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Contribution of Bone Scintigraphy in the Metastatic Extension Assessment of Prostate Cancer: A Study of 288 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital, Dakar
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作者 El Hadji Amadou Lamine Bathily Ousseynou Diop +7 位作者 Mamoudou Salif Djigo Gora Thiaw Kalidou Gueye Mohamed Chekhma Olatounde Herbert Fachinan Boucar Ndong Omar Ndoye Mamadou Mbodj 《Open Journal of Biophysics》 2024年第2期79-98,共20页
Introduction: Prostate cancer is the most frequently diagnosed male malignancy and the fifth leading cause of cancer death in men worldwide. Since the advent of screening methods such as Prostate Specific Antigen (PSA... Introduction: Prostate cancer is the most frequently diagnosed male malignancy and the fifth leading cause of cancer death in men worldwide. Since the advent of screening methods such as Prostate Specific Antigen (PSA) assay, digital rectal examination (DRE) and prostate biopsy, its incidence has increased significantly. The aim of our study was to analyse aspects of bone scintigraphy (BS) as part of the metastatic extension assessment of prostate cancer in Senegal. Patients and Methods: This was a retrospective descriptive and analytical study, running from January 1<sup>er</sup> 2022 to August 31 2023. Patients with histologically confirmed prostate cancer were included. Whole-body scans (WBS) were performed using a dual-head SPECT gamma camera (Mediso Nucline TM Spirit DH-V type), 3 hours after intravenous injection of 8 MBq/kg (555 to 740 MBq) of <sup>99m</sup>Tc-HMDP. Results: A total of 288 patients with a mean age of 68.37 ± 7.79 years were included. The median total PSA level was 97.6 ng/ml, with 144 patients having a level greater than or equal to 20 ng/ml. All patients had adenocarcinoma, and the Gleason score was available in 202 (70.13%) patients, 75.75% of whom had a score greater than or equal to 7. BS was contributory in 70.48% of cases, with 30.90% positive and 39.58% negative. The result was inconclusive in 85 patients (29.51%). The mean PSA for patients with a positive scan was 190.2 ng/ml and 40.6 ng/ml for those with a negative scan. Multiple metastatic lesions predominated (87.35% of cases). Metastatic lesions occurred preferentially in the axial skeleton, with a proportion of 68% versus 32% in the appendicular skeleton. Classification of bone metastases according to the SOLOWAY score revealed grade I (62.07%), grade II (35.63%) and grade IV (2.30%). Conclusion: In Senegal, prostate cancer is generally diagnosed in men of advanced age. The presence of bone metastases is frequent in its evolution, transforming a curable localized disease into a generalized disease with a compromised prognosis. Bone scintigraphy remains an essential part of the initial work-up and evaluation of response to treatment. 展开更多
关键词 Prostate Cancer bone Metastasis bone scintigraphy Senegal
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Contribution of Bone Scintigraphy in the Diagnosis of a Case of SAPHO in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar, Senegal)
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作者 El Hadji Amadou Lamine Bathily Kalidou Gueye +13 位作者 Serigne Moussa Badiane Mamoudou Salif Djigo Gora Thiaw Ousseynou Diop Olatounde Herbert Fachinan Papa Mady Sy Alfonse Rodrigue Djiboune Kokou Fofo Toussaint Adambounou Louis Augustin Diaga Diouf Boucar Ndong Gora Mbaye Omar Ndoye Mounibé Diarra Mamadou Mbodj 《Open Journal of Medical Imaging》 2024年第1期1-9,共9页
Introduction: The acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a syndrome combining osteoarticular and cutaneous manifestations. It occurs mainly between the ages of 30 and 50. Sternocosto... Introduction: The acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a syndrome combining osteoarticular and cutaneous manifestations. It occurs mainly between the ages of 30 and 50. Sternocostoclavicular hyperostosis is one of the main distinguishing features. We report a case of SAPHO in Dakar diagnosed by bone scintigraphy. Observation: 28-year-old Senegalese women presented with left shoulder pain and relative functional impotence for over 2 years. Examination revealed right sternoclavicular hyperostosis and left shoulder pain on palpation. Questioning revealed a history of acne and hyperostosis of the right first toe. Bone scintigraphy, performed after injection of 630 MBq of <sup>99m</sup>Tc-HMDP, revealed: hyperfixation of the bilateral (right++) manubrio-sternal