[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fa...[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly.展开更多
BACKGROUND:The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia,etc.Thus it has become one of the target for treating cerebral infarct...BACKGROUND:The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia,etc.Thus it has become one of the target for treating cerebral infarction to decrease blood viscosity by integrated Chinese and western medicine.OBJECTIVE:To investigate the influence and clinical therapeutic effects of cinepazide maleate combined with tanshinone Ⅱ A sodium sulfonate on the hemorrheologic indexes and blood lipids of patients with acute cerebral infarction,and compare the results with those of simple cinepazide maleate treatment.DESIGN:A non-randomized case-controlled observation.SETTINGS:Hebei North University;the Second Affiliated Hospitals of Hebei North University;the Third Affiliated Hospitals of Hebei North University.PARTICIPANTS:Eighty-six inpatients with cerebral infarction were selected from the infirmary,the Second and Third Affiliated Hospitals of Hebei North University from September 2004 to October 2006.They were all diagnosed to have acute cerebral infarction by CT or MRI,and accorded with the diagnostic standards for acute cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1995.Meanwhile,40 teachers and medical staff of voluntary physical examinees were selected as the control group.Informed contents were obtained from all the patients and their relatives.METHODS:The patients were divided into combined treatment group(n=43)and simple treatment group(n=43).In the combined treatment group,the patients were administrated with 160 mg cinepazide maleate injection(Beijing Four-ring Pharmaceutical,Co.,Ltd,No.H200220125;80 mg/2 mL)added in 5% glucose,and 40 mg tanshinone Ⅱ sodium sulfonate(Shanghai No.1 Biochemical & Pharmaceutical Co.,Ltd.,No.H31022558,10 mg/2 mL)added in 250 mL normal saline.In the simple treatment group,the patients were only administrated with cinepazide maleate 320 mg added in 5% glucose or 250 mL normal saline.They were treated for 1 or 2 courses,once a day,and 14 days as a course.The patients were detected before treatment and at 14 and 28 days after treatment respectively.① Determination of hemorrheologic indexes:Whole blood viscosity was determined with LBY-N6B automatic hemorrheologic meter;Plasma viscosity with LBY-F200B automatic plasma viscosity meter;Volume of fibrinogen was determined by the method of 12.5% sodium nitrate depositing biuret reaction.② Determination of blood lipids:The serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were determined.③ Severity of neurological deficit:The total score of neurological deficit score(NDS)ranged from 0 to 45 points,0-15 points was taken as mild,16-30 points as moderate and 31-45 points as severe.④ Evaluation of curative effects:Generally cured:NDS decreased by 91%-100%,and disabled severity of grade 0;Significantly improved:NDS decreased by 46%-90%,and disabled severity of grades 1-3;Improved:NDS decreased by 18%-45%;No change:NDS decreased by less than 18%;Aggravated:NDS increased by more than 18%.Generally cured and significant improved were taken as significant effect.⑤ The adverse events and side effects after medication were observed.MAIN OUTCOME MEASURES:① Results of hemorrheologic indexes and blood lipids;② NDS results in the combined treatment group and simple treatment group;③ Therapeutic effects and adverse events.RESULTS:All the 86 patients with cerebral infarction and 40 healthy controls were involved in the analysis of results.① Results of hemorrheologic indexes and blood lipids:The hemorrheologic indexes and blood lipids before treatment were manifested as abnormalities to different extents in both the combined treatment group and simple treatment group;The hemorrheologic indexes after treatment were obviously improved in both groups.But the hemorrheologic indexes were improved more obviously in the combined treatment group as compared with those in the simple treatment group(P < 0.05);The levels of TC,TG and LDL-Cafter treatment in the combined treatment group were obviously lowered(P < 0.05),whereas those in the simple treatment group were not significantly changed(P > 0.05).