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Information-Body Relation and Information as a Solution of the Consciousness Problem in the Biological Structures
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作者 Florin Gaiseanu 《Journal of Philosophy Study》 2022年第5期287-303,共17页
This paper approaches two main philosophical questions concerning the biological structures,from unicellular to multicellular organisms:one of them(i),referred to the information-body relation,as an extension of the m... This paper approaches two main philosophical questions concerning the biological structures,from unicellular to multicellular organisms:one of them(i),referred to the information-body relation,as an extension of the mind-body relation at human,and another one(ii),to the consciousness problem,concerning the existence and nature of consciousness(if any),at the inferior organisms on the complexity scale,as this concept is known at humans.As philosophy benefits of the privilege to use data/concepts from other sciences to obtain philosophical conclusions,there were included detailed descriptions of some key biologic mechanisms,analyzed from informational perspective,necessary just to support/demonstrate/reinforce the informational nature/substrate of the mentioned relations.The analysis of the close relation between information and body,related to the structuration and functional properties of the biological organisms,from cells to multicellular structures,shows that all of them are able to“embody/disembody”information during/by structuration/destructuration processes of matter,in particular that of DNA/RNA/proteins,their functions appearing as a result of their informational capabilities to internally manage the inter-connection with environment,primarily due to their permanent dependence on the food resources and adaptation/survival needs.The experimental and theoretical studies,revealing/documenting on one hand the automatic management of maintenance metabolic processes,the reproduction,and growth/development,and on the other hand the adaptive decision-making/sentient processes as a responsive reaction to the environmental cues,show/support the consistency of the informational model of the human body and living structures on the entire biological scale,providing support to the informational solution of the stated problems(i)and(ii).A distinct attention is paid to plants,which are organisms without nervous system,but which show/manifest also informational capabilities to detect/react to information and to modulate their behavior accordingly.The question if the living organisms possess a pseudo/proto-consciousness level as a consequence of the informational activity of their body,distinct from human,but active in any biological structure under certain conditions is furthermore discussed,and a reliable definition of rudimentary pseudo/proto-consciousness level is given/described and compared with other empirical/theoretical concepts. 展开更多
关键词 information in biological structures informationally-driven processes structuration/destructuration growth/differentiation/maintenance functionality/informational structure info-intra/inter-communication cognitive centers proto/pseudo-consciousness problem
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Syntheses,Crystal Structures and Biological Activities of the 2-Oxo-butyric Acid Salicylacylhydrazone Dibenzyltin Complexes 被引量:4
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作者 谭宇星 张志坚 +4 位作者 冯泳兰 庾江喜 朱小明 邝代治 蒋伍玖 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2017年第6期925-936,共12页
2-Oxo-butyric acid salicylacylhydrazone dibenzyltin(IV) complexes 1 {[o-OHC6H4(O)C=N-N=C(Et)COO](CH3OH)[(C6H5CH2)2Sn]}2 and 2 {[o-OH-C6H4(O)C=N-N=C(Et)-COO](CH3OH)[(2,4-Cl2C6H3CH2)2Sn]}2 have been sy... 2-Oxo-butyric acid salicylacylhydrazone dibenzyltin(IV) complexes 1 {[o-OHC6H4(O)C=N-N=C(Et)COO](CH3OH)[(C6H5CH2)2Sn]}2 and 2 {[o-OH-C6H4(O)C=N-N=C(Et)-COO](CH3OH)[(2,4-Cl2C6H3CH2)2Sn]}2 have been synthesized. The complexes were characterized by IR, 1H, 13C and 119Sn NMR spectra, elemental analysis and thermal stability analysis, and the crystal structures were determined by X-ray diffraction. The crystal of complex 1 belongs to triclinic system, space group P1 with a = 8.9121(6), b = 10.3875(7), c = 14.5658(10) ?, α = 89.534(5), β = 86.790(5), γ = 70.103(6)°, Z = 1, V = 1265.85(15) ?3, Dc = 1.488 Mg·m^(-3), m(Mo Kα) = 1.047 mm-1, F(000) = 576, R = 0.0466 and w R = 0.1054. The crystal of complex 2 belongs to monoclinic system, space group P21/n, a = 12.7165(10), b = 17.8466(14), c = 12.8538(10) ?, β = 95.1310(10)°, Z = 2, V = 2905.4(4) ?