Seventy-two type II diabetic subjects were given Konjac food for 65 days. The data analyzed by multiple F test indicate that the fasting blood glucose (FBG) and the 2-h postprandial blood glucose (PBG) on the 30th and...Seventy-two type II diabetic subjects were given Konjac food for 65 days. The data analyzed by multiple F test indicate that the fasting blood glucose (FBG) and the 2-h postprandial blood glucose (PBG) on the 30th and the 65th days after the food was ingested were significantly reduced (P = 0.001, P < 0.001, respectively), as was the glycosylated hemoglobin level at the end of the trial (P < 0.05). The final FBG and PBG of the subjects with initial FBG-O >200 mg% decreased on the average by 51.8 and 84.6 mg%. respectively; those with FBG-0 150-200 mg% decreased by 24.1 and 68.7 mg%; and those with FBG-O < 150 mg% decreased by 4.8 and 21.4 mg%. No significant changes in blood lipid indexes were observed, except that the triglycer-ide values of subjects with hypertriglyceridemia (>200 mg%) significantly decreased by 118.7 mg%. It was concluded that Konjac food is very useful in the prevention and treatment of hyperglycemia. (C)1990 Academic Press. Inc.展开更多
The study of edible plants, especially in developing countries, might provide more affordable means for the management of diabetes. Telfairia occidentalis is one of the plants whose leaves are commonly consumed in Cam...The study of edible plants, especially in developing countries, might provide more affordable means for the management of diabetes. Telfairia occidentalis is one of the plants whose leaves are commonly consumed in Cameroon. This work hereby studied the antiamylasic potential of its aqueous leaves extract and the effect of its dietary supplementation on fasting blood glucose in Wistar rats. An aqueous extract (1:6) was prepared from shed-dried T. occidentalis leaves by maceration. Its antiamylase activity was evaluated in vitro and a phytochemical screening was realized. Its acute toxicity and its effect on an oral glucose tolerance test (OGTT) were evaluated in rats. The effect of T. occidentalis leaves dietary supplementation (10%) on fasting blood glucose was studied for 28 days in rats fed with carbohydrate enriched diet, using Glibenclamide (0.3 mg/kg body weight) as reference hypoglycemic drug. Results showed that there was total inhibition of α-amylase activity in vitro by T. occidentalis aqueous leaves extract at 0.075 mg/ml. The presence of tannins, flavonoids and anthocyanins was revealed by the phytochemical screening. No sign of toxicity was observed in rats after an oral administration of the extract at 2000 mg/kg body weight. The extract significantly hindered a rise in blood glucose at 400 mg/kg body weight during an oral glucose tolerance test. Dietary supplementation with T. occidentalis leaves caused a significant decrease (p < 0.05) in fasting blood glucose as compared to the positive control. Telfairia occidentalis leaves and their aqueous extract could be used in the management of hyperglycemia and diabetes.展开更多
