Heparin was covalently immobilized onto polyurethane surface via a PEG spacer by a microwave-assisted approach to improve blood compatibility. Firstly, amino-terminated poly（ethylene glycol） （APEG） was rapidly gra...Heparin was covalently immobilized onto polyurethane surface via a PEG spacer by a microwave-assisted approach to improve blood compatibility. Firstly, amino-terminated poly（ethylene glycol） （APEG） was rapidly grafted onto PU surface within 20 rain by a two-step method involving microwave-assisted MDI-functionalization and subsequent microwave-assisted APEG coupling. Then, heparin was eovalently immobilized through an amide linkage by the direct coupling of the carboxylic acid of heparin with the amino group of APEG on PU surface using carbodiimide coupling reaction. The surface structure and properties were characterized by X-ray photoelectron spectroscopy （XPS）, atomic force microscopy （AFM） and water contact angle measurements. The results revealed that hepadn-immobilized PU surface had slightly increased roughness and significantly improved hydrophilicity in comparison to the original PU surface. The anticoagulant activity of films was evaluated by whole blood clotting time （CT） and prothrombin time （PT）. Complement activation was assessed by detecting complement fragment 3a concentrations of serum exposed to the films. The results revealed that the microwave-assisted heparin-immobilized PU films had excellent antithrombogenicity and suppressed complement activation, indicating improved blood compatibility.展开更多
The aim of this study was to investigate the link between changes in a subject’s serum uric acid levels and the estimated glomerular filtration rate (eGFR) in Japanese women. We used data for 161 Japanese women (49.8...The aim of this study was to investigate the link between changes in a subject’s serum uric acid levels and the estimated glomerular filtration rate (eGFR) in Japanese women. We used data for 161 Japanese women (49.8 ± 11.7 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. eGFR was negatively correlated with serum uric acid levels (r = -0.402, p展开更多
A filter media was developed comprising ionic activated cellulosic material with enormous sorption activity to ions-active dissolved and colloidal substances in aqueous systems evoking so-called surface flocculation a...A filter media was developed comprising ionic activated cellulosic material with enormous sorption activity to ions-active dissolved and colloidal substances in aqueous systems evoking so-called surface flocculation and a filling material having a filter effect. The dilemma of the art of low sorption efficiency and high flow rate of filtrated aqueous dispersions without sacrificing its separation efficiency of fines has been solved by use of activated cellulosic material having multi-fold (roughly tenfold to hundredfold) sorption capacity for ions-active dissolved and submicron particulate contaminants compared to untreated cellulosic material.展开更多
基金Funded by the National Natural Science Foundation of China(No.31170911)Research Development and Innovation Fund of Jinan University(No.21611410)Open Fund of The First Afliated Hospital,Jinan University
文摘Heparin was covalently immobilized onto polyurethane surface via a PEG spacer by a microwave-assisted approach to improve blood compatibility. Firstly, amino-terminated poly（ethylene glycol） （APEG） was rapidly grafted onto PU surface within 20 rain by a two-step method involving microwave-assisted MDI-functionalization and subsequent microwave-assisted APEG coupling. Then, heparin was eovalently immobilized through an amide linkage by the direct coupling of the carboxylic acid of heparin with the amino group of APEG on PU surface using carbodiimide coupling reaction. The surface structure and properties were characterized by X-ray photoelectron spectroscopy （XPS）, atomic force microscopy （AFM） and water contact angle measurements. The results revealed that hepadn-immobilized PU surface had slightly increased roughness and significantly improved hydrophilicity in comparison to the original PU surface. The anticoagulant activity of films was evaluated by whole blood clotting time （CT） and prothrombin time （PT）. Complement activation was assessed by detecting complement fragment 3a concentrations of serum exposed to the films. The results revealed that the microwave-assisted heparin-immobilized PU films had excellent antithrombogenicity and suppressed complement activation, indicating improved blood compatibility.
文摘The aim of this study was to investigate the link between changes in a subject’s serum uric acid levels and the estimated glomerular filtration rate (eGFR) in Japanese women. We used data for 161 Japanese women (49.8 ± 11.7 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. eGFR was negatively correlated with serum uric acid levels (r = -0.402, p
基金supported by the Ministry of Education,Youth and Sports of the Czech Republic under the Research Projects VEPA EE2.3.20.0236.
文摘A filter media was developed comprising ionic activated cellulosic material with enormous sorption activity to ions-active dissolved and colloidal substances in aqueous systems evoking so-called surface flocculation and a filling material having a filter effect. The dilemma of the art of low sorption efficiency and high flow rate of filtrated aqueous dispersions without sacrificing its separation efficiency of fines has been solved by use of activated cellulosic material having multi-fold (roughly tenfold to hundredfold) sorption capacity for ions-active dissolved and submicron particulate contaminants compared to untreated cellulosic material.
