The assessment of time dependent flow of Williamson fluid with radiative blood flow against a wedge

The present pagination reports both Brownian diffusion and thermophoresis aspects subject to magneto hydrodynamic Williamson fluid model.Assuming the flow is unsteady and blood is treated as Williamson fluid over a wedge with radiation.The governing equations are transformed into ordinary differential equations by using similarity variables.The analytical solutions of the transformed governing equations are obtained by using the RK 4th order method along with shooting technique solver.The effects of various physical parameters such as Hartmann number,local Weissenberg number,radiation parameter,unsteadiness parameter,Prandtl number,Lewis number,Brownian diffusion,thermophoresis,wedge angle parameter,moving wedge parameter,on velocity,temperature,concentration,skin friction,heat transfer rate and mass transfer rate have been discussed in detail.The velocity and temperature profile deprives for larger We and an opposite trend is observed for concentration.The radiation parameter is propositional to temperature and a counter behaviour is observed for Pr.

Clinical Efficacy of Modified Erchen Decoction on Cervical Spondylotic Vertebral Arteriopathy with Stagnation and Blockade of Phlegm-dampness Syndrome and Effects on Cerebral Blood Flow Parameters

OBJECTIVE: To observe the effect of Modified Erchen Decoction on cervical spondylotic vertebral arteriopathy with stagnation and blockade of phlegm-dampness syndrome and effects on cerebral blood flow parameters. METHODS: A total of 80 cervical spondylotic vertebral arteriopathy(CSA) patients with stagnation and blockade of phlegmdampness syndrome admitted to our hospital from October 2016 to April 2017 were selected and randomly divided into observation group and control group, with 40 cases in each group. The observation group was treated with Modified Erchen Decoction and the control group was given conventional treatment with Western medicine. After 4 weeks of treatment, the main clinical symptoms and signs(vertigo, neck and shoulder pain, headache, psychological and social adjustment, daily life and work) and cerebral blood flow parameters [the peak values of intracranial vertebral-basal artery diastolic blood flow velocity(Vd) and systolic blood flow velocity(Vp)] were compared between the 2 groups. The total clinical effective rate and adverse reactions during treatment were also compared. RESULTS: After treatment, the total effective rate of the observation group was 90.0%, which was significantly higher than that of the control group(77.5%). The difference between the two groups was statistically significant(P < 0.05). After treatment, The scores of vertigo, neck and shoulder pain, headache, psychology and society adaptation, daily life and work were significantly increased(P < 0.05), and the above scores of the observation group were increased more obviously. The difference between the groups was statistically significant(P < 0.05). After treatment, the levels of Vd and Vp were significantly increased(P < 0.05), and the increase of the above indexes was more obvious in the observation group. The difference between the 2 groups was statistically significant(P < 0.05). There were no significant abnormalities in blood routine, urine routine, liver function and renal function. There was no significant difference in the incidence of adverse reactions between the 2 groups.(P > 0.05). CONCLUSION: The treatment of vertebral artery type cervical spondylopathy with stagnation and blockade of phlegm-dampness syndrome by Modified Erchen Decoction can effectively relieve the main clinical symptoms and signs, improve cerebral blood flow parameters, and improve the peak values of vertebral-basal artery diastolic blood flow velocity(Vd) and systolic blood flow velocity(Vp), which is safe and effective, and helps to promote the recovery of cervical function.

Effects of <i>Nigella sativa</i>L. Seed Extract on Fatigue, Blood Biochemical Parameters and Thyroid Function in Male Mice

Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.

