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计算机模拟在物理化学BET多分子层吸附理论教学中的应用 被引量:1
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作者 黄建花 张伟 《大学化学》 CAS 2024年第1期369-376,共8页
BET多分子层吸附理论抽象但应用广泛,BET公式的推导过程涉及较多数学知识,学生很难透彻理解BET公式的物理意义。面对比表面分析仪输出的吸附脱附等温线和比表面积,学生只能生搬硬套,难以达到预期的教学效果。本文利用计算机模拟气体分... BET多分子层吸附理论抽象但应用广泛,BET公式的推导过程涉及较多数学知识,学生很难透彻理解BET公式的物理意义。面对比表面分析仪输出的吸附脱附等温线和比表面积,学生只能生搬硬套,难以达到预期的教学效果。本文利用计算机模拟气体分子在固体表面的吸附脱附过程,通过调整吸附脱附常数,可分别得到第I、II、III类吸附等温线;结合实时可视化使学生能直观看到气体分子在固体表面的吸附脱附动力学,从而能更好地理解BET理论。计算机模拟辅助教学还能活跃课堂气氛,实现教与学互动,激发学生的求知欲和科研兴趣,提高教学质量。 展开更多
关键词 计算机模拟 固体表面 bet公式 吸附-脱附动力学 吸附等温线
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基于改进的BET多层吸附模型的深层页岩吸附气含量测井评价方法
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作者 钟光海 李跃纲 李生杰 《测井技术》 CAS 2024年第1期84-93,共10页
含气量是页岩储层评价的一项关键指标,页岩含气量受温度-压力耦合影响,特别在地层压力较高情况下,准确预测页岩储层吸附气含量较为困难。针对深层页岩气储层高温高压环境下甲烷吸附特性,提出了改进的BET多层吸附模型,建立了一套深层页... 含气量是页岩储层评价的一项关键指标,页岩含气量受温度-压力耦合影响,特别在地层压力较高情况下,准确预测页岩储层吸附气含量较为困难。针对深层页岩气储层高温高压环境下甲烷吸附特性,提出了改进的BET多层吸附模型,建立了一套深层页岩储层吸附气含量测井评价方法。应用该方法对川南深层页岩储层进行含气量评价,结果表明:利用改进的BET多层吸附模型计算的吸附气含量更符合实际地质情况,结合相应层段游离气含量,计算所得的页岩总含气量精度较高,且与现场保压取心获取的总含气量较为一致。基于改进的BET多层吸附模型的吸附气含量评价方法在川南深层页岩气区块具有较好的适应性,可为深层页岩地质甜点评价和资源潜力分析提供技术支撑。 展开更多
关键词 四川盆地 吸附气含量 等温吸附实验 bet吸附 含气量
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High Altitude Frogs (Rana kukonoris) Adopt a Diversified Bethedging Strategy in the Face of Environmental Unpredictability 被引量:1
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作者 Wei CHEN Liqing PENG +3 位作者 Lichun JIANG David A.PIKE Christopher R.FRIESEN Gregory BROWN 《Asian Herpetological Research》 SCIE CSCD 2018年第1期43-49,共7页
Environmental unpredictability can influence strategies of maternal investment among eggs within a clutch. Models predict that breeding females should adopt a diversified bet-hedging strategy in unpredictable environm... Environmental unpredictability can influence strategies of maternal investment among eggs within a clutch. Models predict that breeding females should adopt a diversified bet-hedging strategy in unpredictable environments, but empirical field evidence from Asia is scarce. Here we tested this hypothesis by exploring spatial patterns in egg size along an altitudinal gradient in a frog species (Rana kukunoris) inhabiting the Tibetan Plateau. Within-clutch variability in egg size increased as the environment became variable (e.g., lower mean monthly temperature and mean monthly rainfall at higher altitudes), and populations in environments with more unpredictable rainfall produced eggs that were smaller and more variable in size. We provide support for a diversified bet-hedging strategy in high-altitude environments, which experience dynamic weather patterns and therefore are of unpredictable environmental quality. This strategy may be an adaptive response to lower environmental quality and higher unpredictable environmental variance. Such a strategy should increase the likelihood of breeding success and maximize maternal lifetime fitness by producing offspring that are adapted to current environmental conditions. We speculate that in high-altitude environments prone to physical disturbance, breeding females are unable to consistently produce the optimal egg size due to physiological constraints imposed by environmental conditions (e.g., duration of the active season, food availability). Species and populations whose breeding strategies are adapted to cope with uncertain environmental conditions by adjusting offspring size and therefore quality show a remarkable degree of ability to cope with future climatic changes. 展开更多
关键词 altitude bet-hedging strategy environmental quality egg size within-clutch variation unpredictable environment
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A Corpus-based Contrastive Study on Hedging in English Business Cor-respondences between Chinese English Learners and Native Speakers
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作者 周敏仪 《海外英语》 2013年第1X期261-262,共2页
This is a corpus-based contrastive study projected to find out the differences in using hedges in English business corre spondences between Chinese English learners and native speakers.
