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Bimetallic ZIFs-derived electrospun carbon nanofiber membrane as bifunctional oxygen electrocatalyst for rechargeable zinc-air battery 被引量:2
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作者 Yanan Ma Shaoru Tang +5 位作者 Haimeng Wang Yuxuan Liang Dingyu Zhang Xiaoyang Xu Qian Wang Wei Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第8期138-149,I0006,共13页
The recharged zinc-air battery(ZAB) has drawn significant attention owing to increasing requirement for energy conversion and storage devices.Fabricating the efficient bifunctional oxygen catalyst using a convenient s... The recharged zinc-air battery(ZAB) has drawn significant attention owing to increasing requirement for energy conversion and storage devices.Fabricating the efficient bifunctional oxygen catalyst using a convenient strategy is vitally important for the rechargeable ZAB.In this study,the bimetallic ZIFs-containing electrospun(ES) carbon nanofibers membrane with hierarchically porous structure was prepared by coaxial electrospinning and carbonization process,which was expected to be a bifunctional electrocatalyst for ZABs.Owing to the formed dual single-atomic sites of Co-N_(4) and Zn-N_(4),the obtained ES-Co/ZnCNZIFexhibited the preferable performance toward oxygen reduction reaction(ORR) with E1/2of 0.857 V and JLof 5.52 mA cm^(-2),which were more than Pt/C.Meanwhile,it exhibited a marked oxygen evolution reaction(OER) property with overpotential of 462 mV due to the agglomerated metallic Co nanoparticles.Furthermore,the ZAB based on the ES-Co/Zn-CNZIFcarbon nanofibers membranes delivered peak power density of 215 mW cm^(-2),specific capacity of 802.6 mA h g^(-1),and exceptional cycling stability,far larger than Pt/C+RuO_(2)-based ZABs.A solid-state ZAB based on ES-Co/Zn-CNZIFshowed better flexibility and stability with different bending angles. 展开更多
关键词 Electrospun nanofibers membranes Zeolite imidazole framework Zinc-air battery ORR/OER bifunction Dual single-atomic sites catalysts
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Edge atomic Fe sites decorated porous graphitic carbon as an efficient bifunctional oxygen catalyst for Zinc-air batteries
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作者 Ruihui Gan Yali Wang +3 位作者 Xiangwu Zhang Yan Song Jingli Shi Chang Ma 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第8期602-611,I0014,共11页
The development of advanced bifunctional oxygen electrocatalysts for oxygen reduction and evolution reactions(ORR and OER) is critical to the practical application of zinc-air batteries(ZABs). Herein, a silica-assiste... The development of advanced bifunctional oxygen electrocatalysts for oxygen reduction and evolution reactions(ORR and OER) is critical to the practical application of zinc-air batteries(ZABs). Herein, a silica-assisted method is reported to integrate numerous accessible edge Fe-Nx sites into porous graphitic carbon(named Fe-N-G) for achieving highly active and robust oxygen electrocatalysis. Silica facilitates the formation of edge Fe-Nx sites and dense graphitic domains in carbon by inhibiting iron aggregation.The purification process creates a well-developed mass transfer channel for Fe-N-G. Consequently,Fe-N-G delivers a half-wave potential of 0.859 V in ORR and an overpotential of 344 m V at10 m A cm^(-2)in OER. During long-term operation, the graphitic layers protect edge Fe-Nx sites from demetallation in ORR and synergize with Fe OOH species endowing Fe-N-G with enhanced OER activity.Density functional theory calculations reveal that the edge Fe-Nx site is superior to the in-plane Fe-Nx site in terms of OH* dissociation in ORR and OOH* formation in OER. The constructed ZAB based on Fe-N-G cathode shows a higher peak power density of 133 m W cm^(-2)and more stable cycling performance than Pt/C + RuO2counterparts. This work provides a novel strategy to obtain high-efficiency bifunctional oxygen electrocatalysts through space mediation. 展开更多
关键词 Bifunctionality EdgeFe-Nxsites Oxygen catalysis Graphitic domains Zinc-air batteries
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Continuous nitrogen-doped carbon nanotube matrix for boosting oxygen electrocatalysis in rechargeable Zn-air batteries 被引量:9
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作者 Guangda Chen Yangyang Xu +2 位作者 Lei Huang Aboulkader Ibro Douka Bao Yu Xia 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第4期183-189,共7页
