Serum Bone Gla Protein (BGP) was observed in sera from entreated and treated within 6 months and more than 6 months patients with hyperthyroidism and hypothyroidism. Serum BGP in untreated hyperthyroidism and hypothyr...Serum Bone Gla Protein (BGP) was observed in sera from entreated and treated within 6 months and more than 6 months patients with hyperthyroidism and hypothyroidism. Serum BGP in untreated hyperthyroidism and hypothyroidism were 21. 2±2. 8 and 3. 8±0.5μg/L respectively,which were significantly different from those of normal control (all, P<0. 001). Serum T3 and T4 of treated Patients with hyperthyroidism within 6 months had normalized, but serum BGP was still higher than the normal one. Serum BGP returned to normal in treated patients with hyperthyroidism more than 6 months. We consider serum BGP is a sensitive marker of hyperthyroid osteopathy and besides thyroxine, there are also some unknown factors that participate in serum BGP secretion,which is worthy to be further investigated.展开更多
Objective To investigate the influence of sodium fluoride(NaF)on alkaline phosphatase(ALP)activity and bone gla protein(BGP)synthesis in yellow ligament cells from different surgical simples in vitro.Methods The human...Objective To investigate the influence of sodium fluoride(NaF)on alkaline phosphatase(ALP)activity and bone gla protein(BGP)synthesis in yellow ligament cells from different surgical simples in vitro.Methods The human ligament cells展开更多
This study observed the changes of BMD, serum calcium, bone Gla protein and calcitonin of patients with hypoparathyroidism controlled by age and sex matched healthy persons. It was found that BMD was 10% greater in hy...This study observed the changes of BMD, serum calcium, bone Gla protein and calcitonin of patients with hypoparathyroidism controlled by age and sex matched healthy persons. It was found that BMD was 10% greater in hypoparathyroidism patients than in controls, but the difference was not statistically significant. Serum BGP was significantly lower in hypoparathyroidism patients than in controls (P<0. 02). We postulate that PTH deficiency and long term treatment with calcium and vitamin D for hypoparathyroidism appear to be main mediator of this increased bone mass,and that hone mass is not affected by endogenous calcitonin.展开更多
文摘Serum Bone Gla Protein (BGP) was observed in sera from entreated and treated within 6 months and more than 6 months patients with hyperthyroidism and hypothyroidism. Serum BGP in untreated hyperthyroidism and hypothyroidism were 21. 2±2. 8 and 3. 8±0.5μg/L respectively,which were significantly different from those of normal control (all, P<0. 001). Serum T3 and T4 of treated Patients with hyperthyroidism within 6 months had normalized, but serum BGP was still higher than the normal one. Serum BGP returned to normal in treated patients with hyperthyroidism more than 6 months. We consider serum BGP is a sensitive marker of hyperthyroid osteopathy and besides thyroxine, there are also some unknown factors that participate in serum BGP secretion,which is worthy to be further investigated.
文摘Objective To investigate the influence of sodium fluoride(NaF)on alkaline phosphatase(ALP)activity and bone gla protein(BGP)synthesis in yellow ligament cells from different surgical simples in vitro.Methods The human ligament cells
文摘This study observed the changes of BMD, serum calcium, bone Gla protein and calcitonin of patients with hypoparathyroidism controlled by age and sex matched healthy persons. It was found that BMD was 10% greater in hypoparathyroidism patients than in controls, but the difference was not statistically significant. Serum BGP was significantly lower in hypoparathyroidism patients than in controls (P<0. 02). We postulate that PTH deficiency and long term treatment with calcium and vitamin D for hypoparathyroidism appear to be main mediator of this increased bone mass,and that hone mass is not affected by endogenous calcitonin.