关键词 hedgES CORPUS CONTRASTIVE study NS CEL
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BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition
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作者 Yu Meng Hui-Yan Sun +7 位作者 Yi He Qian Zhou Yi-Huang Liu Hui Su Ming-Zhu Yin Fu-Rong Zeng Xiang Chen Guang-Tong Deng 《Military Medical Research》 SCIE CAS CSCD 2024年第4期620-624,共5页
Dear Editor,Ferroptosis,an iron-dependent form of cell death driven by overwhelming lipid peroxidation,represents a vulnerability in cancers,and therapeutic strategies to further potentiate ferroptosis hold great pote... Dear Editor,Ferroptosis,an iron-dependent form of cell death driven by overwhelming lipid peroxidation,represents a vulnerability in cancers,and therapeutic strategies to further potentiate ferroptosis hold great potential for melanoma treatment. 展开更多
关键词 MELANOMA Bromodomain and extra terminal domain(bet)inhibitor Ferroptosis Cell death AKR1C2 IMMUNOTHERAPY
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BET蛋白功能及其抑制剂研究进展
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作者 杨震 《中文科技期刊数据库(文摘版)医药卫生》 2024年第2期0201-0205,共5页
对于肿瘤表观遗传学的研究一直是抗肿瘤治疗的热点话题。BET家族含有溴结构域,通过识别乙酰化组蛋白并将转录因子和转录延伸复合物募集到染色质上,从而促进RNA聚合酶II的磷酸化和随后的转录起始和延伸,进而影响染色质重塑。近年来一些BE... 对于肿瘤表观遗传学的研究一直是抗肿瘤治疗的热点话题。BET家族含有溴结构域,通过识别乙酰化组蛋白并将转录因子和转录延伸复合物募集到染色质上,从而促进RNA聚合酶II的磷酸化和随后的转录起始和延伸,进而影响染色质重塑。近年来一些BET抑制剂已投入相关临床试验研究中,为不同肿瘤的治疗带来新的希望。本文结合BET蛋白的结构阐明其在相关疾病发生发展中的重要作用,并介绍其抑制剂目前的发展状况及应用前景。 展开更多
关键词 bet 抑制剂研究 .bet蛋白
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BET蛋白抑制剂JQ1对MRL/lpr狼疮小鼠外周B细胞分化的影响 被引量:2
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作者 曾珊 肖游君 +6 位作者 邱茜 李昊 徐思琪 王竞男 石茂华 梁柳琴 许韩师 《中国免疫学杂志》 CAS CSCD 北大核心 2023年第7期1345-1350,共6页
目的:探讨BET蛋白抑制剂JQ1对MRL/lpr狼疮小鼠外周B细胞分化的影响及其治疗作用。方法:12周龄MRL/lpr小鼠分别腹腔注射JQ150 mg/(kg·d)或10%DMSO;每2周检测24 h尿蛋白定量;6周后检测血清中尿素氮(BUN)、肌酐(Cr)、补体C3、补体C4、... 目的:探讨BET蛋白抑制剂JQ1对MRL/lpr狼疮小鼠外周B细胞分化的影响及其治疗作用。方法:12周龄MRL/lpr小鼠分别腹腔注射JQ150 mg/(kg·d)或10%DMSO;每2周检测24 h尿蛋白定量;6周后检测血清中尿素氮(BUN)、肌酐(Cr)、补体C3、补体C4、抗ds-DNA抗体、ANA及IgG、IgG1、IgG2a、IgM等免疫球蛋白水平;PAS染色观察肾脏组织病理学改变,免疫荧光染色观察IgG和C3免疫复合物沉积情况。利用流式细胞术检测小鼠B细胞各亚群细胞的比例;RT-qPCR检测脾脏prdm1 mRNA表达水平。结果:与DMSO组相比,JQ1治疗组小鼠24 h尿蛋白定量显著减少,血清BUN、Cr水平明显降低,补体C3、C4水平明显升高,抗ds-DNA抗体、ANA以及IgG、IgG1、IgG2a和IgM等免疫球蛋白水平明显降低;此外,JQ1治疗组小鼠肾小球、肾血管的病理损害程度均明显减轻,肾脏IgG和C3免疫复合物沉积显著减少。同时,JQ1治疗组小鼠脾脏、淋巴结、外周血B细胞中浆细胞和记忆B细胞亚群的比例显著下降;JQ1治疗亦显著抑制狼疮小鼠B细胞内调节浆细胞分化的关键转录因子prdm1 mRNA表达。结论:BET蛋白抑制剂JQ1对MRL/lpr狼疮小鼠具有显著的治疗作用,通过抑制Blimp1表达进而调节浆细胞分化可能是其发挥治疗作用的机制之一。BET蛋白可能是SLE治疗的新靶标。 展开更多
关键词 bet蛋白抑制剂 MRL/lpr狼疮小鼠 B细胞
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An Exploratory Study of Hedging in Chinese ESL Learners' Academic
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作者 陈玮 《海外英语》 2013年第11X期41-43,49,共4页
Hedging, referring to the use of various lexical and syntactic features modifying and mitigating propositions and claims, is extensively employed in effective academic writing. However, the use of hedges seems to be q... Hedging, referring to the use of various lexical and syntactic features modifying and mitigating propositions and claims, is extensively employed in effective academic writing. However, the use of hedges seems to be quite problematic for lots of Chinese ESL learners. In view of the situation, this study explores the use of hedges in academic abstracts by a group of undergraduate English majors in a university in Hainan Province. After analyzing data from a corpus and interviews, several problems have been found in the use of hedging devices of these students, and relevant implications have been drawn to the teaching of hedging in the context, which can help the students produce more effective academic writing and to achieve greater university success. 展开更多