Developing robust oxygen electrocatalyst with high-performance is very significant for practical rechargeable Zn-air battery.We report herein the preparation of three-dimensional continuous nanocarbon network composed... Developing robust oxygen electrocatalyst with high-performance is very significant for practical rechargeable Zn-air battery.We report herein the preparation of three-dimensional continuous nanocarbon network composed of interconnected nitrogen-doped carbon nanotubes and its application as oxygen electrocatalysis in rechargeable Zn-air battery.Except the excellent electrochemical bifunctionality,this carbon nanotube matrix also delivers an impressive battery performance.Specifically,an opencircuit voltage of 1.50 V as well as a high power density of 220 m W cm^(-2) with remarkable cycling stability for 1600 h is achieved in the rechargeable Zn-air battery.The study not only provides an efficient bifunctional oxygen electrocatalyst but more importantly may pave significant concepts in designing robust electrode for long-life rechargeable Zn-air battery and other energy technologies. 展开更多
关键词 Zeolitic-imidazolate framework Carbon nanotube Bifunctionality ELECTROCATALYST Zn-air battery
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Carbon-based bifunctional electrocatalysts for oxygen reduction and oxygen evolution reactions:Optimization strategies and mechanistic analysis 被引量:4
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作者 Huidong Xu Jack Yang +6 位作者 Riyue Ge Jiujun Zhang Ying Li Mingyuan Zhu Liming Dai Sean Li Wenxian Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2022年第8期234-265,I0008,共33页
Electrocatalysts are one of the essential components for the devices of high-efficiency green energy storage and conversion,such as metal-air cells,fuel cells,and water electrolysis systems.While catalysts made from n... Electrocatalysts are one of the essential components for the devices of high-efficiency green energy storage and conversion,such as metal-air cells,fuel cells,and water electrolysis systems.While catalysts made from noble metals possess high catalytic performance in both oxygen reduction reaction(ORR)and oxygen evolution reaction(OER),their scarcity and expensiveness significantly limit large-scale applications.In this regard,metal-free/non-noble metal carbon-based catalysts have become competitive alternatives to replace catalysts made of noble metals.Nevertheless,low catalytic ORR/OER performance is the challenge of carbon-based catalysts for the commercial applications of metal-air batteries.To solve the problem of poor catalytic performance,two strategies have been proposed:(1)controlling the microstructure of the catalysts to expose more active sites as the channels of rapid mass and electron transfer;and(2)reducing the reaction energy barrier by optimizing the electronic structures of the catalysts via surface engineering.Here,we review different types of bifunctional ORR/OER electrocatalysts with the activated surface sites.We focus on how the challenge can be overcome with different methods of material synthesis,structural and surface characterization,performance validation/optimization,to outline the principles of surface modifications behind catalyst designs.In particular,we provide critical analysis in the challenges that we are facing in structural design and surface engineering of bifunctional ORR/OER catalysts and indicate the possible solution for these problems,providing the society with clearer ideas on the practical prospects of noble-metal-free electrocatalysts for their future applications. 展开更多
关键词 ELECTROCATALYST Bifunctionality Oxygen reduction Oxygen evolution Carbons transition metals Surface engineering MICROSTRUCTURE
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Production of propene from 1-butene metathesis reaction on tungsten based heterogeneous catalysts 被引量:3
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作者 Huijuan Liu Ling Zhang +5 位作者 Xiujie Li Shengjun Huang Shenglin Liu Wenjie Xin Sujuan Xie Longya Xu 《Journal of Natural Gas Chemistry》 EI CAS CSCD 2009年第3期331-336,共6页
