This paper reviews a novel cell-based biosensor and Bio-MEMS which incorporate living cells as sensing elements that convert a change in immediate environment to signals conducive for processing.It is characterized wi...This paper reviews a novel cell-based biosensor and Bio-MEMS which incorporate living cells as sensing elements that convert a change in immediate environment to signals conducive for processing.It is characterized with high sensitivity,excellent selectivity and fast response and have been implemented for a number of applications ranging from pharmaceutical screening to environmental pollutant detection.This paper also introduces our recent work about Light-Addressable Potentiometric Sensors (LAPS),Field Effect Transistor (FET),Micro-Electrode Array Sensors (MEAS) and Bio-MEMS for detecting the changes of concentration of extracellular ions and the action potential of living cell under effect of drugs and environmental parameters.Finely, the paper gives some prospects of cell-based biosensors in the future.展开更多
Mandibular single denture opposed by maxillary natural dentition showed a great problem. However, mandibular implant overdenture treatment has gained considerable recognition. Ten male patients with complete mandibula...Mandibular single denture opposed by maxillary natural dentition showed a great problem. However, mandibular implant overdenture treatment has gained considerable recognition. Ten male patients with complete mandibular edentulous arch and opposing arch have full natural dentition. Patients were divided into two groups. All patients received two endosseous titanium implants. In Group I, patients were rehabilitated with conventional implant retained overdentures. While in Group II, Patients were rehabilitated with occlusal reactive implant overdentures. A Novel proposed biosensor was used to measure the amount of biting force on the implant retained overdenture. Quantitative electromyographic (EMG) signals of the masseter and anterior fibers of temporalis muscles were recorded, filtered and directly interfaced with a computer to represent the data graphically. The mean amplitude (μV), turn, and activity were recorded at the baseline and after three months. The results revealed an increase in the muscle activity in group II after three months as compared to group I. Significant difference in bilateral biting force at the premolar-molar area was found between group I and group II after three months. This study concluded that a resilient implant overdenture denture could be a desirable treatment in mandibular overdenture supported by two implants with resilient attachment and opposing natural dentition due to its easy fabrication and durability in use and increased muscle activity.展开更多
This paper presents a low-power CMOS analog front-end (AFE) IC designed with a selectable on-chip dual AC/DC- coupled paths for bio-sensor applications. The DC-coupled path can be selected to sense a biosignal with us...This paper presents a low-power CMOS analog front-end (AFE) IC designed with a selectable on-chip dual AC/DC- coupled paths for bio-sensor applications. The DC-coupled path can be selected to sense a biosignal with useful DC information, and the AC-coupled path can be selected for sensing the AC content of the biosignal by attenuating the unwanted DC component. The AFE IC includes a DC-coupled instrumentation amplifier (INA), two variable-gain 1st-order low pass filters (LPF) with tunable cut-off frequencies, a fixed gain 2nd-order Sallen-Key high-pass filter (HPF) with tunable cut-off frequencies, a buffer and an 8-bit differential successive approximation register (SAR) ADC. The entire AFE channel is designed and fabricated in a proprietary 0.35-μm CMOS technology. Excluding an external buffer needed to properly drive the ADC, the measured AFE IC consumes only 2.37 μA/channel with an input referred noise of ~40 μVrms in [1 Hz, 1 kHz], and successfully displays proper ECG (electrocardiogram) and electrogram (EGM) waveforms for QRS peaks detection. We expect that the low-power dual-path design of this AFE IC can enable it to periodically record both the AC and the DC signals for proper sensing and calibration for various bio-sensing applications.展开更多
A compacted and low-offset low-power CMOS am- plifier for biosensor application is presented in this paper. It includes a low offset Op-Amp and a high precision current reference. With a novel continuous-time DC offse...A compacted and low-offset low-power CMOS am- plifier for biosensor application is presented in this paper. It includes a low offset Op-Amp and a high precision current reference. With a novel continuous-time DC offset rejection scheme, the IC achieves lower offset voltage and lower power consumption compared to previous designs. This configuration rejects large DC offset and drift that exist at the skin-electrode interface without the need of external components. The proposed amplifier has been implemented in SMIC 0.18-μm 1P6M CMOS technol-ogy, with an active silicon area of 100 μm by 120 μm. The back-annotated simulation results demonstrated the circuit features the systematic offset voltage less than 80 μV, the offset drift about 0.27 μV/℃ for temperature ranging from –30℃ to 100℃ and the total power dissipation consumed as low as 37.8 μW from a 1.8 V single supply. It dedicated to monitor low amplitude biomedical signals recording.展开更多
Bio-sensor arrays for multi-channel recording have been developed recently and signal processing platforms for those signals have been studied actively.But it’s thereal situation which these technologies are generall...Bio-sensor arrays for multi-channel recording have been developed recently and signal processing platforms for those signals have been studied actively.But it’s thereal situation which these technologies are generally developed and studied respectively.So the interface design between recording array and signal processing platform is also an important issue to make bio-sensor signal processing system.In this paper,we proposed interface which has unique protocols to control sensor array and operate platform.There are two types of protocols in the interface.One is between sensor array and MCU in platform and the other is between MCU and board for wireless communication.Basically,each protocol has two kinds of modes(single,frame)and it can be extended if needed.展开更多
基金Acknowledgement： This work was supported by the National Natural Science Foundation of China （Grant Nos. 30270387, No. 30570492）；the Project of State Key Laboratory of Transducer Technology of China （Grant No. SKT0403）；the Foundation for the Bureau of Zhejiang Province of China （Grant No. 20040197）.