OBJECTIVE： To assess the effect of activating blood drugs （AB drugs） on blood glucose and lipid levels of diabetic patients METHODS： Systematic searches were conducted on 6 electronic databases and the search time...OBJECTIVE： To assess the effect of activating blood drugs （AB drugs） on blood glucose and lipid levels of diabetic patients METHODS： Systematic searches were conducted on 6 electronic databases and the search time was cut off in May 2016. Randomized controlled trials （RCTs） were included if they investigated diabetic patients who received Western medicine combined withAB drugs in the experimental groups and solitary usage of corresponding Western medicine or placebo in the control groups. 6 outcome measures, which were considered as inclusion, were changes in fasting blood glucose （FBG）, glycosylated haemoglobin A1 c （HbA 1 c）, total triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-c） and high density lipoprotein cholesterol （HDL-c）. The literature quality was assessed by Cochrane score for risk of bias in Review Manager 5.2, as well as meta-analysis was performed. RESULTS： 7 RCTs comprising 999 patients met all inclusion criteria. Meta-analysis showed beneficial effects of Western medicine combined with AB drugs on modulating FBG, TC, LDL-c and HDL-c compared with Western medicine or placebo （P〈0.05）, while no difference was observed in HbAlc, and TG （P〉0.05）. To some extent, the therapeutic effects of Western medicine combined with AB drugs were better than that of solitary usage of Western medicine or placebo. Besides, AB drugs were safe and reliable with little toxic and side-effects. CONCLUSIONS： The meta-analysis suggests beneficial effects of Western medicine combined with AB drugs on modulating blood glucose and lipids in diabetic patients.展开更多
Dark tea(containing Eurotium cristatum)and black tea have hypoglycemic effects.The black brick tea with fungal growth is obtained from black tea by adding E.cristatum,followed by steaming,pressing,fungal growth,and dr...Dark tea(containing Eurotium cristatum)and black tea have hypoglycemic effects.The black brick tea with fungal growth is obtained from black tea by adding E.cristatum,followed by steaming,pressing,fungal growth,and drying.However,the hypoglycemic effects of black brick tea are still unexplored.Here,we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice model.Both these types of black tea could lower the content of blood glucose and increase the content of hepatic glycogen by upregulating the proteins and m RNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase,glycogen synthase,protein kinase B and phosphoinositidedependent protein kinase-1 and downregulating the protein and m RNA expression of glycogen synthase kinase 3β.These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low content of malondialdehyde.These teas can promote blood glucose transport and absorption by upregulating the protein and m RNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and m RNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2.Our study suggests that the black brick tea was more effective than the black tea in terms of hypoglycemic.展开更多
目的探究二甲双胍与门冬胰岛素联合治疗2型糖尿病(Diabetes Mellitus Type 2,T2DM)对血糖的控制效果。方法选取2021年6月—2023年6月吉林省人民医院收治的100例T2DM患者为研究对象,以投掷硬币法分为参照组(n=50,二甲双胍治疗)、观察组(n...目的探究二甲双胍与门冬胰岛素联合治疗2型糖尿病(Diabetes Mellitus Type 2,T2DM)对血糖的控制效果。方法选取2021年6月—2023年6月吉林省人民医院收治的100例T2DM患者为研究对象,以投掷硬币法分为参照组(n=50,二甲双胍治疗)、观察组(n=50,二甲双胍与门冬胰岛素联合治疗)。比较两组临床治疗效果、不良反应总发生率、血糖控制情况及血清炎性因子水平。结果观察组治疗总有效率(96.00%)高于参照组(84.00%),差异有统计学意义(χ^(2)=4.000,P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。与治疗前相比,两组治疗半年后血糖水平、白细胞介素-6、白细胞介素-12水平均降低、白细胞介素-10水平升高,且观察组上述指标优于参照组,差异有统计学意义(P均<0.05)。结论二甲双胍与门冬胰岛素联合治疗T2DM患者时可提高疗效,患者血糖控制情况更佳,血清炎性因子水平也得到明显改善,安全性较高。展开更多
