The distribution and geochemical significance of dibenzofurans,phenyldibenzofurans and benzo[b]naptho-furans in source rocks from Niger Delta basin,Nigeria,were investigated by Rock-Eval pyrolysis and gas chro-matogra...The distribution and geochemical significance of dibenzofurans,phenyldibenzofurans and benzo[b]naptho-furans in source rocks from Niger Delta basin,Nigeria,were investigated by Rock-Eval pyrolysis and gas chro-matography--mass spectrometry(GC--MS).The data obtained from the source rocks evaluation showed that the rock samples contained type 1/III kerogen capable of generating oil and gas and were within immature to early mature stage.The relative abundance of the Cor,C1-and C2-dibenzofurans range from 1.75%to 29.82%,27.60%to 40.52%and 29.66%to 6889%,respectively.The diben-zofurans were dominated by C-dibenzofurans.Among the C1-dibenzofurans,2-+3-methyldibenzofuran was the most abundant in the rock samples while 1-methy ldibenzofuran appeared to be the least.The relative abundance of benzo[b]naphtho[1,2-d]furan(1,2]BNF),benzo[b]naph-tha[2,1-d]furan(2.1]BNF)and benzo[b]naphtha[2,3-d]fu-ran([2.3]BNF)in the rock extracts range from 12.01%to 52.58%,32.61%to 75.219%and 10.27%to 52.43%.The wide range of values recorded for the three isomers of benzo[b lnapthofurans in the samples suggest source rocks formed from mixed organic matter.Among the pheny ldibenzofuran isomers,4-pheny ldibenzofuran was the most abundant while 1-phenyldibenzofuran was the least.Phenyldibenzofuran ratio-1(PhFR-1)and pheny ldibenzofuran ratio-2(PhFR-2)values range from 0.13 to 1.20 and 0.11 to 2.11,respectively.The resuls showed that the relative abundance of PhFR-1 and PhFR-2 increase gradually with increasing burial depth and maturity(VRo≤0.77%,MPI-1≤0.62.Tmax s 443℃),and have a good correlations with calculated vitrinite reflectance.MPI-I and maximum Temperature(Tmax)-This range of values suggested immature to early mature source rocks.The source rocks were found to have shale and coul lithologics and deposited in a lacustrine/fuvial deltaic settings within immature to early mature stages based on the distribution of dibenzofurans,pheny ldiben-zofurans and benzo[b]naphthofurans in the source rocks.This study showed that dibenzof urans,phenyldibenzofu-rans and benzo[b]naphthofurans were ffcive in deter-mining the origin,depositional environment and thermal maturity of source rocks in Niger Delta basin,Nigeria.展开更多
A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3- methoxy-4hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structure...A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3- methoxy-4hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structures of the new compounds were confirmed by 1H NMR, IR and MS. The structure of compound 14 was further confirmed by single crystal X-ray. Compound 17 showed cytotoxic activity against human lung carcinoma A549.展开更多
The title compound methyl (7,7-dimethyl-2-amino-4-(4-chlorophenyl)-5-oxo- 5,6,7,8-tetrahydro-4H-benzo-[b]-pyran-3-yl) carboxylate (C19H20ClNO4, Mr = 361.81) was synthesized and crystallized. The crystal belongs to tri...The title compound methyl (7,7-dimethyl-2-amino-4-(4-chlorophenyl)-5-oxo- 5,6,7,8-tetrahydro-4H-benzo-[b]-pyran-3-yl) carboxylate (C19H20ClNO4, Mr = 361.81) was synthesized and crystallized. The crystal belongs to triclinic, space group P ī with a = 8.519(2), b = 10.346(2), c = 11.481(3) ?, ( = 108.16(1), ( = 107.78(2), ( = 91.83(2)(, Z = 2, V = 906.5(3) ?3, Dc = 1.326 g/cm3, ((MoK() = 0.234 mm-1, F(000) = 380, R = 0.0467 and wR = 0.1270 for 3142 observed reflections (I ( 2((I)). X-ray analysis reveals that the C(7), C(8), C(9), O(1), C(10) and C(11) atoms form a six-membered ring which adopts a boat conformation. In the ring, the distances of C(8)-C(9) and C(10)-C(11) are 1.332(3) and 1.357(3) (A), respectively, which indicates that they are C=C double bonds. Another six-membered ring (C(8)-C(9)-C(15)-C(14)-C(13)-C(12)) adopts the half-chair conformation. In addition, there are intermolecular hydrogen bonds in the crystal structure.展开更多
