Errors will be caused in calculating the fatigue damages of details in liquid cargo tanks by using the traditional spectral analysis method which is based on linear system, for the nonlinear relationship between the d...Errors will be caused in calculating the fatigue damages of details in liquid cargo tanks by using the traditional spectral analysis method which is based on linear system, for the nonlinear relationship between the dynamic stress and the ship acceleration. An improved spectral analysis method for the assessment of the fatigue damage in detail of a liquid cargo tank is proposed in this paper. Based on assumptions that the wave process can be simulated by summing the sinusoidal waves in different frequencies and the stress process can be simulated by summing the stress processes induced by these sinusoidal waves, the stress power spectral density(PSD) is calculated by expanding the stress processes induced by the sinusoidal waves into Fourier series and adding the amplitudes of each harmonic component with the same frequency. This analysis method can take the nonlinear relationship into consideration and the fatigue damage is then calculated based on the PSD of stress. Take an independent tank in an LNG carrier for example, the accuracy of the improved spectral analysis method is proved much better than that of the traditional spectral analysis method by comparing the calculated damage results with the results calculated by the time domain method. The proposed spectral analysis method is more accurate in calculating the fatigue damages in detail of ship liquid cargo tanks.展开更多
In connection with the design of floating wind turbines,stochastic dynamic analysis is a critical task considering nonlinear wind and wave forces.To study the random structural responses of a newly designed submerged ...In connection with the design of floating wind turbines,stochastic dynamic analysis is a critical task considering nonlinear wind and wave forces.To study the random structural responses of a newly designed submerged tension leg platform(STLP)wind turbine,a set of dynamic simulations and comparison analysis with the MIT/NREL TLP wind turbine are carried out.The signal filter method is used to evaluate the mean and standard deviations of the structural response.Furthermore,the extreme responses are estimated by using the mean upcrossing rate method.The fatigue damages for blade root,tower,and mooring line are also studied according to the simulated time-series.The results and comparison analysis show that the STLP gives small surge and pitch motions and mooring line tensions in operational sea states due to the small water-plane area.Additionally,in severe sea states,the STLP gives lower extreme values of platform pitch,slightly larger surge and heave motions and better towerbase and mooring line fatigue performances than those of the MIT/NREL TLP.It is found that the STLP wind turbine has good performances in structural responses and could be a potential type for exploiting the wind resources located in deep waters.展开更多
High strength threaded fasteners are widely used in the aircraft industry, and service experience shows that for structures where shear loading of the joints is significant, like skin splices, fuselage joints or spar ...High strength threaded fasteners are widely used in the aircraft industry, and service experience shows that for structures where shear loading of the joints is significant, like skin splices, fuselage joints or spar caps-web attachments, more cracks are initiated and grow from the edges of the fastener holes than from features like fillets radii and corners or from large access holes. The main causes of this cracking are the stress concentrations introduced by the fastener holes and by the threaded fasteners themselves, with the most common damage site being at the edge of the fastener holes. Intuitively, it is easy to visualize that after the crack initiation, during the growth stages, some of the load transferred initially by the fastener at the cracked hole will decrease, and it will be shed to the adjacent fasteners that will carry higher loads than in uncracked condition. Using currently available computer software, the method presented in this paper provides a relatively quick and quantitatively defined solution to account for the effects of crack length on the fastener loads transfer, and on the far field and bypass loads at each fastener adjacent to the crack. At each location, these variations are determined from the 3-dimensional distribution of stresses in the joint, and accounting for secondary bending effects and fastener tilt. Two cases of a typical skins lap splice with eight fasteners in a two rows configuration loaded in tension are presented and discussed, one representative for wing or fuselage skins configurations, and the second case representative for cost effective laboratory testing. Each case presents five cracking scenarios, with the cracks growing from approx. 0.03 inch to either the free edge, next hole or both simultaneously.展开更多