A new propene production route from 1-butene metathesis has been developed on heterogeneous 10WO3/Al2O3-HY catalysts with different HY contents. It is found that the catalysts play bi-functionally first for the isomer... A new propene production route from 1-butene metathesis has been developed on heterogeneous 10WO3/Al2O3-HY catalysts with different HY contents. It is found that the catalysts play bi-functionally first for the isomerization of 1-butene to 2-butene and then for the cross-metathesis between 1-butene and 2-butene to propene and 2-pentene. The combination of HY zeolite and Al2O3 is prerequisite for the production of propene. The propene yield keeps increasing with the HY content in the range of 10-70 wt%, where 10WO3/Al2O3-70HY exhibits the highest propene yield. The MS-H2-TPR and MS-O2-TPO characterizations indicate that the increase of HY content in the catalysts weakens the interaction between W species and supports, whereas enhance the probability of coking on the metal species and acid sites. 展开更多
关键词 PROPENE 1-BUTENE METATHESIS 10WO3/Al2O3-xHY bifunction
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Study on Bifunctionality of Mo/HZSM-5 Catalysts for Methane Dehydro-Aromatization under Non-oxidative Condition 被引量:2
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作者 LinglingSu YideXu 《Journal of Natural Gas Chemistry》 CAS CSCD 2002年第1期18-27,共10页
The optimum Mo/[H^+] ratio per unit cell of the active precursors in Mo/HZSM-5 catalysts for methane dehydro-aromatization, measured by1H MAS NMR, was found to be about 1 when adjusting the acid sites by altering eith... The optimum Mo/[H^+] ratio per unit cell of the active precursors in Mo/HZSM-5 catalysts for methane dehydro-aromatization, measured by1H MAS NMR, was found to be about 1 when adjusting the acid sites by altering either the SiO2/Al2O3 ratios or the Mo loading. This implies that a concerted interaction between the Mo species and the Bronsted acid sites probably features the bifunctionality of the Mo/HZSM-5 catalyst. On the other hand, it was found that the driving force for Mo species to move into the HSZM-5 zeolite channels and the interaction between the Mo species and the Bronsted acid sites are closely and proportionably related with the amount of Bronsted acid sites per unit cell. 展开更多
关键词 methane dehydro-aromatization MO/HZSM-5 SiO2/Al2O3 ratio bifunctionality
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Pore-mouth catalysis boosting the formation of iso-paraffins from syngas over bifunctional catalysts 被引量:1
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作者 Mengheng Wang Yaoyao Han +6 位作者 Suhan Liu Zhiming Liu Dongli An Zhiqiang Zhang Kang Cheng Qinghong Zhang Ye Wang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2021年第12期2197-2205,共9页
Recent studies confirm that the emerging bifunctional catalysts consisting of metal oxide and zeolites can directly convert syngas into high-quality gasoline,however,the formation mechanism of iso-paraffins and the di... Recent studies confirm that the emerging bifunctional catalysts consisting of metal oxide and zeolites can directly convert syngas into high-quality gasoline,however,the formation mechanism of iso-paraffins and the difference with the conventional FT/zeolite catalyst have not been investigated.Herein,three one-dimensional SAPO zeolites with diverse micropore sizes were synthesized and assembled with ZnAlO_(x)with spinel structure.It was found that ZnAlO_(x)/SAPO-41 and ZnAlO_(x)/SAPO-11 with medium micropore sizes favored the formation of C_(5)–C_(11)hydrocarbons with a high content of iso-paraffins.The characterizations pointed out that the formation of iso-paraffins over SAPO-11 followed a pore-mouth catalysis mechanism,which means the isomerization of linear hydrocarbons can only take place near the pore mouth region of zeolites.This mechanism only allows the formation of mono-branched iso-paraffins in the C_(5)–C_(11)range,which are less prone to be cracked than their di-branched isomers.A careful comparative analysis between ZnAlO_(x)/SAPO-11 and Co/H-meso-ZSM-5 was also made in terms of product distribution,activity,and stability. 展开更多
关键词 Pore-mouth catalysis Shape-selective catalysis Bifunction SYNGAS Gasoline
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Efficient Co@Co_(3)O_(4) core-shell catalysts for photocatalytic water oxidation and its behaviors in two different photocatalytic systems 被引量:1
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作者 Di Wang Shanshan Qiao +4 位作者 Jia Guo Yuan Guo Qian Xu Naeem Akram Jide Wang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第6期83-91,I0003,共10页
