Predictive visual field outcomes after optic chiasm decompressive surgery by retinal vessels parameters using optical coherence tomography angiography

AIM:To evaluate the predictive value of superficial retinal capillary plexus(SRCP)and radial peripapillary capillary(RPC)for visual field recovery after optic cross decompression and compare them with peripapillary nerve fiber layer(pRNFL)and ganglion cell complex(GCC).METHODS:This prospective longitudinal observational study included patients with chiasmal compression due to sellar region mass scheduled for decompressive surgery.Generalized estimating equations were used to compare retinal vessel density and retinal layer thickness preand post-operatively and with healthy controls.Logistic regression models were used to assess the relationship between preoperative GCC,pRNFL,SRCP,and RPC parameters and visual field recovery after surgery.RESULTS:The study included 43 eyes of 24 patients and 48 eyes of 24 healthy controls.Preoperative RPC and SRCP vessel density and pRNFL and GCC thickness were lower than healthy controls and higher than postoperative values.The best predictive GCC and pRNFL models were based on the superior GCC[area under the curve(AUC)=0.866]and the tempo-inferior pRNFL(AUC=0.824),and the best predictive SRCP and RPC models were based on the nasal SRCP(AUC=0.718)and tempo-inferior RPC(AUC=0.825).There was no statistical difference in the predictive value of the superior GCC,tempo-inferior pRNFL,and tempo-inferior RPC(all P>0.05).CONCLUSION:Compression of the optic chiasm by tumors in the saddle area can reduce retinal thickness and blood perfusion.This reduction persists despite the recovery of the visual field after decompression surgery.GCC,pRNFL,and RPC can be used as sensitive predictors of visual field recovery after decompression surgery.

Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma

AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced glaucoma.METHODS:Totally 127 eyes from 89 participants(36 eyes of 19 healthy participants,45 eyes of 31 early glaucoma patients and 46 eyes of 39 advanced glaucoma patients)were included.The relationships between the optical coherence tomography(OCT)-derived parameters and VF sensitivity were determined.Patients with early glaucoma were divided into eyes with or without central 10°of the VF damages(CVFDs),and the diagnostic performances of OCT-derived parameters were assessed.RESULTS:In early glaucoma,the mGCIPLT was significantly correlated with 10-2 VF pattern standard deviation(PSD;with average mGCIPLT:β=-0.046,95%CI,-0.067 to-0.024,P<0.001).In advanced glaucoma,the mGCIPLT was related to the 24-2 VF mean deviation(MD;with average mGCIPLT:β=0.397,95%CI,0.199 to 0.595,P<0.001),10-2 VF MD(with average mGCIPLT:β=0.762,95%CI,0.485 to 1.038,P<0.001)and 24-2 VF PSD(with average mGCIPLT:β=0.244,95%CI,0.124 to 0.364,P<0.001).Except for the minimum and superotemporal mGCIPLT,the decrease of mGCIPLT in early glaucomatous eyes with CVFDs was more severe than that of early glaucomatous eyes without CVFDs.The area under the curve(AUC)of the average mGCIPLT(AUC=0.949,95%CI,0.868 to 0.982)was greater than that of the average circumpapillary retinal nerve fiber layer thickness(cpRNFLT;AUC=0.827,95%CI,0.674 to 0.918)and rim area(AUC=0.799,95%CI,0.610 to 0.907)in early glaucomatous eyes with CVFDs versus normal eyes.CONCLUSION:The 10-2 VF and mGCIPLT parameters are complementary to 24-2 VF,cpRNFLT and ONH parameters,especially in detecting early glaucoma with CVFDs and evaluating the severity of advanced glaucoma in group level.

Visualization of Explosive Field

Aim To visualize the explosive field and design a useful and practicable software tool to analyze explosive field. Methods An ideal model of the explosive field with a protective wall, which was simulated by another program MMIC(multi material in cell), was brought forward. The physical data output by MMIC were changed into image data represented by DIB bitmaps through the following steps: normalizing, coding, mapping and displaying. The object oriented method was applied in programming. Results and Conclusion With the tool, the explosive field with a protective wall is visualized. The overview of explosive field and some details about the transmission of shock wave in the field, such as reflection, flow over an obstacle and Mach reflection, are shown.