A new continuum damage mechanics model for fretting fatigue life prediction is established. In this model, the damage evolution rate is described by two kinds of quantities. One is associated with the cyclic stress ch...A new continuum damage mechanics model for fretting fatigue life prediction is established. In this model, the damage evolution rate is described by two kinds of quantities. One is associated with the cyclic stress characteristics obtained by the finite element (FE) analysis, and the other is associated with the material fatigue property identified from the fatigue test data of standard specimens. The wear is modeled by the energy wear law to simulate the contact geometry evolution. A two-dimensional (2D) plane strain FE implementation of the damage mechanics model and the energy wear model is presented in the platform of ABAQUS to simulate the evolutions of the fatigue damage and the wear scar. The effect of the specimen thickness is also investigated. The predicted results of the crack initiation site and the fretting fatigue life agree well with available experimental data. Comparisons are made with the critical plane Smith- Watson-Topper (SWT) method.展开更多
A full-range nonlinear analysis method for fatigue damage in prestressed concrete beams is presented. New damage accumulation models are proposed to describe the fatigue damage evolution in concrete and reinforcement ...A full-range nonlinear analysis method for fatigue damage in prestressed concrete beams is presented. New damage accumulation models are proposed to describe the fatigue damage evolution in concrete and reinforcement respectively. Based on the stress analysis for cross section, the stress redistrbution in the fatigue damage process, due to the different damage mechanisms of concrete and reinforcement, is considered. The nonlinear damage analysis is achieved by means of piecewise linearity, and it is applicable on the condition of repeated loadings with variable amplitude. Fatigue damage modeling of a beam is implemented to illustrate that the proposed method can preferably fit the experimental results.展开更多
As a reliable alternative option for traditional steel catenary risers(SCRs),steep wave risers(SWRs)have been widely applied to deepwater oil and gas production.However,the nonlinear dynamic analysis of SWRs is more c...As a reliable alternative option for traditional steel catenary risers(SCRs),steep wave risers(SWRs)have been widely applied to deepwater oil and gas production.However,the nonlinear dynamic analysis of SWRs is more complicated than that of traditional SCRs due to their special configuration and significant geometric nonlinearity.Moreover,SWRs are highly susceptible to fatigue failure under the combined excitation of irregular waves and top floater motions(TFMs).In this study,considering irregular waves and TFMs,a numerical SWR model with an internal flow is constructed based on the slender rod model and finite element method.The Newmark-βmethod is adopted to solve the dynamic behavior of SWR.Moreover,the Palmgren-Miner rule,a specified S-N curve,and rainflow counting method are applied to estimate the fatigue damage.An efficient numerical computation procedure,i.e.,DRSWR,is programmed with MATLAB in this study.Calculation results are compared with those of OrcaFlex to verify the accuracy of the DRSWR.The nonlinear dynamic response and fatigue damage of an SWR under the combined excitation of irregular waves and TFMs are obtained,and a comprehensive parametric analysis is then conducted.The analysis results show that the buoyancy section undergoes the highest level of stress and fatigue damage under the combined excitation of irregular waves and TFMs.An internal flow with high velocity and high density produces a high level of fatigue damage.The buoyancy factor and length of the buoyancy section should be set moderately to reconcile the reduction of the top tension with increased fatigue life.These results are expected to provide some reference significance for the engineering design of SWR.展开更多
On the basis of the statistical characteristics of fatigue cumulative damageand its critical value, a new dynamic interference model for reliability analysis is presented. Because the nonlinearity of fatigue damage ac...On the basis of the statistical characteristics of fatigue cumulative damageand its critical value, a new dynamic interference model for reliability analysis is presented. Because the nonlinearity of fatigue damage accumulation is taken into account,this model is able to predict the fatigue reliability for random spectrum loadingconveniently. To verify the predicted results, a special fatigue expenment, in which thenumber of specimen is up to 101, is conducted using a fighter spectrum loading. It isshown that the new model is reliable, practicable and better than existing models.展开更多
Fatigue failures of driveline and suspension notched components for ground vehicles under multiaxial loading conditions are common, since most of those components are subjected to complex multiaxial loadings in servic...Fatigue failures of driveline and suspension notched components for ground vehicles under multiaxial loading conditions are common, since most of those components are subjected to complex multiaxial loadings in service. A computational fatigue analysis methodology has been proposed here for performing multiaxial fatigue life prediction for notched components using analytical and numerical methods. The proposed multiaxial fatigue analysis methodology consists of an elastic-plastic stress/strain model and a multiaxial fatigue damage parameter. Results of the proposed multiaxial fatigue analysis methodology are compared to sets of experimental data published in the literature to verify the prediction capability of the elastic-plastic stress/strain model and the multiaxial fatigue damage parameter. Based on the comparison between calculated results and experimental data, it is found that the multiaxial elastic-plastic stress/strain model correlates well with experimental strain data for SAE 1070 steel notched shafts subjected to several non-proportional load paths. In addition, the proposed fatigue damage parameter is found to correlate reasonably well with experimental fatigue data of SAE 1045 steel notched shafts subjected to proportional and non-proportional loadings.展开更多