Effect of aerobic exercise training on red blood cell parameters, vascular endothelial function in elderly patients with coronary heart disease and chronic heart failure

Objective: To investigate effect of aerobic exercise training combined with conventional drug on red blood cell parameters, vascular endothelial function and cardiac function in elderly patients with coronary heart disease complicated with chronic heart failure. Methods: A total of 110 elderly patients with coronary heart disease and chronic heart failure according to random data table were divided into control group (n=54) and observation group (n=56). The patients in control group were treated with conventional drug, and patients in the observation group received conventional drug combined with aerobic exercise training. Before and after treatment, levels of red blood cell parameters, vascular endothelial function and cardiac function indexes were compared between the two groups. Results: Before treatment, the difference of HCT, RDW, RBC, NO, ET-1, LVEF, LVEDD and LVESD levels in the two groups were not significantly. After treatment, HCT and RBC levels in two groups were no statistically significant difference;The levels of RDW, ET-1, LVEDD and LVESD in observation group were significantly lower than those in this group before treatment, and significantly lower than those in the control group after treatment;The levels of NO and LVEF in two groups were significantly higher than those in the group before treatment, and levels of NO and LVEF in the observation group were significantly higher than those in control group after treatment. Conclusion: The clinical effect of aerobic exercise training combined with conventional drug in treatment of senile coronary heart disease with chronic heart failure was significant, which can effectively increase the RDW level of patients, improve vascular endothelial function and heart function, it has important clinical value.

Effect of adjuvant noninvasive positive pressure ventilation on blood gas parameters, cardiac function and inflammatory state in patients with COPD and type II respiratory failure

Objective:T o analyze the effect of adjuvant noninvasive positive pressure ventilation on blood gas parameters, cardiac function and inflammatory state in patients with chronic obstructive pulmonary disease (COPD) and type II respiratory failure. Methods:90 patients with COPD and type II respiratory failure were randomly divided into observation group and control group (n=45). Control group received conventional therapy, observation group received conventional therapy+adjuvant noninvasive positive pressure ventilation, and differences in blood gas parameters, cardiac function, inflammatory state, etc., were compared between two groups of patients 2 weeks after treatment. Results:Arterial blood gas parameters pH and alveolar-arterial partial pressure of oxygen [P(A-a)O2] levels of observation group were higher than those of control group while, potassium ion (K+), chloride ion (Cl-) and carbon dioxide combining power (CO2CP) levels were lower than those of control group 2 weeks after treatment;echocardiography parameters Doppler-derived tricuspid lateral annular systolic velocity (DTIS) and pulmonary arterial velocity (PAV) levels were lower than those of control group (P<0.05) while pulmonary artery accelerating time (PAACT), left ventricular end-diastolic dimension (LVDd) and right atrioventricular tricuspid annular plane systolic excursion (TAPSE) levels were higher than those of control group (P<0.05);serum cardiac function indexes adiponectin (APN), Copeptin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), cystatin C (CysC), growth differentiation factor-15 (GDF-15) and heart type fatty acid binding protein (H-FABP) content were lower than those of control group (P<0.05);serum inflammatory factors hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), IL-8, IL-10, and transforming growth factor-β1 (TGF-β1) content were lower than those of control group (P<0.05). Conclusions:Adjuvant noninvasive positive pressure ventilation can optimize the blood gas parameters, cardiac function and inflammatory state in patients with COPD and type II respiratory failure, and it is of positive significance in improving the overall treatment outcome.

Curative Effects of Warming Needle Moxibustion Combined with Manipulation Massage on Cervical Spondylotic Vertebral Arteriopathy and Its Influence on the Cerebral Blood Flow Parameters and Cervical Vertebral Function