~3, Dc = 1.612 Mg·m^(-3), m(Mo Kα) = 1.286 mm-1, F(000) = 1408, R = 0.0369 and w R = 0.0958. In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay against three human cancer cell lines(NCI-H460, HepG2, MCF7) and one human cell line(HL7702). Two complexes exhibited strong antitumor activity, and then they were expected after further chemical optimization of candidate compounds as anti-cancer drugs. The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe. The interactions of the two complexes with calf thymus DNA were intercalation. 展开更多
关键词 organotin hydrazone synthesis crystal structure biological activity
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Synthesis, Crystal Structure and Biological Activity of 2-((2,2-Dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-N-(3-(furan-2-yl)-1-phenyl-1H-pyrazol-5-yl)acetamide
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作者 霍静倩 马刘勇 +4 位作者 张哲 范志金 张金林 Tetyana Beryozkina Vasiliy A.Bakulev 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2016年第7期1011-1018,共8页
The title compound 2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-N-(3-(furan-2-yl)-1-phenyl-1H-pyrazol-5-yl) acetamide(C25H23N3O4, Mr = 429.46) has been synthesized, and its structure was characterized by... The title compound 2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-N-(3-(furan-2-yl)-1-phenyl-1H-pyrazol-5-yl) acetamide(C25H23N3O4, Mr = 429.46) has been synthesized, and its structure was characterized by 1H-NMR, 13C-NMR, H RMS, and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P21/c with a = 20.6205(18), b = 5.2930(5), c = 18.9282(17) A, β = 94.089(2)°, V = 2060.6(3) A^3, Z = 4, Dc = 1.384 g/cm^3, μ(Mo Ka) = 0.71073 mm^-1, F(000) = 904, R = 0.0345 and w R = 0.0930. The intramolecular hydrogen bond at N(1)–H(1)…O(2), intermolecular weak interactions at O(3)…H(4) and weak π-π interactions connected the molecules to lead to one-dimensional tapes. Bioassay results indicated that the title compound had moderate herbicidal and fungicidal activities. 展开更多
关键词 benzofuran pyrazole furan crystal structure biological activity
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Synthesis, Crystal Structure, Two-photon Absorption and Biological Imaging Application of a Water Soluble Carbazole Quaternary Ammonium Compound
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作者 王聪 孙婉 +3 位作者 王安然 李胜利 吴杰颖 田玉鹏 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2017年第4期589-598,共10页
A novel carbazole quaternary ammonium compound(abbreviated as T_2) had been synthesized and characterized by ~1H NMR, ^(13)C NMR and Mass spectrometry. The single-crystal structure has been determined by X-ray sin... A novel carbazole quaternary ammonium compound(abbreviated as T_2) had been synthesized and characterized by ~1H NMR, ^(13)C NMR and Mass spectrometry. The single-crystal structure has been determined by X-ray single-crystal diffraction. The electrochemical and two-photon absorption properties of T_2 were systematically studied by cyclic voltammetry and Z-scan determination methods, respectively. The results suggested that T_2 had a good oxidation-reduction and excellent nonlinear optical property. The two-photon absorption(TPA) value has a maximum corresponding to cross section σ = 7963.3 GM(Goeppert-Mayer units) at 700 nm, indicating potential applications in nonlinear optical materials. Furthermore, attributing to the excellent water solubility and low cytotoxicity, the compound was explored on its primary application in biological imaging. 展开更多
关键词 carbazole quaternary ammonium crystal structure two-photon absorption one-photon fluorescence biological imaging
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Transient response of doubly-curved bio-inspired composite shells resting on viscoelastic foundation subject to blast load using improved first-order shear theory and isogeometric approach 被引量:1
