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The influence of Lactobacillus plantarum fermentation in selenium-enriched Brassica napus L.:changes in the nutritional constituents,bioactivities and bioaccessibility
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作者 Wen Wang Zhixiong He +3 位作者 Ruiying Zhang Min Li Zhenxia Xu Xia Xiang 《Oil Crop Science》 CSCD 2024年第2期81-90,共10页
Selenium(Se)-enriched Brassica napus L.is a valuable organic Se supplement.In this study,the fermentation broth enriched with organic Se(FFS)was prepared using Lactobacillus plantarum to ferment the substrate of Se-en... Selenium(Se)-enriched Brassica napus L.is a valuable organic Se supplement.In this study,the fermentation broth enriched with organic Se(FFS)was prepared using Lactobacillus plantarum to ferment the substrate of Se-enriched Brassica napus L.Significant increases were observed after fermentation in total sugars,reducing sugars,soluble proteins,total phenolic content(TPC),and total flavonoid content(TFC).The organic Se was retained at a concentration of 54.75 mg/g in the freeze-dried sample.Principal component analysis and cluster analysis showed good separation between the FFS and unfermented(FS)groups.Fragrant 2-ethyloxetane had the highest content among all volatiles,while sinapine had the highest content among all phenolic compounds.The fermentation process showed remarkable improvement in the abundance and concentration of volatile compounds and phenolic contents,making FFS exhibit strong antioxidant activity and inhibitory capacity againstα-glucosidase activity.The bioaccessibility of phenolic compounds was significantly greater in FFS compared to FS.ADMET analysis revealed that the majority of phenolic compounds contained in FFS did not exhibit mutagenicity toxicity,hepatotoxicity,skin sensitization,or blood-brain barrier penetration,indicating a favorable level of biosafety.Overall,our study provides a new insight into the further utilization of Se-enriched Brassica napus L.in foods. 展开更多
关键词 Se-enriched Brassica napus L. FERMENTATION Antioxidant activity Inhibitory activity bioaccessibility
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Bioaccessibility of Vanadium from Soil and Mineral Measured by in vitro Model 被引量:2
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作者 何建州 杨金燕 +1 位作者 田丽燕 唐亚 《Agricultural Science & Technology》 CAS 2012年第10期2142-2146,共5页
[Objective] This study aimed to investigate the existing forms and bioaccessibility of vanadium(V) from soil and mineral of Panzhihua region.[Method] The representative Xigeda soil and vanadium-titanium magnetite we... [Objective] This study aimed to investigate the existing forms and bioaccessibility of vanadium(V) from soil and mineral of Panzhihua region.[Method] The representative Xigeda soil and vanadium-titanium magnetite were collected from Panzhihua region to determine the existing forms of vanadium from soil and mineral;in vitro bionic digestion model was established to measure the bioaccessibility of vanadium.