Sanggua Drink(SGD)consists of Momordica charantia,Mulberry leaves,Pueraria lobata and Dioscorea opposzite.It has been extensively prescribed owing to notable medicinal benefits.This article aims to investigate the hyp...Sanggua Drink(SGD)consists of Momordica charantia,Mulberry leaves,Pueraria lobata and Dioscorea opposzite.It has been extensively prescribed owing to notable medicinal benefits.This article aims to investigate the hypoglycemic mechanism of SGD in diabetic mice.Streptozotocin-induced diabetic mice were divided into five groups:normal control group,model group,SGD water extraction group。展开更多
目的探讨子午流注择时耳穴压豆治疗对2型糖尿病(T2DM)患者血糖控制、上消症状及失眠状况的影响。方法选取2020年1月至2022年12月河南省中西医结合医院内分泌科收治的138例T2DM患者作为研究对象,依据电脑数表随机抽取法分为西医组(常规...目的探讨子午流注择时耳穴压豆治疗对2型糖尿病(T2DM)患者血糖控制、上消症状及失眠状况的影响。方法选取2020年1月至2022年12月河南省中西医结合医院内分泌科收治的138例T2DM患者作为研究对象,依据电脑数表随机抽取法分为西医组(常规西医干预)46例、中医1组(耳穴压豆干预)46例和中医2组(子午流注择时耳穴压豆干预)46例,连续干预4周。比较三组患者的治疗总有效率、治疗前后的血糖水平[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb1Ac)]、上消症状、睡眠质量[匹兹堡睡眠治疗指数(PSQI)]、Toll样受体4(TLR4)/细胞核因子κB(NF-κB)炎症信号通路因子[外周血TLR4、NF-κB、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平及不良反应发生情况。结果中医2组、中医1组患者的治疗总有效率分别为93.48%、84.78%,明显高于西医组的71.74%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的FBG、2 h PBG、Hb1Ac水平分别为(6.36±0.83)mmol/L、(8.18±1.05)mmol/L、(6.13±0.59)%,明显低于中医1组的(7.05±1.02)mmol/L、(9.37±1.16)mmol/L、(6.91±0.83)%及西医组的(7.81±1.10)mmol/L、(10.80±1.44)mmol/L、(7.88±0.75)%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的口干、多饮症状积分、PSQI各维度评分及总分明显低于中医1组、西医组,中医1组明显低于西医组,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的外周血TLR4、NF-κB蛋白及血清TNF-α、IL-6水平分别为1.26±0.24、1.31±0.25、(26.76±4.38)pg/mL、(17.72±3.34)pg/mL,明显低于中医1组的1.59±0.31、1.53±0.29、(31.54±4.71)pg/mL、(20.53±4.11)pg/mL及西医组的2.02±0.35、2.06±0.37、(34.07±5.23)pg/mL、(23.18±3.62)pg/mL,差异均有统计学意义(P<0.05);三组患者治疗期间的总不良反应发生率比较差异无统计学意义(P>0.05)。结论子午流注择时耳穴压豆治疗T2DM具有一定的治疗效果,其可控制血糖水平,改善上消症状,提高睡眠质量,且具有一定安全性,其治疗机制可能与调节TLR4/NF-κB炎症信号通路有关。展开更多
目的采用Meta分析方法系统评价补肾活血中药联合孕三烯酮用于子宫内膜异位症术后治疗的效果和安全性。方法计算机检索中国知网(CNKI)、万方数据、维普网、中国生物医学文献数据库(CBM)、PubMed、Embase和Web of Science等数据库从建库至...目的采用Meta分析方法系统评价补肾活血中药联合孕三烯酮用于子宫内膜异位症术后治疗的效果和安全性。方法计算机检索中国知网(CNKI)、万方数据、维普网、中国生物医学文献数据库(CBM)、PubMed、Embase和Web of Science等数据库从建库至2022年11月有关补肾活血中药联合孕三烯酮用于子宫内膜异位症术后治疗的临床随机对照试验(RCT),制定纳入和排除标准,筛选符合标准的文献。以给予补肾活血中药联合孕三烯酮治疗的患者作为试验组,单纯给予孕三烯酮治疗的患者作为对照组,提取相关资料运用RevMan 5.4.1软件进行Meta分析。结果共纳入7项RCT研究,涉及患者816例。Meta分析结果显示:与对照组相比,试验组的总有效率[比值比(OR)=2.35,95%CI(1.47,3.77),P=0.0004]、妊娠率[OR=2.34,95%CI(1.62,3.38),P<0.00001]显著增高,复发率[OR=0.38,95%CI(0.24,0.59),P<0.0001]、FSH水平[均数差(MD)=-1.53,95%CI(-1.87,-1.20),P<0.00001]、糖类抗原125(CA125)水平[MD=-13.53,95%CI(-16.78,-10.28),P<0.00001]及LH水平[MD=-1.64,95%CI(-1.86,-1.42),P<0.00001]显著降低;两组的不良反应发生率及E 2水平变化无显著性差异(P>0.05)。结论与单纯使用孕三烯酮比较,补肾活血中药联合孕三烯酮用于子宫内膜异位症术后治疗在提高治疗有效率及妊娠率、降低复发率等方面可能更有优势,但因为本研究纳入文献的数量及质量有限,后续仍需要更多高质量的RCT研究进一步验证。展开更多
文摘Seventy-two type II diabetic subjects were given Konjac food for 65 days. The data analyzed by multiple F test indicate that the fasting blood glucose (FBG) and the 2-h postprandial blood glucose (PBG) on the 30th and the 65th days after the food was ingested were significantly reduced (P = 0.001, P < 0.001, respectively), as was the glycosylated hemoglobin level at the end of the trial (P < 0.05). The final FBG and PBG of the subjects with initial FBG-O >200 mg% decreased on the average by 51.8 and 84.6 mg%. respectively; those with FBG-0 150-200 mg% decreased by 24.1 and 68.7 mg%; and those with FBG-O < 150 mg% decreased by 4.8 and 21.4 mg%. No significant changes in blood lipid indexes were observed, except that the triglycer-ide values of subjects with hypertriglyceridemia (>200 mg%) significantly decreased by 118.7 mg%. It was concluded that Konjac food is very useful in the prevention and treatment of hyperglycemia. (C)1990 Academic Press. Inc.
