Macleayine （1）, a new natural occurring alkaloid with a unique spiro [furanone-piperidinedione] framework, was isolated from the aerial parts ofMacleaya cordata. Its unusual structure was established by extensive sp...Macleayine （1）, a new natural occurring alkaloid with a unique spiro [furanone-piperidinedione] framework, was isolated from the aerial parts ofMacleaya cordata. Its unusual structure was established by extensive spectroscopic analyses, computer-assisted structure elucidation software （ACD/Structure Elucidator）, quantum chemistry calculations and ECD calculation. The result of virtual molecular docking predicted the compound can enhance the effects of insulin, and may be used to treat tvpe II diabetes.展开更多
Six sesquiterpenes, including three guaiane type sesquiterpenes （1-3）, one oplopanone type sesquiterpene （4）, one xanthane type sesquiterpene （5） and one salvialane type sesquiterpene （6）, were isolated from A...Six sesquiterpenes, including three guaiane type sesquiterpenes （1-3）, one oplopanone type sesquiterpene （4）, one xanthane type sesquiterpene （5） and one salvialane type sesquiterpene （6）, were isolated from Alisma plantago-aquatica for the first time. The structures of these six compounds were elucidated as alismoxide （1）, alismol （2）, orientalol B （3）, oplopanone （4）, gibberodione （5）, and 7a, lOa-epoxy-salvialan-1Ofl-ol （6）, respectively, among which 6 was a new natural product. Xanthane type and salvialane type sesquiterpenes were obtained from the genus Alisma for the first time. In addition, a plausible biosynthetic pathway for all isolates was discussed.展开更多
Three new indole alkaloids, flueindolines A–C(1–3), along with nine known alkaloids(4–12), were isolated from the fruits of Flueggea virosa(Roxb. ex Willd.) Voigt. Compounds 1 and 2 are two new fused tricyclic indo...Three new indole alkaloids, flueindolines A–C(1–3), along with nine known alkaloids(4–12), were isolated from the fruits of Flueggea virosa(Roxb. ex Willd.) Voigt. Compounds 1 and 2 are two new fused tricyclic indole alkaloids possessing an unusual pyrido[1, 2-a]indole framework, and 3 presents a rare spiro(pyrrolizidinyl-oxindole) backbone. Their structures with absolute configurations were elucidated by means of comprehensive spectroscopic analysis, chemical calculation, as well as X-ray crystallography. Chiral resolution and absolute configuration determination of the known compounds 4, 10, and 11 were reported for the first time. The hypothetical biogenetical pathways of 1–3 were herein also proposed.展开更多
基金financially supported by the National Natural Science Foundation of China(No.81172958)the Basic Research Subject of Key Laboratory Supported by Educational Commission of Liaoning Province of China(No.LZ2014044)
文摘Macleayine （1）, a new natural occurring alkaloid with a unique spiro [furanone-piperidinedione] framework, was isolated from the aerial parts ofMacleaya cordata. Its unusual structure was established by extensive spectroscopic analyses, computer-assisted structure elucidation software （ACD/Structure Elucidator）, quantum chemistry calculations and ECD calculation. The result of virtual molecular docking predicted the compound can enhance the effects of insulin, and may be used to treat tvpe II diabetes.
基金The National Science and Technology Major Project of“Technological study on the safety and standards of Chinese materia medica”(Grant No.2014ZX09304307-001-011)Chinese materia medica supporting program of“Quality control base construction of Chinese material medica including Isatidis Radix,Carthami Flos,etc”by Ministry of Industry and Information Technology of Peoples Republic of China
文摘Six sesquiterpenes, including three guaiane type sesquiterpenes （1-3）, one oplopanone type sesquiterpene （4）, one xanthane type sesquiterpene （5） and one salvialane type sesquiterpene （6）, were isolated from Alisma plantago-aquatica for the first time. The structures of these six compounds were elucidated as alismoxide （1）, alismol （2）, orientalol B （3）, oplopanone （4）, gibberodione （5）, and 7a, lOa-epoxy-salvialan-1Ofl-ol （6）, respectively, among which 6 was a new natural product. Xanthane type and salvialane type sesquiterpenes were obtained from the genus Alisma for the first time. In addition, a plausible biosynthetic pathway for all isolates was discussed.
基金the National Key R & D Program of China (No. 2018YFC1706200)the National Natural Science Foundation of China (Nos. 81630095, 81622045, and 81803379)+2 种基金the Science & Technology Program of China (No.2019ZX09735002-003)the China Postdoctoral Science Foundation(Nos. 2019T120794, and 2018M633291)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (No. 2017BT01Y036)。
文摘Three new indole alkaloids, flueindolines A–C(1–3), along with nine known alkaloids(4–12), were isolated from the fruits of Flueggea virosa(Roxb. ex Willd.) Voigt. Compounds 1 and 2 are two new fused tricyclic indole alkaloids possessing an unusual pyrido[1, 2-a]indole framework, and 3 presents a rare spiro(pyrrolizidinyl-oxindole) backbone. Their structures with absolute configurations were elucidated by means of comprehensive spectroscopic analysis, chemical calculation, as well as X-ray crystallography. Chiral resolution and absolute configuration determination of the known compounds 4, 10, and 11 were reported for the first time. The hypothetical biogenetical pathways of 1–3 were herein also proposed.