and sternoclavicular junction, producing the classic bull’s horn image;hyperfixation of the left shoulder with an inflammatory appearance;hyperfixation of the sacroiliac joints suggestive of bilateral sacroiliitis;hyperfixation of the right first toe;two mandibular hyper fixations probably related to dental damage. This scintigraphic appearance in one was strongly suggestive of SAPHO syndrome. Conclusion: SAPHO syndrome, related to spondyloarthropathy, associates cutaneous and osteoarticular signs. It is characterized by frequent delays in diagnosis due to poor recognition. Soy is an invaluable diagnostic tool, enabling us to assess the extent of the disease and its evolution. 展开更多
关键词 SAPHO bone scintigraphy Young Woman Senegalese
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Place of Bone Scintigraphy in the Assessment of Extension and Follow-Up of Breast Cancer in Senegal: Study of 165 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar)
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作者 El Hadji Amadou Lamine Bathily Mamoudou Salif Djigo +7 位作者 Djimby Ba Gora Thiaw Ousseynou Diop Kalidou Gueye Olatounde Herbert Fachinan Boucar Ndong Omar Ndoye Mamadou Mbodj 《Open Journal of Medical Imaging》 2024年第1期10-30,共21页
Introduction: Breast cancer is the most common cancer in women worldwide, accounting for an estimated 22% of all female cancers. It is the leading cause of cancer mortality in women, almost all of which is due to meta... Introduction: Breast cancer is the most common cancer in women worldwide, accounting for an estimated 22% of all female cancers. It is the leading cause of cancer mortality in women, almost all of which is due to metastases, with 73% of metastases occurring in the bone. In oncology, metastable technetium 99-labelled methylene bisphosphonate bone scintigraphy (BS) remains the standard examination for detecting and assessing the extent of bone metastases. The aim of this study was to assess the role of BS in the evaluation and follow-up of breast cancer in Senegal. Methodology: This was a retrospective study of breast cancer patients who underwent bone scintigraphy with <sup>99m</sup>Tc-HMDP in the nuclear medicine department of Idrissa Pouye General Hospital (IPGHO), from July 2009 to June 2022. Results: We enrolled 165 patients, mean age 46.79 years (27 - 87 years). BS was performed in 94.37% of cases for post-therapeutic monitoring and in 5.63% for pre-therapeutic assessment. Results were contributory in 131 patients (92.25%), of whom 72 cases (50.70%) were normal and 59 cases (41.55%) positive or presenting bone metastases;and non-contributory or doubtful in 11 cases (7.75%). Secondary bone locations were multiple in 57 cases (96.61%) and single or solitary in 2 cases (3.39%). The scintigraphic appearance of bone metastases was hyper-fixative in 58 cases (98.31%) and mixed in 1 case (1.69%). Bone lesions were quantified using the Soloway’s grading classification. Conclusion: BS with <sup>99m</sup>Tc-labelled bisphosphonates remains the examination of choice for skeletal exploration, in the detection and extension of bone metastases in breast cancer. Performance has been enhanced by the development of SPECT coupled with CT (SPECT-CT). 展开更多
关键词 Breast Cancer bone scintigraphy 99mTc-HMDP bone Metastases
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The value of bone scintigraphy on the determination of the full extent of tumor involvement in jaw bones 被引量:2
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作者 Jiawei Xie Chao Ma +3 位作者 Guoming Wang Shuyao Zuo Ningyi Li Muyun Jia 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第1期42-45,共4页
Objective: To prospectively investigate the value of bone scintigraphy on determining the full extent of tumor involvement in jaw bones and to assess the presence of metastases. Methods: This study had local ethical... Objective: To prospectively investigate the value of bone scintigraphy on determining the full extent of tumor involvement in jaw bones and to assess the presence of metastases. Methods: This study had local ethical committee approval, and all patients gave written informed consent. Thirty seven consecutive patients with primary malignant tumor in jaw bones were recruited for the study. Bone scintigraphy was performed in all patients before surgery to measure the full extent of bony involvement, which was compared with histologic findings. Results: Whole body scan revealed one case with multiple bony metastases. Resection specimens of 36 bone