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作者 Thuy Tran Thi Thu Tu Nguyen Anh +1 位作者 Hue Nguyen Thi Hong Nguyen Thi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第8期171-193,共23页
Investigating natural-inspired applications is a perennially appealing subject for scientists. The current increase in the speed of natural-origin structure growth may be linked to their superior mechanical properties... Investigating natural-inspired applications is a perennially appealing subject for scientists. The current increase in the speed of natural-origin structure growth may be linked to their superior mechanical properties and environmental resilience. Biological composite structures with helicoidal schemes and designs have remarkable capacities to absorb impact energy and withstand damage. However, there is a dearth of extensive study on the influence of fiber redirection and reorientation inside the matrix of a helicoid structure on its mechanical performance and reactivity. The present study aimed to explore the static and transient responses of a bio-inspired helicoid laminated composite(B-iHLC) shell under the influence of an explosive load using an isomorphic method. The structural integrity of the shell is maintained by a viscoelastic basis known as the Pasternak foundation, which encompasses two coefficients of stiffness and one coefficient of damping. The equilibrium equations governing shell dynamics are obtained by using Hamilton's principle and including the modified first-order shear theory,therefore obviating the need to employ a shear correction factor. The paper's model and approach are validated by doing numerical comparisons with respected publications. The findings of this study may be used in the construction of military and civilian infrastructure in situations when the structure is subjected to severe stresses that might potentially result in catastrophic collapse. The findings of this paper serve as the foundation for several other issues, including geometric optimization and the dynamic response of similar mechanical structures. 展开更多
关键词 Blast load Modified first-order shear theory biological composite structures
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Synthesis,Crystal Structure and Anti-fungal Activity of 2-(4-Chlorophenyl)-(1,3-dimethyl-2,3-dihydro-1H)-perimidine 被引量:4
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作者 袁霖 李中燕 +1 位作者 张敏 袁先友 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2016年第8期1181-1185,共5页
The title compound 2-(4-chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine(C(19)H(17)ClN2) was synthesized and characterized by elemental analysis, ^1H NMR, HRMS and single-crystal X-ray diffraction. The cry... The title compound 2-(4-chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine(C(19)H(17)ClN2) was synthesized and characterized by elemental analysis, ^1H NMR, HRMS and single-crystal X-ray diffraction. The crystal of the title compound belongs to orthorhombic system,space group Pnma with a = 11.385(2), b = 12.170(2), c = 11.210(2)A, V = 1553.2(5)A^3, Z = 4, Dc =1.321 g/cm^3, m(Mo-Ka) = 0.244 mm^-1, F(000) = 648, S = 1.309, R = 0.0400 and w R(I 〉 2s(I)) =0.1065. X-ray diffraction results showed that the molecular structure is highly symmetric and the new-formed N-heterocyclic ring is non-planar. In addition, the biological experiment showed that the title compound showed inhibitory activities against fungi with varied potencies. 展开更多
关键词 perimidine synthesis crystal structure biological activity
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Synthesis,Crystal Structure,Thermal Stability and Anti-tumor Activity In Vitro of Bis(tricyclohexyltin) Pimelicarboxylate 被引量:2
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作者 朱小明 邝代治 +4 位作者 冯泳兰 张复兴 庾江喜 蒋伍玖 张志坚 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2015年第11期1652-1658,共7页