The photocatalytic performances of water oxidation were usually carried out in two different systems,photosensitizer and non-photosensitizer systems.There is few report about the same catalyst used in two systems and ... The photocatalytic performances of water oxidation were usually carried out in two different systems,photosensitizer and non-photosensitizer systems.There is few report about the same catalyst used in two systems and therefore it is of great significant to compare its role of the same catalyst in two systems and explore its different reaction mechanisms.In this work,first 4 kinds of metallic Co microparticles were obtained by different reduction methods through hydrothermal processes,and Co@Co_(3)O_(4) coreshell microparticles(1-4)were obtained from these metallic Co microparticles oxidized in air or in the reacting solution in situ.The core-shell structure of 1 was characterized by a series of analytical techniques.1-4 exhibited excellent activities and stabilities in the[Ru(bpy)3]^(2+)/S_(2) O_(8)^(2-)/light system when they were used as catalysts for the photocata lytic water oxidation.The maximum O2 evolution of 1 after 20 min’s illumination was 98.2 pmol,the O_(2) yield was 65.5%,the initial turnover frequency was 6.6×10^(-3),the initial quantum efficiency(ΦQYinitial)was 15.0%higher than Co(8.3%),CoO(11.7%),Co_(2)O_(3)(1.2%),Co_(3)O_(4)(2.8%)and 5(2.2%).Even after the sixth run,the catalytic activity of recovered 1 still remained 85.1%of initial activity.In addition,the photocatalytic performances of 1 in the[Ru(bpy)_(3)]^(2+)/S_(2)O_(8)2-/light system and S_(2) O_(8)^(2-)/light system were compared for the first time.In the nonphotosensitizer system,1 shows bifunctional roles and acts as optical absorption center and active catalytic site,and oxygen evolution rate is lower and it takes longer time.In the photosensitizer system,1 only acts as a catalyst,the photosensitizer enhances the light absorption and promotes water oxidation reaction with higher O_(2) yield and QE,meanwhile the photosensitizer brings the defect of high cost and instability into the system.Based on the results the two different reaction mechanisms were deeply discussed. 展开更多
关键词 Water splitting Bifunction Semiconductor Metal@metal oxide PHOTOSENSITIZER
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Geometric and electronic effects on the performance of a bifunctional Ru2P catalyst in the hydrogenation and acceptorless dehydrogenation of N‐heteroarenes 被引量:1
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作者 Fangjun Shao Zihao Yao +7 位作者 Yijing Gao Qiang Zhou Zhikang Bao Guilin Zhuang Xing Zhong Chuan Wu Zhongzhe Wei Jianguo Wang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2021年第7期1185-1194,共10页
The development of bifunctional catalysts for the efficient hydrogenation and acceptorless dehydrogenation of N‐heterocycles is a challenge.In this study,Ru_(2)P/AC effectively promoted reversible transformations bet... The development of bifunctional catalysts for the efficient hydrogenation and acceptorless dehydrogenation of N‐heterocycles is a challenge.In this study,Ru_(2)P/AC effectively promoted reversible transformations between unsaturated and saturated N‐heterocycles affording yields of 98%and 99%,respectively.Moreover,a remarkable enhancement in the reusability of Ru_(2)P/AC was observed compared with other Ru‐based catalysts.According to density functional theory calculations,the superior performance of Ru_(2)P/AC was ascribed to specific synergistic factors,namely geometric and electronic effects induced by P.P greatly reduced the large Ru‐Ru ensembles and finely modified the electronic structures,leading to a low reaction barrier and high desorption ability of the catalyst,further boosting the hydrogenation and acceptorless dehydrogenation processes. 展开更多
关键词 Ruthenium phosphide Bifunction catalyst Reaction mechanism Geometric and electronic effects HYDROGENATION Acceptorless dehydrogenation
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Bifunctionality of Cu/ZnO catalysts for alcohol-assisted low-temperature methanol synthesis from syngas:Effect of copper content 被引量:1
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作者 Ilho Kim Gihoon Lee +2 位作者 Heondo Jeong Jong Ho Park Ji Chul Jung 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2017年第3期373-379,共7页
