Traumatic brain injury（TBI）and spinal cord injury（SCI）are leading causes of death and disability worldwide（Center for Disease Control,2006）.Both injuries are induced by external traumatic event and likely happen...Traumatic brain injury（TBI）and spinal cord injury（SCI）are leading causes of death and disability worldwide（Center for Disease Control,2006）.Both injuries are induced by external traumatic event and likely happen together.After the primary traumatic incident,the secondary injury,including ischemic,inflammatory,metabolic and biochemical cascades,is likely more devastating（Blumbergs,1997）.To date,all clinical trials have failed to cure TBI and SCI,due to the展开更多
Traumatic injuries to the central nervous system,such as traumatic brain injury,spinal cord injury and stroke,have a high prevalence,enormous financial costs and lack clinical treatments that restore neurological func...Traumatic injuries to the central nervous system,such as traumatic brain injury,spinal cord injury and stroke,have a high prevalence,enormous financial costs and lack clinical treatments that restore neurological function（Ma et al.,2014）These injuries trigger a series of secondary biochemical and cellular responses that ultimately lead to cellular death and themaintenance of an unsupportive extracellular matrix （ECM） for tissue regeneration （Silva et al., 2014）. Artificial ECM or scaf- folds represent a way to alter this unsupportive environment to improve the efficacy of stem cell therapies and enhance neural tissue regeneration （Figure 1）.展开更多
文摘Traumatic brain injury（TBI）and spinal cord injury（SCI）are leading causes of death and disability worldwide（Center for Disease Control,2006）.Both injuries are induced by external traumatic event and likely happen together.After the primary traumatic incident,the secondary injury,including ischemic,inflammatory,metabolic and biochemical cascades,is likely more devastating（Blumbergs,1997）.To date,all clinical trials have failed to cure TBI and SCI,due to the
基金funded in part by Mission Connecta program of TIRR foundationthe University of Texas Health Science Center at Houston Bentsen Stroke Center and Department of Neurosurgery William Stamps Farish Fund
文摘Traumatic injuries to the central nervous system,such as traumatic brain injury,spinal cord injury and stroke,have a high prevalence,enormous financial costs and lack clinical treatments that restore neurological function（Ma et al.,2014）These injuries trigger a series of secondary biochemical and cellular responses that ultimately lead to cellular death and themaintenance of an unsupportive extracellular matrix （ECM） for tissue regeneration （Silva et al., 2014）. Artificial ECM or scaf- folds represent a way to alter this unsupportive environment to improve the efficacy of stem cell therapies and enhance neural tissue regeneration （Figure 1）.