[Result] The dissolved concentrations of vanadium from farmland,mining area and vanadium-titanium magnetite in gastric juice were respectively 5.02,9.50 and 3.88 mg/kg,and the bioaccessibility ranged from 0.09% to 3.00%;the dissolved concentrations of vanadium in intestinal juice were respectively 2.98,5.43 and 4.49 mg/kg,and the bioaccessibility ranged from 0.10% to 1.78%.The content of vanadium in various existing forms varied significantly,the contents of vanadium in non-specific adsorption state and specific adsorption state were low,but residual content was completely high,which accounted for 75.06%,95.32% and 86.27% of the total content of vanadium in samples.[Conclusion] Bioaccessibility of dissolved vanadium in gastric juice was higher than that in small intestinal juice.Vanadium from soil and mineral was difficult to generate morphological transformation and migration,which was the main reason for low bioaccessibility. 展开更多
关键词 Heavy metal in vitro Morphological analysis bioaccessibility SOIL MINERAL
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The Application of Nutrimetabolomics to Investigating the Bioaccessibility of Nutrients in Ham Using a Batch <i>in Vitro</i>Digestion Model 被引量:1
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作者 Xiaoyan Pan Frances Smith +2 位作者 Matthew T. Cliff Francesco Capozzi E. N. Clare Mills 《Food and Nutrition Sciences》 2014年第1期17-26,共10页
Delivering high quality dietary protein at an affordable price is a major aim of the EU-funded CHANCE project. Foods have been formulated with this aim and as part of their nutritional assessment;the bioaccessbility o... Delivering high quality dietary protein at an affordable price is a major aim of the EU-funded CHANCE project. Foods have been formulated with this aim and as part of their nutritional assessment;the bioaccessbility of nutrients following simulated gastroduodenal digestion is being investigated. Nutrimetabolomics approaches can be used to comprehensively and quantitatively analyse nutrients and metabolites. They have been applied to monitor nutrient release from ham, formulated in the CHANCE project, during in vitro digestion. SDS-PAGE analysis shows that constituent ham proteins were broken down to lower molecular weight polypeptides (Mr ≤ 10 kDa) after 120 min simulated gastric digestion which was digested further by subsequent duodenal digestion. Digestion of porteins resulted in the appearance of coalesced lipid droplets associated with the loss of the muscle protein matrix of the ham. Important nutrients, such as choline, creatine, carnosine, sucrose, cholesterol, triacylglyceride and fatty acids (saturated and unsaturated) were identified using 1H NMR. Chance ham is a good source of dietary protein and the combined approach can provide representative data on the bioaccessibility of all detectable nutrients contained in CHANCE ham to human digestive system. 展开更多
关键词 In VITRO DIGESTION HAM Nutrimetabolomics NMR bioaccessibility
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Characterization and Bioaccessibility of Minerals in Seeds of Salvia hispanica L. 被引量:1