Alcohol-assisted low-temperature methanol synthesis was conducted over Cu/ZnO;catalysts while varying the copper content(X). Unlike conventional methanol synthesis, ethanol acted as both solvent and reaction interme... Alcohol-assisted low-temperature methanol synthesis was conducted over Cu/ZnO;catalysts while varying the copper content(X). Unlike conventional methanol synthesis, ethanol acted as both solvent and reaction intermediate in this reaction, creating a different reaction pathway. The formation of crystalline phases and characteristic morphology of the co-precipitated precursors during the co-precipitation step were important factors in obtaining an efficient Cu/ZnO catalyst with a high dispersion of metallic copper,which is one of the main active sites for methanol synthesis. The acidic properties of the Cu/ZnO catalyst were also revealed as important factors, since alcohol esterification is considered the rate-limiting step in alcohol-assisted low-temperature methanol synthesis. As a consequence, bifunctionality of the Cu/ZnO catalyst such as metallic copper and acidic properties was required for this reaction. In this respect, the copper content(X) strongly affected the catalytic activity of the Cu/ZnO;catalysts, and accordingly, the Cu/ZnO;.5 catalyst with a high copper dispersion and sufficient acid sites exhibited the best catalytic performance in this reaction. 展开更多
关键词 Low-temperature methanol synthesis Alcohol-assisted Bifunctionality Cu/ZnO catalysts Copper content
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Recent advances in transition-metal catalyzed nitrene transfer reactions with carbamates
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作者 Yanshu Luo Xinyu Zhang Yuanzhi Xia 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第3期76-86,共11页
Nitrene transfer reactions are powerful tools in synthetic organic chemistry.In recent years,transitionmetal catalyzed nitrene transfer reactions with carbamates as the nitrene precursors have been widely pursued.Such... Nitrene transfer reactions are powerful tools in synthetic organic chemistry.In recent years,transitionmetal catalyzed nitrene transfer reactions with carbamates as the nitrene precursors have been widely pursued.Such species undergoes facile C-H amination,aziridination,and bifunctionalization of alkenes under the catalysis of different transition metals including Rh,Fe,Ru and others,enabling the efficient construction of various nitrogen-containing molecules.In this review,the recent developments in nitrene transfer reactions with carbamates via N-O bond cleavage were introduced based on different types of reaction,and the key mechanistic information and synthetic applications of the methodologies were discussed. 展开更多
关键词 Transition-metal catalysis Nitrene transfer CARBAMATE C—H amination AZIRIDINATION bifunctionalization
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Ultrasmall NiFe layered double hydroxide strongly coupled on atomically dispersed FeCo-NC nanoflowers as efficient bifunctional catalyst for rechargeable Zn-air battery 被引量:12
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作者 Yiyan Wang Guoxin Zhang +6 位作者 Mang Ma Yan Ma Jiankun Huang Chen Chen Ying Zhang Xiaoming Sun Zifeng Yan 《Science China Materials》 SCIE EI CSCD 2020年第7期1182-1195,共14页
An atomically dispersed FeCo-NC material with the 3D flower-like morphology was used as a unique substrate for the controllable deposition of ultrasmall NiFe layered double hydroxide nanodots(termed as NiFe-NDs)to sim... An atomically dispersed FeCo-NC material with the 3D flower-like morphology was used as a unique substrate for the controllable deposition of ultrasmall NiFe layered double hydroxide nanodots(termed as NiFe-NDs)to simultaneously promote the sluggish kinetics of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).The size-limiting growth of NiFe-NDs(~4.0 nm in diameter)was realized via the confinement of the 3D flower-like mesoporous structure and the rich N/O functionality of FeCo-NC.Benefiting from the distinctive structure with the simultaneously maximum exposure of both OER and ORR active sites,the NiFe-ND/FeCo-NC composite showed an ORR halfwave potential of 0.85 V and an OER potential of 1.66 V in0.1 mol L-1KOH at 10.0 mA cm-2.In-situ Raman analysis suggested the activity of OER was derived from the Ni sites on NiFe-ND/FeCo-NC.Moreover,the NiFe-ND/FeCo-NC-assembled Zn-air battery(ZAB)exhibited a very small discharge-charge voltage gap of 0.87 V at 20 mA cm-2and robust cycling stability.Furthermore,the NiFe-ND/FeCo-NC composite was also applicable for fabricating all-solid-state ZAB to power wearable electronics with superior cycling stability under deformation.Our work could enlighten a new applicable branch of atomically dispersed metal-nitrogen-carbon materials as unique substrates for fabricating multifunctional electrocatalysts. 展开更多