OBJECTIVE: To explore the curative effects of warming needle moxibustion combined with manipulation massage on cervical spondylotic vertebral arteriopathy and its influence on the cerebral blood flow and cervical vertebra function. METHODS: A total of 84 patients with cervical spondylotic vertebral arteriopathy admitted to our hospital from February 2016 to June 2017 were selected, and all patients were divided into an observation group (n=42) and a control group (n=42) according to the random number table method. The patients in the control group were given conventional western treatment, and the patients in the observation group were treated with warming needle moxibustion combined with manipulation massage on the basis of the control group. After 4 weeks of treatment, the changes of main clinical symptoms (vertigo, headache, neck and shoulder pain, tinnitus), cervical function (clinical symptoms, clinical examination, daily life action) and cerebral blood flow parameters (average blood flow velocity of left vertebral artery, right vertebral artery and basilar artery) of the 2 groups were observed, and the clinical efficacy of the 2 groups were statistically analyzed. RESULTS: The scores of vertigo, headache, neck and shoulder pain and tinnitus in the 2 groups were all significantly lower than before treatment (P < 0.05), and the clinical symptom scores in the observation group were significantly lower after treatment (P < 0.05);After treatment, the scores of clinical symptoms, clinical examination and daily life action in the 2 groups were significantly higher than those before treatment (P < 0.05), and the increase of cervical vertebral function score in the observation group was better than that in the control group (P < 0.05);The mean blood flow velocity of the left vertebral artery, right vertebral artery and the basilar artery in the 2 groups after treatment were significantly higher than before treatment (P < 0.05), and the increase of the above cerebral blood flow parameters in the observation group were higher than the control group (P < 0.05). The total effective rate was 92.9% in the observation group and 76.2% in the control group after treatment, and the difference between the 2 groups was statistically significant (P < 0.05). CONCLUSION: Warming needle moxibustion combined with manipulation massage can quickly relieve the clinical symptoms of patients with cervical spondylotic vertebral arteriopathy, improve the cervical function and cerebral blood flow parameters, increase the vertebrobasilar artery blood flow, and promote the recovery of the disease.

Effect of different anesthetic mixtures——ketamine-xylazine, ketamine-acepromazine and tiletamine-zolazepam——on the physiological and blood biochemistry parameters of male rhesus monkeys(Macaca mulatta) at different ages

Background: Anesthetic agents are commonly utilized in the handling of non‐human primates for prevent the stress caused in physical exploration or physical restrain. For this reason, the objective of this work was to describe the effect of age and dissociative anesthetics (ketamine and tiletamine), and their combinations with acepromazine, xylazine and zolazepam, on the physiological and blood biochemical parameters in Macaca mulatta. Methods: Eighty male Macaca mulatta were divided into four experimental groups depending on the anesthetic mixture applied. Each group of 20 males was divided into five sub‐groups according to age. Physiological parameters were recorded every five minutes during a 30‐minute period. A blood sample was drawn to analyze blood biochemistry. Results: Statistical analyses revealed significant differences in the physiological parameters between the ketamine‐acepromazine and ketamine‐xylazine groups compared to the control group. The analysis of blood biochemistry found significant differences by age and by anesthetic mixture among all groups. Conclusion: These findings contribute to standardizing this animal model in biological research.

Blood parameters score predicts long-term outcomes in stage Ⅱ-Ⅲ gastric cancer patients

BACKGROUND Increasing numbers of laboratory blood parameters(BPM)have been reported to greatly affect the long-term outcomes of gastric cancer(GC)patients.However,the existing prognostic models do not comprehensively analyze these predictors.AIM To construct a new prognostic tool,based on all the prognostic BPM,to achieve more accurate prognosis prediction for GC.METHODS We retrospectively assessed 850 consecutive patients who underwent curative resection for stage II-III GC from January 2010 to April 2013.The patients were classified into developing(n=567)and validation(n=283)cohorts using computer-generated random numbers.A scoring system,namely BPM score,was then constructed using least absolute shrinkage and selection operator(LASSO)Cox regression model in the developing cohort,and validated in the validation cohort.A nomogram consisting of BPM score and tumor-lymph node-metastasis(TNM)stage was further created.The discrimination and calibration of the nomogram were evaluated via Harrell’s C-statistic and the Hosmer-Lemeshow test.RESULTS Using the LASSO model,we established the BPM score based on five BPM:Albumin,lymphocyte-to-monocyte ratio,neutrophil-to-lymphocyte ratio,carcinoembryonic antigen,and carbohydrate antigen 19-9.The BPM scores were divided into high-and low-BPM groups based on a cut-off value of-0.93.High-BPM patients were significantly older and had more advanced,larger tumors.In the developing cohort,significant differences were found in 5-year overall survival(OS)and 5-year disease-specific survival between the high-BPM and low-BPM patients.Similar results were found in the validation group.Multivariable analysis showed that the BPM score was an independent predictor of OS.High-BPM patients had a poorer 5-year OS for each subgroup.Furthermore,a nomogram that combined the BPM score and TNM stage had significantly better prognostic value compared with TNM stage alone.CONCLUSION The BPM score provides more accurate prognosis prediction in stage Ⅱ-Ⅲ GC patients and is an effective complement to the TNM staging system.