Visualization of 3-D Field of Explosion

In order to visualize the 3-D field of explosion and describe the complex physical phenomena of explosion, the 3-D data resulting from numerical simulation by 3-D multi-material in cell (MMIC), and the application of volume visualization is explored, based on the characteristics of explosion and shock. Based on this, a visualization system for 3-D explosion--ViSC3D is designed. Approaches for the visualization of 3-D field of explosion are presented. The algorithm and the functions of ViSC3D are also presented. ViSC3D is thus a useful tool to observe and analyze either the full picture or the details of a 3-D field of explosion, that are difficult to observe and analyze directly. With ViSC3D, the field of explosion between the hill slopes is visualized. The cutaway views and 2-D slices are also given. The full picture and partial details of 3-D field of explosion can be observed clearly. Furthermore, ViSC3D can be used to visualize other similar 3-D data fields.

Reversibility of visual field defects through induction of brain plasticity: vision restoration, recovery and rehabilitation using alternating current stimulation

For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low.Nevertheless,there is always some potential for partial recovery of the visual field defect that can be achieved through induction of neuroplasticity.Neuroplasticity refers to the ability of the brain to change its own functional architecture by modulating synaptic efficacy.It is maintained throughout life and just as neurological rehabilitation can improve motor coordination,visual field defects in glaucoma,diabetic retinopathy or optic neuropathy can be improved by inducing neuroplasticity.In ophthalmology many new treatment paradigms have been tested that can induce neuroplastic changes,including non-invasive alternating current stimulation.Treatment with alternating current stimulation(e.g.,30 minutes,daily for 10 days using transorbital electrodes and^10 Hz)activates the entire retina and parts of the brain.Electroencephalography and functional magnetic resonance imaging studies revealed local activation of the visual cortex,global reorganization of functional brain networks,and enhanced blood flow,which together activate neurons and their networks.The future of low vision is optimistic because vision loss is indeed,partially reversible.

Statistical Analysis on Field Efficacy Trial of Pesticide Using Visual Basic

[Objective] To introduce a convenient and easy way for the statistical anal- ysis on field efficacy trials of pesticide by using Visual Basic. [Method] The calcula- tion procedure of using Visual Basic to conduct statistical analysis on the field efficacy of pesticides was introduced, and an example was used to illustrate the usage and skill of the program. [Result] The procedure could quickly and accurately con- duct statistical analysis on the field efficacy of pesticide by only inputting initial data of the test, and it could compare the significance of differences between various fac- tors. Its calculated results were consistent with the results of the specialized statisti- cal software DPS. [Conclusion] It is a quick and simple method with high accuracy and reliability, which can greatly improve the efficiency of pesticide formulation opti- mization.

Factors influencing improvement of visual field after trans-sphenoidal resection of pituitary macroadenomas:a retrospective cohort study

AIM: To investigate the influencing factors of visual field improvement after trans-sphenoidal resection of pituitary macroadenomas. METHODS: This retrospective cohort study included 201 patients (366 eyes) with visual field defect induced by pituitary macroadenomas. All of them were treated with trans-sphenoidal surgery. Ophthalmologic evaluation, best -corrected visual acuity (BCVA), and visual field examination were performed before and 3mo after surgery. BCVA, visual field defect index mean deviation (MD), duration of symptoms, age, sex, and volume of tumors were compared. Expression of vascular endothelial growth factor (VEGF) and Ki-67 of tumor tissue were detected by immunohistochemical technique. RESULTS: The mean age of patients was 44.23 +/- 1.29y. Ninety -three patients were female and 108 were male. The mean tumor volume was 14.36 +/- 6.23 cm(3). The mean duration of preoperative symptoms was 11.50 +/- 0.88mo. Mean preoperative MD was -17.50 +/- 0.82 dB. Mean Preoperative visual acuity was 0.64 +/- 0.04. Postoperative visual field improved in 270 (73.77%) eyes, unchanged in 96 (26.23%) eyes. Multivariate logistic regression displayed that the factors independently influencing visual field improvement were young age (OR=1.71, 95%CI: 1.325-2.387, P=0.013), low preoperative MD absolute value (OR=1.277, 95%CI: 1.205-1.355, P<0.001), small volume of tumor (OR=1.458, 95%CI: 1.060-4.289, P<0.001), low expression of VEGF in tumor tissue (OR=1.554, 95%CI: 1.089-2.457, P=0.022), and low expression of Ki-67 in tumor tissue (OR=1.552, 95%CI: 1.161-2.847, P=0.026). CONCLUSION: After pituitary macroadenomas trans sphenoidal resection, the independent influencing factors of the visual fields recovery were low preoperative MD absolute value, young age, small volume of tumor, and expression levels of VEGF/Ki-67.