The LY12CZ aluminum alloy specimens were corroded under the conditions of different test temperatures and exposure durations. After corrosion exposure, fatigue tests were performed. Scanning electron microscopy and op...The LY12CZ aluminum alloy specimens were corroded under the conditions of different test temperatures and exposure durations. After corrosion exposure, fatigue tests were performed. Scanning electron microscopy and optical microscope analyses on corrosion damage were carried out. The definition of surface corrosion damage ratio was provided to describe the extent of surface corrosion damage. On the basis of the measured data sets of the corrosion damage ratio, the probabilistic model of corrosion damage evolution was built. The corrosion damage decreased the fatigue life by a factor of about 1.25 to 2.38 and the prediction method of residual strength of the corroded structure was presented.展开更多
During the life of an offshore structure, its structural strength declines due to various kinds of damages related to the time factor. In this paper, four major kinds of damages, including damages caused by fatigue, d...During the life of an offshore structure, its structural strength declines due to various kinds of damages related to the time factor. In this paper, four major kinds of damages, including damages caused by fatigue, dent, corrosion and marine life, are discussed. Based on these analyses, formulas for the evaluation of the damaged structure reliability are derived. Furthermore the computer program ISM for the analysis of structural reliability is developed by the use of Advanced First Order Second Moment method and Monte-Carlo Importance Sampling method. The reliability of a turbular joint and a beam are studied as numerical examples. The results show that the theory and the analysis method given in this paper are reasonable and effective.展开更多
Under variable loading,fatigue life prediction is very important for the selection,design,and safety assessments of these components.In this study,based on the Miner rule,an improved damage accumulation rule was propo...Under variable loading,fatigue life prediction is very important for the selection,design,and safety assessments of these components.In this study,based on the Miner rule,an improved damage accumulation rule was proposed to consider the strengthening and damaging of low amplitude loads.The complexity of fatigue phenomenon results in predicting fatigue life difficulty.Since grey models(GMs)only require a limited amount of data to estimate the behavior of unknown systems,they are used in this paper to account for the uncertainties resulting from various sources when fatigue life of component is predicted.An improved unequal interval GM(IUGM(1,1))has been developed and applied successfully to estimation of fatigue life.An example is used to illustrate how the method works.The results show that the proposed model not only overcomes the limitations of the traditional grey forecasting model of linear change series,but also increases the scope of GM in the fatigue life prediction of mechanical components,and its accuracy is higher than that of the traditional model.Moreover,the results indicate that the IUGM(1,1)is capable of predicting component fatigue life better than the traditional Miner rule,and yields a high prediction precision.展开更多
In order to clarify the physical background of the scatter in fatigue behaviour, rotary bending fatigue tests are carried out using smooth speciments of a medium carbon steel with two kinds of grain sizes. The statis...In order to clarify the physical background of the scatter in fatigue behaviour, rotary bending fatigue tests are carried out using smooth speciments of a medium carbon steel with two kinds of grain sizes. The statistical characteristics of short carck initiation and growth lives are investigated by a new definition of short fatigue crack initiation. Detailed analysis reveals that the distribution of short crack initiation life can be expressed by two or threeparameter Weibull distribution, and the threeparameter Weibull distribution is well fitted to the distribution of short crack growth life, and the grain size and stress level have a great influence on the statistical characteristics of crack initiation and growth life.展开更多
Microdamage is produced in bone tissue under the long-termeffects of physiological loading,as well as age,disease and other factors.Bone remodeling can repair microdamage,otherwise this damage will undermine bone qual...Microdamage is produced in bone tissue under the long-termeffects of physiological loading,as well as age,disease and other factors.Bone remodeling can repair microdamage,otherwise this damage will undermine bone quality and even lead to fractures.In this paper,the damage variable was introduced into the remodeling algorithm.The new remodeling algorithm contains a quadratic term that can simulate reduction in bone density after large numbers of loading cycles.The model was applied in conjunction with the 3Dfinite elementmethod(FEM)to the remodeling of the proximal femur.The results showed that the initial accumulation of fatigue damage led to an increase in density but when the damage reached a certain level,the bone density decreased rapidly until the femur failed.With the accumulation of damage,bone remodeling was coupled with fatigue damage to maintain the function of bone.When the accumulation of damage reached a certain level,bone remodeling failed to repair the accumulated fatigue damage in time,and continued cyclic loading significantly weakened the loadbearing capacity of the bone.The new mathematical model not only predicts fatigue life,but also helps to further understand the compromise between damage repair and damage accumulation,which is of great significance for the prevention and treatment of clinical bone diseases.展开更多