关键词 atomically dispersed catalyst NiFe layered double hydroxide oxygen electrocatalyst bifunctionality zinc-air battery
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Metal@Silica Yolk-Shell Nanostructures as Versatile Bifunctional Nanocatalysts 被引量:6
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作者 Ji Chan Park Hyunjoon Song 《Nano Research》 SCIE EI CAS CSCD 2011年第1期33-49,共17页
Recent developments in nanochemistry offer precise morphology control of nanomaterials, which has significant impacts in the field of heterogeneous catalysis. Rational design of bifunctional catalysts can influence va... Recent developments in nanochemistry offer precise morphology control of nanomaterials, which has significant impacts in the field of heterogeneous catalysis. Rational design of bifunctional catalysts can influence various aspects of catalytic properties. In this review, a new class of bifunctional catalysts with a metal@silica yolk-shell nanostructure is introduced. This structure has many advantages as a heterogeneous catalyst since it ensures a homogeneous environment around each metal core, and particle sintering is effectively eliminated during high temperature reactions. The catalysts exhibit high activity and recyclability in gas- and solution-phase reactions. It is anticipated that appropriate selection of bifunctional components and optimal structural control will significantly further enhance the catalytic properties, and enable target reaction-oriented development of new catalysts. 展开更多
关键词 Yolk-shell nanostructure NANOCATALYST bifunctionality metal nanoparticles heterogeneous catalytic reactions
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Mesoporous silica SBA-15 functionalized with phosphonate and amino groups for uranium uptake 被引量:6
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作者 WANG XiaoLiang YUANLiYong +6 位作者 WANG YanFei LI ZiJie LIU YaLan FENG YiXiao ZHAO YuLiang CHAI ZhiFang SHI WeiQun 《Science China Chemistry》 SCIE EI CAS 2012年第9期1705-1711,共7页
Mesoporous silicas have a very attractive ability of sorption and enrichment of metal ions due to their huge surface area and facile functionalization by organic ligands. In this work, phosphonate-amino hifunctionaliz... Mesoporous silicas have a very attractive ability of sorption and enrichment of metal ions due to their huge surface area and facile functionalization by organic ligands. In this work, phosphonate-amino hifunctionalized mesoporous silica SBA-15 (PA-SBA-15) as U(VI) sorbent was fabricated through post-grafting method. The obtained mesoporous silica was character- ized by SEM, XRD, NMR and nitrogen sorption/desorption experiments, which revealed the existence of ordered mesoporous structure with uniform pore diameter and large surface area. The adsorptivity of PA-SBA-15 for U(VI) from aqueous solution was investigated using batch sorption technique under different experimental conditions. The preliminary results show that the U(VI) sorption by PA-SBA-15 is very quick with equilibrium time of less than 1 h, and the U(VI) uptake is as large as 373 mg/g at pH 5.5 under 95℃. The sorption isotherm has been successfully modeled by the Langmuir isotherm, suggesting a monolayer homogeneous sorption of U(VI) in PA-SBA-15. The sorption is pH-dependent due to the pH-dependent charge of sorbent in the aqueous solution. The thermodynamics research shows that the sorption is a feasible and endothermic process. Based on these results, PA-SBA-15 could be a promising solid phase sorbent for highly-efficient removal of U(VI) ions from waste water and enrichment of U(VI) from a solution at a very low level. 展开更多
关键词 mesoporous silica SBA-15 PHOSPHONATE amino group bifunctionalized SORPTION URANIUM
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Engineering the protein targeting two pathways of cerebral ischemia reperfusion injury provides better neuroprotective effect than targeting one pathway 被引量:1
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作者 Kuai Yu Ruyi Li +2 位作者 Yuanjun Zhu Xiaoyan Liu Yinye Wang 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2019年第11期760-769,共10页