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作者 Aline D. Barreto Érika M. R. Gutierrez +5 位作者 Mauro R. Silva Fabiano O. Silva Nilton O. C. Silva Inayara C. A. Lacerda Renata A. Labanca Raquel L. B. Araújo 《American Journal of Plant Sciences》 2016年第15期2323-2337,共16页
Salvia hispanica L. is a herbacia plant that originates from Mexico and Guatemala, and it is currently known by the popular name of chia. Currently, chia seeds have been considered to be of great importance for human ... Salvia hispanica L. is a herbacia plant that originates from Mexico and Guatemala, and it is currently known by the popular name of chia. Currently, chia seeds have been considered to be of great importance for human health and nutrition because they have a high concentration of polyunsaturated fatty acids. They contain the largest known percentage of fatty α-linolenic acid (ALA) in plants—approximately 68%. Furthermore, they are an excellent source of protein, dietary fiber, calcium, magnesium, iron, vitamin B and phenolic compounds that have antioxidant properties. However, despite the high nutritional value present in the food and the possible health benefits of its nutrients, there is a need to evaluate the bioaccessibility of its micronutrients to measure their effectiveness. Thus, we evaluated the chemical composition of chia seeds from different producers, their lipid profiles and the bioaccessibility of some of their minerals. 展开更多
关键词 Salvia hispanica L. Chemical Composition Lipid Profile bioaccessibility
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Antioxidant Capacity and Bioaccessibility of Synergic Mango (cv. Ataulfo) Peel Phenolic Compounds in Edible Coatings Applied to Fresh-Cut Papaya
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作者 Gustavo Rubén Velderrain-Rodríguez Maribel Ovando-Martínez +7 位作者 Mónica Villegas-Ochoa Jesús Fernando Ayala-Zavala Abraham Wall-Medrano Emilio álvarez-Parrilla Tomás Jesús Madera-Santana Humberto Astiazarán-García Orlando Tortoledo-Ortiz Gustavo Adolfo González-Aguilar 《Food and Nutrition Sciences》 2015年第3期365-373,共9页
Edible coatings (EC) applied to fresh-cut fruits are used to increase their shelf-life and to deliver antioxidant bioactives such as phenolic compounds (PC) that reduce their oxidative damage while enhance their funct... Edible coatings (EC) applied to fresh-cut fruits are used to increase their shelf-life and to deliver antioxidant bioactives such as phenolic compounds (PC) that reduce their oxidative damage while enhance their functional value. However, the combination of different PC may have synergetic, additive or antagonic effects on the final antioxidant capacity (AOXC). The aim of this study was to examine the AOXC of binary combinations of selected PC from mango peel and their bioaccessibility from 6% alginate-based EC applied to fresh-cut papaya, under simulated gastrointestinal conditions. Among equimolar (0.1 mM) combinations, gallic + protocatechuic acids (AB) were synergic in radical scavenging activity (RSA) as assayed by DPPH (90% RSA) and FRAP (0.39 mg TE/mL) methods;when assayed in 6% alginate-based EC, their RSA increased (117.85% RSA, 0.88 mg TE/mL). The application of EC + AB to papaya cubes and further in vitro digestion decreased their AOXC probably due to interactions between EC and papaya’s matrix. Therefore, further studies are needed in order to evaluate the effect of combination of phenolic and EC applied in other fruits matrix on antioxidants bioaccessibility. 展开更多
