Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure

AIM： To investigate the protective effect of stronger neo-minophafen C （SNMC） on fulminant hepatic failure （FHF） and its underlying mechanism. METHODS： A mouse model of FHF was established by intraperitoneal injection of galactosamine （D-Gal N） and lipopolysaccharide （LPS）. The survival rate, liver function, inflammatory factor and liver pathological change were obtained with and without SNMC treatment. Hepatoo/te survival was estimated by observing the stained mitochondria structure with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling （TUNEL） method and antibodies against cytochrome C （Cyt-C） and caspase-3. RESULTS： The levels of plasma tumor necrosis factor alpha （TNF-α）, nitric oxide （NO）, ET-1, interleukin-6 （IL-6）, and the degree of hepatic tissue injury were decreased in the SNMC-treated groups compared with those in the model group （P 〈 0.01）. However, there were no differences after different dosages administered at different time points. There was a significant difference in survival rates between the SNMC-treated groups and the model group （P 〈 0.01）. The apoptosis index was 32.3% at 6 h after a low dose of SNMC, which was considerably decreased from 32.3% ± 4.7% vs 5% ± 2.83% （P 〈 0.05） to 5% on d 7. The expression of Cyt-C and caspase-3 decreased with the prolongation of therapeutic time. Typical hepatocyte apoptosis was obviously ameliorated under electron microscope with the prolongation of therapeutic time. CONCLUSION： SNMC can effectively protect liver against FHF induced by LPS/D-Gal N. SNMC can prevent hepatocyte apoptosis by inhibiting inflammatory reaction and stabilizing mitochondria membrane to suppress the release of Cyt-C and sequent activation of caspase-3.

Potential Applications of Milk Fractions and Valorization of Dairy By-Products: A Review of the State-of-the-Art Available Data, Outlining the Innovation Potential from a Bigger Data Standpoint

The unique composition of milk makes this basic foodstuff into an exceptional raw material for the production of new ingredients with desired properties and diverse applications in the food industry. The fractionation of milk is the key in the development of those ingredients and products;hence continuous research and development on this field, especially various levels of fractionation and separation by filtration, have been carried out. This review focuses on the production of milk fractions as well as their particular properties, applications and processes that increase their exploitation. Whey proteins and caseins from the protein fraction are excellent emulsifiers and protein supplements. Besides, they can be chemically or enzymatically modified to obtain bioactive peptides with numerous functional and nutritional properties. In this context, valorization techniques of cheese-whey proteins, by-product of dairy industry that constitutes both economic and environmental problems, are being developed. Phospholipids from the milk fat fraction are powerful emulsifiers and also have exclusive nutraceutical properties. In addition, enzyme modification of milk phospholipids makes it possible to tailor emulsifiers with particular properties. However, several aspects remain to be overcome;those refer to a deeper understanding of the healthy, functional and nutritional properties of these new ingredients that might be barriers for its use and acceptability. Additionally, in this review, alternative applications of milk constituents in the non-food area such as in the manufacture of plastic materials and textile fibers are also introduced. The unmet needs, the cross-fertilization in between various protein domains,the carbon footprint requirements, the environmental necessities, the health and wellness new demand, etc., are dominant factors in the search for innovation approaches;these factors are also outlining the further innovation potential deriving from those “apparent” constrains obliging science and technology to take them into account.

Recent Strategies for the Development of Biosourced-Monomers, Oligomers and Polymers-Based Materials: A Review with an Innovation and a Bigger Data Focus