② NDS results:The NDS scores at 14 and 28 days after treatment in the combined treatment group(6.23±2.34),(4.27±1.83)points were obviously lower than those in the simple treatment group(8.76±3.41),(6.65±2.49)points,P < 0.05.③ Therapeutic effects and side effects:The total significant effective rates in the combined treatment group and simple treatment group were 93% and 81% respectively.In the combined treatment group,1 case suffered from palpitation,dizziness and agrypnia.In the simple treatment group,1 case suffered from palpitation,dizziness and agrypnia,1 case had itch of skin.All the above symptoms disappeared gradually after the transfusing speed was adjusted to be slower.No drug withdrawal occurred in the patients due to the adverse events.CONCLUSION:Cinepazide maleate combined with tanshinon can obviously improve the abnormalities of hemorrheologic indexes and blood lipids and nerve function in patients with acute cerebral infarction,and its curative effect is faster than that of simple cinepazide maleate treatment.展开更多
Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can sup...Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can suppress the development of atherosclerosis.The aim of this study was to validate the potential application of YDHP in atherosclerosis therapy and search for its potential mechanisms.Methods:Seven-week-old ApoE^(-/-)mice were randomly divided into a normal group fed a normal diet,an atherosclerosis model group fed a high-fat diet,YDHP groups fed a high-fat diet mixed with different doses of YDHP and positive control groups fed a high-fat diet mixed with atorvastatin or rosuvastatin.After feeding for 10 weeks,body weight,blood lipids,liver and kidney function indexes,serum inflammatory cytokines and atherosclerotic plaque areas were measured.Serum metabolic profiles were detected by an automatic biochemical analyser.Serum inflammatory cytokines were quantified by enzyme-linked immunosorbent assay kits.Atherosclerotic plaque areas were analysed using Oil Red O staining.Results:The YDHP(200,400 and 800 mg/kg/d)treated groups showed reduced serum levels of low density lipoprotein-cholesterol(P<0.05,when 200 or 400 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 800 mg/kg/d of YDHP group compared with the atherosclerosis model group),total cholesterol(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and triglyceride(P<0.01),however,elevated serum levels of high-density lipoprotein cholesterol(P<0.01)compared to the atherosclerosis model group.YDHP inhibited the area of atherosclerotic lesions.In addition,YDHP suppressed the levels of serum inflammatory cytokines such as interleukin 6(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and tumor necrosis factorα(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group).Conclusion:Our study demonstrated that YDHP showed considerable activity in alleviating the formation of atherosclerotic plaques in ApoE^(-/-)mice by reducing blood lipids and exerting anti-inflammatory activity.展开更多
目的评估丁苯酞与尤瑞克林联合治疗急性期脑梗死临床疗效以及远期神经功能恢复的影响。方法选取2020年2月—2022年4月滕州市中医医院行急性期脑梗死治疗的90例患者为研究对象。依据统计学软件生成的随机分组序列均分为参照组与研究组,每...目的评估丁苯酞与尤瑞克林联合治疗急性期脑梗死临床疗效以及远期神经功能恢复的影响。方法选取2020年2月—2022年4月滕州市中医医院行急性期脑梗死治疗的90例患者为研究对象。依据统计学软件生成的随机分组序列均分为参照组与研究组,每组45例;参照组就脑梗死常规支持治疗基础上予尤瑞克林治疗;研究组则予丁苯酞与尤瑞克林联合治疗。比较两组不同时期神经功能缺损评分(National Institute of Health Stroke scale,NIHSS)、生活能力评分(Barthel Index,Barthel)、血脂及临床疗效。结果治疗180 d后,研究组神经功能缺损评分低于参照组;日常活动能力评分高于参照组;总胆固醇、三酰甘油均低于参照组,高密度脂蛋白胆固醇高于参照组,差异有统计学意义(P<0.05);研究组临床总有效率(93.33%)高于参照组(77.78%),差异有统计学意义(χ^(2)=4.406,P<0.05)。结论针对急性期脑梗死使用丁苯酞与尤瑞克林联合治疗效果较单一治疗更为优异,其对于患者神经状态的调节,机体能力、指标的恢复拥有理想的效果,进一步改善了预后及疗效。展开更多
基金Supported by the National Innovation Planning Project for University Students in 2022 in Guangxi(S202210599012).
