目的探讨初诊肥胖2型糖尿病患者血清Betatrophin水平与胰岛β细胞功能的关系。方法方便选择2014年1月—2015年1月初诊肥胖2型糖尿病患者100例为研究对象(观察组),另选择同期该院体检健康者(NGT)者100名为对照观察(对照组)。测量人体指标...目的探讨初诊肥胖2型糖尿病患者血清Betatrophin水平与胰岛β细胞功能的关系。方法方便选择2014年1月—2015年1月初诊肥胖2型糖尿病患者100例为研究对象(观察组),另选择同期该院体检健康者(NGT)者100名为对照观察(对照组)。测量人体指标,检测相关代谢血生化指标,采用酶联免疫吸附实验(ELISA)法测定空腹血清Betatrophin水平,采用直线相关分析研究betatrophin与胰岛β细胞功能、体测及代谢指标的相关关系。结果观察组血清Betatrophin水平(422.5±247.60)pg/m L明显高于对照组(316.3±293.30)pg/m L,差异有统计学意义(P<0.05);相关性分析提示Betatrophin与腰臀比、HOMA-IR、FPG、2 h PG、HbA1c、FINS、TG呈正相关(r=0.215、0.216、0.249、0.447、0.338、0.452、0.470,P<0.01),与HDL-C、HOMA-β成负相关(r=-0.256、-0.363,P<0.05),差异有统计学意义(P<0.05)。结论初诊肥胖2型糖尿病患者的血清betatrophin水平较NGT组明显升高,并且与胰岛β细胞功能密切相关,推测其参与了糖尿病的发生。展开更多
Takotsubo cardiomyopathy (also referred to as transient apical ballooning syndrome, broken heart syndrome or stress cardiomyopathy) is an increasingly recognized entity in the western world typically characterized by ...Takotsubo cardiomyopathy (also referred to as transient apical ballooning syndrome, broken heart syndrome or stress cardiomyopathy) is an increasingly recognized entity in the western world typically characterized by reversible left ventricular dysfunction that develops in the setting of acute severe emotional or physical stress. Increased catecholamine levels have been proposed to play a central role in the pathogenesis of the disease, although the specific pathophysiology of this condition remains elusive at the present moment. In recent times, there have been reports of takotsubo cardiomyopathy (TC) following medical interventions such as invasive or surgical procedures or specific medical regimens. In the current report, we present a patient with multiple recurrences of TC triggered by the same medical therapeutic intervention; in our particular case, repetitive exposure to inhaled beta-2-adrenoceptor agonist.展开更多
AIM: To investigate the diagnostic utility of beta 2 microglobulin (B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease (IBD).
基金Supported by the National Natural Science Foundation of China(No.51572232,No.51561135015)Key Technology Research and Development Program of Ningbo(No.2011B1001)
文摘目的探讨初诊肥胖2型糖尿病患者血清Betatrophin水平与胰岛β细胞功能的关系。方法方便选择2014年1月—2015年1月初诊肥胖2型糖尿病患者100例为研究对象(观察组),另选择同期该院体检健康者(NGT)者100名为对照观察(对照组)。测量人体指标,检测相关代谢血生化指标,采用酶联免疫吸附实验(ELISA)法测定空腹血清Betatrophin水平,采用直线相关分析研究betatrophin与胰岛β细胞功能、体测及代谢指标的相关关系。结果观察组血清Betatrophin水平(422.5±247.60)pg/m L明显高于对照组(316.3±293.30)pg/m L,差异有统计学意义(P<0.05);相关性分析提示Betatrophin与腰臀比、HOMA-IR、FPG、2 h PG、HbA1c、FINS、TG呈正相关(r=0.215、0.216、0.249、0.447、0.338、0.452、0.470,P<0.01),与HDL-C、HOMA-β成负相关(r=-0.256、-0.363,P<0.05),差异有统计学意义(P<0.05)。结论初诊肥胖2型糖尿病患者的血清betatrophin水平较NGT组明显升高,并且与胰岛β细胞功能密切相关,推测其参与了糖尿病的发生。
文摘Takotsubo cardiomyopathy (also referred to as transient apical ballooning syndrome, broken heart syndrome or stress cardiomyopathy) is an increasingly recognized entity in the western world typically characterized by reversible left ventricular dysfunction that develops in the setting of acute severe emotional or physical stress. Increased catecholamine levels have been proposed to play a central role in the pathogenesis of the disease, although the specific pathophysiology of this condition remains elusive at the present moment. In recent times, there have been reports of takotsubo cardiomyopathy (TC) following medical interventions such as invasive or surgical procedures or specific medical regimens. In the current report, we present a patient with multiple recurrences of TC triggered by the same medical therapeutic intervention; in our particular case, repetitive exposure to inhaled beta-2-adrenoceptor agonist.
文摘AIM: To investigate the diagnostic utility of beta 2 microglobulin (B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease (IBD).