Study on Digitization of TCM Diagnosis Applied Extraction Method of Blood Vessel

This paper presents a study on digitization of Traditional Chinese Medicine diagnosis. The research consists of two aspects: a) algorithms for blood vessels extraction in sclera-conjunctiva images, which can be applied in syndrome differentiation by observing human eyes (named Ocular Diagnostic in Traditional Chinese Medicine);b) digitization of extracted vessels. First, sclera-conjunctiva region is isolated by optimal threshold segmentation and mathematical operation;Scanning and edge detection methods are used to gain the edge of the blood vessels. Moreover, the edge feature parameters are gained, which can be used to reconstruct the blood vessels. Experimental results show that blood vessels information can be obtained fast and accurately for the further TCM diagnosis by artificial system.

流变荷载试验曲线的模型识别及其应用

基于粘弹性理论,建立了流变荷载试验的Maxwell、广义Kelvin和Burgers3种流变模型的位移反演模式,并给出了根据现场试验流变曲线进行流变模型识别的简便方法。分析了岩体流变荷载试验曲线,给出了能反映试验区域内岩体变形规律的最佳流变模型,反演获得了试验区域内岩体的瞬时弹性模量、长期弹性模量、粘弹性模量和粘弹性系数。结果表明,描述试验点岩体在不同荷载级别情况下的最佳流变模型均为广义Kelvin模型,但其弹性模量有所差异,其量值范围为4194～5235MPa,平均弹性模量为4900.316MPa;平均长期弹性模量为3081.65MPa。计算表明所建立的反演公式是正确的,模型及参数识别过程简便、实用。

Traction rheological properties of simulative soil for deep-sea sediment

The traction capacity of the mining machine is greatly in?uenced by the traction rheological properties of the deep-sea sediments. The best simulative soil was prepared for substituting the deep-sea sediment based on the deep-sea sediment collected from the Paci?c C-C mining area. Traction rheological properties of the simulative soil were studied by a home-made test apparatus. In order to accurately describe the traction rheological properties and determine traction rheological parameters, the Newtonian dashpot in Maxwell body of Burgers model was replaced by a self-similarity spring-dashpot fractance and a new rheological constitutive model was deduced by fractional derivative theory. The results show the simulative soil has obvious non-attenuate rheological properties. The transient creep and stable creep rate increase with the traction, but they decrease with ground pressure. The fractional derivative Burgers model are better in describing non-attenuate rheological properties of the simulative soil than the classical Burgers model. For the new traction rheological constitutive equation of the simulative soil, the traction rheological parameters can be obtained by ?tting the tested traction creep data with the traction creep constitutive equation. The ground contact length of track and walking velocity of the mining machine predicted by the traction rheological constitutive equation can be used to take full advantages of the maximum traction provided by the soil and safely improve mining effciency.

饲喂含不同秸秆的全日粮颗粒料对绵羊瘤胃及血液代谢参数的影响

选用4只1岁左右,装有瘤胃瘘管的杂种生长羯羊,按2×3交叉试验设计,交替饲喂以玉米秸和苜蓿为粗料(A处理)及以小麦秸和苜蓿为粗料(B处理)的等消化能、等氮全日粮颗粒料,测定了瘤胃消化代谢参数(pH值、NH3-N、尿素氮)和血浆尿素氮(PUN)浓度。结果表明:采食两种日粮试羊的瘤胃代谢参数及PUN均无显著差异(P>0.05),均处于正常范围;但摄食A料时瘤胃pH值有高于B料的趋势,NH3-N浓度的动态变化较B料平稳。