Bis(tricyclohexyltin) pimelicarboxylate, [(CH2)5(CO2SnCy3)2] (1), has been synthesized by the reaction of tricyclohexyltin hydroxide with pimelic acid and characterized by means of 1R, 1H and 13C NMR, elementa... Bis(tricyclohexyltin) pimelicarboxylate, [(CH2)5(CO2SnCy3)2] (1), has been synthesized by the reaction of tricyclohexyltin hydroxide with pimelic acid and characterized by means of 1R, 1H and 13C NMR, elemental analysis and X-ray diffraction. Complex 1 crystallizes in triclinic space group Pi with a = 11.569(3), b = 12.0419(2), c = 17.3988(4) A, α = 81.4310(10), β = 79.8270(10), ), = 69.7060(10)°, V = 2227.60(9) A3, Z = 2, C43H7604Sn2, Mr = 894.42, Dc = 1.333 g.cm-3, μ = 1.157 mm-1, F(000) = 932, GOOF = 1.339, the final R = 0.0452 and wR = 0.1333 for 6709 observed reflections (1〉 2σ(I). Complex 1 shows discrete dimeric structures and the tin atoms have a distorted tetrahedral geometry. The 1D chain structure of complex 1 is formed by intermolecular Sn…O interactions. Complex 1 displays good thermal stability under 553 K and has selective antibacterial property. Complex 1 is strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460, and is significantly higher than that in the clinical use of carboplatin. 展开更多
关键词 tricyciohexyltin pimelicarboxylate synthesis crystal structure biological activity
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Synthesis and Biological Activities of 10-Substituted 9-Aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-diones
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作者 汪芳明 胡兵相 +3 位作者 陈传祥 周泽宇 鲍丹 陈立庄 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2016年第3期442-448,共7页
A series of 10-substituted 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione derivatives 2 were synthesized by a two-step reaction.All the compounds were characterized by IR,MS,and ^1H NMR.Crystals of 1a and 2c... A series of 10-substituted 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione derivatives 2 were synthesized by a two-step reaction.All the compounds were characterized by IR,MS,and ^1H NMR.Crystals of 1a and 2c were obtained and determined by X-ray single-crystal diffraction.Crystal data of 1a:C_(20)H_(22)O_5,orthorhombic system,space group Pbcn,a = 15.8888(19),b = 18.228(2),c = 11.6926(13) A,V = 3386.4(7) A^3,Z = 8,F(000) = 1456,Dc = 1.343 g/cm^3,R = 0.0456 and w R = 0.1600.Crystal data of 2c:C_(26)H_(24) Cl NO_3,monoclinic system,space group P2_1/n,a = 8.628(2),b = 10.912(3),c = 22.425(7) A,β = 90.786(4)°,V = 2111.1(10) A^3,Z = 4,F(000) = 912,D_c = 1.365 g/cm^3,R = 0.0613,and w R = 0.1196.The results of biological experiments show that compounds 2b and 2c could inhibit the proliferation of Hep G2 cells. 展开更多
关键词 xanthenes acridones synthesis crystal structure biological activity
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Interaction between B-Doped C60 Fullerene and Glycine Amino Acid from First-Principles Simulation
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作者 M. D. Ganji H. Yazdani 《Chinese Physics Letters》 SCIE CAS CSCD 2010年第4期83-86,共4页
The possibility of formation of complexes between glycine and boron doped C60 (C59B) fullerene is investigated and compared with that of C60 fullerene by using the density functional theory calculations. It has been... The possibility of formation of complexes between glycine and boron doped C60 (C59B) fullerene is investigated and compared with that of C60 fullerene by using the density functional theory calculations. It has been found that the binding of glycine to C59B generated the most stable complexes via its carbonyl oxygen active site, with a binding energy of-37.89 kcal/mol, while the glycine molecule prefers to bind to the pure C60 cage via its amino nitrogen active site, consistent with the recent experimental and theoretical studies. We have also tested the stability of the most stable Gly-C59B complex with ab initio molecular dynamics simulation, carried out at room temperature. These indicate that the B-doped C60 fullerenes seem to be more suitable materials for bindings to proteins than pure C60 fullerenes. 展开更多
关键词 Surfaces interfaces and thin films biological physics Condensed matter: structural mechanical & thermal Chemical physics and physical chemistry
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Effect of Poly(Ether Urethane) Introduction on the Performance of Polymer Electrolyte for All-Solid-State Dye-Sensitized Solar Cells
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作者 周艳方 向万春 +4 位作者 方世璧 陈申 周晓文 张敬波 林原 《Chinese Physics Letters》 SCIE CAS CSCD 2009年第12期240-242,共3页