关键词 hedging use of hedgES ACADEMIC abstracts problems
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BET溴域抑制通过阻断VEGFR2介导的PAK1和eNOS激活抑制糖尿病大鼠视网膜病变机制
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作者 余婧 祝莹 +2 位作者 孙李永眷 许琳 侯桂梅 《临床和实验医学杂志》 2023年第8期791-795,共5页
目的探究BET溴域抑制通过阻断血管内皮生长因子受体2(VEGFR2)介导的p21激活激酶1(PAK1)和内皮型一氧化氮合成酶(eNOS)激活抑制糖尿病大鼠视网膜病变机制。方法选择36只雄性SD大鼠,随机选取10只大鼠作为对照组,余下大鼠采用单次注射链脲... 目的探究BET溴域抑制通过阻断血管内皮生长因子受体2(VEGFR2)介导的p21激活激酶1(PAK1)和内皮型一氧化氮合成酶(eNOS)激活抑制糖尿病大鼠视网膜病变机制。方法选择36只雄性SD大鼠,随机选取10只大鼠作为对照组,余下大鼠采用单次注射链脲霉素60 mg/kg建立糖尿病模型。将建模成功的20只大鼠随机分为模型组和BET抑制组,每组10只。对照组大鼠不建模。BET抑制组大鼠建模后,腹腔注射80 mg·kg^(-1)·d^(-1)剂量的JQ1。使用ZEISS数码显微镜和免疫组织化学分析大鼠视网膜心血管生成。通过蛋白质印迹法分析视网膜屏障功能相关蛋白的表达。通过FITC-葡聚糖泄漏实验检测大鼠内外视网膜屏障完整性。通过RT-qPCR分析大鼠视网膜炎症因子的表达。通过酶联免疫吸附试验试剂盒检测大鼠房水VEGF浓度。通过蛋白质印迹法分析视网膜VEGFR2/PAK1/eNOS的蛋白表达。结果与对照组相比,模型组和BET抑制组视网膜新血管生成量、CD34表达、albumin蛋白表达、内外视网膜FITC-葡聚糖泄漏量、IL-1β、iNOS和ICAM-1 mRNA表达、VEGF浓度、视网膜P-PAK1、P-VEGFR2和eNOS蛋白表达均升高,ZO-1和occludin蛋白表达均降低,差异均有统计学意义(P<0.05);与模型组相比,BET抑制组视网膜新血管生成量、CD34表达、albumin表达、内外视网膜FITC-葡聚糖泄漏量、IL-1β、iNOS和ICAM-1mRNA表达、VEGF浓度、P-PAK1、P-VEGFR2和eNOS蛋白表达均降低,ZO-1和occludin蛋白表达均升高,差异均有统计学意义(P<0.05)。结论BET溴化域通过调节VEGFR2介导的PAK1和eNOS信号通路激活抑制血管生成,降低血管通透性,改善糖尿病大鼠视网膜病变。抑制BET溴化域的策略可能为限制血管生成相关疾病提供一种新的治疗方法。 展开更多
关键词 bet溴域抑制 VEGFR2 PAK1 eNOS 视网膜病变
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COVID‑19 pandemic and the crude oil market risk:hedging options with non‑energy financial innovations 被引量:1
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作者 Afees A.Salisu Kingsley Obiora 《Financial Innovation》 2021年第1期722-740,共19页
This study examines the hedging effectiveness of financial innovations against crude oil investment risks,both before and during the COVID-19 pandemic.We focus on the non-energy exchange traded funds(ETFs)as proxies f... This study examines the hedging effectiveness of financial innovations against crude oil investment risks,both before and during the COVID-19 pandemic.We focus on the non-energy exchange traded funds(ETFs)as proxies for financial innovations given the potential positive correlation between energy variants and crude oil proxies.We employ a multivariate volatility modeling framework that accounts for important statistical features of the non-energy ETFs and oil price series in the computation of optimal weights and optimal hedging ratios.Results show evidence of hedging effectiveness for the financial innovations against oil market risks,with higher hedging performance observed during the pandemic.Overall,we show that sectoral financial innovations provide resilient investment options.Therefore,we propose that including the ETFs in an investment portfolio containing oil could improve risk-adjusted returns,especially in similar financial crisis as witnessed during the pandemic.In essence,our results are useful for investors in the global oil market seeking to maximize risk-adjusted returns when making investment decisions.Moreover,by exploring the role of structural breaks in the multivariate volatility framework,our attempts at establishing robustness for the results reveal that ignoring the same may lead to wrong conclusions about the hedging effectiveness. 展开更多