Visual field mean deviation and relevant factors in 928 Chinese retinitis pigmentosa patients

AIM: To investigate the associations between demographic and clinical factors with the rate of visual field mean derivation(MD) decline in retinitis pigmentosa(RP) patients.METHODS: Correlations of MDs with the visual acuity and retinal pigmentation were analyzed in 928 RP patients. MD decreasing rate in 10 y and potential influences of gender, age, family history and retinal pigmentation on the rate were explored in 201 RP patients. RESULTS: In the 928 patients, average MD and visual acuity were-14.44±8.61 dB and 0.79±0.35 respectively and when MD was lower than-9.18 dB the visual acuity would be below 1.0(20/20). The average MD medium between eyes with or without retinal pigmentation was-14.82 dB. In 123 non-pigmented eyes, the average MD were lower than the medium but in 153 pigmented eyes it was higher than that. In the 201 patients, the average decreasing value of MD in 10 years’ period was-8.01±3.66 dB and the value were correlated to retinal pigmentation but not to gender, age or RP family history. CONCLUSION: The rate of MD decline in RP eyes is significantly related to retinal pigmentation. Our study demonstrates the quantitative rate of MD decline in RP patients and the value of MD could well reflect the severity of RP.

Synchronization between frontal eye field and area V4 during free-gaze visual search

Information flow between the prefrontal and visual cortices is critical for visual behaviors such as visual search. To investigate its mechanisms, we simultaneously recorded spike and local field potential (LFP) signals in the frontal eye field (FEF) and area V4 while monkeys performed a free-gaze visual search task. During free-gaze search, spike-LFP coherence between FEF and V4 was enhanced in the theta rhythm (4–8 Hz) but suppressed in the alpha rhythm (8–13 Hz). Cross-frequency couplings during the Cue period before the search phase were related to monkey performance, with higher FEF theta-V4 gamma coupling and lower FEF alpha-V4 gamma coupling associated with faster search. Finally, feature-based attention during search enhanced spike-LFP coherence between FEF and V4 in the gamma and beta rhythms, whereas overt spatial attention reduced coherence at frequencies up to 30 Hz. These results suggest that oscillatory coupling may play an important role in mediating interactions between the prefrontal and visual cortices during visual search.

Dynamic visual simulation of marine vector field based on LIC——a case study of surface wave field in typhoon condition

Line integral convolution(LIC)is a useful visualization technique for a vector field.However,the output image produced by LIC has many problems in a marine vector field.We focus on the visual quality improvement when LIC is applied in the ocean steady and unsteady flow field in the following aspects.When a white noise is used as the input in a steady flow field,interpolation is used to turn the discrete white noise into continuous white noise to solve the problem of discontinuity.The"cross"high-pass filtering is used to enhance the textures of streamlines to be more concentrated and continuity strengthened for each streamline.When a sparse noise is used as the input in a steady flow field,we change the directions of background sparse noise according to the directions of vector field to make the streamlines clearer and brighter.In addition,we provide a random initial phase for every streamline to avoid the pulsation effect during animation.The velocities of vector field are encoded in the speed of the same length streamlines so that the running speed of streamlines can express flow rate.Meanwhile,to solve the problem of obvious boundaries when stitching image,we change the streamline tracking constraints.When a white noise is used as an input in an unsteady flow field,double value scattering is used to enhance the contrast of streamlines;moreover,the"cross"high-pass filtering is also adopt instead of two-dimensional high-pass filtering.Finally,we apply the above methods to a case of the surface wave field in typhoon condition.Our experimental results show that applying the methods can generate high-quality wave images and animations.Therefore,it is helpful to understand and study waves in typhoon condition to avoid the potential harm of the waves to people's lives and property.