After setting the ground of the quantum innovation potential of biosourced entities and outlining the inventive spectrum of adjacent technologies that can derive from those, the current review highlights, with the support of Bigger Data approaches, and a fairly large number of articles, more than 250 and 10,000 patents, the following. It covers an overview of biosourced chemicals and materials, mainly biomonomers, biooligomers and biopolymers;these are produced today in a way that allows reducing the fossil resources depletion and dependency, and obtaining environmentally-friendlier goods in a leaner energy consuming society. A process with a realistic productivity is underlined thanks to the implementation of recent and specifically effective processes where engineered microorganisms are capable to convert natural non-fossil goods, at industrial scale, into fuels and useful high-value chemicals in good yield. Those processes, further detailed, integrate: metabolic engineering involving 1) system biology, 2) synthetic biology and 3) evolutionary engineering. They enable acceptable production yield and productivity, meet the targeted chemical profiles, minimize the consumption of inputs, reduce the production of by-products and further diminish the overall operation costs. As generally admitted the properties of most natural occurring biopolymers (e.g., starch, poly (lactic acid), PHAs.) are often inferior to those of the polymers derived from petroleum;blends and composites, exhibiting improved properties, are now successfully produced. Specific attention is paid to these aspects. Then further evidence is provided to support the important potential and role of products deriving from the biomass in general. The need to enter into the era of Bigger Data, to grow and increase the awareness and multidimensional role and opportunity of biosourcing serves as a conclusion and future prospects. Although providing a large reference database, this review is largely initiatory, therefore not mimicking previous classic reviews but putting them in a multiplying synergistic prospective.

A Review: On Smart Materials Based on Some Polysaccharides;within the Contextual Bigger Data, Insiders, “Improvisation” and Said Artificial Intelligence Trends

Smart Materials are along with Innovation attributes and Artificial Intelligence among the most used “buzz” words in all media. Central to their practical occurrence, many talents are to be gathered within new contextual data influxes. Has this, in the last 20 years, changed some of the essential fundamental dimensions and the required skills of the actors such as providers, users, insiders, etc.? This is a preliminary focus and prelude of this review. As an example, polysaccharide materials are the most abundant macromolecules present as an integral part of the natural system of our planet. They are renewable, biodegradable, carbon neutral with low environmental, health and safety risks and serve as structural materials in the cell walls of plants. Most of them are used, for many years, as engineering materials in many important industrial processes, such as pulp and papermaking and manufacture of synthetic textile fibres. They are also used in other domains such as conversion into biofuels and, more recently, in the design of processes using polysaccharide nanoparticles. The main properties of polysaccharides (e.g. low density, thermal stability, chemical resistance, high mechanical strength…), together with their biocompatibility, biodegradability, functionality, durability and uniformity, allow their use for manufacturing smart materials such as blends and composites, electroactive polymers and hydrogels which can be obtained 1) through direct utilization and/or 2) after chemical or physical modifications of the polysaccharides. This paper reviews recent works developed on polysaccharides, mainly on cellulose, hemicelluloses, chitin, chitosans, alginates, and their by-products (blends and composites), with the objectives of manufacturing smart materials. It is worth noting that, today, the fundamental understanding of the molecular level interactions that confer smartness to polysaccharides remains poor and one can predict that new experimental and theoretical tools will emerge to develop the necessary understanding of the structure-property-function relationships that will enable polysaccharide-smartness to be better understood and controlled, giving rise to the development of new and innovative applications such as nanotechnology, foods, cosmetics and medicine (e.g. controlled drug release and regenerative medicine) and so, opening up major commercial markets in the context of green chemistry.

Bigger Strides in Shandong's Foreign Trade

The year 1994 will see the promotion of further economic restructuring in China and key breakthroughs. The reform of the foreign exchange system, in particular, has provided a rare opportunity for exports in foreign trade. Facing this favourable situation, the Shandong provincial government has decided export earnings are its main priority and wants to see a 16 to 20 percent growth above the US$5.7 billion earned last year. It will speed up the linking

Sino-African Ties Stronger and Deeper

The year 2016 was rich in events for China-Africa cooperation, with significant progress being made on key aspects at different levels. Major breakthroughs have been achieved for both sides dur- ing the year＇s major international events, including China＇s strong support for a plan on Africa＇s industrialization during the Hang- zhou G20 Summit.