关键词 EDIBLE Coating Phenolic Acids Antioxidant Capacity bioaccessibility
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Inhalation Bioaccessibility of Potentially Toxic Metals in Tobacco Snuff and Related Exposure Risks
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作者 Boisa Ndokiari Brown Holly +1 位作者 Odinga Tamuno-Boma Cookey Julie 《Journal of Environmental Protection》 2021年第4期237-248,共12页
This study determined the concentrations and inhalation bioaccessibility of cadmium, chromium, nickel and zinc in some foreign and locally available tobacco snuff and leaves. For the determination of the heavy metals ... This study determined the concentrations and inhalation bioaccessibility of cadmium, chromium, nickel and zinc in some foreign and locally available tobacco snuff and leaves. For the determination of the heavy metals concentration, the samples were ashed and washed with hydrochloric acid according to standard method. The bioaccessibility test employed the Stimulated Epithelial Lung Fluid (SELF). The total concentration of heavy metals in the four samples investigated ranged between 9.7 - 14.9 μg/g, 24.1 - 37.0 μg/g, 41 - 69 μg/g and 153 - 183 μg/g for cadmium, chromium, nickel and zinc respectively. The percentage inhalation bioaccessibility fraction of the four samples investigated ranged between 20.8% - 59.8%, 3.3% - 8.1%, 21.7% - 48.8% and 7.6% - 12.5% for cadmium, chromium, nickel, and zinc respectively. Statistical analyses using SPSS 21, revealed significant differences in the total concentration of heavy metals in the samples investigated except for Zinc. Risk assessment based on daily consumption of 10 g of the tobacco snuff employing total concentration of the heavy metals suggests that excluding nickel, all other metals investigated indicated daily intake values above WHO permissible levels. However, with the bioaccessible fractions, only cadmium, a known carcinogen indicated levels above WHO limits. From the results of this study, it can be deduced that consumption of tobacco snuff may induce negative health effects such as cancer and its attendant complications, the risk analysis based on bioaccessible concentration suggests lower health risk than analysis based on total heavy metal concentration;hence the assumption that snuff is a safe alternative to tobacco smoking may be erroneous. 展开更多
关键词 TOBACCO LEAVES SNUFF INHALATION bioaccessibility Heavy Metals Stimulated Epithelial Lung Fluid SELF Exposure Risk
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Bioaccessibility of Phenolic Compounds of Araucaria angustifolia from Seed Water Extracts during In Vitro Simulated Gastrointestinal Conditions
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作者 Iria Pedroso da Cunha Denise Wibelinger de Melo +3 位作者 Silvani Verruck Bruna Marchesan Maran Elane Schwinden Prudencio Edna Regina Amante 《Food and Nutrition Sciences》 2018年第10期1137-1146,共10页