文摘[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly.
基金a grant from Zhangjiakou Bureau of Technology,No. 060132
文摘BACKGROUND:The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia,etc.Thus it has become one of the target for treating cerebral infarction to decrease blood viscosity by integrated Chinese and western medicine.OBJECTIVE:To investigate the influence and clinical therapeutic effects of cinepazide maleate combined with tanshinone Ⅱ A sodium sulfonate on the hemorrheologic indexes and blood lipids of patients with acute cerebral infarction,and compare the results with those of simple cinepazide maleate treatment.DESIGN:A non-randomized case-controlled observation.SETTINGS:Hebei North University;the Second Affiliated Hospitals of Hebei North University;the Third Affiliated Hospitals of Hebei North University.PARTICIPANTS:Eighty-six inpatients with cerebral infarction were selected from the infirmary,the Second and Third Affiliated Hospitals of Hebei North University from September 2004 to October 2006.They were all diagnosed to have acute cerebral infarction by CT or MRI,and accorded with the diagnostic standards for acute cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1995.Meanwhile,40 teachers and medical staff of voluntary physical examinees were selected as the control group.Informed contents were obtained from all the patients and their relatives.METHODS:The patients were divided into combined treatment group(n=43)and simple treatment group(n=43).In the combined treatment group,the patients were administrated with 160 mg cinepazide maleate injection(Beijing Four-ring Pharmaceutical,Co.,Ltd,No.H200220125;80 mg/2 mL)added in 5% glucose,and 40 mg tanshinone Ⅱ sodium sulfonate(Shanghai No.1 Biochemical & Pharmaceutical Co.,Ltd.,No.H31022558,10 mg/2 mL)added in 250 mL normal saline.In the simple treatment group,the patients were only administrated with cinepazide maleate 320 mg added in 5% glucose or 250 mL normal saline.They were treated for 1 or 2 courses,once a day,and 14 days as a course.The patients were detected before treatment and at 14 and 28 days after treatment respectively.① Determination of hemorrheologic indexes:Whole blood viscosity was determined with LBY-N6B automatic hemorrheologic meter;Plasma viscosity with LBY-F200B automatic plasma viscosity meter;Volume of fibrinogen was determined by the method of 12.5% sodium nitrate depositing biuret reaction.② Determination of blood lipids:The serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were determined.③ Severity of neurological deficit:The total score of neurological deficit score(NDS)ranged from 0 to 45 points,0-15 points was taken as mild,16-30 points as moderate and 31-45 points as severe.④ Evaluation of curative effects:Generally cured:NDS decreased by 91%-100%,and disabled severity of grade 0;Significantly improved:NDS decreased by 46%-90%,and disabled severity of grades 1-3;Improved:NDS decreased by 18%-45%;No change:NDS decreased by less than 18%;Aggravated:NDS increased by more than 18%.Generally cured and significant improved were taken as significant effect.⑤ The adverse events and side effects after medication were observed.MAIN OUTCOME MEASURES:① Results of hemorrheologic indexes and blood lipids;② NDS results in the combined treatment group and simple treatment group;③ Therapeutic effects and adverse events.RESULTS:All the 86 patients with cerebral infarction and 40 healthy controls were involved in the analysis of results.① Results of hemorrheologic indexes and blood lipids:The hemorrheologic indexes and blood lipids before treatment were manifested as abnormalities to different extents in both the combined treatment group and simple treatment group;The hemorrheologic indexes after treatment were obviously improved in both groups.But the hemorrheologic indexes were improved more obviously in the combined treatment group as compared with those in the simple treatment group(P < 0.05);The levels of TC,TG and LDL-Cafter treatment in the combined treatment group were obviously lowered(P < 0.05),whereas those in the simple treatment group were not significantly changed(P > 0.05).② NDS results:The NDS scores at 14 and 28 days after treatment in the combined treatment group(6.23±2.34),(4.27±1.83)points were obviously lower than those in the simple treatment group(8.76±3.41),(6.65±2.49)points,P < 0.05.③ Therapeutic effects and side effects:The total significant effective rates in the combined treatment group and simple treatment group were 93% and 81% respectively.In the combined treatment group,1 case suffered from palpitation,dizziness and agrypnia.In the simple treatment group,1 case suffered from palpitation,dizziness and agrypnia,1 case had itch of skin.All the above symptoms disappeared gradually after the transfusing speed was adjusted to be slower.No drug withdrawal occurred in the patients due to the adverse events.CONCLUSION:Cinepazide maleate combined with tanshinon can obviously improve the abnormalities of hemorrheologic indexes and blood lipids and nerve function in patients with acute cerebral infarction,and its curative effect is faster than that of simple cinepazide maleate treatment.
