems can allow manufacturers to select best product portfolios from marketing, product design and manufacturing perspectives. A methodology for the concurrent design of a product portfolio and assembly system is presented. The objective of the concurrent product portfolio planning and assembly system design problem is to obtain the product variants that will make up the product portfolio such that oversupply of optional modules is minimized and the assembly line efficiency is maximized. Explicit design of the assembly system is obtained during the solution of the problem. It is assumed that the demand for optional modules and the assembly times for these modules are known a priori. A genetic algorithm is used in the solution of the problem. The basic premise of this methodology is that the selected product portfolio has a significant impact on the solution of the assembly line balancing problem. An example is used to validate this hypothesis. The example is then further developed to demonstrate how the methodology can be used to obtain the optimal product portfolio. This approach is intended for use by manufacturers during the early design stages of product family design.