Research on Visualization in Scientific Computation of Grinding Temperature Field

The paper introduces the concepts, classification and method of visualization in scientific computation. Visual C++ developing tool is used to compute surface grinding forces and grinding temperature field models. The three-dimensional entity model of workpiece is made with OpenGL tool, and the different colors on the workpiece entity show different value of temperature, so the visualization of grinding temperature field is realized. The temperature value of every points in grinding temperature field, the curves on surface temperature field and along depth direction are all given. The paper introduces method of visualization in scientific computation, and applies the visualization in scientific computation to the visualization of grinding temperature field. The displaying entity model of workpiece is made with OpenGL tool. The workpiece model is divided into griddings. The heat model is chosen and numerically computed, so the temperature values of every points can be attained. Three different view classes are used to display temperature data, temperature curves on the surface and along the depth direction, and the visualization distribution of three-dimensional temperature field. The visualization of grinding temperature is realized, and the display results of grinding temperature field can be dynamically changed by changing input parameters. Thus, a new path for researching grinding temperature field is developed.

Visualizing diffusion tensor fields on streamsurfaces with merging ellipsoids

Streamsurfaces in diffusion tensor fields are used to represent structures with pri- marily planar diffusion. So far, however, no effort has been made on the visualization of the anisotropy of diffusion on them, although this information is very important to identify the problematic regions of these structures. We propose two methods to display this anisotropy information. The first one employs a set of merging ellipsoids, which simultaneously character- ize the local tensor details - anisotropy - on them and portray the shape of the streamsurfaces. The weight between the streamsurfaces continuity and the discrete local tensors can be inter- actively adjusted by changing some given parameters. The second one generates a dense LIC （line integral convolution） texture of the two tangent eigenvector fields along the streamsurfaces firstly, and then blends in some color mapping indicating the anisotropy information. For high speed and high quality of texture images, we confine both the generation and the advection of the LIC texture in the image space. Merging ellipsoids method reveals the entire anisotropy information at discrete points by exploiting the geometric attribute of ellipsoids, and thus suits for local and detailed examination of the anisotropy; the texture-based method gives a global representation of the anisotropy on the whole streamsurfaces with texture and color attributes. To reveal the anisotropy information more efficiently, we integrate the two methods and use them at two different levels of details.

Characteristics of central visual field defect after macular hole surgery

AIM: To investigate the characteristics of postoperative central visual field defect(cVFD) in patients with macular hole(MH).METHODS: Eighteen eyes from 18 MH patients were involved in this retrospective study which reviewed square root of loss variance(sLV) and mean defect(MD) of the visual field test in all subjects. The relationship between cVFD and MH stage, as well as the postoperative ellipsoid zone disruption were evaluated using Spearman's correlation test. RESULTS: Our analysis determined Spearman coefficient is 0.705 for the correlation between sLV and MH stage(P<0.01), 0.877 for the correlation between sLV and postoperative ellipsoid zone disruption(P<0.01) and 0.721 for the correlation between MD and postoperative ellipsoid zone disruption(P<0.01). A significant relationship was also detected between postoperative ellipsoid zone disruption and MH stage(r=0.470, P<0.05). Univariate regression analysis indicated that sLV and MD were associated with postoperative ellipsoid zone disruption(P<0.01, P<0.01, respectively). CONCLUSION: Postoperative cVFD is highly correlated with MH stage and postoperative ellipsoid zone disruption in patients with MH.