基金the Wuhan Municipal Health Commission Foundation(No.wx21Q38).
文摘Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can suppress the development of atherosclerosis.The aim of this study was to validate the potential application of YDHP in atherosclerosis therapy and search for its potential mechanisms.Methods:Seven-week-old ApoE^(-/-)mice were randomly divided into a normal group fed a normal diet,an atherosclerosis model group fed a high-fat diet,YDHP groups fed a high-fat diet mixed with different doses of YDHP and positive control groups fed a high-fat diet mixed with atorvastatin or rosuvastatin.After feeding for 10 weeks,body weight,blood lipids,liver and kidney function indexes,serum inflammatory cytokines and atherosclerotic plaque areas were measured.Serum metabolic profiles were detected by an automatic biochemical analyser.Serum inflammatory cytokines were quantified by enzyme-linked immunosorbent assay kits.Atherosclerotic plaque areas were analysed using Oil Red O staining.Results:The YDHP(200,400 and 800 mg/kg/d)treated groups showed reduced serum levels of low density lipoprotein-cholesterol(P<0.05,when 200 or 400 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 800 mg/kg/d of YDHP group compared with the atherosclerosis model group),total cholesterol(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and triglyceride(P<0.01),however,elevated serum levels of high-density lipoprotein cholesterol(P<0.01)compared to the atherosclerosis model group.YDHP inhibited the area of atherosclerotic lesions.In addition,YDHP suppressed the levels of serum inflammatory cytokines such as interleukin 6(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and tumor necrosis factorα(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group).Conclusion:Our study demonstrated that YDHP showed considerable activity in alleviating the formation of atherosclerotic plaques in ApoE^(-/-)mice by reducing blood lipids and exerting anti-inflammatory activity.
文摘目的评估丁苯酞与尤瑞克林联合治疗急性期脑梗死临床疗效以及远期神经功能恢复的影响。方法选取2020年2月—2022年4月滕州市中医医院行急性期脑梗死治疗的90例患者为研究对象。依据统计学软件生成的随机分组序列均分为参照组与研究组,每组45例;参照组就脑梗死常规支持治疗基础上予尤瑞克林治疗;研究组则予丁苯酞与尤瑞克林联合治疗。比较两组不同时期神经功能缺损评分(National Institute of Health Stroke scale,NIHSS)、生活能力评分(Barthel Index,Barthel)、血脂及临床疗效。结果治疗180 d后,研究组神经功能缺损评分低于参照组;日常活动能力评分高于参照组;总胆固醇、三酰甘油均低于参照组,高密度脂蛋白胆固醇高于参照组,差异有统计学意义(P<0.05);研究组临床总有效率(93.33%)高于参照组(77.78%),差异有统计学意义(χ^(2)=4.406,P<0.05)。结论针对急性期脑梗死使用丁苯酞与尤瑞克林联合治疗效果较单一治疗更为优异,其对于患者神经状态的调节,机体能力、指标的恢复拥有理想的效果,进一步改善了预后及疗效。