neoplasms were pathologically analyzed to identify type and size of each tumor. The lengths of the tumor involvement in jaw bones defined by bone scintigraphy and pathology were 5.62 ± 1.58 cm, 4.48 ± 1.57 cm, respectively (P 〈 0.05). The tumor negative margins from removed specimens according to bone scintigraphy were pathologically confirmed. With histologic findings as the standard of reference, the accuracy of bone scintigraphy was 100% (36 of 36 patients) in determining the full extent of tumor involvement in jaw bones. Conclusion: Bone scintigraphy tends to offer specific guidelines in determining the appropriate extent of bone resection while entirely clearing the tumor cells and preserving functions whenever possible and in establishing the bony metastases. 展开更多
关键词 bone scintigraphy jaw bone NEOPLASM
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Contribution of Bone Scintigraphy in the Diagnosis of a Calcaneus Fatigue Fracture in a Case at the Nuclear Medicine Department of Idrissa Pouye General Hospital (HOGIP) in Dakar 被引量:1
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作者 El-Hadji Amadou Lamine Bathily B. Ndong +12 位作者 O. Diop M. S. Djigo K. Gueye A. Kokou G. Thiaw G. Mbaye L. A. D. Diouf M. Soumboundou A. R. Djiboune P. M. Sy O. Ndoye M. Diarra M. Mbodj 《Open Journal of Medical Imaging》 2020年第1期62-71,共10页
Introduction: Fatigue fractures are secondary to excessive, unusual, repeated mechanical stress, occurring on healthy bone. Bone scintigraphy (BS) with 99mTc-HMDP is an excellent means of diagnosis. We report a case o... Introduction: Fatigue fractures are secondary to excessive, unusual, repeated mechanical stress, occurring on healthy bone. Bone scintigraphy (BS) with 99mTc-HMDP is an excellent means of diagnosis. We report a case of stress fracture of the calcaneus with scintigraphic diagnosis, in a marathon runner. Patient and Methods: He is a 40-year-old athlete in overtraining with right calcaneal pain on running, intense at first, moderate in the middle and then persistent after exercise. The interrogation found no trauma to the right foot and the x-ray of the foot was without abnormality. The so 3 phases were performed following an injection of 564 MBq of 99mTc-HMDP, with a SPECT gamma camera. Results: Bone scintigraphy found in the early phase, hyper-perfusion and hyper-fixation of the right calcaneal region compared to its left counterpart and in the bone phase persistence of focal hyperfixation opposite the right calcaneus. This scintigraphic aspect of the right calcaneus in an overtrained marathon runner, in a painful context and in front of a normal X-ray, made us evoke a fracture of fatigue. A complementary CT scan performed two days after the BS was without abnormality. Conclusion: Fatigue fractures are micro-fractures generally not noticed on radiography and CT. BS due to its high sensitivity is an excellent or the best tool for the early diagnosis of stress fractures. 展开更多
关键词 Fatigue Fracture bone scintigraphy SPORTS
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The diagnostic correlations of bone scintigraphy,pathological grade and PSA for metastatic prostate cancers
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作者 Guifeng Yang Shuyao Zuo Chao Ma Bin Liu Guoming Wang Xufu Wang Hongyu Wu 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第12期702-704,共3页
Objective: The aim of the study was to investigate the correlations between pathological grade, serum prostatespecific antigen (PSA) and bone scintigraphy in the diagnosis of metastasis diseases for prostate cancer... Objective: The aim of the study was to investigate the correlations between pathological grade, serum prostatespecific antigen (PSA) and bone scintigraphy in the diagnosis of metastasis diseases for prostate cancers, and to explore the characteristics of bone metastases for prostate cancer. Methods: Seventy-seven newly diagnosed prostate cancers were reviewed in the study. All the cases underwent bone scintigraphy, total serum PSA measurement by luminescent immunoassay before operation and were classified according to post-operative pathology diagnosis. We analyzed the correlations of the bone metastasis incidences and different pathological grades or different PSA levels. Results: Bone scans were indicative of metastases in 33 cases (42.86%). Significantly higher incidence of bone metastasis was observed in patients with poorly differentiated prostate cancer compared with patients with well (X2 = 10.880, P = 0.001 〈 0.05) and moderately (X2 = 6.166, P = 0.013 〈 0.05) differentiated prostate cancers. No significant difference between the well differentiated and moderately differentiated prostate cancers was found (X2 = 0.612, P = 0.434 〉 0.05). The serum PSA concentration had'significant correlation with the incidence of bone metastasis. In 26 patients with PSA 〈 20 ng/mL, 5 cases (19.23%) had bone metastasis while 28 of 51 cases (54.90%) with PSA〉 20 ng/mL had bone metastasis. The serum PSA concentration had positive correlation with pathological grades of prostate cancer (r = 0.535, P = 0.01). Conclusion: Bone scintigraphy plays a great role in the diagnosis of bone metastasis for prostate cancer patients currently. The poorly differentiated prostate cancer and PSA 〉 20 ng/mL most likely suggested the possibility of bone metastasis. 展开更多
关键词 prostate cancers bone scintigraphy pathological grade bone metastasis prostate-specific antigen (PSA)
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Correlation Study between Skeletal Scintigraphy and CT Scan in Diagnosing Bone Metastases
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作者 Saeed Bafaraj Ali Algamdi Abdulaziz Almorjan 《Open Journal of Medical Imaging》 2014年第4期178-186,共9页
A retrospective study for 98 patient suspected to bone scan at department of radiology take place, to find out which imaging modality is more sensitive between computed tomography (CT) and bone scan;age group of patie... A retrospective study for 98 patient suspected to bone scan at department of radiology take place, to find out which imaging modality is more sensitive between computed tomography (CT) and bone scan;age group of patient was from 1 year to 90 year, the highest Site of Metastases for both Bone scan & CT was at vertebra with 31%, and the positive finding was also 31% for bone scan, while for CT the highest Site of Metastases was at forearm with 34%, and the sensitivity for CT was 44%, and 56% for bone scan. The study recommends that patients with bone metastases are kindly recommended to bone scan investigation rather than CT scan. 展开更多
关键词 SKELETAL scintigraphy CT SCAN bone METASTASES
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Correlation of PSA Level and ISUP Grade Group with Scintigraphic Bone Metastases Detection in 36 Prostate Cancer Patients
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作者 Jean Sossa Lionelle Fanou +3 位作者 Yao Félicien Hounto Dodji Magloire Inès Yevi Fred Jean-Martin Hodonou Déjinnin Josué Georges Avakoudjo 《Open Journal of Urology》 2023年第8期309-316,共8页
Background: We need population-specific clinical features that can predict bone metastases as an affordable therapeutic decision-making tool in newly diagnosed prostate cancer patients as scintigraphy or positron emis... Background: We need population-specific clinical features that can predict bone metastases as an affordable therapeutic decision-making tool in newly diagnosed prostate cancer patients as scintigraphy or positron emission tomography are not available and as no such study had ever been performed in our country. Objective: To determine biologic and pathologic criteria that can predict the scintigraphic detection of bone metastases in our prostate cancer patients. Patients and Method: We analyzed with student’s t test and logistic regression the PSA level, the ISUP grade and the scintigraphic data retrospectively collected in newly diagnosed prostate cancer patients. Results: In ten years, 36 prostate cancer patients were sent to the Korle Bu Teaching Hospital in Accra (Ghana) for bone scintigraphy (mean age = 63.9 years;55.6%, 19.4% and 25.0% ISUP grade ≤ 2, 3 or ≥4). Among 28 patients who had performed the bone scintigraphy, 6 (21.4%) presented bone metastases, 22 (78.6%) had no bone metastasis. The mean PSA level was 36.7ng/mL in the non-metastatic patients and 97.7 ng/mL in the metastatic patients. The difference in PSA level between the 2 groups was significative (p = 0.041). 63.6% of the non-metastatic cancers versus 16.7% of the metastatic cancers were ISUP grade 2 or less. Inversely, 36.4% of the non-metastatic cancers versus 83.3% of the metastatic cancers were ISUP grade 3 or more. The difference was significative in the ISUP grade 2 or less (p = 0.035), was significative in the ISUP grade group 3 or more (p = 0.035). Metastasis was more likely in prostate cancer patients with PSA equal 30 ng/mL or more and ISUP grade 3 or more (83.3%) than in prostate cancer patients with PSA less than 30 ng/mL and ISUP grade less than 3 (16.7%) [OR = 13.7;CI 95% (1.59;31.0);p = 0.035]. Conclusion: The scintigraphic detection of bone metastases is low in patients with PSA < 30 ng/mL and ISUP grade < 3. This can be helpful in curative therapy decision making for prostate cancer when nuclear medicine or other metastases detection tools are lacking. 展开更多