关键词 Pandemics Financial innovations Energy markets hedging Optimal portfolio
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Hedging in Discourse Analysis
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作者 肖欣 《海外英语》 2015年第12期232-234,共3页
In this article an attempt to enhance the awareness of hedging use in discourse analysis and academic writing is madeby analyzing hedges employed in two comparable texts.The discourse analysis is conducted from"c... In this article an attempt to enhance the awareness of hedging use in discourse analysis and academic writing is madeby analyzing hedges employed in two comparable texts.The discourse analysis is conducted from"content-oriented"hedges and"reader-oriented"hedges.The article suggests that hedging can dampen utterances and statements,weaken the force of what onesays and show politeness to the listeners or readers,which varies from different discourse styles of various genres.discourse marker;hedging;research article;news 展开更多
关键词 DISCOURSE MARKER hedging research ARTICLE NEWS report
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The Relative Ordering of Optimal Hedging Points in a Class of Failure Prone Manufacturing Systems
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作者 俞新贞 宋文忠 《Journal of Southeast University(English Edition)》 EI CAS 1997年第1期114-117,共4页
For a class of manufacturing systems with homogeneous Markov machine failure rates,the stationary probability distribution of the part surplus can be calculated for given tentative values of hedging points. Some prope... For a class of manufacturing systems with homogeneous Markov machine failure rates,the stationary probability distribution of the part surplus can be calculated for given tentative values of hedging points. Some properties on the ordering of optimal hedging points are obtained. 展开更多
关键词 MANUFACTURING SYSTEM MARKOV chain transition rate SYSTEM state hedging point policy
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BET流动法测固体比表面积实验的改进 被引量:1
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作者 王安鼎 陈小娟 +1 位作者 朱远飞 杨洋溢 《实验室研究与探索》 CAS 北大核心 2023年第6期231-234,287,共5页
多层吸附(BET吸附)理论作为本科实验课的固体比表面积测定原理,通常应用于流动法测固体样品比表面的实验。实验中,吸附剂的支撑材料——玻璃纤维丝使用过程中不可避免地产生大量的细微玻璃纤维在空气中飘浮,对师生健康产生严重危害;新... 多层吸附(BET吸附)理论作为本科实验课的固体比表面积测定原理,通常应用于流动法测固体样品比表面的实验。实验中,吸附剂的支撑材料——玻璃纤维丝使用过程中不可避免地产生大量的细微玻璃纤维在空气中飘浮,对师生健康产生严重危害;新型多功能材料——聚四氟乙烯具有良好的安全性、稳定性,及易加工、可重复利用等性能已被应用于一些特殊场合。基于对师生安全的考虑,选用了聚四氟乙烯塑料丝替代玻璃纤维丝作为吸附剂的支撑材料。实验结果表明,使用聚四氟乙烯的BET吸附实验数据稳定可靠,而且安全环保,测试方法简便,教学效果显著提高。 展开更多
关键词 聚四氟乙烯 bet法测定比表面 流动吸附法 单点法
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Insiders' Hedging for Jump Diffusion Processes with Applications to Index Tracking
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作者 苏小囡 王伟 王文胜 《Journal of Donghua University(English Edition)》 EI CAS 2011年第6期571-575,共5页
The hedging problem for insiders is very important in the financial market.The locally risk minimizing hedging was adopted to solve this problem.Since the market was incomplete,the minimal martingale measure was chose... The hedging problem for insiders is very important in the financial market.The locally risk minimizing hedging was adopted to solve this problem.Since the market was incomplete,the minimal martingale measure was chosen as the equivalent martingale measure.By the F-S decomposition,the expression of the locally risk minimizing strategy was presented.Finally,the local risk minimization was applied to index tracking and its relationship with tracking error variance (TEV)-minimizing strategy was obtained. 展开更多
