Objective: To explore the correlation between different types of osteonecrosis of the femoral head and blood lipids and coagulation indexes, in order to provide relevant references for the pathogenesis of osteonecrosi...Objective: To explore the correlation between different types of osteonecrosis of the femoral head and blood lipids and coagulation indexes, in order to provide relevant references for the pathogenesis of osteonecrosis of the femoral head. Methods: 308 cases of ONFH were divided into alcohol group (165 cases), hormone group (113 cases), trauma group (30 cases), and basic data of patients were collected. Blood lipid indicators: total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B;coagulation indicators: activated partial thromboplastin time, plasma prothrombin time, fibrinogen, thrombin time indicators, using analysis of variance method for different types of osteonecrosis of the femoral head and blood lipids, coagulation indicators Search for relevance. Results: 1. Comparison of three groups of blood lipid indicators: total cholesterol and low density lipoprotein cholesterol in the alcohol group were higher than those in the trauma group (P<0.05);total cholesterol, triglycerides, and low density lipoprotein in the alcohol group The three indexes of cholesterol were higher than those of the hormone group (P<0.05). There was no significant difference in the serum lipid indexes of the hormone group and the trauma group (P>0.05). 2. Comparison of three groups of coagulation indicators: hormone The fibrinogen index of the group was higher than that of the trauma group (P<0.05). There was no significant difference in the coagulation index between the alcohol group and the trauma group (P>0.05). The coagulation index of the hormone group and the alcohol group was compared. The differences were not statistically significant (P>0.05). Conclusions: 1. Non-traumatic osteonecrosis of the femoral head (alcoholic, hormonal) patients are characterized by markedly elevated blood lipids (total cholesterol, low density lipoprotein cholesterol) and coagulation (fibrinogen) indicators;2. Intravascular coagulation and lipid metabolism disorders may be the pathological basis of non-traumatic Osteonecrosis of the femoral head.展开更多
Osteonecrosis of the femoral head is a common disability disease of the hip joint in China,and osteonecrosis of the femoral head caused by hormone factors is the most common,which is related to the gradual increase in...Osteonecrosis of the femoral head is a common disability disease of the hip joint in China,and osteonecrosis of the femoral head caused by hormone factors is the most common,which is related to the gradual increase in the utilization rate of glucocorticoids in recent years.It is a refractory disease in orthopaedics with a poor prognosis.For this disease,the treatment of traditional Chinese medicine has certain advantages.In view of this,the author reads,analyzes and summarizes its materials by searching China Journal full-text Database and Wanfang Database.This paper reviews the mechanism and clinical research progress of tonifying kidney and activating blood circulation in the prevention and treatment of steroid-induced osteonecrosis of the femoral head,hoping to provide help for the clinical treatment of hormone-related osteonecrosis of the femoral head.展开更多
Objective：To observe the effect and mechanism of Chinese medicine therapy for activating blood and dredging collaterals（ABDC） on treating systemic lupus erythematosus complicated with avascular necrosis of the femo...Objective：To observe the effect and mechanism of Chinese medicine therapy for activating blood and dredging collaterals（ABDC） on treating systemic lupus erythematosus complicated with avascular necrosis of the femoral head（SLE-ANFH）.Methods：Thirty-four patients（51 joints） with SLE-ANFH were assigned by a random number table to two groups：22 patients（32 joints） in the treatment group and 12 patients （19 joints） in the control group.All received Western medical conventional treatment for anti-inflammation and immunosuppression,but an additional Chinese medicine decoction prescribed based on ABDC principle was administered to patients in the treatment group.The observation on the patients＇ condition and therapeutic effect lasted for 3 years.Results：The patients＇ conditions in the two groups,as assessed by Association for Research Circulation Osseous（ARCO） staging,were similar before treatment.After