A novel phenanthro [2,3-b] furan 1, named (3-hydroxy-9-(4′-hydroxy-3′-methoxyphenyl)-11-methoxy-5,6,9,10-tetrahydrophenanthro [2,3-b] furan-10-yl) methyl acetate, and two known phenolic compounds were isolated from ...A novel phenanthro [2,3-b] furan 1, named (3-hydroxy-9-(4′-hydroxy-3′-methoxyphenyl)-11-methoxy-5,6,9,10-tetrahydrophenanthro [2,3-b] furan-10-yl) methyl acetate, and two known phenolic compounds were isolated from the tubers of Pleione bulbocodioides (Franch.) Rolfe. Their structures were elucidated by spectroscopic methods.展开更多
The toxic effects of benzo[α]pyrene (B[α]P) at different concentrations (0.1, 0.5, 1, 2.5 and 7.5 μgL-1) on scallop (Chlamys farreri) immune system were studied. The results showed that B[α]P had significant toxic...The toxic effects of benzo[α]pyrene (B[α]P) at different concentrations (0.1, 0.5, 1, 2.5 and 7.5 μgL-1) on scallop (Chlamys farreri) immune system were studied. The results showed that B[α]P had significant toxic effects on the haemocyte counts, neutral red uptake, phagocytosis, bacteriolytic and antibacterial activity (P<0.05), while the seawater control and acetone control had no significant differences. The haemocyte counts, neutral red uptake, phagocytosis and bacteriolytic activity in all B[α]P treatment groups as well as antibacterial activity in groups of 0.5, 1, 2.5 and 7.5 μgL-1 B[α]P decreased significantly (P<0.05). Some of these indices tended to be stable on the sixth day and others on the ninth day, and the indices showed clear time-and concentra- tion-response to B[α]P. Bacteriolytic activity in 0.1μgL-1 B[α]P treatment group and antibacterial activity in 0.1 μgL-1 and 0.5 μgL-1 B[α]P treatment groups increased at the beginning of exposure and reached their peaks on day 1 and day 6, respectively. Following that, both activities decreased gradually and became stable after day 9. When all the indices reached stability, they were significantly lower than those in control group (P<0.05), except for antibacterial activity in 0.1 μgL-1 B[α]P treatment group (P>0.05). Thus, B[α]P has evident toxic effects on scallop immune system, which supports the view that a relationship exists between pollution and immunomodulation in aquatic organisms.展开更多
A series of tetrahydrobenzo-[b]-pyran derivative was synthesized by the reaction of arylmethylene malononitrile or arylmethylene cyanoacetate with dimedone in ethylene glycol at 80C without catalyst. The structures o...A series of tetrahydrobenzo-[b]-pyran derivative was synthesized by the reaction of arylmethylene malononitrile or arylmethylene cyanoacetate with dimedone in ethylene glycol at 80C without catalyst. The structures of the two products were characterized by X-ray diffraction.展开更多
The preparation of several functionalized furan derivatives and attempts to transform them into a derivative containing 6H-furo[3,4-b]furanone skeleton towards the construction of naphtho[2,3-b] furan are described. A...The preparation of several functionalized furan derivatives and attempts to transform them into a derivative containing 6H-furo[3,4-b]furanone skeleton towards the construction of naphtho[2,3-b] furan are described. Attempted Pummerer reaction of a furan sulfoxide derivative produced four interesting furan derivatives. Base promoted annulation between methyl 2-(phenylsulfinylmethyl)-3-furoate and 2-cyclohexenone proceeded to give dihydro naphtho[2,3-b]furanone derivative in a regiospecific manner.展开更多
The title compound ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-lH-isoindol-2(3H)- yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl) butanoate 3 was synthesized by the reaction of ethyl 2-(6-amino-7-fluoro-3-ox...The title compound ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-lH-isoindol-2(3H)- yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl) butanoate 3 was synthesized by the reaction of ethyl 2-(6-amino-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl) butanoate with 4,5,6,7- tetraydrophthalic anhydride, and its structure was determined by X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group P2 1/n with a = 9.3469(2), b = 16.7715(5), c = 13.7153(4) A, β= 104.9680(10)°, μ = 0.107 mm^-1, Mr = 430.42, V= 2077.08(10) ,A3, Z= 4, Dc = 1.376 g/cm3, F(000) = 904, T= 296(2) K, R = 0.0508 and wR = 0.1478.展开更多
基金The authors gratefully acknowledge the State Key Laboratory of Petroleum Resources and Prospecting,College of Geoscience,China University of Petroleum,Beijing,China for granting A.B.Ogbesejana an international visiting research fellowship towards this research work.