基金financially supported by the National Natural Science Foundation of China(Grant No.51279102)the High-Technology Ship Research Project of the Ministry of Industry and Information Technology of China(Grant No.2012-534)
文摘Errors will be caused in calculating the fatigue damages of details in liquid cargo tanks by using the traditional spectral analysis method which is based on linear system, for the nonlinear relationship between the dynamic stress and the ship acceleration. An improved spectral analysis method for the assessment of the fatigue damage in detail of a liquid cargo tank is proposed in this paper. Based on assumptions that the wave process can be simulated by summing the sinusoidal waves in different frequencies and the stress process can be simulated by summing the stress processes induced by these sinusoidal waves, the stress power spectral density(PSD) is calculated by expanding the stress processes induced by the sinusoidal waves into Fourier series and adding the amplitudes of each harmonic component with the same frequency. This analysis method can take the nonlinear relationship into consideration and the fatigue damage is then calculated based on the PSD of stress. Take an independent tank in an LNG carrier for example, the accuracy of the improved spectral analysis method is proved much better than that of the traditional spectral analysis method by comparing the calculated damage results with the results calculated by the time domain method. The proposed spectral analysis method is more accurate in calculating the fatigue damages in detail of ship liquid cargo tanks.
基金the National Natural Science Foundation of China(Grant No.51809135)the National Natural Science Foundation of China-Shandong Joint Fund(Grant No.U1806227)the Natural Science Foundation of Shandong Province(Grant No.ZR2018BEE047).
文摘In connection with the design of floating wind turbines,stochastic dynamic analysis is a critical task considering nonlinear wind and wave forces.To study the random structural responses of a newly designed submerged tension leg platform(STLP)wind turbine,a set of dynamic simulations and comparison analysis with the MIT/NREL TLP wind turbine are carried out.The signal filter method is used to evaluate the mean and standard deviations of the structural response.Furthermore,the extreme responses are estimated by using the mean upcrossing rate method.The fatigue damages for blade root,tower,and mooring line are also studied according to the simulated time-series.The results and comparison analysis show that the STLP gives small surge and pitch motions and mooring line tensions in operational sea states due to the small water-plane area.Additionally,in severe sea states,the STLP gives lower extreme values of platform pitch,slightly larger surge and heave motions and better towerbase and mooring line fatigue performances than those of the MIT/NREL TLP.It is found that the STLP wind turbine has good performances in structural responses and could be a potential type for exploiting the wind resources located in deep waters.
文摘High strength threaded fasteners are widely used in the aircraft industry, and service experience shows that for structures where shear loading of the joints is significant, like skin splices, fuselage joints or spar caps-web attachments, more cracks are initiated and grow from the edges of the fastener holes than from features like fillets radii and corners or from large access holes. The main causes of this cracking are the stress concentrations introduced by the fastener holes and by the threaded fasteners themselves, with the most common damage site being at the edge of the fastener holes. Intuitively, it is easy to visualize that after the crack initiation, during the growth stages, some of the load transferred initially by the fastener at the cracked hole will decrease, and it will be shed to the adjacent fasteners that will carry higher loads than in uncracked condition. Using currently available computer software, the method presented in this paper provides a relatively quick and quantitatively defined solution to account for the effects of crack length on the fastener loads transfer, and on the far field and bypass loads at each fastener adjacent to the crack. At each location, these variations are determined from the 3-dimensional distribution of stresses in the joint, and accounting for secondary bending effects and fastener tilt. Two cases of a typical skins lap splice with eight fasteners in a two rows configuration loaded in tension are presented and discussed, one representative for wing or fuselage skins configurations, and the second case representative for cost effective laboratory testing. Each case presents five cracking scenarios, with the cracks growing from approx. 0.03 inch to either the free edge, next hole or both simultaneously.