关键词 METASTASIS Prostate Cancer bone scintigraphy
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Occult Fractures in the Carpal Region:Incidental Findings on Bone Scintigraphy
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作者 Sahel Zoakman Roderick van Leerdam +1 位作者 Frank Beeres Steven Rhemrev 《Open Journal of Orthopedics》 2013年第1期29-34,共6页
The aim of this study was to evaluate the number and distribution of fractures around the wrist found on bone scintigraphy in patients with a clinically suspected scaphoid fracture and negative initial radiographs. We... The aim of this study was to evaluate the number and distribution of fractures around the wrist found on bone scintigraphy in patients with a clinically suspected scaphoid fracture and negative initial radiographs. We retrospectively included 445 consecutive patients with a suspected scaphoid fracture who underwent routine bone scintigraphy. None of the radiographs showed evidence of a fracture. We analyzed the type and number of other fractures incidentally found on bone scintigraphy. On average, bone scintigraphy was done in 4 days (1 - 9). The outcome of bone scintigraphy: 80 (18.0%) a scaphoid fracture, 145 (32.6%) another fracture in the carpal region, 208 (46.7%) normal and the diagnosis of 12 (2.8%) was unclear. In the present study, we demonstrated that in patients with a clinically suspected scaphoid fracture and negative initial radiographs, bone scintigraphy detected in many cases (64.4%) other fractures in the carpal region. This suggests that radiographs not only miss scaphoid but also many other carpal and distal radius fractures. Solutions should be found to solve this problem and probably advanced imaging techniques like CT, MRI or bone scintigraphy should be used in the correct clinical scenario. 展开更多
关键词 Wrist Injury Carpal Fractures bone scintigraphy Scaphoid Fracture Scaphoid Radiographs
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FEASIBILITY OF WHOLE BODY DIFFUSION WEIGHTED IMAGING IN DETECTING BONE METASTASIS ON 3.0T MR SCANNER 被引量:12
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作者 Xian Xu Lin Ma +5 位作者 Jin-shan Zhang You-quan Cai Bai-xuan Xu Liu-quan Chen Fei Sun Xing-gao Guo 《Chinese Medical Sciences Journal》 CAS CSCD 2008年第3期151-157,共7页
Objective To evaluate the feasibility of whole body diffusion weighted imaging (DWI) in bone metastasis detection using bone scintigraphy as comparison. Methods Forty-five patients with malignancy history were enrolle... Objective To evaluate the feasibility of whole body diffusion weighted imaging (DWI) in bone metastasis detection using bone scintigraphy as comparison. Methods Forty-five patients with malignancy history were enrolled in our study. All the patients received the whole body DWI and bone scintigraphy scan within 1 week. The magnetic resonance (MR) examination was performed on 3.0T MR scanner using embedded body coil. The images were reviewed separately by two radiologists and two nuclear medicine physicians, who were blinded to the results of the other imaging modality. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the two techniques for detecting bone metastasis were analyzed. Results A total of 181 metastatic lesions in 77 regions of 34 patients were detected by whole body DWI, and 167 metastatic lesions in 76 regions of 31 patients were identified by bone scintigraphy. The patient-based sensitivity and PPV of whole body DWI and bone scintigraphy were similar (89.5% vs. 81.6%, 97.1% vs. 91.2%), whereas, the patient-based specificity and NPV of whole body DWI were obviously higher than those of bone scintigraphy (85.7% vs. 57.1%, 60.0% vs. 36.4%). Ten regions negative in scintigraphy but positive in whole body DWI, mainly located in spine, pelvis, and femur; nine regions only detected by scintigraphy, mainly located in skull, sternum, clavicle, and scapula. The region-based sensitivity and specificity of whole body DWI were slightly higher than those of bone scintigraphy (89.5% vs. 88.4%, 95.6% vs. 87.6%). Conclusion Whole body DWI reveals excellent concordance with bone scintigraphy regarding detection of bone metastasis, and the two techniques are complementary for each other. 展开更多