treatment,comparison between groups showed significant difference（P0.05）,and the raised Harris functional scores in the treatment group were higher than that in the control group（P0.01）.The post-treatment symptom improving rate in the treated group was 72.73%,which was higher than that in the control group（50.00%,P0.05）.Moreover,the former was superior in improving hematologic and hemorrheologic parameters in terms of prolonging activated partial thromboplastin time,lowering whole blood middle/low shear viscosity,and plasma viscosity（P0.05 or P0.01）. Two patients in the control group but none in the treatment group received hip joint replacement operation during the observation period.Conclusions：Chinese medicine ABDC therapy could effectively alleviate clinical symptoms and improve joint function of patients with SLE-ANFH.The mechanism may be related to its effects on improving high coagulation manner and trend for getting embolism.展开更多
Background Osteonecrosis of the femoral head （ONFH） is the result of dysfunctional blood supply, but associations between specific damaged arteries, imaging changes and clinical sign require more understanding. We i...Background Osteonecrosis of the femoral head （ONFH） is the result of dysfunctional blood supply, but associations between specific damaged arteries, imaging changes and clinical sign require more understanding. We investigated characteristics of ONFH that pertain to blood supply, imaging appearance, and clinical feature to judge the prognosis of ONFH.展开更多
目的以股骨头坏死(osteonecrosis of the femoral head,ONFH)患者为参照,探究在多模式血液管理措施下,行单侧全髋关节置换术(total hip arthroplasty,THA)的血友病关节炎(hemophilia arthritis,HA)患者围术期失血及异体输血风险。方法...目的以股骨头坏死(osteonecrosis of the femoral head,ONFH)患者为参照,探究在多模式血液管理措施下,行单侧全髋关节置换术(total hip arthroplasty,THA)的血友病关节炎(hemophilia arthritis,HA)患者围术期失血及异体输血风险。方法回顾性收集2010年1月至2022年6月于北京协和医院接受单侧THA治疗的HA患者及按性别进行1∶3匹配的ONFH患者临床资料,比较两组围术期失血相关指标及并发症发生率差异。结果共入选符合纳入与排除标准的HA患者26例,ONFH患者76例。相较于ONFH患者,HA患者总失血量[(1927.08±956.59)mL比(1475.88±924.43)mL,P=0.036]、大出血率(38.46%比14.47%,P=0.009)、异体输血率(15.38%比3.95%,P=0.046)、并发症发生率(34.62%比7.89%,P=0.000)均更高,术后第3天血红蛋白[(112.94±12.26)g/L比(117.40±11.17)g/L,P=0.000]、红细胞压积[(29.44±7.96)%比(32.80±5.52)%,P=0.019]水平均更低。结论在多模式血液管理措施下,行单侧THA治疗的HA患者围术期失血及异体输血风险仍较高,需进一步优化血液管理策略。展开更多
基金State administration of traditional Chinese medicine national clinical research base of traditional Chinese medicine business construction research project(No.JDZX2015272).
文摘Objective: To explore the correlation between different types of osteonecrosis of the femoral head and blood lipids and coagulation indexes, in order to provide relevant references for the pathogenesis of osteonecrosis of the femoral head. Methods: 308 cases of ONFH were divided into alcohol group (165 cases), hormone group (113 cases), trauma group (30 cases), and basic data of patients were collected. Blood lipid indicators: total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B;coagulation indicators: activated partial thromboplastin time, plasma prothrombin time, fibrinogen, thrombin time indicators, using analysis of variance method for different types of osteonecrosis of the femoral head and blood lipids, coagulation indicators Search for relevance. Results: 1. Comparison of three groups of blood lipid indicators: total cholesterol and low density lipoprotein cholesterol in the alcohol group were higher than those in the trauma group (P<0.05);total cholesterol, triglycerides, and low density lipoprotein in the alcohol group The three indexes of cholesterol were higher than those of the hormone group (P<0.05). There was no significant difference in the serum lipid indexes of the hormone group and the trauma group (P>0.05). 2. Comparison of three groups of coagulation indicators: hormone The fibrinogen index of the group was higher than that of the trauma group (P<0.05). There was no significant difference in the coagulation index between the alcohol group and the trauma group (P>0.05). The coagulation index of the hormone group and the alcohol group was compared. The differences were not statistically significant (P>0.05). Conclusions: 1. Non-traumatic osteonecrosis of the femoral head (alcoholic, hormonal) patients are characterized by markedly elevated blood lipids (total cholesterol, low density lipoprotein cholesterol) and coagulation (fibrinogen) indicators;2. Intravascular coagulation and lipid metabolism disorders may be the pathological basis of non-traumatic Osteonecrosis of the femoral head.
