Traditional Chinese medicine （TCM） has an ancient history and unique system, including theory, methodology, prescription, formulation and medicines. There are differences between TCM and chemical drugs. For TCM, the...Traditional Chinese medicine （TCM） has an ancient history and unique system, including theory, methodology, prescription, formulation and medicines. There are differences between TCM and chemical drugs. For TCM, the multiple components in vivo are possibly to be detected; the number of components is relatively restricted; they could represent the therapeutic effect of the parent recipe; the concentrations and pharmacokinetics （PK） could affected by the combination of traditional medicines in recipe; the effects of new bioactive compounds （metabolites） related with those of their recipe; and the PK can be affected by body state in TCM treatment significantly. Therefore, the difficulty and challenge are far greater in PK study of TCMs than the chemical drugs.展开更多
A fluorescent cyclodextrin/carbon nanotube assembly was easily constructed through the non-covalent attach- ment of adamantanylpyrene on carbon nanotube and the following association of cyclodextrin derivative bearing...A fluorescent cyclodextrin/carbon nanotube assembly was easily constructed through the non-covalent attach- ment of adamantanylpyrene on carbon nanotube and the following association of cyclodextrin derivative bearing fluorescent substituent, and its structure was fully characterized by UV/Vis/NIR spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy and atomic force microscopy. Fluorescence spectroscopic and fluorescence microscopic studies showed that the resultant non-covalently functionalized fluo- rescent nanotube could be used as a highly selective fluorescent probe for Zn2＋ in both water and living cells. Without carbon nanotube, the fluorescence probe was unable to enter the cell but only anchored on the cell mem- brane. This approach will overcome the disadvantage of many spectral sensors that are unable to enter living cells and greatly improve the application of naotube-related supramolecular architecture in nanoscience and technology.展开更多
文摘Traditional Chinese medicine （TCM） has an ancient history and unique system, including theory, methodology, prescription, formulation and medicines. There are differences between TCM and chemical drugs. For TCM, the multiple components in vivo are possibly to be detected; the number of components is relatively restricted; they could represent the therapeutic effect of the parent recipe; the concentrations and pharmacokinetics （PK） could affected by the combination of traditional medicines in recipe; the effects of new bioactive compounds （metabolites） related with those of their recipe; and the PK can be affected by body state in TCM treatment significantly. Therefore, the difficulty and challenge are far greater in PK study of TCMs than the chemical drugs.
文摘A fluorescent cyclodextrin/carbon nanotube assembly was easily constructed through the non-covalent attach- ment of adamantanylpyrene on carbon nanotube and the following association of cyclodextrin derivative bearing fluorescent substituent, and its structure was fully characterized by UV/Vis/NIR spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy and atomic force microscopy. Fluorescence spectroscopic and fluorescence microscopic studies showed that the resultant non-covalently functionalized fluo- rescent nanotube could be used as a highly selective fluorescent probe for Zn2＋ in both water and living cells. Without carbon nanotube, the fluorescence probe was unable to enter the cell but only anchored on the cell mem- brane. This approach will overcome the disadvantage of many spectral sensors that are unable to enter living cells and greatly improve the application of naotube-related supramolecular architecture in nanoscience and technology.