Food by-products containing bioactive substances, such as phenolic compounds, have garnered attention due to the possibility to increase the value of what would otherwise be considered residue. The present work sought... Food by-products containing bioactive substances, such as phenolic compounds, have garnered attention due to the possibility to increase the value of what would otherwise be considered residue. The present work sought to evaluate the extraction of phenolic compounds and their bioaccessibility from pinh&atilde;o “comum” (Araucaria angustifolia var. angustifolia) and pinh&atilde;o “macaco” (Araucaria angustifolia var. indehiscens) cooking water extracts during in vitro simulated gastrointestinal conditions. Our findings indicate that changes occurred depending on the type of extract and the gastrointestinal step. Although both of the evaluated pinh&atilde;o extracts displayed bioaccessible phenolic compounds, the gradual bioaccessibility decrease of pinh&atilde;o “macaco” extract during in vitro simulated gastrointestinal condition steps, characterizes this extract as the one with the best functional property. The functional property is related to antioxidant properties which are able to generate protective effects against various diseases. 展开更多
关键词 Araucaria angustifolia Pinhao Extract PHENOLIC In Vitro bioaccessibility Functional Properties
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Mineralogical controls on the bioaccessibility of arsenic in weathered gold mine tailings
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作者 Madeleine C. Corriveau Michael B. Parsons +3 位作者 Heather E. Jamieson Iris Koch Ken J. Reime Gwendy E.M. Hall 《Chinese Journal Of Geochemistry》 EI CAS 2006年第B08期33-33,共1页
关键词 尾矿 水银 生物可达性 同步加速器 金矿 风化
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中国优控多环芳烃土壤污染特征及国内外生物可给性研究进展 被引量:1
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作者 陈梦舫 周源 +4 位作者 韩璐 李义连 陈雪艳 侯少林 李婧 《土壤学报》 CAS CSCD 北大核心 2024年第4期892-915,共24页
多环芳烃(PolycyclicAromaticHydrocarbons,PAHs)是一类持久性有机污染物,容易在土壤中累积并且毒性显著,但PAHs在土壤固相上的吸附性较强,基于土壤污染总量暴露会导致高估人群健康风险。本研究基于2000―2020年间发表的123篇文献,总结... 多环芳烃(PolycyclicAromaticHydrocarbons,PAHs)是一类持久性有机污染物,容易在土壤中累积并且毒性显著,但PAHs在土壤固相上的吸附性较强,基于土壤污染总量暴露会导致高估人群健康风险。本研究基于2000―2020年间发表的123篇文献,总结了我国土壤中16种优先控制多环芳烃(∑_(16)PAHs)的污染浓度分布和组成特征,介绍了11种常见的模拟PAHs生物可给性测试方法和主要影响因素,并总结了PAHs的生物可给性系数范围。调研表明土壤∑_(16)PAHs最高与平均浓度分别为23250和1314.7μg·kg^(–1),污染较为严重;近年来PAHs生物可给性测试方法主要基于生理原理提取法(PBET),在模拟消化过程和吸附剂等方面不断完善和改进,并且消化条件、土壤性质等因素对生物可给性结果影响较大。16种PAHs的生物可给性平均值范围为13.2%~72.4%,其中■和苯并[b]荧蒽的生物可给性较高,对∑_(16)PAHs暴露产生贡献较高。本调研结果为开展土壤PAHs污染精细化风险评估研究提供重要理论参考依据。 展开更多
关键词 土壤 PAHS 生物有效性 生物可给性 体外胃肠模拟法 精细化风险评估
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城市公园绿地土壤重金属的生物可利用性分析
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作者 孙境蔚 赵洁妮 +1 位作者 张云峰 侯雅涵 《泉州师范学院学报》 2024年第5期1-9,共9页
采用电感耦合等离子体质谱仪对福建省泉州市4个绿地公园的表层土壤中6种重金属(Cr、Mn、Ni、Cu、Zn、Pb)的总量、赋存形态含量和植物样品(兰花草、龙船花、鬼针草、肾蕨)中的重金属含量进行测定,分析其重金属在土壤-植物体系中的迁移特... 采用电感耦合等离子体质谱仪对福建省泉州市4个绿地公园的表层土壤中6种重金属(Cr、Mn、Ni、Cu、Zn、Pb)的总量、赋存形态含量和植物样品(兰花草、龙船花、鬼针草、肾蕨)中的重金属含量进行测定,分析其重金属在土壤-植物体系中的迁移特征和生物可利用性.结果表明:(1)表层土壤中Mn、Ni、Cu、Zn、Pb平均含量均大于福建省土壤背景值;(2)Mn、Zn、Pb、Cr以有效态为主,生物可利用性高,Ni、Cu以残渣态为主,但不能忽略其他形态在土壤中的迁移转化,次生相与原生相比值结果表明,Zn、Pb和Mn的生物可利用性较强;(3)不同植物不同部位对不同金属具有不同的富集迁移能力,植物对重金属的富集与迁移能力并非呈现相关关系. 展开更多