The introduction of poly(ether urethane) (PEUR) into polymer electrolyte based on poly(ethylene oxide), LiI and I2, has significantly increased the ionic conductivity by nearly two orders of magnitudes. An incre... The introduction of poly(ether urethane) (PEUR) into polymer electrolyte based on poly(ethylene oxide), LiI and I2, has significantly increased the ionic conductivity by nearly two orders of magnitudes. An increment of I3- diffusion coefficient is also observed. All-solid-state dye-sensitized solar cells are constructed using the polymer electrolytes. It was found that PEUR incorporation has a beneficial effect on the enhancement of open circuit voltage VOC by shifting the band edge of TiO2 to a negative value. Scanningelectron microscope images indicate the perfect interfacial contact between the TiO2 electrode and the blend electrolyte. 展开更多
关键词 Soft matter liquids and polymers Electronics and devices biological physics Condensed matter: structural mechanical & thermal Chemical physics and physical chemistry
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Characterization of the P450 Monooxygenase LobP1 as C-32 Hydroxylase in Lobophorin Biosynthesis
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作者 Bin Tan Qingbo Zhang +6 位作者 Ji Xiao Chengshan Yuan Yuchan Chen Siqiang Chen Weimin Zhang Yiguang Zhu Changsheng Zhang 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2023年第12期1478-1484,共7页
Lobophorins(LOBs)belong to a large family of spirotetronate antibiotics with antibacterial and antitumor activities.In this study,we demonstrated the function of LobP1,a P450 monooxygenase encoded in the LOB biosynthe... Lobophorins(LOBs)belong to a large family of spirotetronate antibiotics with antibacterial and antitumor activities.In this study,we demonstrated the function of LobP1,a P450 monooxygenase encoded in the LOB biosynthetic gene cluster,by in vivo deletion and in vitro biochemical assays.The disruption of lobP1 led to the isolation of three new LOBs derivatives(3-5)and three known ones(6-8)without the hydroxyl group at C-32.LobP1 was shown to have relatively broad substrate scope.Determining the kinetic parameters of LobP1 towards different substrates revealed that LobP1 preferred substrate with a nitrosugar.The new LOBs 3-5 displayed significant antibacterial activities against Bacillus subtilis and Micrococcus luteus with MIC values of 0.125 to 1μg·mL^(-1),and the major product LOB E(6)from the∆lobP1 mutant showed moderate cytotoxic activities against several cancer cell lines. 展开更多
关键词 Lobophorins BIOSYNTHESIS Post modifications P450 monooxygenase HYDROXYLATION Enzymes biological activity structure elucidation
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Resistance reduction by bionic coupling of the earthworm lubrication function 被引量:12
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作者 LI JianQiao KOU BingXue +2 位作者 LIU GuoMin FAN WenFeng LIU LinLin 《Science China(Technological Sciences)》 SCIE EI CAS 2010年第11期2989-2995,共7页
Based on the biological coupling theory, the resistance reduction characteristic of the surface morphology and surface wettability of the earthworm were studied in this paper. The parameters of surface dorsal pore and... Based on the biological coupling theory, the resistance reduction characteristic of the surface morphology and surface wettability of the earthworm were studied in this paper. The parameters of surface dorsal pore and corrugation were extracted. According to these parameters, the lubrication mechanism of the earthworm surface was analyzed. The distribution of the pores and surface morphology were designed and the bionic coupling samples were prepared. The positive pressure, lubricant flow rate and advancing velocity were selected as the experiment factors while the soil friction resistance as observed object. According to the obtained data of bionic coupling samples from the testing system of biologic signal for tiny soil adhesion test, the optimal samples from the bionic coupling resistance reduction tests were selected through the range analysis. Compared to the normal ones, the soil resistance of bionic coupling samples was reduced by 76.8%. This is of great significance and offers bright prospects for reducing energy loss in terrain mechanics. 展开更多
关键词 bionic coupling EARTHWORM biological surface structure soil resistance reduction
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