The Shanghai Institute of Biological Sciences(SIBS) under the Chinese Academy of Sciences(CAS) was formally founded on July 3, 1999. It wasbased on eight CAS research institutes and tworesearch centers in the Shanghai...The Shanghai Institute of Biological Sciences(SIBS) under the Chinese Academy of Sciences(CAS) was formally founded on July 3, 1999. It wasbased on eight CAS research institutes and tworesearch centers in the Shanghai area, namely, theShanghai institutes of Biochemistry, Cell Biology,Materia Medica, Physiology, Brain Research, PlantPhysiology, Entomology, and Biotechnology, aswell as the Shanghai Life Sciences Research展开更多
1 Background and purpose of workshop The Southern Ocean plays a fundamental role in the function of the Earth System, influencing climate, sea level, biogeochemical cycles, and biological productivity on a variety of ...1 Background and purpose of workshop The Southern Ocean plays a fundamental role in the function of the Earth System, influencing climate, sea level, biogeochemical cycles, and biological productivity on a variety of scalesIll. Observations from the Southern Ocean suggest that dramatic changes are taking place, which are of global concern, yet because of its remote location, seasonal sea ice, and harsh environment, the Southern Ocean remains one of the least sampled zones in the world.展开更多
The school consists of four first-level interdisciplines： chemistry, biological science, chemical engineering and technology, and food science and engineering. There are three basic teaching divisions： chemistry, bi...The school consists of four first-level interdisciplines： chemistry, biological science, chemical engineering and technology, and food science and engineering. There are three basic teaching divisions： chemistry, biological science and chemical engineering; four research institutes： biological science and technology, food science and technology, chemical materials, and applied chemistry; four basic experimental teaching centers： biology, chemistry, chemical engineering and technique, and food science and engineering; and one food quality and safety testing and detecting center.展开更多
Group 3 innate lymphoid cells(ILC3s)play important roles in maintaining intestinal homeostasis by protecting the host from pathogen infections and tissue inflammation.The transcription factor PLZF(promyelocytic leukem...Group 3 innate lymphoid cells(ILC3s)play important roles in maintaining intestinal homeostasis by protecting the host from pathogen infections and tissue inflammation.The transcription factor PLZF(promyelocytic leukemia zinc finger),encoded by zinc finger BTB domain containing 16(Zbtb16),is highly and transiently expressed in ILC precursors(ILCPs).However,the role of PLZF in regulating ILC3 development and function remains unknown.Here,we show that PLZF was specifically expressed in mature intestinal ILC3s compared with other ILC subsets.PLZF was dispensable for ILC3 development.However,PLZF deficiency in ILC3s resulted in increased innate interleukin-22(IL-22)secretion and protection against gut infection and inflammation.Mechanistically,PLZF negatively regulated IL-22 expression by ILC3s in a cell-intrinsic manner by binding to the IL-22 promoter region for transcriptional repression.Together,our data suggest that PLZF restricts intestinal ILC3 function to regulate gut immune homeostasis.展开更多
文摘The Shanghai Institute of Biological Sciences(SIBS) under the Chinese Academy of Sciences(CAS) was formally founded on July 3, 1999. It wasbased on eight CAS research institutes and tworesearch centers in the Shanghai area, namely, theShanghai institutes of Biochemistry, Cell Biology,Materia Medica, Physiology, Brain Research, PlantPhysiology, Entomology, and Biotechnology, aswell as the Shanghai Life Sciences Research
基金hosted and sponsored by the Polar Research Institute of China (PRIC), with additional sponsorship by the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG), Institute of Atmospheric Physics, Chinese Academy of Sciences (IAP/CAS), the World Climate Research Programme (WCRP) "Climate and the Cryosphere" project (CliC), the Scientific Committee on Antarctic Research (SCAR), and the Scientific Committee on Oceanic Research (SCOR). SOOS acknowledges the support of its host institute, the Institute for Marine and Antarctic Studies (IMAS, University of Tasmania, Australia), and sponsors, Australian Antarctic Division, Antarctica New Zealand, and the New Zealand Antarctic Research Institute.
文摘1 Background and purpose of workshop The Southern Ocean plays a fundamental role in the function of the Earth System, influencing climate, sea level, biogeochemical cycles, and biological productivity on a variety of scalesIll. Observations from the Southern Ocean suggest that dramatic changes are taking place, which are of global concern, yet because of its remote location, seasonal sea ice, and harsh environment, the Southern Ocean remains one of the least sampled zones in the world.
文摘The school consists of four first-level interdisciplines： chemistry, biological science, chemical engineering and technology, and food science and engineering. There are three basic teaching divisions： chemistry, biological science and chemical engineering; four research institutes： biological science and technology, food science and technology, chemical materials, and applied chemistry; four basic experimental teaching centers： biology, chemistry, chemical engineering and technique, and food science and engineering; and one food quality and safety testing and detecting center.
基金grant 2020YFA0509200(to LS)from the Ministry of Science and Technology of Chinagrant 81971487(to LS)from the National Natural Science Foundation of China+1 种基金grants 20ZR1430200 and 20142202300(to LS)from the Science and Technology Commission of Shanghai Municipalitygrant 20194Y0275(to JS)from the Shanghai Municipal Health Commission,and the Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases.
文摘Group 3 innate lymphoid cells(ILC3s)play important roles in maintaining intestinal homeostasis by protecting the host from pathogen infections and tissue inflammation.The transcription factor PLZF(promyelocytic leukemia zinc finger),encoded by zinc finger BTB domain containing 16(Zbtb16),is highly and transiently expressed in ILC precursors(ILCPs).However,the role of PLZF in regulating ILC3 development and function remains unknown.Here,we show that PLZF was specifically expressed in mature intestinal ILC3s compared with other ILC subsets.PLZF was dispensable for ILC3 development.However,PLZF deficiency in ILC3s resulted in increased innate interleukin-22(IL-22)secretion and protection against gut infection and inflammation.Mechanistically,PLZF negatively regulated IL-22 expression by ILC3s in a cell-intrinsic manner by binding to the IL-22 promoter region for transcriptional repression.Together,our data suggest that PLZF restricts intestinal ILC3 function to regulate gut immune homeostasis.