关键词 jump diffusion processes local risk minimization insiders’ hedging index tracking
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Option Pricing and Hedging under a Markov Switching Lévy Process Model
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作者 宋瑞丽 王波 《Chinese Quarterly Journal of Mathematics》 2017年第1期66-78,共13页
In this paper, we consider a Markov switching Lévy process model in which the underlying risky assets are driven by the stochastic exponential of Markov switching Lévy process and then apply the model to opt... In this paper, we consider a Markov switching Lévy process model in which the underlying risky assets are driven by the stochastic exponential of Markov switching Lévy process and then apply the model to option pricing and hedging. In this model, the market interest rate, the volatility of the underlying risky assets and the N-state compensator,depend on unobservable states of the economy which are modeled by a continuous-time Hidden Markov process. We use the MEMM(minimal entropy martingale measure) as the equivalent martingale measure. The option price using this model is obtained by the Fourier transform method. We obtain a closed-form solution for the hedge ratio by applying the local risk minimizing hedging. 展开更多
关键词 Markov chain model MEMM Lévy process option pricing hedging
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Power Purchase Model of Provincial Grids Based on Diverse Energy Coordination Hedging Optimization
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作者 Dunnan Liu Yujie Xu +3 位作者 Weimin Zeng Jiangping Liu Min Fan Xinming Liu 《Journal of Power and Energy Engineering》 2014年第4期463-469,共7页
Under the background of energy conservation, the grid companies should give priority to consumptive hydropower, wind power and other clean electricity to fulfill their social responsibility and promote the carbon emis... Under the background of energy conservation, the grid companies should give priority to consumptive hydropower, wind power and other clean electricity to fulfill their social responsibility and promote the carbon emission reduction in power industry. But under the current power purchase mode, grid companies must first perform the contract. This is extremely uneconomical and not environmentally friendly. Based on hedging theory, this paper proposes a power purchase optimization model using the strategy of “compression and compensation”. If outer price is lower than the contract price, the grid can compress contract power appropriately, leaving more space for purchasing electricity;if outer price is not attractive enough, the grid should timely improve contract proportion, compensating the deviations of contract caused by "compression". Based on the strategy of "compression and compensation", it can effectively reduce the abandoned wind and water, enhance the economic and social benefits of provincial power grid. 展开更多
关键词 Power PURCHASE OPTIMIZATION hedging "Compression and Compensation" Large-Scale System Decomposition-Coordination
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Mean-Variance Hedging for General Claims in an Incomplete Market: Numeraire Method
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作者 王桂兰 叶中行 《Journal of Shanghai Jiaotong university(Science)》 EI 2003年第2期175-178,共4页