文摘The study of edible plants, especially in developing countries, might provide more affordable means for the management of diabetes. Telfairia occidentalis is one of the plants whose leaves are commonly consumed in Cameroon. This work hereby studied the antiamylasic potential of its aqueous leaves extract and the effect of its dietary supplementation on fasting blood glucose in Wistar rats. An aqueous extract (1:6) was prepared from shed-dried T. occidentalis leaves by maceration. Its antiamylase activity was evaluated in vitro and a phytochemical screening was realized. Its acute toxicity and its effect on an oral glucose tolerance test (OGTT) were evaluated in rats. The effect of T. occidentalis leaves dietary supplementation (10%) on fasting blood glucose was studied for 28 days in rats fed with carbohydrate enriched diet, using Glibenclamide (0.3 mg/kg body weight) as reference hypoglycemic drug. Results showed that there was total inhibition of α-amylase activity in vitro by T. occidentalis aqueous leaves extract at 0.075 mg/ml. The presence of tannins, flavonoids and anthocyanins was revealed by the phytochemical screening. No sign of toxicity was observed in rats after an oral administration of the extract at 2000 mg/kg body weight. The extract significantly hindered a rise in blood glucose at 400 mg/kg body weight during an oral glucose tolerance test. Dietary supplementation with T. occidentalis leaves caused a significant decrease (p < 0.05) in fasting blood glucose as compared to the positive control. Telfairia occidentalis leaves and their aqueous extract could be used in the management of hyperglycemia and diabetes.
基金Natural Science Foundation of China(81173179)Major project of Fujian Science and technology(2014Y0063)Natural Science Foundation of Fujian Province(2012J01392)
文摘OBJECTIVE： To assess the effect of activating blood drugs （AB drugs） on blood glucose and lipid levels of diabetic patients METHODS： Systematic searches were conducted on 6 electronic databases and the search time was cut off in May 2016. Randomized controlled trials （RCTs） were included if they investigated diabetic patients who received Western medicine combined withAB drugs in the experimental groups and solitary usage of corresponding Western medicine or placebo in the control groups. 6 outcome measures, which were considered as inclusion, were changes in fasting blood glucose （FBG）, glycosylated haemoglobin A1 c （HbA 1 c）, total triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-c） and high density lipoprotein cholesterol （HDL-c）. The literature quality was assessed by Cochrane score for risk of bias in Review Manager 5.2, as well as meta-analysis was performed. RESULTS： 7 RCTs comprising 999 patients met all inclusion criteria. Meta-analysis showed beneficial effects of Western medicine combined with AB drugs on modulating FBG, TC, LDL-c and HDL-c compared with Western medicine or placebo （P〈0.05）, while no difference was observed in HbAlc, and TG （P〉0.05）. To some extent, the therapeutic effects of Western medicine combined with AB drugs were better than that of solitary usage of Western medicine or placebo. Besides, AB drugs were safe and reliable with little toxic and side-effects. CONCLUSIONS： The meta-analysis suggests beneficial effects of Western medicine combined with AB drugs on modulating blood glucose and lipids in diabetic patients.
基金supported by The National Natural Science Foundation of China(grant number 31871804)Natural Science Foundation Project of Hunan Province,China(grant number 2020JJ4036)the Key R&D Program of Hunan Province(2020NK2030)。
文摘Dark tea(containing Eurotium cristatum)and black tea have hypoglycemic effects.The black brick tea with fungal growth is obtained from black tea by adding E.cristatum,followed by steaming,pressing,fungal growth,and drying.However,the hypoglycemic effects of black brick tea are still unexplored.Here,we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice model.Both these types of black tea could lower the content of blood glucose and increase the content of hepatic glycogen by upregulating the proteins and m RNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase,glycogen synthase,protein kinase B and phosphoinositidedependent protein kinase-1 and downregulating the protein and m RNA expression of glycogen synthase kinase 3β.These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low content of malondialdehyde.These teas can promote blood glucose transport and absorption by upregulating the protein and m RNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and m RNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2.Our study suggests that the black brick tea was more effective than the black tea in terms of hypoglycemic.