A STUDY ON THE RELATIONS BETWEEN DIETARY PARAMETERS AND BLOOD PRESSURE IN 8 CHINESE COMMUNITIES

Relations between 67 dietary parameters and blood pressure in 8 Chinese communities （745 men aged 40～59 years） were studied. Results showed. UNa, Na/K, Ca, Ca/Mg, parameters reflecting the protein-intake, serum levels of Sr, valine, cysteine,threonine, Vit A, Vit E, cholesterol, C16:0, C18:0, （saturated fatty acid）/（polyunsaturated fatty acid）,（C20:5+C22:6 （ω3））/（C18:2+C20:3+C20:4 （ω6））, γ-glutamyl transferase （an index of alcohol consumption） and plasma glucose correlated positively with BP, while serum levels of K, Mg, glycine, phenylalanine, leucine, VitC, C18:2, Ni, V, Co, Cr and Cd, inversely. And also, a metabolic imbalance among BP, blood glucose and lipids was exhibited.

The Effects of Frying Oils Supplemented with Vitamin E on Blood Parameters and Growth Performance of Rats

This study aimed at investigating effects of frying oils supplemented with vitamin E on blood parameters and growth performance of rats. Three experimental diets containing fresh corn oil or frying oil (FO) with or without vitamin E were fed to Wistar rats over a 90-day. Blood Chemistry, blood parameters (hematocrit and erythrocyte osmotic fragility) and growth performance were determined. Neither FO alone nor vitamin E had any considerable impact on the growth performance. Hematocrit of FO group did not change significantly compared to animals fed fresh oil. Although, vitamin E increased hematocrit to 16.37%, but still it had no considerable effect on restoring hematocrit to normal values. Serum triacylglycerol (TAG) did not change significantly among FO animals, while significant increase in TAG was noted between FO and vitamin E treated animals compared with other treatments. Serum total cholesterol (TC) did not change significantly among experimental animals compared with the control. Vitamin E resulted in an insignificant increase in high-density lipoprotein (HDL-C) level compared to the control. Serum low-density lipoprotein (LDL-C) level did not display any considerable difference among the three treatments. Frying oil with or without vitamin E had no significant effects on growth performance, lipid chemistry, and blood parameters. The only significant effect of FO was shown on erythrocytes hemolysis at higher concentration. Vitamin E supplementation had no impacts on undesired effects caused by frying oil.

Influence of Procedure Parameters on Rheological Property of Semi-Solid AZ91D Magnesium Alloy

Semi-solid AZ91D magnesium alloy was investigated in isothermal steady-state condition. The influence of stirring technological parameters such as stirring temperature and shear rate to apparent viscosity of semi-solid alloy slurry was discussed. Apparent viscosity increases with stirring temperature decreases at the same shear rate. At the same stirring temperature, apparent viscosity decreases rapidly at first with shear rate increases, and then apparent viscosity decreases slowly with shear rate increases, when shear rate reaches a certain value, apparent viscosity appears tiny increase. According to the experimental data, the relation between solid volume fraction and apparent viscosity of semi-solid AZ9l D alloy at shear rate 238 s- 1 is fitted by regression method, it supplies useful data to the numerical simulation of semi-solid AZ91D alloy die casting process.

Well test analysis on pressure of viscoelastic polymer solution with variable rheological parameters

According to the behavior that the polymer solution has both the characteristics of viscosity and elastic properties, the transient flow mathe- matical model considered the viscoelasticity of the polymer solution has been established. The model, in which the variation of the rheological parameters during the seepage flow has been also taken into consideration, has been solved using finite-difference method. The type curves have been plotted. The influence of some properties of polymer solution including the viscocity, the elastic properties and the rheological parameters has been analyzed. Compared with the curves of the power-law fluid, it is shown that the pressure derivative curve considering the elasticity of the polymer solution upwarps less at the radial flow regime. Besides, it will come down as the variation of the rheological parameters, which is quite different from the case regarding them as constants. Therefore, in well test analysis on pressure of polymer solution, it’s necessary to consider the elasticity and the variation of the rheological parameters.