Paving the High-Way to Sustainable, Value Adding Open-Innovation Integrating Bigger-Data Challenges: Three Examples from Bio-Ingredients to Robust Durable Applications of Electrochemical Impacts

A trilogy review, based on more than 300 references, is used to underline three challenges facing 1) the supply of sustainable, durable and protected biosourced ingredients such as lipids, 2) the accounting for valuable bio-by-products, such as whey proteins that have added-value potential removing their environmental weight and 3) the practical reliable synthetic biology and evolutionary engineering that already serve as a technology and science basis to expand from, such as for biopolymer growth. Bioresources, which are the major topic of this review, must provide answers to several major challenges related to health, food, energy or chemistry of tomorrow. They offer a wide range of ingredients which are available in trees, plants, grasses, vegetables, algae, milk, food wastes, animal manures and other organic wastes. Researches in this domain must be oriented towards a bio-sustainable-economy based on new valuations of the potential of those renewable biological resources. This will aim at the substitution of fossil raw materials with renewable raw materials to ensure the sustainability of industrial processes by providing bioproducts through innovative processes using for instance micro-organisms and enzymes (the so-called white biotechnology). The final stage objective is to manufacture high value-added products gifted with the right set of physical, chemical and biological properties leading to particularly innovative applications. In this review, three examples are considered in a green context open innovation and bigger data environment. Two of them (lipids antioxidants and milk proteins) concern food industry while the third (biomonomers and corresponding bioplastics and derivatives) relates to biomaterials industry. Lipids play a crucial role in the food industry, but they are chemically unstable and very sensitive to atmospheric oxidation which leads to the formation of numerous by-compounds which have adverse effects on lipids quality attributes and on the nutritive value of meat. To overcome this problem, natural antioxidants, with a positive impact on the safety and acceptability of the food system, have been discovered and evaluated. In the same context, milk proteins and their derivatives are of great interest. They can be modified by enzymatic means leading to the formation of by-products that are able to increase their functionality and possible applications. They can also produce bioactive peptides, a field with almost unlimited research potential. On the other hand, biosourced chemicals and materials, mainly biomonomers and biopolymers, are already produced today. Metabolic engineering tools and strategies to engineer synthetic enzyme pathways are developed to manufacture, from renewable feedstocks, with high yields, a number of monomer building-block chemicals that can be used to produce replacements to many conventional plastic materials. Through those three examples this review aims to highlight recent and important advancements in production, modification and applications of the studied bioproducts. Bigger data analysis and artificial intelligence may help reweight practical and theoretical observations and concepts in these fields;helping to cross the boarders of expert traditional exploration fields and sometime fortresses.

Method discussion for quick response grey prediction of stronger aftershocks of an earthquake sequence

In this paper, we take occurrence process of early strong aftershocks of a main after shock type′s earthquake sequence as a complex grey system, and introduce predicting method for its stronger aftershocks by grey predicting theory. Through inspection prediction for 1998 Zhangbei M S=6.2 earthquake sequence, it shows that the grey predicting method maybe has active significance for the investigation of quick response prediction problems of stronger aftershocks of an earthquake sequence.

Combining Effects between LHW and IBW Injections on EAST

The quasilinear combining effects between lower hybrid wave(LHW)and ion Bernstein wave(IBW)injections on current drive profiles are systematically studied based on the MHD equilibrium profiles of the Experimental Advanced Superconducting Tokamak(EAST).The simulation results indicate that the modifications of the distribution function due to IBW injection are nonlocalized in space and can affect the current drive profiles.The lower hybrid current drive efficiency can be either enhanced or reduced depending on the spectrum of the IBW injected into the plasma.In order to achieve stronger driven current,an appropriate IBW spectrum should be chosen for the combination of the LHW and IBW injections.

Observation of Coulomb Gap and Enhanced Superconducting Gap in Nano-Sized Pb Islands Grown on SrTiO3

We report high-resolution scanning tunneling microscopy(STM)study of nano-sized Pb islands grown on SrTiO3,where three distinct types of gaps with different energy scales are revealed.At low temperature,we find that the superconducting gap(△s)in nano-sized Pb islands is significantly enhanced from the one in bulk Pb,while there is no essential change in superconducting transition temperature Tc,giving rise to a larger BCS ratio 2△s/kBTc^8.31 and implying stronger electron-phonon coupling.The stronger coupling can originate from the interface electron-phonon interactions between Pb islands and SrTiO3.As the superconducting gap is totally suppressed under applied magnetic field,the Coulomb gap with apparent V-shape emerges.Moreover,the size of Coulomb gap(Ac)depends on the lateral size of Pb islands(R)with △c-1/R^035,indicating that quantum size effect can significantly influence electronic correlations.Our experimental results shall shed important light on the interplay among superconductivity,quantum size effect and correlations in nano-sized strong-coupling superconductors.

