A detailed analysis of benzofuranone compounds under multiple tandem mass spectrometry （ESI-MS^n） conditions is reported. Element composition data of the fragment ions were obtained with the aid of comparison of the...A detailed analysis of benzofuranone compounds under multiple tandem mass spectrometry （ESI-MS^n） conditions is reported. Element composition data of the fragment ions were obtained with the aid of comparison of the multiple tandem mass spectra of four compounds, and the structures of which are identical except for some substituted groups or epimers or cis-trans-isomers. Attempts have been made to provide rational pathways for the formation of the fragment ions from these protonated compounds. And the structure-fragmentation relationships will facilitate the characterization of the structures of other analogs.展开更多
The enantioselective double Michael reaction of benzofuranone with dienones catalyzed by Cinchona-based primary amines was developed. A number of optically active spirocyclic benzofuranones were obtained in up to 89% ...The enantioselective double Michael reaction of benzofuranone with dienones catalyzed by Cinchona-based primary amines was developed. A number of optically active spirocyclic benzofuranones were obtained in up to 89% yield and 91% ee.展开更多
Aim To establish the method for determination of benzofuranones derivative, griffonilide, in the roots of Semiaquilegia adoxoides （DC.） Makino by RP- HPLC. Methods Kromasil C18 column was used with a mobile phase of...Aim To establish the method for determination of benzofuranones derivative, griffonilide, in the roots of Semiaquilegia adoxoides （DC.） Makino by RP- HPLC. Methods Kromasil C18 column was used with a mobile phase of methanol-water （ containing 0. 01% trifluoroacetic acid and 0. 05 % tetrahydrofuran） （3：97）. The detecting wavelength was 260 nm. Results The calibration curve was linear over the range of 0. 004 - 0. 4 mg·mL^-1 with the correlation coefficient of 1.00 000. The average recovery was 98. 77 % with RSD 2. 77 %. Determinations of ten samples from different areas showed that the contents of griffonilide in the roots of S. adoxoides are 0. 17 -0. 49 mg·g^-1. Conclusion The method provides an accurate and sensitive way to detect griffonilide in the roots of S. adoxoides .展开更多
文摘A detailed analysis of benzofuranone compounds under multiple tandem mass spectrometry （ESI-MS^n） conditions is reported. Element composition data of the fragment ions were obtained with the aid of comparison of the multiple tandem mass spectra of four compounds, and the structures of which are identical except for some substituted groups or epimers or cis-trans-isomers. Attempts have been made to provide rational pathways for the formation of the fragment ions from these protonated compounds. And the structure-fragmentation relationships will facilitate the characterization of the structures of other analogs.
基金Acknowledgement This work was supported by National Natural Science Foundation of China （Nos. 20802075 and No. 21042006）.
文摘The enantioselective double Michael reaction of benzofuranone with dienones catalyzed by Cinchona-based primary amines was developed. A number of optically active spirocyclic benzofuranones were obtained in up to 89% yield and 91% ee.
基金Ministry of Science and Technology of People'sRepublic of China (No. 2004AA2Z3730)
文摘Aim To establish the method for determination of benzofuranones derivative, griffonilide, in the roots of Semiaquilegia adoxoides （DC.） Makino by RP- HPLC. Methods Kromasil C18 column was used with a mobile phase of methanol-water （ containing 0. 01% trifluoroacetic acid and 0. 05 % tetrahydrofuran） （3：97）. The detecting wavelength was 260 nm. Results The calibration curve was linear over the range of 0. 004 - 0. 4 mg·mL^-1 with the correlation coefficient of 1.00 000. The average recovery was 98. 77 % with RSD 2. 77 %. Determinations of ten samples from different areas showed that the contents of griffonilide in the roots of S. adoxoides are 0. 17 -0. 49 mg·g^-1. Conclusion The method provides an accurate and sensitive way to detect griffonilide in the roots of S. adoxoides .