文摘目的探究二甲双胍与门冬胰岛素联合治疗2型糖尿病(Diabetes Mellitus Type 2,T2DM)对血糖的控制效果。方法选取2021年6月—2023年6月吉林省人民医院收治的100例T2DM患者为研究对象,以投掷硬币法分为参照组(n=50,二甲双胍治疗)、观察组(n=50,二甲双胍与门冬胰岛素联合治疗)。比较两组临床治疗效果、不良反应总发生率、血糖控制情况及血清炎性因子水平。结果观察组治疗总有效率(96.00%)高于参照组(84.00%),差异有统计学意义(χ^(2)=4.000,P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。与治疗前相比,两组治疗半年后血糖水平、白细胞介素-6、白细胞介素-12水平均降低、白细胞介素-10水平升高,且观察组上述指标优于参照组,差异有统计学意义(P均<0.05)。结论二甲双胍与门冬胰岛素联合治疗T2DM患者时可提高疗效,患者血糖控制情况更佳,血清炎性因子水平也得到明显改善,安全性较高。
文摘Sanggua Drink(SGD)consists of Momordica charantia,Mulberry leaves,Pueraria lobata and Dioscorea opposzite.It has been extensively prescribed owing to notable medicinal benefits.This article aims to investigate the hypoglycemic mechanism of SGD in diabetic mice.Streptozotocin-induced diabetic mice were divided into five groups:normal control group,model group,SGD water extraction group。
文摘目的探讨子午流注择时耳穴压豆治疗对2型糖尿病(T2DM)患者血糖控制、上消症状及失眠状况的影响。方法选取2020年1月至2022年12月河南省中西医结合医院内分泌科收治的138例T2DM患者作为研究对象,依据电脑数表随机抽取法分为西医组(常规西医干预)46例、中医1组(耳穴压豆干预)46例和中医2组(子午流注择时耳穴压豆干预)46例,连续干预4周。比较三组患者的治疗总有效率、治疗前后的血糖水平[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb1Ac)]、上消症状、睡眠质量[匹兹堡睡眠治疗指数(PSQI)]、Toll样受体4(TLR4)/细胞核因子κB(NF-κB)炎症信号通路因子[外周血TLR4、NF-κB、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平及不良反应发生情况。结果中医2组、中医1组患者的治疗总有效率分别为93.48%、84.78%,明显高于西医组的71.74%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的FBG、2 h PBG、Hb1Ac水平分别为(6.36±0.83)mmol/L、(8.18±1.05)mmol/L、(6.13±0.59)%,明显低于中医1组的(7.05±1.02)mmol/L、(9.37±1.16)mmol/L、(6.91±0.83)%及西医组的(7.81±1.10)mmol/L、(10.80±1.44)mmol/L、(7.88±0.75)%,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的口干、多饮症状积分、PSQI各维度评分及总分明显低于中医1组、西医组,中医1组明显低于西医组,差异均有统计学意义(P<0.05);干预4周后,中医2组患者的外周血TLR4、NF-κB蛋白及血清TNF-α、IL-6水平分别为1.26±0.24、1.31±0.25、(26.76±4.38)pg/mL、(17.72±3.34)pg/mL,明显低于中医1组的1.59±0.31、1.53±0.29、(31.54±4.71)pg/mL、(20.53±4.11)pg/mL及西医组的2.02±0.35、2.06±0.37、(34.07±5.23)pg/mL、(23.18±3.62)pg/mL,差异均有统计学意义(P<0.05);三组患者治疗期间的总不良反应发生率比较差异无统计学意义(P>0.05)。结论子午流注择时耳穴压豆治疗T2DM具有一定的治疗效果,其可控制血糖水平,改善上消症状,提高睡眠质量,且具有一定安全性,其治疗机制可能与调节TLR4/NF-κB炎症信号通路有关。
文摘目的采用Meta分析方法系统评价补肾活血中药联合孕三烯酮用于子宫内膜异位症术后治疗的效果和安全性。方法计算机检索中国知网(CNKI)、万方数据、维普网、中国生物医学文献数据库(CBM)、PubMed、Embase和Web of Science等数据库从建库至2022年11月有关补肾活血中药联合孕三烯酮用于子宫内膜异位症术后治疗的临床随机对照试验(RCT),制定纳入和排除标准,筛选符合标准的文献。以给予补肾活血中药联合孕三烯酮治疗的患者作为试验组,单纯给予孕三烯酮治疗的患者作为对照组,提取相关资料运用RevMan 5.4.1软件进行Meta分析。结果共纳入7项RCT研究,涉及患者816例。Meta分析结果显示:与对照组相比,试验组的总有效率[比值比(OR)=2.35,95%CI(1.47,3.77),P=0.0004]、妊娠率[OR=2.34,95%CI(1.62,3.38),P<0.00001]显著增高,复发率[OR=0.38,95%CI(0.24,0.59),P<0.0001]、FSH水平[均数差(MD)=-1.53,95%CI(-1.87,-1.20),P<0.00001]、糖类抗原125(CA125)水平[MD=-13.53,95%CI(-16.78,-10.28),P<0.00001]及LH水平[MD=-1.64,95%CI(-1.86,-1.42),P<0.00001]显著降低;两组的不良反应发生率及E 2水平变化无显著性差异(P>0.05)。结论与单纯使用孕三烯酮比较,补肾活血中药联合孕三烯酮用于子宫内膜异位症术后治疗在提高治疗有效率及妊娠率、降低复发率等方面可能更有优势,但因为本研究纳入文献的数量及质量有限,后续仍需要更多高质量的RCT研究进一步验证。