Comparison of corneal biomechanical properties in normal tension glaucoma patients with different visual field progression speed

AIM：To compare the corneal biomechanical properties difference by ocular response analyzer（ORA） in normal tension glaucoma（NTG） patients with different visual field（VF） progression speed. METHODS：NTG patients with well-controlled Goldmann applanation tonometer（GAT） who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were enrolled.GAT and ORA parameters including corneal compensated intraocular pressure（lOPcc）,Goldmann estimated intraocular pressure（lOPg）,corneal hysteresis（CH）,corneal resistance factor（CRF） were recorded.VF was tested by Swedish interactive threshold algorithm（SITA）-standard 30-2 fields.All patients underwent VF measurement regularly and GAT did not exceed 15 mm Hg at any time during the 3y follow up.Patients were divided into four groups according to VF change over 3y,and ORA findings were compared between the upper 25th percentile group（slow progression group） and the lower 25th percentile group（rapid progression group）.RESULTS：Eighty-two eyes of 56 patients were studied.There were 21 eyes（21 patients） each in rapid and slow progression groups respectively.GAT,lOPcc,lOPg,CH,CRF were 12.1＋1.4 mm Hg,15.8±1.8 mm Hg,12.8±2.0 mm Hg,8.4±1.1 mm Hg,7.9±1.3 mm Hg respectively in rapid progression group and 11.5±1.3 mm Hg,13.5±2.1 mm Hg,11.2±1.6 mm Hg,9.3±1.1 mm Hg,8.2±0.9 mm Hg respectively in slow progression group（P=0.214,〈0.001,0.007,0.017,0.413,respectively）.In bivariate correlation analysis,lOPcc,lOPcc-GAT and CH were significant correlated with m△MD（r =-0.292,-0.312,0.228 respectively,P =0.008,0.004,0.039 respectively）.CONCLUSION：Relatively rapid VF progression occurred in NTG patients whose lOPcc are rather high,CH are rather low and the difference between lOPcc and GAT are relatively large.Higher lOPcc and lower CH are associated with VF progression in NTG patients.This study suggests that GAT measures might underestimate the IOP in such patients.

Bruch's membrane opening-minimum rim width and visual field loss in glaucoma:a broken stick analysis

AIM：To determine the Bruch＇s membrane opening-minimum rim width（BMO-MRW） tipping point where corresponding visual field（VF） damages become detectable.METHODS：A total of 85 normal subjects and 83 glaucoma patients（one eye per participant） were recruited for the study.All of the patients had VF examinations and spectral-domain optical coherence tomography to measure the BMO-MRW.Total deviation values for 52 VF points were allocated to the corresponding sector according to the Garway-Heath distribution map.To evaluate the relationship between VF loss and BMOMRW measurements,a ＂broken-stick＂ statistical model was used.The tipping point where the VF values started to sharply decrease as a function of BMO-MRW measurements was estimated and the slopes above and below this tipping point were compared.RESULTS：A 25.9% global BMO-MRW loss from normative value was required for the VF loss to be detectable.Sectorally,substantial BMO-MRW thinning in inferotemporal sector（33.1%） and relatively less BMO-MRW thinning in the superotemporal sector（8.9%） were necessary for the detection of the VF loss.Beyond the tipping point,the slopes were close to zero throughout all of the sectors and the VF loss was unrelated to the BMO-MRW loss.The VF loss was related to the BMO-MRW loss below the tipping point.The difference between the two slopes was statistically significant（P≤0.002）.CONCLUSION：Substantial BMO-MRW loss appears to be necessary for VF loss to be detectable in patients with open angle glaucoma with standard achromatic perimetry.

Integrated modeling and 3D visualization for mine complex fields

Proposed a novel approach to the problem of mine complex fields in a perspective of digital modeling and visual representation, and it aimed at developing a theoretical framework for mine complex fields with the factors and their relationships delineated in a unified manner and at building a prototype for an integrated system of methods, models, and techniques with mine complex fields modeled digitally and represented visually. Specifically, the paper addressed the issues of data mining and knowledge discovery techniques as used in the processing of geological and ore deposit samples, digital modeling techniques as used in the description of mine complex fields, 3D visual simulation techniques as used in the representation of ore bodies and underground excavations, seamless interfacing techniques with other systems such as CAD and web GIS as used in the restructuring of 2D data into 3D models and mapping of 3D models onto 2D graphics, and implementation techniques as used in the case of building a web based prototype system for the integrated modeling and visualization of underground mines.