STUDY OF THE RELATIONSHIP BETWEEN THE HEPATOTOXICITY AND FREE RADICAL INDUCED BY 1,1,2-TRICHLOROETHANE AND 1,1,1-TRICHLOROETHANE IN RAT LIANG-FU XIA,DEPARTMENT OF TOXICOLOGY,SECOND MILITARY MEDICAL UNIVERSITY,SHANGHAI,CHINA.

1,1,2-trichloroethane(1,1,2-TCE) and 1,1,1-trichloro-ethane(1,1,1-TCE) were administered to rats to evaluatethe toxic effects on the rat liver.During whole animalstest the serum enzymes were assayed at 8 hr,12 hr,24 hr,36 hr,48 hr and 72 hr after the rat receiving 1,1,2-TCEand 1,1,1-TCE.The results showed that 1,1,2-TCE let tomuch higher values for SGPT,SSDH and SGDH than 1,1,1-TCEdid,especially at 24 hr after administration.At

STUDY ON MUTAGENICITY OF RAW COAGULATION-SEDIMENIED AND CHLORINATED DRINKING WATER FROM CHAO LAKE

During the period of algal growth of Chao Lake.We collectedits raw,coagulation-sedimented and chlorinated water and studiedthe mutagenicity of these water samples by using four bioassaymethods.The results showed that the organic concentrate of

THE CHARACTERISTICS OF THE OPTICS AND RADIO EMISSION OF THE ACTIVE REGION 5395 OF MARCH, 1989

The fast rotation of sunspot group 5395 ( first, it exhibited inverse clockwise rotation, then clockwise rotation, the rotative angle was the lagrest 1-2 days before proton flare.) the stronger emission of SVC and the spectral maximun (near 8800MHz) of both the SVC and peak fluxes of the bursts et al are close correlated with occurrence of proton flares. Flares often generated in the regions of emerging or disappearing of new magnetic flux with opposite polarity, of the faster and more complex variation of the gradient and configuration of magnetic field, and of the neck and tail of magnetic gulf.

Understanding the CPC—The CPC Through the Lens of Foreign Observations

The CPC centenary has polarized world attention for obvious reasons.During its 70-plus years of running the country,the Communist Party of China(CPC)has empowered the Chinese nation to advance from standing up,to becoming rich,to being ever stronger.China’s GDP has skyrocketed from the modest US$12.3 billion in 1949,when the People’s Republic was founded,to US$14.73 trillion in 2020.The country has been the world’s second largest economy for more than 10 years.

Urtra-Hard Bonds in P-Carbon Stronger than Diamond

The hardness and ideal strength of P-carbon, i.e., a new carbon phase for the cold-compressed carbon with an orthogonal structure recently proposed and named as P-carbon, are investigated by means of first-principles calculations. The strength calculations reveal that the failure mode in P-carbon is dominated by the tensile type. The ideal tensile strength of P-carbon is calculated to be 76.T GPa in the [001] direction, which is higher than that of the previously known most stable Z-carbon, of 71.4 GPa. Meanwhile, the theoretical Vickers hardness of P-carbon is estimated as 89 GPa, which is comparable with that of diamond. Especially, two types of bonds in P-carbon with hardness values of 114 GPa and 105 GPa are significantly stronger than those of diamond. The results provide insight into exploration of the ultra-hard P-carbon for potentially technological applications.