基金supported by the National Natural Science Foundation of China(No.11002010)
文摘A new continuum damage mechanics model for fretting fatigue life prediction is established. In this model, the damage evolution rate is described by two kinds of quantities. One is associated with the cyclic stress characteristics obtained by the finite element (FE) analysis, and the other is associated with the material fatigue property identified from the fatigue test data of standard specimens. The wear is modeled by the energy wear law to simulate the contact geometry evolution. A two-dimensional (2D) plane strain FE implementation of the damage mechanics model and the energy wear model is presented in the platform of ABAQUS to simulate the evolutions of the fatigue damage and the wear scar. The effect of the specimen thickness is also investigated. The predicted results of the crack initiation site and the fretting fatigue life agree well with available experimental data. Comparisons are made with the critical plane Smith- Watson-Topper (SWT) method.
文摘A full-range nonlinear analysis method for fatigue damage in prestressed concrete beams is presented. New damage accumulation models are proposed to describe the fatigue damage evolution in concrete and reinforcement respectively. Based on the stress analysis for cross section, the stress redistrbution in the fatigue damage process, due to the different damage mechanisms of concrete and reinforcement, is considered. The nonlinear damage analysis is achieved by means of piecewise linearity, and it is applicable on the condition of repeated loadings with variable amplitude. Fatigue damage modeling of a beam is implemented to illustrate that the proposed method can preferably fit the experimental results.
基金the Natural Science Foundation of Shandong Province(Nos.ZR2019MEE032 and ZR2020ME261)the National Natural Science Foundation of China(Nos.U2006226 and 51979257)the Shandong Provincial Key Laboratory of Ocean Engineering(No.kloe202002)。
文摘As a reliable alternative option for traditional steel catenary risers(SCRs),steep wave risers(SWRs)have been widely applied to deepwater oil and gas production.However,the nonlinear dynamic analysis of SWRs is more complicated than that of traditional SCRs due to their special configuration and significant geometric nonlinearity.Moreover,SWRs are highly susceptible to fatigue failure under the combined excitation of irregular waves and top floater motions(TFMs).In this study,considering irregular waves and TFMs,a numerical SWR model with an internal flow is constructed based on the slender rod model and finite element method.The Newmark-βmethod is adopted to solve the dynamic behavior of SWR.Moreover,the Palmgren-Miner rule,a specified S-N curve,and rainflow counting method are applied to estimate the fatigue damage.An efficient numerical computation procedure,i.e.,DRSWR,is programmed with MATLAB in this study.Calculation results are compared with those of OrcaFlex to verify the accuracy of the DRSWR.The nonlinear dynamic response and fatigue damage of an SWR under the combined excitation of irregular waves and TFMs are obtained,and a comprehensive parametric analysis is then conducted.The analysis results show that the buoyancy section undergoes the highest level of stress and fatigue damage under the combined excitation of irregular waves and TFMs.An internal flow with high velocity and high density produces a high level of fatigue damage.The buoyancy factor and length of the buoyancy section should be set moderately to reconcile the reduction of the top tension with increased fatigue life.These results are expected to provide some reference significance for the engineering design of SWR.
文摘On the basis of the statistical characteristics of fatigue cumulative damageand its critical value, a new dynamic interference model for reliability analysis is presented. Because the nonlinearity of fatigue damage accumulation is taken into account,this model is able to predict the fatigue reliability for random spectrum loadingconveniently. To verify the predicted results, a special fatigue expenment, in which thenumber of specimen is up to 101, is conducted using a fighter spectrum loading. It isshown that the new model is reliable, practicable and better than existing models.
文摘Fatigue failures of driveline and suspension notched components for ground vehicles under multiaxial loading conditions are common, since most of those components are subjected to complex multiaxial loadings in service. A computational fatigue analysis methodology has been proposed here for performing multiaxial fatigue life prediction for notched components using analytical and numerical methods. The proposed multiaxial fatigue analysis methodology consists of an elastic-plastic stress/strain model and a multiaxial fatigue damage parameter. Results of the proposed multiaxial fatigue analysis methodology are compared to sets of experimental data published in the literature to verify the prediction capability of the elastic-plastic stress/strain model and the multiaxial fatigue damage parameter. Based on the comparison between calculated results and experimental data, it is found that the multiaxial elastic-plastic stress/strain model correlates well with experimental strain data for SAE 1070 steel notched shafts subjected to several non-proportional load paths. In addition, the proposed fatigue damage parameter is found to correlate reasonably well with experimental fatigue data of SAE 1045 steel notched shafts subjected to proportional and non-proportional loadings.