Validation and reproducibility of the Heidelberg Edge Perimeter in the detection of glaucomatous visual field defects

AIM: To validate the ability of the Heidelberg Edge Perimeter(HEP) in detecting glaucomatous visual field(VF) defects compared to the Octopus Visual Field(OVF) Analyzer and to determine the test-retest repeatability of both modalities.METHODS: This prospective, cross-sectional study was conducted at Wills Eye Hospital, Philadelphia, PA. Glaucoma subjects and unaffected controls underwent VF testing using HEP standard automated perimetry(SAP) Ⅲ 30-2 Adaptive Staircase Thresholding Algorithm(ASTA) FAST protocol and OVF G-TOP white-on-white strategy. Testing order was randomized. Pearson's correlation coefficient was calculated for both mean deviation(MD) and pattern standard deviation/square root of loss of variance(PSD/s LV). Receiver operating characteristic(ROC) curves were used to determine the diagnostic abilities of both modalities. Glaucoma subjects returned for repeat testing and intraclass correlation coefficients(ICCs) were calculated to assess test-retest repeatability. RESULTS: Seventy-nine subjects with glaucoma and 36 unaffected controls were enrolled. HEP and OVF were significantly correlated for both MD(r=-0.84; P<0.01) and PSD/s LV(r=0.79; P<0.01). Areas under the ROC curves(AUCs) were also comparable between HEP and OVF for both MD(0.74 and 0.79, respectively; P=0.26) and PSD/sL V(0.74 and 0.82; P=0.08). ICC was high for both HEP (0.96 for MD, 0.95 for PSD/s LV) and OVF(0.82 and 0.88, respectively). Mean test duration(min) was significantly shorter for OVF(2.63) compared to HEP(5.15; P<0.01). CONCLUSION: HEP and OVF show strong correlation for both MD and PSD/s LV, and have similar validity for detecting glaucoma. The test-retest repeatability is high for both HEP and OVF, however the average testing duration of HEP is significantly longer than that of OVF.

Explosive Field Visualization Based on Image Fusion

The advantages and disadvantages of two existing methods for explosive field visualization are analyzed in this paper. And a new method based on image fusion is proposed to integrate their complementary advantages. With the method, two source images built by equal mapping and modulus mapping are individually decomposed into two Gauss-Laplacian pyramid sequences. Then, the two individual sequences are used to make a composite one according to the process of fusion. Finally, a new image is reconstructed from the composite sequence. Experimental results show that the new images integrate the advantages of sources, effectively improve the visualization, and disclose more information about explosive field.

EXTREMELY LOW FREQUENCY MAGNETIC FIELD SUSCEPTIBILITY OF VISUAL DISPLAY UNITS

Extremely low frequency (ELF) magnetic field susceptibility is an index of visual display unit (VDU) quality and performance. This paper provided field measured data on the susceptibility for a large variety of VDUs. A test rig was built to study the susceptibility of VDUs to magnetic fields at fundamental and third harmonic frequencies. It was found that the susceptibility level is largely dependent on refresh rate of the VDU and the orientation of the external ELF field. It was also found that the VDU susceptibility is significantly increased in the presence of harmonic frequency magnetic fields. About 30% of the tested samples have susceptibility levels higher than that stated in IEC 1000-4-8 standard.

The Effect of Monocular Blur on the Binocular Visual Field

Purpose/Aim: We aimed to investigate the effect of monocular blur on the binocular visual field. Materials and Methods: A total of 13 healthy young volunteers participated in this study. The mean subjective refractive error of the dominant eye (DE) was -3.33 ± 1.65D, and the non-dominant eye (NDE) was -3.15 ± 2.84D. The DE was determined by using the hole-in-the-card test. The visual field was examined by the Humphrey Visual Field Analyzer using the 30-2 SITA Standard program. The visual field was measured while wearing soft contact lens under three conditions;① both eyes: near vision correction;② DE: near vision correction +3.00D added, NDE: near vision correction;and ③ DE: near vision correction, NDE: near vision correction +3.00D added. The foveal threshold, mean deviation (MD), and pattern standard deviation (PSD) values were investigated. Results: The foveal threshold value (dB) at ①, ②, and ③ was 41.2, 37.8, and 38.1, respectively. The values at ② and ③ were both significantly lower than that at ① (p Conclusion: These results suggest that monocular blur reduced the sensitivity within the binocular visual field.