Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarke...Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed in manic patients compared to controls, and dysregulation of miR-134,-152,-607,-633,-652,-155 occurred in euthymic patients compared to controls. Finally, microRNAs such as miR-34a,-34b,-34c,-137, and-140-3p,-21-3p,-30d-5p,-330-5p,-378a-5p,-134,-19b-3p were shown to have diagnostic potential in distinguishing bipolar disorder patients from schizophrenia or major depressive disorder patients, respectively. Further studies are warranted with adolescents and young adults having bipolar disorder and consideration should be given to using animal models of the disorder to investigate the effects of suppressing or overexpressing specific microRNAs.展开更多
为研究分网接入方式下电网换相换流器高压直流输电(line commutated converter based high voltage direct current,LCC-HVDC)系统的交互振荡模式及阻尼特征,基于系统的状态空间模型及系列文章(一)建立的运动方程模型,提取了表征逆变侧...为研究分网接入方式下电网换相换流器高压直流输电(line commutated converter based high voltage direct current,LCC-HVDC)系统的交互振荡模式及阻尼特征,基于系统的状态空间模型及系列文章(一)建立的运动方程模型,提取了表征逆变侧电气与控制环节强耦合特性的多个弱阻尼交互振荡模式,研究了不同短路比工况下交互振荡模式的变化特征。在此基础上,通过复转矩系数法量化评估了整流侧/逆变侧内部自稳性路径及双极交互作用致稳性路径对主导交互振荡模式阻尼特性的贡献度。结果表明:1)不同短路比工况下交互振荡模式的阻尼比会进行重新分配;2)当逆变侧正负极短路比相差较大时,双极交互作用较弱,正负极系统的稳定性由2个交互振荡模式各自主导,且稳定性特征有所差异;3)当逆变侧正负极短路比相近时,双极间动态交互加强,交互振荡模式会同时主导参与系统两极的稳定性,正负极稳定性特征相似。展开更多
Design and characterization of a G-band（140–220 GHz） terahertz monolithic integrated circuit（TMIC） amplifier in eight-stage common-emitter topology are performed based on the 0.5-μm In Ga As/In P double heteroju...Design and characterization of a G-band（140–220 GHz） terahertz monolithic integrated circuit（TMIC） amplifier in eight-stage common-emitter topology are performed based on the 0.5-μm In Ga As/In P double heterojunction bipolar transistor（DHBT）. An inverted microstrip line is implemented to avoid a parasitic mode between the ground plane and the In P substrate. The on-wafer measurement results show that peak gains are 20 dB at 140 GHz and more than 15-dB gain at 140–190 GHz respectively. The saturation output powers are-2.688 dBm at 210 GHz and-2.88 dBm at 220 GHz,respectively. It is the first report on an amplifier operating at the G-band based on 0.5-μm InP DHBT technology. Compared with the hybrid integrated circuit of vacuum electronic devices, the monolithic integrated circuit has the advantage of reliability and consistency. This TMIC demonstrates the feasibility of the 0.5-μm InGaAs/InP DHBT amplifier in G-band frequencies applications.展开更多
为提高双极直流输电线路单端保护的可靠性和速动性,提出了一种基于特定频率电流的横差保护方法。首先,基于直流滤波环节的阻抗特性,选取特定频率电流;然后利用直流线路故障谐波计算模型,分析了直流线路区内、外故障时,直流分流器处特定...为提高双极直流输电线路单端保护的可靠性和速动性,提出了一种基于特定频率电流的横差保护方法。首先,基于直流滤波环节的阻抗特性,选取特定频率电流;然后利用直流线路故障谐波计算模型,分析了直流线路区内、外故障时,直流分流器处特定频率电流及其横差值的特征。分析研究发现,区内故障时,可能出现的特定频率电流横差值的最小值明显大于区外故障时的特定频率电流横差值;利用该特征构造了直流线路区内、外故障判据;此外,还发现单极线路故障时,故障极线路分流器处特定频率电流比非故障极的大,利用该特征提出了一种故障选极方法。由于该保护方法采用600 Hz的频率电流作为保护判据,因此理论上2 k Hz的采样频率即可满足保护需求;该保护采用特定频率电流横差值实现故障判别,克服了传统仅利用单端暂态谐波电流幅值的保护无法区分线路末端和区外故障的缺陷。仿真结果表明,该保护方案能可靠地区分区内、外故障,实现故障类型判别,且在一定的不对称运行方式下同样适用。展开更多
文摘Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed in manic patients compared to controls, and dysregulation of miR-134,-152,-607,-633,-652,-155 occurred in euthymic patients compared to controls. Finally, microRNAs such as miR-34a,-34b,-34c,-137, and-140-3p,-21-3p,-30d-5p,-330-5p,-378a-5p,-134,-19b-3p were shown to have diagnostic potential in distinguishing bipolar disorder patients from schizophrenia or major depressive disorder patients, respectively. Further studies are warranted with adolescents and young adults having bipolar disorder and consideration should be given to using animal models of the disorder to investigate the effects of suppressing or overexpressing specific microRNAs.