Extemal Quality Control and its Impacts on Quality in Auditing Companies With Focus on Small and Medium-sized Audit Companies

After numerous spectacular balance scandals in the United States and Europe, an international discussion about the quality of audits as well as the necessity to raise the quality of financial audits arose. The United States of America responded to this discussion with the ＂Sarbanes-Oxley Act＂, while the European Union decreed the directive 2006/43/EC. The mentioned directive updated the statutory provisions for the professional guild of auditors to increase the quality of audits. In detail, it demanded an external quality-control-system combined with public supervision for the profession of auditors to ensure a better quality. Due to this fact, the audit companies now have to fulfill a large range of requirements to provide evidence of their consistent auditing-quality and furthermore of the quality standards within their company. Since many small and medium-sized companies are not able to fulfill these new requirements, the number of small and medium-sized audit companies decreases noticeably. This paper discusses the research results on the effects of external quality control^given by law---on the auditor market in Germany focusing on small and medium-sized audit companies. Additionally the research examines that, if the external quality control, which was one of the justifications of the conversions of the EU-directive 2006/43/EC is able to increase the quality in audit companies at all. Therefore it needs to be tested whether there is a uniform and fits all approach of quality in audits. The research questions and the tests were analyzed scientifically and confirmed in several expert interviews with four different expert groups in Germany.

Autotoxicity of Water Extracts and Decomposition Liquids of Tumorous Stem Mustard(Brassica juncea var.tumida Tsen et Lee) Residues on Seed Germination and Seedling Growth of Tumorous Stem Mustard

[Objective] This study aimed to explore whether there is autotoxicity in tumorous stem mustard through studying the allelopathic effects of water extracts and decomposition liquids of tumorous stem mustard residues on seed germination and seedling growth of tumorous stem mustard.[Method] With Fuza No.2 as the experimental material,the effects of different concentrations of leaf extract,root extract,7-d decomposition liquid,15-d decomposition liquid of tumorous stem mustard on seed germination and seedling growth of tumorous stem mustard were investigated.[Result] Compared with those in the control,the four kinds of 100% treatment solutions all significantly reduced the seed germination rate,seed germination vigor,root length,plant height and fresh weight of tumorous stem mustard(P<0.05),and significantly increased the malondialdehyde(MDA) content,catalase(CAT) activity,peroxidase(POD) activity and superoxide dismutase(SOD) activity of young seedlings of tumorous stem mustard;the allelopathic effects of the four kinds of water extracts and decomposition liquids on seed germination and root length of tumorous stem mustard were weakened with the decreased concentration;for the four kinds of water extracts and decomposition liquids,low-concentration treatment solutions promoted the increase of plant height and fresh weight,while high-concentration treatment solutions inhibited the increase of plant height and fresh weight of young seedlings of tumorous stem mustard;the allelopathic effect of leaf extract on seed germination of tumorous stem mustard was stronger than those of root extract and decomposition liquids,the allelopathic effects of decomposition liquids on seedling growth of tumorous stem mustard were stronger than those of water extracts,the inhibitory effect of leaf extract on seed germination and seedling growth of tumorous stem mustard were stronger than that of root extract,and the inhibitory effect of 15-d decomposition liquid on seed germination and seedling growth of tumorous stem mustard was stronger than that of 7-d decomposition liquid.[Conclusion] The water extracts and decomposition liquids of tumorous stem mustard residues had certain autotoxicity on seed germination and seedling growth of tumorous stem mustard,and their allelopathic effects had a concentration-dependent manner.It could be presumed that the autotoxicity of tumorous stem mustard is the main cause of continuous cropping obstacle.

Nobel Prize Winner Konstantin Novoselov: Like Graphene, the Softer, the Stronger

If one day,mobile phones and cameras can be bendable and foldable,and they are not taken as something stiff in our pockets or carried as a burden on our shoulders anymore;If one day,new energy vehicles no longer need to be recharged every night for the next day’s commute or for long-distance journeys,and we would never be embarrassed and troubled by lack of power;

Time-Tested Ties Twenty years on, FOCAC drives stronger China-Africa cooperation on multiple levels

The biggest challenge to his diplomatic career-that s how Ethiopian Ambassador to China Teshom e Toga Chanaka describes 2020.The unexpected novel coronavims pan demic resulted in 300 Ethiopian students stuck in Wuhan,the capital city of central China's Hubei Province(where the country's first case was reported).