关键词 neoplasm metastasis diffusion weighted imaging bone tissue scintigraphy
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MULTIVARIATE ANALYSIS OF BONE METASTASES IN BREAST CARCINOMA
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作者 石根明 王跃珍 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2006年第1期62-66,共5页
Objective: To investigate the risk factors of bone metastases in breast carcinoma. Methods: By cross sectional study, the data of 225 breast cancer patients who were inpatients in four hospitals in Hangzhou were ana... Objective: To investigate the risk factors of bone metastases in breast carcinoma. Methods: By cross sectional study, the data of 225 breast cancer patients who were inpatients in four hospitals in Hangzhou were analyzed. All patients underwent total body bone scan with single photon emission computed tomography (SPECT) at least once during 1995 to 2000. Results: All patients were followed-up to 294 months after operation, bone metastases were found in 113 cases, suspected bone metastases 3 cases, with a bone metastases rate of 50.9% (113/222). Multivariate analysis by Cox's proportional hazards regression model showed that there were four risk factors of bone metastases in breast cancer: (1) clinical stage, Ⅰ~Ⅳ stages with a hazard ratio of bone metastases of 1.945, 95% confidence interval 1.396~2.710; (2) number of invaded axillary lymph nodes, with a hazard ratio of 1.039, 95% confidence interval 1.0142~1.068; (3) skeletal complications (yes vs. no), with a hazard ratio of bone metastases of 1.722, 95% confidence interval 1.060~2.796; (4) age at the time of surgery or diagnosis, with a hazard ratio of 2.048, 95% confidence interval 1.123~3.876 for patients of age 40~50 y versus patients bellow 40 y of age and 2.837, 95% confidence interval 1.473~5.465 for patients of age above 50 y versus patients of ages between 40 and 50. Kaplan-Meier curves showed that for patients with more than 5 invasive axillary lymph nodes, compared with those with 1~5, the bone metastasis rates increased significantly (x^2 =6.3319, P=0.012). Conclusion: The clinical stage, number of metastatic axillary lymph nodes, age at the time of operation and skeletal complications are essential risk factors of bone metastases. 展开更多
关键词 Breast neoplasms bone scintigraphy Risk factors COX model
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Bone Scan Index Is a Prognostic Factor for Breast Cancer Patients with Bone Metastasis Being Treated with Zoledronic Acid
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作者 Yukinori Okada Tatsuyuki Abe +5 位作者 Yasuo Nakajima Itsuko Okuda Brandon D. Lohman Yoshihide Kanemaki Yasuyuki Kojima Kouichirou Tsugawa 《Open Journal of Radiology》 2015年第3期149-158,共10页
Bone scan index (BSI) has been used to quantify the spread of bone metastasis and be a prognostic indicator in prostate cancer with bone metastases. However, the utility of BSI in breast cancer patients with bone meta... Bone scan index (BSI) has been used to quantify the spread of bone metastasis and be a prognostic indicator in prostate cancer with bone metastases. However, the utility of BSI in breast cancer patients with bone metastasis has not been yet established. We retrospectively reviewed 57 female breast cancer patients with osteoblastic/lytic combined type bone metastases and treated with zoledronic acid after bone metastasis was identified. Serial bone scintigrams were taken at the time of bone metastasis detection and during the 6- and 12-month follow-ups. The scintigrams were analyzed by BONE NAVITM version 1 and the BSI value was calculated. Additionally, serum cancer antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA) were measured. The patients were divided in 2 distinct groups—group A representing all follow-up BSI values ≤ initial BSI values and group B representing all follow-up BSI values ≥ initial BSI values. The interval changes of CA15-3 and CEA were divided in the same fashion. Kaplan-Meier method and log-rank test revealed that the overall survival rate was significantly greater in group A than those of group B after 6 months (p = 0.011) and 12 months (p = 0.016). Univariate analysis revealed that the overall survival rate was significantly greater in group A than those of group B, after a 6 month period (Hazard Ratio [HR] 5.841;95% confidence interval [CI] 1.248 - 27.34;p = 0.025) and 12 month period (HR: 4.22;95% CI 1.17615.15;p = 0.027). Multivariate analysis demonstrated that BSI changes after 6 and 12 months trended toward significance regarding parameters affecting survival rate (age and CA15-3) with a HR = 12.760 (95%CI 1.8110 - 89.850) at 6 months with a p = 0.010 and a HR = 5.0640 (95%CI 1.0590 - 24.220) at 12 months with a p = 0.042. BSI changes after 6 and 12 months appear to be a prognostic factor in breast cancer patients with bone metastasis treated with zoledronic acid. 展开更多