文摘Osteonecrosis of the femoral head is a common disability disease of the hip joint in China,and osteonecrosis of the femoral head caused by hormone factors is the most common,which is related to the gradual increase in the utilization rate of glucocorticoids in recent years.It is a refractory disease in orthopaedics with a poor prognosis.For this disease,the treatment of traditional Chinese medicine has certain advantages.In view of this,the author reads,analyzes and summarizes its materials by searching China Journal full-text Database and Wanfang Database.This paper reviews the mechanism and clinical research progress of tonifying kidney and activating blood circulation in the prevention and treatment of steroid-induced osteonecrosis of the femoral head,hoping to provide help for the clinical treatment of hormone-related osteonecrosis of the femoral head.
文摘Objective：To observe the effect and mechanism of Chinese medicine therapy for activating blood and dredging collaterals（ABDC） on treating systemic lupus erythematosus complicated with avascular necrosis of the femoral head（SLE-ANFH）.Methods：Thirty-four patients（51 joints） with SLE-ANFH were assigned by a random number table to two groups：22 patients（32 joints） in the treatment group and 12 patients （19 joints） in the control group.All received Western medical conventional treatment for anti-inflammation and immunosuppression,but an additional Chinese medicine decoction prescribed based on ABDC principle was administered to patients in the treatment group.The observation on the patients＇ condition and therapeutic effect lasted for 3 years.Results：The patients＇ conditions in the two groups,as assessed by Association for Research Circulation Osseous（ARCO） staging,were similar before treatment.After treatment,comparison between groups showed significant difference（P0.05）,and the raised Harris functional scores in the treatment group were higher than that in the control group（P0.01）.The post-treatment symptom improving rate in the treated group was 72.73%,which was higher than that in the control group（50.00%,P0.05）.Moreover,the former was superior in improving hematologic and hemorrheologic parameters in terms of prolonging activated partial thromboplastin time,lowering whole blood middle/low shear viscosity,and plasma viscosity（P0.05 or P0.01）. Two patients in the control group but none in the treatment group received hip joint replacement operation during the observation period.Conclusions：Chinese medicine ABDC therapy could effectively alleviate clinical symptoms and improve joint function of patients with SLE-ANFH.The mechanism may be related to its effects on improving high coagulation manner and trend for getting embolism.
文摘Background Osteonecrosis of the femoral head （ONFH） is the result of dysfunctional blood supply, but associations between specific damaged arteries, imaging changes and clinical sign require more understanding. We investigated characteristics of ONFH that pertain to blood supply, imaging appearance, and clinical feature to judge the prognosis of ONFH.
文摘目的以股骨头坏死(osteonecrosis of the femoral head,ONFH)患者为参照,探究在多模式血液管理措施下,行单侧全髋关节置换术(total hip arthroplasty,THA)的血友病关节炎(hemophilia arthritis,HA)患者围术期失血及异体输血风险。方法回顾性收集2010年1月至2022年6月于北京协和医院接受单侧THA治疗的HA患者及按性别进行1∶3匹配的ONFH患者临床资料,比较两组围术期失血相关指标及并发症发生率差异。结果共入选符合纳入与排除标准的HA患者26例,ONFH患者76例。相较于ONFH患者,HA患者总失血量[(1927.08±956.59)mL比(1475.88±924.43)mL,P=0.036]、大出血率(38.46%比14.47%,P=0.009)、异体输血率(15.38%比3.95%,P=0.046)、并发症发生率(34.62%比7.89%,P=0.000)均更高,术后第3天血红蛋白[(112.94±12.26)g/L比(117.40±11.17)g/L,P=0.000]、红细胞压积[(29.44±7.96)%比(32.80±5.52)%,P=0.019]水平均更低。结论在多模式血液管理措施下,行单侧THA治疗的HA患者围术期失血及异体输血风险仍较高,需进一步优化血液管理策略。