关键词 重金属形态 绿地公园 土壤-植物体系 生物可利用性
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福州市道路灰尘中多环芳烃粒径分布、生物可利用度及其毒性当量 被引量:1
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作者 马晓丽 何雨恒 +3 位作者 张辉 王子淳 魏然 倪进治 《环境化学》 CAS CSCD 北大核心 2024年第2期515-523,共9页
以福州道路灰尘为研究对象,研究了不同粒径灰尘(>250μm、250—53μm和<53μm)中多环芳烃(PAHs)的含量和组成,并利用体外消化模型结合固相萃取技术评估了不同粒径灰尘中PAHs的生物可利用度以及有效态PAHs的苯并(a)芘(BaP)毒性当... 以福州道路灰尘为研究对象,研究了不同粒径灰尘(>250μm、250—53μm和<53μm)中多环芳烃(PAHs)的含量和组成,并利用体外消化模型结合固相萃取技术评估了不同粒径灰尘中PAHs的生物可利用度以及有效态PAHs的苯并(a)芘(BaP)毒性当量浓度(TEQBaP).结果表明,(1)不同粒径灰尘中PAHs总量随粒径减小而增加(>250μm,0.597 mg·kg^(-1);250—53μm,1.235 mg·kg^(-1);<53μm,3.931 mg·kg^(-1)).不同粒径灰尘中PAHs组成基本相同,都为4环(58.5%±0.8%)>5环(21.5%±0.4%)>3环(13.3%±0.9%)>6环(4.8%±0.2%)>2环(2.0%±0.3%);(2)不同粒径灰尘中有效态PAHs总量随粒径减小而增加,但>250μm粒径灰尘中PAHs的生物可利用度显著高于250—53μm和<53μm粒径灰尘(P<0.05).总体上,低环(2环、3环和4环)PAHs生物可利用度要大于高环(5环和6环)PAHs;(3)不同粒径灰尘中有效态PAHs的总TEQBaP值随粒径减小而增大,且不同粒径灰尘中4环和5环PAHs的TEQBaP值都显著高于其他环数PAHs(P<0.05).由于不同粒径灰尘中4环PAHs含量都最高,且其具有较高的生物可利用度和TEQBaP值,因而在人体内潜在毒性风险最高. 展开更多
关键词 多环芳烃 组成 粒径 体外消化模型 生物可利用度 毒性当量
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植物基食品中多酚的生物转化及生物活性研究进展
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作者 林登蕃 郑志豪 +6 位作者 周映君 龚文兵 朱作华 严理 胡镇修 彭源德 谢纯良 《食品科学》 EI CAS CSCD 北大核心 2024年第14期319-327,共9页
多酚是植物次生代谢产物中重要的一类化合物,具有抗氧化、抗炎、抗癌等生物活性,对人体健康有益。然而,大部分多酚在进入肠道后存在生物利用度低等问题,研究表明,利用微生物转化可以提高植物基食品生物利用度。因此,本文对植物基食品发... 多酚是植物次生代谢产物中重要的一类化合物,具有抗氧化、抗炎、抗癌等生物活性,对人体健康有益。然而,大部分多酚在进入肠道后存在生物利用度低等问题,研究表明,利用微生物转化可以提高植物基食品生物利用度。因此,本文对植物基食品发酵过程中微生物对不同酚类的生物转化进行综述,分析发酵前后多酚和生物活性的变化,对揭示微生物对多酚的转化机制及优化多酚的应用和开发具有重要意义。 展开更多
关键词 发酵 生物转化 多酚 生物利用度 生物可及性
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玻璃生产场地土壤中砷的污染特征及其概率风险评估
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作者 杨丹华 贾晓洋 +3 位作者 李文波 梁竞 夏天翔 吴志远 《环境科学研究》 CAS CSCD 北大核心 2024年第4期887-900,共14页
砷(As)主要通过采矿、冶炼和燃煤等工业过程进入环境,然而玻璃生产中使用大量含砷原料,却鲜见相关土壤污染的报道.为探究玻璃生产场地土壤中As污染及健康风险情况,采用统计分析、正定矩阵因子模型(PMF)、体外测试、蒙特卡洛模拟等方法,... 砷(As)主要通过采矿、冶炼和燃煤等工业过程进入环境,然而玻璃生产中使用大量含砷原料,却鲜见相关土壤污染的报道.为探究玻璃生产场地土壤中As污染及健康风险情况,采用统计分析、正定矩阵因子模型(PMF)、体外测试、蒙特卡洛模拟等方法,研究了曾进行50余年生产活动的某平板玻璃厂土壤中As的污染浓度、空间分布及来源,并进一步结合生物可给性和本土化暴露参数(体质量、室内暴露频率、室外暴露频率、每日空气呼吸量),计算了健康风险水平及风险控制值.结果表明:该平板玻璃厂493件土壤样品中As的超标率达21.5%,As最大浓度位于平拉车间,高达317 mg/kg,其中80.3%来自配合料泄露.土壤中As的生物可给性范围为10.24%~54.35%,土壤理化性质对生物可给性结果具有显著影响.As的致癌风险范围为2.23×10^(−7)~1.22×10^(−3),95%分位值为5.77×10^(−5),危害商范围为9.49×10^(−3)~56.08,95%分位值为2.62;相应地,基于致癌风险的As风险控制值为0.50~3.57 mg/kg,其5%分位值为0.75 mg/kg,略低于传统点评估方法(DRA)的风险控制值(1.13 mg/kg).参数敏感性分析结果表明,生物可给性对风险控制值计算结果的影响(−64.38%)最大,其次是体质量,成人与儿童的敏感性分别为10.96%及19.18%,其余参数的敏感性均小于10%.总之,玻璃生产场地土壤中As污染不可忽视,使用本土化的暴露参数,并且将生物可给性纳入现有健康风险方法有助于更加全面客观地评估其健康风险水平,可为环境管理提供决策依据. 展开更多
关键词 平板玻璃厂 土壤 生物可给性 概率风险评估
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叶绿素对叶黄素生物可给率的影响
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作者 黄千千 陈丽君 +5 位作者 李韵唱 陈雪寒 陈乾睿 王元楷 蔡甜 陈科伟 《食品工业科技》 CAS 北大核心 2024年第5期108-117,共10页