This paper considered the problem of hedging a European call (put) option for a diffusion model where the asset price is influenced by n uncertain factors. The market is thus incomplete implying that perfect hedging i... This paper considered the problem of hedging a European call (put) option for a diffusion model where the asset price is influenced by n uncertain factors. The market is thus incomplete implying that perfect hedging is not possible. To derive a hedging strategy, it follows the approach based on the idea of hedging under a mean-variance criterion suggested by Schweizer. A very simple solution of this hedging problem by using the numeraire method was presented and some examples with explicit solutions were given. 展开更多
关键词 Mean-variance hedging incomplete market NUMERAIRE European options
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Optimal Hedging Strategies of Stock Index Futures Based on the Perspective of Information Asymmetry
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作者 Jianhua Guo 《Open Journal of Applied Sciences》 2020年第2期15-24,共10页
Based on two different risk measurement criteria, this article studied the optimal hedging strategies of stock index futures in the case of asymmetric information, and discussed the influence of insider information on... Based on two different risk measurement criteria, this article studied the optimal hedging strategies of stock index futures in the case of asymmetric information, and discussed the influence of insider information on the hedging effect. Through simulation analysis, it can be shown that hedging people with insider information can save hedging costs to a certain extent, which also explains the reason why investors try to obtain corporate information in actual investment activities. 展开更多
关键词 STOCK INDEX FUTURES OPTIMAL hedging Strategy Information Asymmetry
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转录因子T-bet在慢性阻塞性肺疾病发病中作用的研究进展
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作者 陈瑜婷 黄玲 +3 位作者 夏俊杰 邱宇 弋可 王金诚 《基础医学与临床》 2023年第8期1322-1325,共4页
慢性阻塞性肺疾病(COPD)是一种慢性进行性发展的呼吸系统疾病。转录因子T-bet在抗炎作用、免疫调节等方面参与COPD发病的炎性反应及肺功能改变,有望成为防治COPD发病的新靶点,为COPD的靶向研究提供新思路。
关键词 T-bet TH1细胞 TH2细胞 TH17细胞 慢性阻塞性肺疾病
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On discrete time hedging errors in a fractional Black-Scholes model
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作者 WANG Wen-sheng 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2017年第2期211-224,共14页
In this paper we investigate asymptotic behavior of error of a discrete time hedging strategy in a fractional Black-Scholes model in the sense of Wick-ItS-Skorohod integration. The rate of convergence of the hedging e... In this paper we investigate asymptotic behavior of error of a discrete time hedging strategy in a fractional Black-Scholes model in the sense of Wick-ItS-Skorohod integration. The rate of convergence of the hedging error due to discrete-time trading when the true strategy is known for the trader, is investigated. The result provides new statistical tools to study and detect the effect of the long-memory and the Hurst parameter for the error of discrete time hedging. 展开更多
关键词 discrete time hedging Wick-Itö-Skorohod integral rate of convergence weak convergence incomplete market fractional Brownian motion replicate Black-Scholes model
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