A new series of bone affinity compounds were synthesized by linking chrysophanol with 5-fluorouracil derivatives. Their bone affinity was established by hydroxyapative （HA） affinity experiment in vitro, and their cy...A new series of bone affinity compounds were synthesized by linking chrysophanol with 5-fluorouracil derivatives. Their bone affinity was established by hydroxyapative （HA） affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.展开更多
A new series of bone affinity compounds were synthesized by linking emodin with 5-fluorouracil derivatives. Their bone affinities were established by hydroxyapative (HA) affinity experiment in vitro, and their cytosta...A new series of bone affinity compounds were synthesized by linking emodin with 5-fluorouracil derivatives. Their bone affinities were established by hydroxyapative (HA) affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.展开更多
Tetracycline analogs were designed and synthesized and their bone affinities were tested on hydroxyapatite. The results showed that the carbonyl-amide-enol structure in A ring and phenol-ketone structure in BCD ring m...Tetracycline analogs were designed and synthesized and their bone affinities were tested on hydroxyapatite. The results showed that the carbonyl-amide-enol structure in A ring and phenol-ketone structure in BCD ring may be responsible for tetracycline＇s high bone affinity and either A ring or BCD ring has a planar conformation is essential. 2007 Ling Ling Weng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
基金the National Natural Science Foundation of China （No.30371682）.
文摘A new series of bone affinity compounds were synthesized by linking chrysophanol with 5-fluorouracil derivatives. Their bone affinity was established by hydroxyapative （HA） affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.
文摘A new series of bone affinity compounds were synthesized by linking emodin with 5-fluorouracil derivatives. Their bone affinities were established by hydroxyapative (HA) affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.
基金This work was supported by the National Natural Science Foundation of China （No. 30070883）.
文摘Tetracycline analogs were designed and synthesized and their bone affinities were tested on hydroxyapatite. The results showed that the carbonyl-amide-enol structure in A ring and phenol-ketone structure in BCD ring may be responsible for tetracycline＇s high bone affinity and either A ring or BCD ring has a planar conformation is essential. 2007 Ling Ling Weng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