叶黄素具有多种生理活性,它在人体内不能合成,只能从外界获取,但叶黄素因其脂溶性的特点导致生物可给率低,如何高效补充叶黄素成为研究热点。叶绿素常与叶黄素共同出现在人类饮食中,且二者均为脂溶性物质,会产生一定的相互作用。因此研... 叶黄素具有多种生理活性,它在人体内不能合成,只能从外界获取,但叶黄素因其脂溶性的特点导致生物可给率低,如何高效补充叶黄素成为研究热点。叶绿素常与叶黄素共同出现在人类饮食中,且二者均为脂溶性物质,会产生一定的相互作用。因此研究膳食叶绿素及其结构变化对叶黄素生物可给率的影响具有重要意义。通过制备膳食中常见的8种不同结构的叶绿素(叶绿素a和b、脱镁叶绿素a和b、脱植基叶绿素a和b、脱镁叶绿酸a和b),采用体外静态消化模型和胶束化实验研究它们对叶黄素生物可给率的影响,并测定叶黄素和叶绿素形成的混合胶束粒径和电位的变化。结果表明,在共消化时不同结构的叶绿素能够显著提高叶黄素的回收率和生物可给率(P<0.05),其中脱镁叶绿素b的作用最为显著,所对应的叶黄素回收率和生物可给率分别为90.48%和80.44%。在消化过程中,未检测到明显的叶黄素降解产物,而叶绿素的结构则发生了明显的变化。通过消化物和胶束的平均粒径、荧光图像以及Zeta电位值可以确定胶束液体系比消化液体系更稳定,并且叶绿素可以通过与叶黄素形成复合物来保护叶黄素。本研究对如何提高叶黄素的生物可给率及消化利用性能具有一定的指导意义。 展开更多
关键词 叶黄素 叶绿素 相互作用 生物可给率 体外消化 胶束化
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Effect of simulated gastrointestinal digestion on antioxidant,and anti-inflammatory activities of bioactive peptides generated in sausages fermented with Staphylococcus simulans QB7
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作者 Hongying Li Hongbing Fan +2 位作者 Zihan Wang Qiujin Zhu Jianping Wu 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1662-1671,共10页
Dry-fermented sausages are a good source of bioactive peptides,whose stability against gastrointestinal(GI)digestion determines their bioaccessibility.This study focused on evaluating the effect of peptide extracts fr... Dry-fermented sausages are a good source of bioactive peptides,whose stability against gastrointestinal(GI)digestion determines their bioaccessibility.This study focused on evaluating the effect of peptide extracts from sausages fermented with Staphylococcus simulans QB7 during in vitro simulated GI digestion,including peptide profiles and antioxidant and anti-inflammatory activities.Peptides present in sausages were degraded during digestion,with molecular weight reduced from>12 kDa to<1.5 kDa.Besides,the content of amino acids increased from 381.15 to 527.07 mg/g,especially tyrosine being found only after GI digestion.The anti-inflammatory activities were increased after GI digestion,however,the changes in antioxidant activities were the opposite.A total number of 255,252 and 386 peptide sequences were identified in undigested,peptic-digested and GI-digested samples,respectively.PeptideRanker,BIOPEP-UWM and admetSAR were used to further predict the functional properties and intestinal absorption of the identified peptide sequences from GI digestion.Finally,18 peptides were discovered to possess either antioxidant or anti-inflammatory capacities. 展开更多
关键词 Gastrointestinal digestion SAUSAGES bioaccessibility Anti-inflammatory activities
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污染地块土壤砷修复目标值确定方法研究 被引量:1
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作者 刘虎鹏 杜平 +3 位作者 袁贝 张云慧 陈娟 张昊 《环境工程技术学报》 CAS CSCD 北大核心 2024年第1期130-138,共9页
修复目标值的确定是污染地块环境监管的重要环节,通常基于风险评估方法计算风险控制值来确定。而对于砷污染地块,采用HJ25.3—2019《建设用地土壤污染风险评估技术导则》推荐模型和参数推算得到的修复目标值往往低于土壤砷环境背景值,... 修复目标值的确定是污染地块环境监管的重要环节,通常基于风险评估方法计算风险控制值来确定。而对于砷污染地块,采用HJ25.3—2019《建设用地土壤污染风险评估技术导则》推荐模型和参数推算得到的修复目标值往往低于土壤砷环境背景值,难以满足监管需求。系统梳理了国内外污染地块土壤砷修复目标值确定方法,探讨了基于土壤环境标准值、传统风险评估、层次化风险评估、等效风险评估及土壤砷环境背景值修正方法的实现路径与实践应用。结合我国污染地块监管策略和砷污染地块开发再利用现状,提出了基于土壤环境背景值、层次化风险评估和生物可给性相关参数修正的土壤砷修复目标值确定方法,旨在为我国砷污染地块的修复和再利用提供更加科学合理的方案。 展开更多
关键词 污染地块 修复目标值 风险评估 背景值 生物可给性
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我国污染地块土壤砷生物可给性关键影响因素研究