We hypothesized that neuroprotective agents targeting various pathways involved in cerebral ischemia/reperfusion(I/R)injury might be superior to that targeting single pathway.Here,we prepared a fusion protein(B-I)by c... We hypothesized that neuroprotective agents targeting various pathways involved in cerebral ischemia/reperfusion(I/R)injury might be superior to that targeting single pathway.Here,we prepared a fusion protein(B-I)by combining anti-apoptotic Bcl-x L(B)and anti-inflammatory IL-10(I).B-I could cross blood brain barrier by its N-terminal TAT domain,and be cleaved into separate B and I by Caspase-1.B-I treatment significantly reduced the cerebral infarct volume,better than B or I treatment alone,and equivalent to B and I treatment(B+I).Treatment with B or B-I significantly attenuated I/R-induced neuronal apoptosis as shown by the decrease in apoptotic rate and the inhibition of caspase-3 activity.Moreover,all recombinant proteins,especially B-I,remarkably attenuated I/R-induced up-regulation of TNF-α.These results suggested that fusion protein B-I inhibiting both inflammation and apoptosis provided better neuroprotective effects than inhibiting either one alone.Our study suggested that multiple pathways targeting brain I-R injury could enhance the neuroprotective effect,and it provided a new idea for the study of neuroprotective drugs for ischemic stroke. 展开更多
关键词 Cerebral ischemia reperfusion Bifunction Apoptosis Inflammation NEUROPROTECTION
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Organocatalytic Stereoselective Synthesis of 3-Alkyl-3-hydroxy-2-oxindoles Catalyzed by Novel Water-compatible Axially Unfixed Biaryl-based Bifunctional Organocatalysts 被引量:1
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作者 Hongwu Zhao Wei Meng +7 位作者 Zhao Yang Ting Tian Zhihui Sheng Hailong Li Xiuqing Song Yutong Zhang Sen Yang Bo Li 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2014年第5期417-428,共12页
In this work,six novel axially unfixed biaryl-based water-compatible bifunctional organocatalysts were de-signed and synthesized for the organocatalytic access to a variety of 3-alkyl-3-hydroxy-2-oxindole derivatives ... In this work,six novel axially unfixed biaryl-based water-compatible bifunctional organocatalysts were de-signed and synthesized for the organocatalytic access to a variety of 3-alkyl-3-hydroxy-2-oxindole derivatives via aldol reactions in water.Organocatalyzed by 5a,the direct aldol reactions of isatins with enolisable ketones under-went readily in water,furnishing the structurally diverse 3-alkyl-3-hydroxy-2-oxindoles in various stereoselectivi-ties(up to>99%dr and>99%ee).Moreover,a plausible transition state of the conducted aldol reactions was hy-pothesized to shed light on the observed stereoselectivities of the obtained 3-alkyl-3-hydroxy-2-oxindoles. 展开更多
关键词 organocatalysis 3-alkyl-3-hydroxy-2-oxindole water-compatibility bifunctionality
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Activity Origins of Graphdiyne Based Bifunctional Atom Catalysts for Hydrogen Evolution and Water Oxidation
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作者 WU Han HE Feng 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2021年第6期1334-1340,共7页
Graphdiyne(GDY)based atom catalysts(ACs)show extraordinary electrocatalytic activities towards hydrogen evolution reaction(HER)and water oxidation reaction(OER),which have attracted wide attention of scientists.Howeve... Graphdiyne(GDY)based atom catalysts(ACs)show extraordinary electrocatalytic activities towards hydrogen evolution reaction(HER)and water oxidation reaction(OER),which have attracted wide attention of scientists.However,a precise understanding on the activities trends and origins of ACs is still under exploration.We investigate the electrocatalytic performance of a series of ACs in this work.Density functional theory(DFT)calculations reveal that the half reactions of OER and HER are site-dependent on ACs,which are preferentially proceeded on the metal site and the nearby bonded carbon site,respectively.Besides,the d-band center of metal atoms is the most important descriptor,which can perfectly correlate the high activities of ACs towards the two half reactions.Especially for HER,the deeper d-band position of metal atoms corresponds to much stronger d-p_(x)(p_(y))orbital coupling in ACs,which activate more obvious charge transfer between the metal site and the nearby bonded carbon site,resulting in the HER activity enhancement of ACs.These results are of great significance in guiding the precise synthesis of highly efficient bifunctional metal atom catalysts supported by GDY in future. 展开更多
关键词 Graphdiyne Atom catalyst Bifunction Activity origin Density functional theory
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