DESENSITIZATION OF ACETYLCHOLINE ON THE INHIBITION EFFECTS OF BLOOD PRE SSURE IN ANESTHETIZED CANINE

Objective To investigate the desensitization of acetylcholine (ACh) on the inhibition effects of blood pressure (BP) in anesthe tized canine and build a model for studying desensitization in vivo. Methods Through changing the intervals (120, 100, 80, 60, 40, 20 seconds) of twice ACh administration (each was 15μg·kg -1,i.v.), the desensitization on the effect of systemic blood pressure of the first ACh in jection towards the subsequent ACh administration was observed. Results When ACh administration intervals were 40, 60, 80 , 100 seconds, the percentages of desensitization of ACh on systemic blood press ure were significantly increased (P<0.05). However, as the intervals were 20 and 120 seconds, the effects of twice ACh administration had no significant dif ference (P>0.05). Conclusion The results indicated that ACh contents in blo od might influence the action of next ACh administration. To some extent, the hi gher the concentration of ACh in blood, the bigger the ratio of desensitization of exogenous ACh is. In addition, this method of twice drug administration could be used as a model of studying desensitization in vivo.

缺血性中风(中经络)证候分类与血脂、血压、血液流变学关系的研究

目的探讨缺血性中风证侯分类的客观量度。方法本研究对118例缺血性中风患者按中医证类进行分组,观察各证类组病例的血脂、血压及血液流变学改变。结果研究表明,风痰阻络证、痰热腑实证及气虚血瘀证组脂质变化较正常组明显升高(P<0.05～0.01),其中风痰阻络证、痰热腑实证与气虚血瘀证组存在显著差异(P<0.05);气虚血瘀证、风痰阻络证及痰热腑实证组血液流变学指标较正常组有显著差异(P<0.05～0.01);肝阳暴亢证、痰热腑实证组血压明显高于气虚血瘀证、风痰阻络证及阴虚风动证组(P<0.05～0.01)。结论血脂、血压及血液流变学指标可为缺血性中风证候分类提供客观量度。

鄂温克族与鄂伦春族的群体遗传学研究(续)

本次调查采印了645名鄂温克族和424名鄂伦春族中、小学生和部分牧民、猎民的指纹和掌纹。观察了各型指纹出现率、指纹总嵴数、atd角和掌褶纹等指标。 1.各型指纹出现率 弓(A)、尺侧箕(L^u)、桡侧箕(L^r)和斗(W)的出现频率见表11。额左旗和陈旗鄂温克人中斗多于箕,与汉族相似。有些指纹型在某个手指上较为多见。

自发性高血压大鼠左心室肥厚与血压、心肌局部血管紧张素Ⅱ的关系

目的 研究自发性高血压大鼠（ＳＨＲ） 左心室肥厚与血压、心肌局部血管紧张素ＩＩ 的关系。方法 取ＳＨＲ（ｎ ＝ ４０） 及正常对照组 ＷＫＹ（ｎ ＝ ４１） ，分为４ 周龄、８ 周龄、１２ 周龄、２４ 周龄及３６周龄组，测收缩压、体重、左心室重量及用放免法测定心肌局部血管紧张素（ＡＩＩ） 含量，并进行两两线性相关分析。结果 通过对５ 个年龄段的ＳＨＲ 和 ＷＫＹ 的收缩压、左心室重与体重比（ＬＶＭＢＷ）及心肌局部ＡＩＩ含量的测定结果发现三者之间存在相关性，其中ＡＩＩ与心肌肥厚有明显相关性。结论 血压与ＡＩＩ在ＳＨＲ 大鼠的左心室肥厚中起着重要作用。