文摘为研究分网接入方式下电网换相换流器高压直流输电(line commutated converter based high voltage direct current,LCC-HVDC)系统的交互振荡模式及阻尼特征,基于系统的状态空间模型及系列文章(一)建立的运动方程模型,提取了表征逆变侧电气与控制环节强耦合特性的多个弱阻尼交互振荡模式,研究了不同短路比工况下交互振荡模式的变化特征。在此基础上,通过复转矩系数法量化评估了整流侧/逆变侧内部自稳性路径及双极交互作用致稳性路径对主导交互振荡模式阻尼特性的贡献度。结果表明:1)不同短路比工况下交互振荡模式的阻尼比会进行重新分配;2)当逆变侧正负极短路比相差较大时,双极交互作用较弱,正负极系统的稳定性由2个交互振荡模式各自主导,且稳定性特征有所差异;3)当逆变侧正负极短路比相近时,双极间动态交互加强,交互振荡模式会同时主导参与系统两极的稳定性,正负极稳定性特征相似。
基金Project supported by the National Natural Science Foundation of China(Grant No.61501091)the Fundamental Research Funds for the Central Universities of Ministry of Education of China(Grant Nos.ZYGX2014J003 and ZYGX2013J020)
文摘Design and characterization of a G-band（140–220 GHz） terahertz monolithic integrated circuit（TMIC） amplifier in eight-stage common-emitter topology are performed based on the 0.5-μm In Ga As/In P double heterojunction bipolar transistor（DHBT）. An inverted microstrip line is implemented to avoid a parasitic mode between the ground plane and the In P substrate. The on-wafer measurement results show that peak gains are 20 dB at 140 GHz and more than 15-dB gain at 140–190 GHz respectively. The saturation output powers are-2.688 dBm at 210 GHz and-2.88 dBm at 220 GHz,respectively. It is the first report on an amplifier operating at the G-band based on 0.5-μm InP DHBT technology. Compared with the hybrid integrated circuit of vacuum electronic devices, the monolithic integrated circuit has the advantage of reliability and consistency. This TMIC demonstrates the feasibility of the 0.5-μm InGaAs/InP DHBT amplifier in G-band frequencies applications.
文摘为提高双极直流输电线路单端保护的可靠性和速动性,提出了一种基于特定频率电流的横差保护方法。首先,基于直流滤波环节的阻抗特性,选取特定频率电流;然后利用直流线路故障谐波计算模型,分析了直流线路区内、外故障时,直流分流器处特定频率电流及其横差值的特征。分析研究发现,区内故障时,可能出现的特定频率电流横差值的最小值明显大于区外故障时的特定频率电流横差值;利用该特征构造了直流线路区内、外故障判据;此外,还发现单极线路故障时,故障极线路分流器处特定频率电流比非故障极的大,利用该特征提出了一种故障选极方法。由于该保护方法采用600 Hz的频率电流作为保护判据,因此理论上2 k Hz的采样频率即可满足保护需求;该保护采用特定频率电流横差值实现故障判别,克服了传统仅利用单端暂态谐波电流幅值的保护无法区分线路末端和区外故障的缺陷。仿真结果表明,该保护方案能可靠地区分区内、外故障,实现故障类型判别,且在一定的不对称运行方式下同样适用。