铜中毒对雏鸭某些血液指标的影响

选用1日龄天府肉鸭210只,随机分为3组,分别喂以对照日粮(Cu12.16mg/kg)、铜中毒日粮(Cu850mg/kg)和铜中毒日粮(Cu1050mg/kg)。试验期7周。以血液病理学方法观察了铜中毒对雏鸭某些血液学指标的影响。结果显示铜中毒组、组雏鸭分别于2周龄和3周龄开始出现临床症状,死亡18只和5只。血液病理学变化表现为,红细胞大小不等、变形变性、坏死溶解;红细胞数量和血红蛋白含量显著降低(P<0.01),血清谷丙转氨酶、谷草转氨酶活性显著升高(P<0.05或P<0.01),血清铜蓝蛋白活性下降。结果表明,铜中毒对雏鸭的生长发育和上述血液指标影响明显。

Penergetic-t对延边黄牛增重及血液理化指标的影响

选用12头体重相近(480 kg)、24月龄左右的延边黄牛(阉牛),随机分成试验组和对照组,在试验组的精饲料中添加Penergetic-t,对照组中不添加,研究Penergetic-t对延边黄牛(阉牛)增重效果和血液生化指标的影响,结果表明:经过120 d的饲养试验,试验组牛的全期增重和日增重分别为71.1 kg和0.6 kg,明显高于对照组,差异显著(P<0.05);血液生化指标中,试验组的血清总蛋白、球蛋白、乳酸脱氢酶、碱性磷酸酶含量明显高于对照组,差异显著(P<0.05);试验组的血清尿素氮、甘油三酯含量明显低于对照组,差异显著(P<0.05)。结论:Penergetic-t对延边黄牛育肥具有明显的促进作用,能够提高日增重和免疫力,减轻疲劳,降低血液中的胆固醇和甘油三酯。

The changes of blood lipids, Na^+ -K^+ -ATPase and viscoelastic parameters of whole blood in different stages of experimental atherosclerosis in rabbits

In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis (AS) in the rabbit. An experimental model of atherosclerosis was established in cholesterol-fed rabbits. In the 2nd, 4th, 8th and 12th week, the parametersmentioned above were determined and the pathological changes of the aorta examined. It was found that serum triglyceride (TG)was increased in the 4th week and total serum cholesterol (TCh) was significantly higher in the 4th, 8th and 12th week than thatin the control. Erythrocytic Na+ -K+ -ATPase activity decreased progressively and it was negatively correlated to TCh in the 4thand 12th week (r = - 0.67 and - 0.51, P < 0.01 and 0.05). G’ was significantly increased in the 4th week only when theshear rate was 0. 190 Hz whereas G and η’ increased progressively from the 8th to 12th week. It is believed that the determinationof blood lipids, Na+ -K+ -ATPase activity and viscoelastic parameters of the whole blood is useful for the prediction of the propession of the pathological changes in different stages of AS.

The Effect of Cost Effective and Useful Diets on Blood Parameters in Female Mice

The high rate of cardiovascular disease is due to excessive intake of animal protein. The aim of this study was to investigate the effects of the replacement of the soybean as a cost effective protein on the blood parameters. 110 immature female Balb/c mice three weeks of age were randomized, into eleven groups of 10 animals each based on following diets: 1) low protein, 2) full protein without soybean, 3) full protein with 20% soybean, and 4) full protein with 40% soybean,. The animals received their diet orally on a daily basis for three and six months. At the end of the study period, the blood samples were collected and blood parameters were measured. The data were analyzed with SPSS software using one-way ANOVA and Tukey’s test. Results: In the groups that received 20% and 40% soybean diet, the cholesterol, LDH, glucose, creatinine and urea levels showed meaningful decrease, and total protein level showed a significant increase in comparison with the other groups (P However, the mean values of ALT, AST, ALP, triglyceride, calcium and phosphorus did not show significant change among experimental groups (P 0.01). Results of the present study indicated that soybean as a cost effective protein could be suitable replacement for animal protein and soybean may have beneficial effects on health like reduction of cholesterol, LDH and urea.