文摘The distribution and geochemical significance of dibenzofurans,phenyldibenzofurans and benzo[b]naptho-furans in source rocks from Niger Delta basin,Nigeria,were investigated by Rock-Eval pyrolysis and gas chro-matography--mass spectrometry(GC--MS).The data obtained from the source rocks evaluation showed that the rock samples contained type 1/III kerogen capable of generating oil and gas and were within immature to early mature stage.The relative abundance of the Cor,C1-and C2-dibenzofurans range from 1.75%to 29.82%,27.60%to 40.52%and 29.66%to 6889%,respectively.The diben-zofurans were dominated by C-dibenzofurans.Among the C1-dibenzofurans,2-+3-methyldibenzofuran was the most abundant in the rock samples while 1-methy ldibenzofuran appeared to be the least.The relative abundance of benzo[b]naphtho[1,2-d]furan(1,2]BNF),benzo[b]naph-tha[2,1-d]furan(2.1]BNF)and benzo[b]naphtha[2,3-d]fu-ran([2.3]BNF)in the rock extracts range from 12.01%to 52.58%,32.61%to 75.219%and 10.27%to 52.43%.The wide range of values recorded for the three isomers of benzo[b lnapthofurans in the samples suggest source rocks formed from mixed organic matter.Among the pheny ldibenzofuran isomers,4-pheny ldibenzofuran was the most abundant while 1-phenyldibenzofuran was the least.Phenyldibenzofuran ratio-1(PhFR-1)and pheny ldibenzofuran ratio-2(PhFR-2)values range from 0.13 to 1.20 and 0.11 to 2.11,respectively.The resuls showed that the relative abundance of PhFR-1 and PhFR-2 increase gradually with increasing burial depth and maturity(VRo≤0.77%,MPI-1≤0.62.Tmax s 443℃),and have a good correlations with calculated vitrinite reflectance.MPI-I and maximum Temperature(Tmax)-This range of values suggested immature to early mature source rocks.The source rocks were found to have shale and coul lithologics and deposited in a lacustrine/fuvial deltaic settings within immature to early mature stages based on the distribution of dibenzofurans,pheny ldiben-zofurans and benzo[b]naphthofurans in the source rocks.This study showed that dibenzof urans,phenyldibenzofu-rans and benzo[b]naphthofurans were ffcive in deter-mining the origin,depositional environment and thermal maturity of source rocks in Niger Delta basin,Nigeria.
文摘A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3- methoxy-4hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structures of the new compounds were confirmed by 1H NMR, IR and MS. The structure of compound 14 was further confirmed by single crystal X-ray. Compound 17 showed cytotoxic activity against human lung carcinoma A549.
基金This work was supported by the foundation of the "Surpassing Project" of Jiangsu province
文摘The title compound methyl (7,7-dimethyl-2-amino-4-(4-chlorophenyl)-5-oxo- 5,6,7,8-tetrahydro-4H-benzo-[b]-pyran-3-yl) carboxylate (C19H20ClNO4, Mr = 361.81) was synthesized and crystallized. The crystal belongs to triclinic, space group P ī with a = 8.519(2), b = 10.346(2), c = 11.481(3) ?, ( = 108.16(1), ( = 107.78(2), ( = 91.83(2)(, Z = 2, V = 906.5(3) ?3, Dc = 1.326 g/cm3, ((MoK() = 0.234 mm-1, F(000) = 380, R = 0.0467 and wR = 0.1270 for 3142 observed reflections (I ( 2((I)). X-ray analysis reveals that the C(7), C(8), C(9), O(1), C(10) and C(11) atoms form a six-membered ring which adopts a boat conformation. In the ring, the distances of C(8)-C(9) and C(10)-C(11) are 1.332(3) and 1.357(3) (A), respectively, which indicates that they are C=C double bonds. Another six-membered ring (C(8)-C(9)-C(15)-C(14)-C(13)-C(12)) adopts the half-chair conformation. In addition, there are intermolecular hydrogen bonds in the crystal structure.