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作者 刘虎鹏 张云慧 +2 位作者 袁贝 陈娟 杜平 《环境科学研究》 CAS CSCD 北大核心 2024年第9期1986-1996,共11页
土壤砷生物可给性是砷污染地块风险评估的关键影响因素,与土壤理化性质、相关金属含量、砷生物可给性测试方法密切相关。本研究对污染地块土壤砷生物可给性相关研究进行系统的文献调研,收集土壤砷生物可给性、土壤理化性质(pH、有机质... 土壤砷生物可给性是砷污染地块风险评估的关键影响因素,与土壤理化性质、相关金属含量、砷生物可给性测试方法密切相关。本研究对污染地块土壤砷生物可给性相关研究进行系统的文献调研,收集土壤砷生物可给性、土壤理化性质(pH、有机质、黏粒含量等)、土壤中金属(As、Fe、Al及Mn)含量和可给性测试方法,采用相关性分析、主成分分析及生存分析方法研究污染地块土壤砷生物可给性关键影响因素和主要机制。结果表明:土壤砷生物可给性与土壤pH及粉粒含量均呈显著正相关(P<0.001),与砂粒含量均呈显著负相关(P<0.001)。主成分分析表明,土壤pH、粉粒含量对胃、肠阶段砷生物可给性具有重要的正向贡献,说明低土壤pH、细土壤粒径能够降低砷生物可给性。生存分析表明,土壤pH对胃阶段砷生物可给性影响显著(P<0.001),对肠阶段砷生物可给性影响不显著;高黏粒含量会降低胃、肠阶段砷生物可给性。蒙特卡罗模拟表明,我国污染地块土壤砷生物可给性随机抽样的95%分位值最高为64.8%,低反应pH与高固液比可能使测得的砷生物可给性偏高。研究显示,胃阶段、肠阶段砷生物可给性的主要影响因素较为一致,包括土壤pH、粒径、As含量;pH<6.5的土壤相较pH>6.5的土壤胃阶段砷生物可给性显著差异较低,肠阶段差异不明显;我国污染地块砷生物可给性超过65%的概率低于5%,推荐使用65%作为我国污染地块土壤砷生物可给性的默认参数。 展开更多
关键词 污染地块 生物可给性 影响因素
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发芽对莜麦多酚及抗氧化活性生物可及性的影响
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作者 吕俊丽 侯丽丽 +1 位作者 杨昊鹏 张乐道 《中国食品学报》 EI CAS CSCD 北大核心 2024年第6期33-43,共11页
为了提高莜麦中多酚及抗氧化活性的生物可及性,采用体外模拟消化模型和结肠发酵模型,对比发芽和未发芽莜麦在不同消化阶段以及结肠发酵阶段总酚含量及抗氧化活性的变化。结果显示:体外模拟消化阶段,发芽莜麦中多酚生物可及性、DPPH自由... 为了提高莜麦中多酚及抗氧化活性的生物可及性,采用体外模拟消化模型和结肠发酵模型,对比发芽和未发芽莜麦在不同消化阶段以及结肠发酵阶段总酚含量及抗氧化活性的变化。结果显示:体外模拟消化阶段,发芽莜麦中多酚生物可及性、DPPH自由基清除生物可及性、羟自由基清除生物可及性在小肠消化时最高,比未发芽莜麦分别高8.99%,47.75%,9.57%,还原力生物可及性在胃消化时最高,此时,发芽莜麦比未发芽莜麦高39.82%。结肠发酵阶段,不同处理莜麦消化残渣中多酚含量及抗氧化活性在发酵24~30 h时最高。在结肠发酵30 h时,未发芽莜麦消化残渣多酚生物可及性比发芽莜麦消化残渣的高8.83%,DPPH自由基清除力生物可及性比发芽莜麦消化残渣的高8.16%。羟自由基清除生物可及性比发芽莜麦消化残渣的高16.68%。但与胃肠消化阶段的生物可及性几乎相当。结论:发芽不仅能显著提高莜麦多酚及抗氧化活性在胃肠消化道中的生物可及性,也能使多酚等抗氧化组分在结肠发酵中保持较高的生物可及性,这为谷物多酚在人体消化道内的生物利用度的提高提供新的研究思路。 展开更多
关键词 发芽 莜麦 多酚 抗氧化活性 生物可及性
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壳聚糖-叶酸微胶囊的制备及其特性评价
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作者 彭雅萱 丁振江 +7 位作者 李旭燕 杨宗玲 刘金洋 王俊 陆伟 冯煦洸 夏凯 周志桥 《食品与发酵工业》 CAS CSCD 北大核心 2024年第5期149-155,共7页
研究采用喷雾干燥法制备了壳聚糖-叶酸微胶囊,并对该微胶囊的粒度、形态、生物可及性、溶出特性进行了探究。结果表明,制备的壳聚糖-叶酸微胶囊颗粒大小均匀,中位径为17.78μm,形状不规则,表面为多孔状结构。在经过胃肠道4 h消化后,其... 研究采用喷雾干燥法制备了壳聚糖-叶酸微胶囊,并对该微胶囊的粒度、形态、生物可及性、溶出特性进行了探究。结果表明,制备的壳聚糖-叶酸微胶囊颗粒大小均匀,中位径为17.78μm,形状不规则,表面为多孔状结构。在经过胃肠道4 h消化后,其生物可及性相较于未包埋叶酸(73.95%),提高至85.04%,且高于市面上4种叶酸补充剂。溶出特性的研究结果表明,壳聚糖的溶胀过程使叶酸被缓慢释放,通过模型拟合发现Baker-Lonsdale模型与该溶出过程的拟合效果最好。该研究为叶酸的高价值化利用提供理论依据和数据支持。 展开更多
关键词 叶酸 微胶囊 壳聚糖 溶出 生物可及性
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发酵对莜麦多酚及抗氧化活性生物可及性的影响
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作者 任志龙 吕俊丽 《中国粮油学报》 CAS CSCD 北大核心 2024年第7期76-85,共10页
为了提高莜麦中多酚及抗氧化活性的生物可及性,采用体外模拟消化模型和结肠发酵模型,对比了发酵莜麦和未发酵莜麦在不同消化阶段以及结肠发酵阶段总酚含量及抗氧化活性的变化规律,并进一步对其生物可及性进行探究。结果显示:体外模拟消... 为了提高莜麦中多酚及抗氧化活性的生物可及性,采用体外模拟消化模型和结肠发酵模型,对比了发酵莜麦和未发酵莜麦在不同消化阶段以及结肠发酵阶段总酚含量及抗氧化活性的变化规律,并进一步对其生物可及性进行探究。结果显示:体外模拟消化阶段,除还原力外,不同处理莜麦中的多酚及自由基清除生物可及性的顺序依次为:小肠>胃>口腔;与未发酵莜麦相比,发酵莜麦消化后多酚生物可及性提高22.75%,DPPH自由基清除生物可及性提高48.30%,羟自由基清除生物可及性提高11.77%,还原力生物可及性提高59.20%。结肠发酵阶段,除羟自由基生物可及性外,发酵莜麦消化残渣多酚及抗氧化活性的生物可及性均高于未发酵莜麦消化残渣;与未发酵莜麦相比,发酵莜麦消化残渣多酚生物可及性高36.3%,DPPH自由基清除力生物可及性高16.9%,还原力生物可及性高23.1%。研究结果表明发酵能显著提高莜麦多酚及抗氧化活性在胃肠消化道中的生物可及性,并能提高多酚等抗氧化组分在结肠发酵中的生物可及性。 展开更多
关键词 发酵 莜麦 多酚 抗氧化活性 生物可及性
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