文摘The LY12CZ aluminum alloy specimens were corroded under the conditions of different test temperatures and exposure durations. After corrosion exposure, fatigue tests were performed. Scanning electron microscopy and optical microscope analyses on corrosion damage were carried out. The definition of surface corrosion damage ratio was provided to describe the extent of surface corrosion damage. On the basis of the measured data sets of the corrosion damage ratio, the probabilistic model of corrosion damage evolution was built. The corrosion damage decreased the fatigue life by a factor of about 1.25 to 2.38 and the prediction method of residual strength of the corroded structure was presented.
文摘During the life of an offshore structure, its structural strength declines due to various kinds of damages related to the time factor. In this paper, four major kinds of damages, including damages caused by fatigue, dent, corrosion and marine life, are discussed. Based on these analyses, formulas for the evaluation of the damaged structure reliability are derived. Furthermore the computer program ISM for the analysis of structural reliability is developed by the use of Advanced First Order Second Moment method and Monte-Carlo Importance Sampling method. The reliability of a turbular joint and a beam are studied as numerical examples. The results show that the theory and the analysis method given in this paper are reasonable and effective.
基金Joint Funds of the National Natural Soience Foundation of China(NSAF)(No.U1330130)
文摘Under variable loading,fatigue life prediction is very important for the selection,design,and safety assessments of these components.In this study,based on the Miner rule,an improved damage accumulation rule was proposed to consider the strengthening and damaging of low amplitude loads.The complexity of fatigue phenomenon results in predicting fatigue life difficulty.Since grey models(GMs)only require a limited amount of data to estimate the behavior of unknown systems,they are used in this paper to account for the uncertainties resulting from various sources when fatigue life of component is predicted.An improved unequal interval GM(IUGM(1,1))has been developed and applied successfully to estimation of fatigue life.An example is used to illustrate how the method works.The results show that the proposed model not only overcomes the limitations of the traditional grey forecasting model of linear change series,but also increases the scope of GM in the fatigue life prediction of mechanical components,and its accuracy is higher than that of the traditional model.Moreover,the results indicate that the IUGM(1,1)is capable of predicting component fatigue life better than the traditional Miner rule,and yields a high prediction precision.
文摘In order to clarify the physical background of the scatter in fatigue behaviour, rotary bending fatigue tests are carried out using smooth speciments of a medium carbon steel with two kinds of grain sizes. The statistical characteristics of short carck initiation and growth lives are investigated by a new definition of short fatigue crack initiation. Detailed analysis reveals that the distribution of short crack initiation life can be expressed by two or threeparameter Weibull distribution, and the threeparameter Weibull distribution is well fitted to the distribution of short crack growth life, and the grain size and stress level have a great influence on the statistical characteristics of crack initiation and growth life.
基金This research was funded by National Natural Science Foundation of China(Grant No.11972247).
文摘Microdamage is produced in bone tissue under the long-termeffects of physiological loading,as well as age,disease and other factors.Bone remodeling can repair microdamage,otherwise this damage will undermine bone quality and even lead to fractures.In this paper,the damage variable was introduced into the remodeling algorithm.The new remodeling algorithm contains a quadratic term that can simulate reduction in bone density after large numbers of loading cycles.The model was applied in conjunction with the 3Dfinite elementmethod(FEM)to the remodeling of the proximal femur.The results showed that the initial accumulation of fatigue damage led to an increase in density but when the damage reached a certain level,the bone density decreased rapidly until the femur failed.With the accumulation of damage,bone remodeling was coupled with fatigue damage to maintain the function of bone.When the accumulation of damage reached a certain level,bone remodeling failed to repair the accumulated fatigue damage in time,and continued cyclic loading significantly weakened the loadbearing capacity of the bone.The new mathematical model not only predicts fatigue life,but also helps to further understand the compromise between damage repair and damage accumulation,which is of great significance for the prevention and treatment of clinical bone diseases.