文摘A novel phenanthro [2,3-b] furan 1, named (3-hydroxy-9-(4′-hydroxy-3′-methoxyphenyl)-11-methoxy-5,6,9,10-tetrahydrophenanthro [2,3-b] furan-10-yl) methyl acetate, and two known phenolic compounds were isolated from the tubers of Pleione bulbocodioides (Franch.) Rolfe. Their structures were elucidated by spectroscopic methods.
基金supported by Science and Technology Development Project of Qingdao,China (06-2-2-21-jch)
文摘The toxic effects of benzo[α]pyrene (B[α]P) at different concentrations (0.1, 0.5, 1, 2.5 and 7.5 μgL-1) on scallop (Chlamys farreri) immune system were studied. The results showed that B[α]P had significant toxic effects on the haemocyte counts, neutral red uptake, phagocytosis, bacteriolytic and antibacterial activity (P<0.05), while the seawater control and acetone control had no significant differences. The haemocyte counts, neutral red uptake, phagocytosis and bacteriolytic activity in all B[α]P treatment groups as well as antibacterial activity in groups of 0.5, 1, 2.5 and 7.5 μgL-1 B[α]P decreased significantly (P<0.05). Some of these indices tended to be stable on the sixth day and others on the ninth day, and the indices showed clear time-and concentra- tion-response to B[α]P. Bacteriolytic activity in 0.1μgL-1 B[α]P treatment group and antibacterial activity in 0.1 μgL-1 and 0.5 μgL-1 B[α]P treatment groups increased at the beginning of exposure and reached their peaks on day 1 and day 6, respectively. Following that, both activities decreased gradually and became stable after day 9. When all the indices reached stability, they were significantly lower than those in control group (P<0.05), except for antibacterial activity in 0.1 μgL-1 B[α]P treatment group (P>0.05). Thus, B[α]P has evident toxic effects on scallop immune system, which supports the view that a relationship exists between pollution and immunomodulation in aquatic organisms.
文摘A series of tetrahydrobenzo-[b]-pyran derivative was synthesized by the reaction of arylmethylene malononitrile or arylmethylene cyanoacetate with dimedone in ethylene glycol at 80C without catalyst. The structures of the two products were characterized by X-ray diffraction.
文摘The preparation of several functionalized furan derivatives and attempts to transform them into a derivative containing 6H-furo[3,4-b]furanone skeleton towards the construction of naphtho[2,3-b] furan are described. Attempted Pummerer reaction of a furan sulfoxide derivative produced four interesting furan derivatives. Base promoted annulation between methyl 2-(phenylsulfinylmethyl)-3-furoate and 2-cyclohexenone proceeded to give dihydro naphtho[2,3-b]furanone derivative in a regiospecific manner.
基金Supported by the National Natural Science Foundation of China (20872033, 20575019)Natural Science Foundation of Hunan Province (07JJ1003)+1 种基金Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China) (KLCBTCMR2008-14)Scientific Research Fund of Science and Technology Department of Hunan Province (No. 2006GK3067)
文摘The title compound ethyl 2-(6-(1,3-dioxo-4,5,6,7-tetrahydro-lH-isoindol-2(3H)- yl)-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl) butanoate 3 was synthesized by the reaction of ethyl 2-(6-amino-7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl) butanoate with 4,5,6,7- tetraydrophthalic anhydride, and its structure was determined by X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group P2 1/n with a = 9.3469(2), b = 16.7715(5), c = 13.7153(4) A, β= 104.9680(10)°, μ = 0.107 mm^-1, Mr = 430.42, V= 2077.08(10) ,A3, Z= 4, Dc = 1.376 g/cm3, F(000) = 904, T= 296(2) K, R = 0.0508 and wR = 0.1478.