关键词 bone scintigraphy bone SCAN INDEX Zoledronic Acid Overall SURVIVAL Rate
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Contribution of Scintigraphy in the Assessment of Extension of Osteophilic Cancers in Senegal from 2018 to 2021
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作者 Olatoundé Herbert Fachinan El Hadji Lamine Bathily +5 位作者 Mamadou Salif Djigo Gilles David Houndétoungan Djibrillou Moussa Issoufou Boucar Ndong Kuassi Marcellin Amoussou-Guénou Mamadou Mbodj 《Open Journal of Biophysics》 CAS 2023年第1期1-13,共13页
The aim of this study was to highlight the contribution of bone scintigraphy in the assessment of extension of osteophilic cancers in Senegal. This was a retrospective study, with a descriptive and analytical purpose,... The aim of this study was to highlight the contribution of bone scintigraphy in the assessment of extension of osteophilic cancers in Senegal. This was a retrospective study, with a descriptive and analytical purpose, carried out over a period of four (04) years between January 01, 2018 and December 31, 2021. It focused on the files of patients who underwent bone scintigraphy for extension assessment of an osteophilic cancer during the study period. According to the study, prostate cancer was by far the most representative primary cancer (86.9%). Scintigraphy contributed in 75% of cases (362 cases) with 35% positive scintigraphy and 40% negative scintigraphy. The result was doubtful in 25% of cases (120 cases). The metastatic lesions were located preferentially at the level of the axial skeleton and only one case was of an exclusive appendicular site. More than half of patients with metastases (70%) had a poor prognosis with the SOLOWAY score greater than or equal to II. With the improvement of the nuclear imaging technical platform in Senegal (performance of SPECT/CT examinations), doubtful cases in our sample could be better explored with the advantage of adequate patient care. 展开更多
关键词 bone scintigraphy Osteophilic Cancers bone Metastases
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Contribution of <sup>99m</sup>Tc-DPD Scintigraphy in the Diagnosis of Cardiac Amyloidosis in Black Africans
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作者 Djigo Mamoudou Salif Ndong Boucar +5 位作者 Bathily El Hadji Amadou Lamine Diop Ousseynou Gueye Kalidou Thiaw Gora Ndoye Oumar Mbodj Mamadou 《Open Journal of Biophysics》 2022年第1期27-37,共11页
Cardiac amyloidosis presents a picture of hypertrophic cardiomyopathy with heart failure with preserved ejection fraction. It is largely underdiagnosed, especially in black Africans, and therefore falls under the cate... Cardiac amyloidosis presents a picture of hypertrophic cardiomyopathy with heart failure with preserved ejection fraction. It is largely underdiagnosed, especially in black Africans, and therefore falls under the category of heart disease classified as idiopathic. Light chain amyloidosis (AL) is mainly found in Caucasian subjects and the mutant variant of transthyretin (TTRm) in negroid subjects. Numerous studies have shown that ATTRm was found predominantly in black American and black British patients. In African countries the entity of idiopathic heart failure is quite important because of lack of diagnosis, ETT, MRI and immuno-histochemistry are expensive or not available. We can probably assume that the proportion of cardiac amyloidosis is quite important in black Africans. The question is if <sup>99m</sup>Tc-DPD really easy to perform, can probably help to investigate in the nuclear medicine department in Africa. No large-scale study has been able to demonstrate the prevalence or not of cardiac amyloidosis in black-African subjects and by extension reduce this nosological entity of idiopathic heart disease. The <sup>99m</sup>Tc-DPD scintigraphy using Perrugini’s visual sore allows localization and classification of amyloid damage. The mechanism of binding of <sup>99m</sup>Tc-DPD to amyloid fibril deposits is not well known, its binding to TTR-type (mutated or wild type) amyloidosis is greater than the AL variant. In the diagnostic algorithm, endomyocardial biopsy is the gold standard but remains invasive, ETT with