文摘This paper reviews a novel cell-based biosensor and Bio-MEMS which incorporate living cells as sensing elements that convert a change in immediate environment to signals conducive for processing.It is characterized with high sensitivity,excellent selectivity and fast response and have been implemented for a number of applications ranging from pharmaceutical screening to environmental pollutant detection.This paper also introduces our recent work about Light-Addressable Potentiometric Sensors (LAPS),Field Effect Transistor (FET),Micro-Electrode Array Sensors (MEAS) and Bio-MEMS for detecting the changes of concentration of extracellular ions and the action potential of living cell under effect of drugs and environmental parameters.Finely, the paper gives some prospects of cell-based biosensors in the future.
文摘Mandibular single denture opposed by maxillary natural dentition showed a great problem. However, mandibular implant overdenture treatment has gained considerable recognition. Ten male patients with complete mandibular edentulous arch and opposing arch have full natural dentition. Patients were divided into two groups. All patients received two endosseous titanium implants. In Group I, patients were rehabilitated with conventional implant retained overdentures. While in Group II, Patients were rehabilitated with occlusal reactive implant overdentures. A Novel proposed biosensor was used to measure the amount of biting force on the implant retained overdenture. Quantitative electromyographic (EMG) signals of the masseter and anterior fibers of temporalis muscles were recorded, filtered and directly interfaced with a computer to represent the data graphically. The mean amplitude (μV), turn, and activity were recorded at the baseline and after three months. The results revealed an increase in the muscle activity in group II after three months as compared to group I. Significant difference in bilateral biting force at the premolar-molar area was found between group I and group II after three months. This study concluded that a resilient implant overdenture denture could be a desirable treatment in mandibular overdenture supported by two implants with resilient attachment and opposing natural dentition due to its easy fabrication and durability in use and increased muscle activity.
文摘This paper presents a low-power CMOS analog front-end (AFE) IC designed with a selectable on-chip dual AC/DC- coupled paths for bio-sensor applications. The DC-coupled path can be selected to sense a biosignal with useful DC information, and the AC-coupled path can be selected for sensing the AC content of the biosignal by attenuating the unwanted DC component. The AFE IC includes a DC-coupled instrumentation amplifier (INA), two variable-gain 1st-order low pass filters (LPF) with tunable cut-off frequencies, a fixed gain 2nd-order Sallen-Key high-pass filter (HPF) with tunable cut-off frequencies, a buffer and an 8-bit differential successive approximation register (SAR) ADC. The entire AFE channel is designed and fabricated in a proprietary 0.35-μm CMOS technology. Excluding an external buffer needed to properly drive the ADC, the measured AFE IC consumes only 2.37 μA/channel with an input referred noise of ~40 μVrms in [1 Hz, 1 kHz], and successfully displays proper ECG (electrocardiogram) and electrogram (EGM) waveforms for QRS peaks detection. We expect that the low-power dual-path design of this AFE IC can enable it to periodically record both the AC and the DC signals for proper sensing and calibration for various bio-sensing applications.
文摘A compacted and low-offset low-power CMOS am- plifier for biosensor application is presented in this paper. It includes a low offset Op-Amp and a high precision current reference. With a novel continuous-time DC offset rejection scheme, the IC achieves lower offset voltage and lower power consumption compared to previous designs. This configuration rejects large DC offset and drift that exist at the skin-electrode interface without the need of external components. The proposed amplifier has been implemented in SMIC 0.18-μm 1P6M CMOS technol-ogy, with an active silicon area of 100 μm by 120 μm. The back-annotated simulation results demonstrated the circuit features the systematic offset voltage less than 80 μV, the offset drift about 0.27 μV/℃ for temperature ranging from –30℃ to 100℃ and the total power dissipation consumed as low as 37.8 μW from a 1.8 V single supply. It dedicated to monitor low amplitude biomedical signals recording.
文摘Bio-sensor arrays for multi-channel recording have been developed recently and signal processing platforms for those signals have been studied actively.But it’s thereal situation which these technologies are generally developed and studied respectively.So the interface design between recording array and signal processing platform is also an important issue to make bio-sensor signal processing system.In this paper,we proposed interface which has unique protocols to control sensor array and operate platform.There are two types of protocols in the interface.One is between sensor array and MCU in platform and the other is between MCU and board for wireless communication.Basically,each protocol has two kinds of modes(single,frame)and it can be extended if needed.