the strain allows a presumptive diagnosis and remains an operative examination dependent and is not reproducible. Cardiac MRI allows some localization of amyloid deposits but still remains less sensitive than scintigraphy. In addition, performing the whole-body MRI is very restrictive (time, antenna change and cost). The aim of this literature review was to show the superiority of <sup>99m</sup>Tc-DPD scintigraphy compared to other diagnostic modalities and to consider its use given its simplicity when it comes to usage in Sub-Saharan Africa to diagnose the disease. cardiac amyloidosis and by extension reduce the number of cases of heart disease classified as idiopathic and thus allow early and appropriate management. 展开更多
关键词 AMYLOIDOSIS TTRm AL 99mTc-DPD bone scintigraphy
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SAPHO综合征的全身骨显像及SPECT/CT影像分析
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作者 崔璨 李俊秋 +1 位作者 于梅艳 温庆祥 《分子影像学杂志》 2024年第9期941-945,共5页
目的分析滑膜炎-痤疮-脓疱病-骨肥厚-骨炎(SAPHO)综合征全身骨显像和SPECT/CT的影像特点,探讨两种检查方法在SAPHO综合征中的诊断价值。方法回顾性分析2017年1月~2022年12月就诊于首都医科大学附属北京中医医院的41例SAPHO综合征患者的... 目的分析滑膜炎-痤疮-脓疱病-骨肥厚-骨炎(SAPHO)综合征全身骨显像和SPECT/CT的影像特点,探讨两种检查方法在SAPHO综合征中的诊断价值。方法回顾性分析2017年1月~2022年12月就诊于首都医科大学附属北京中医医院的41例SAPHO综合征患者的临床、全身骨显像及SPECT/CT断层显像资料。结果41例患者中,56%合并有皮肤损害,血红细胞沉降率、C反应蛋白、C3补体、C4补体升高的比例分别为63%、59%、17%、6%,14%的患者HLA-B27呈阳性。全身骨显像发现6例前胸壁受累、1例胸椎受累、1例胸腰椎及双侧骶髂关节受累,其余33例为多部位受累,依次为前胸壁(95%)、脊柱(58%)、骶髂关节(46%)、四肢关节(22%)、肋骨(12%)、耻骨(7%)、坐骨(5%)、股骨和颅骨(各2%)。19例行胸部和腰骶部SPECT/CT断层显像,前胸壁病灶主要位于胸锁关节和第一胸肋关节,“牛头征”是本病的特征性表现;脊柱病变多分布在胸腰椎,椎体前角骨质硬化较具特异性;骶髂关节多为双侧、髂骨面受累,多表现为骨质增生硬化。结论全身骨显像能够全面评估全身骨关节受累情况,SPECT/CT同时结合了骨断层显像的代谢信息及CT的解剖信息,二者联合在SAPHO综合征的早期诊断、精准定位和评估病情等方面具有重要价值。 展开更多
关键词 SAPHO综合征 放射性核素显像 骨显像 SPECT/CT
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99Tc^(m)-MDP骨显像对确定新鲜骨质疏松性胸腰椎骨折的诊断价值
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作者 刘红莲 杨峰 +5 位作者 龚亨 陈同磊 胡艳文 金振涛 言湛军 尤徐阳 《标记免疫分析与临床》 CAS 2024年第11期1961-1965,共5页
目的评估99Tc^(m)-MDP骨显像及其半定量分析指标在对确定新鲜骨质疏松性胸腰椎骨折(osteoporotic thoracolumbar fracture,OTLF)的诊断价值。方法回顾性分析2021年2月至2023年6月因日常活动或轻微外伤导致腰背部疼痛至我院就诊,并接受99... 目的评估99Tc^(m)-MDP骨显像及其半定量分析指标在对确定新鲜骨质疏松性胸腰椎骨折(osteoporotic thoracolumbar fracture,OTLF)的诊断价值。方法回顾性分析2021年2月至2023年6月因日常活动或轻微外伤导致腰背部疼痛至我院就诊,并接受99Tc^(m)-MDP骨显像和MRI双项检查的46例OTLF患者资料。①利用图像后处理系统勾画SPECT/CT断层融合图像中骨折椎体(T)及邻近正常椎体(NT),获得骨显像半定量参数(即T/NT值),以MRI检查结果为金标准,通过受试者工作特征(ROC)曲线分析获得曲线下面积(AUC值)、约登指数、灵敏度、特异性、最佳截断值。②将最佳截断值作为分辨新鲜骨折病灶的参考指标,重新统计OTLF病灶数量,应用Kappa检验及配对卡方检验(McNemar检验)对比分析骨显像视觉分析及半定量分析对OTLF的诊断结果与MRI检查的一致性及差异性。结果共发现112个OTLF病灶。①ROC曲线分析获得骨显像两种半定量参数T_(max)/NT_(max)与T_(max)/NT_(mean)的AUC值分别为:0.923(95%CI 0.871~0.975,P<0.001)、0.941(95%CI 0.871~0.975,P<0.001),两者差异有统计学意义(P=0.025),表明T_(max)/NT_(mean)对OTLF患者病灶检出效能更优,对应截断值为2.64,两者的约登指数、灵敏度及特异性均为:0.808、85.3%、95.5%。②骨显像半定量分析参考指标对OTLF病灶检出情况与MRI诊断的一致性(Kappa=0.782,P<0.001),明显高于骨显像视觉分析与MRI的一致性(Kappa=0.578,P<0.001),且所有检查方法阳性检出率的差异均有统计学意义(P<0.05)。③骨显像还发现肋骨、椎体附件、四肢骨、肩胛骨、耻骨等多处椎外骨折。结论99Tc^(m)-MDP骨显像半定量分析方式对新鲜OTLF病灶诊断及临床诊疗决策的制定有重要的临床价值。 展开更多
关键词 骨显像 MRI 骨质疏松性性胸腰椎骨折 诊断价值 ROC曲线
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^(99)mTc-MDP全身骨扫描平面+SPECT/CT在儿童McCune-Albright综合征诊断中的价值研究
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作者 张抒欣 王巍 +2 位作者 阚英 刘洁 杨吉刚 《临床和实验医学杂志》 2024年第13期1431-1434,共4页
目的探讨^(99)mTc标记的亚甲基二膦酸盐(^(99)mTc-MDP)全身骨扫描+单光子发射计算机断层扫描(SPECT)/CT在儿童McCune-Albright综合征(MAS)诊断中的应用价值。方法回顾性选择2019年1月至2023年9月在外院疑诊MAS,后在首都医科大学附属北... 目的探讨^(99)mTc标记的亚甲基二膦酸盐(^(99)mTc-MDP)全身骨扫描+单光子发射计算机断层扫描(SPECT)/CT在儿童McCune-Albright综合征(MAS)诊断中的应用价值。方法回顾性选择2019年1月至2023年9月在外院疑诊MAS,后在首都医科大学附属北京友谊医院核医学科行骨扫描平面及SPECT/CT断层显像的患儿。所有患儿均行^(99)mTc-MDP全身骨扫描+SPECT/CT,记录平面和断层显像病灶数,并随访记录临床诊断结果及相关临床资料。结果经骨扫描检查及进一步临床评估,7例患儿确诊MAS,9例排除MAS诊断。确诊MAS的7例患儿中,6例全身骨扫描+SPECT/CT显示显像剂浓聚灶,分布于颅骨、肋骨、髋骨、尺骨、股骨、胫骨及腓骨,3例较X线平片显示更多病灶;全身骨扫描联合SPECT/CT局部断层显像可较平面显像显示更多病灶,并且排除体外污染、先天变异及体位因素的影响。9例排除MAS诊断的患儿全身骨扫描+SPECT/CT断层扫描结果均为阴性。结论^(99)mTc-MDP全身骨扫描+SPECT/CT能够为诊断及排除MAS综合征提供重要依据,平面扫描图像存在可疑显像剂浓聚灶时,应进一步联合断层扫描。 展开更多
关键词 儿童 MCCUNE-ALBRIGHT综合征 全身骨扫描
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全身骨显像中肾脏显影异常的病因浅析
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作者 孙志勇 杨伟 +4 位作者 周帅 黄叶 周后蓉 王婷 王庆旭 《四川医学》 CAS 2024年第6期655-659,共5页
目的探讨全身骨显像中肾脏显影异常的发生情况并初步分析病因。方法回顾性分析2021年11月至2022年7月在我院行骨显像的患者1674例,对肾区不同类型的显影异常结合患者其他相关影像检查及临床资料进行定性评估。结果共发现肾脏显影异常147... 目的探讨全身骨显像中肾脏显影异常的发生情况并初步分析病因。方法回顾性分析2021年11月至2022年7月在我院行骨显像的患者1674例,对肾区不同类型的显影异常结合患者其他相关影像检查及临床资料进行定性评估。结果共发现肾脏显影异常147例(8.78%),其中肾实质显影明显54例(3.23%),肾脏集合系统(肾盏肾盂或输尿管)异常显影61例(3.64%),单肾不显影14例(0.84%),双肾不显影23例(1.37%),肾脏位置异常8例(0.48%)等异常,并对不同类型显影异常的可能病因进行了分析。结论骨显像中肾脏显影出现异常,可提示肾脏结构异常、尿路排泄障碍以及肾脏功能异常等情况,可引导临床按需要行进一步检查,以明确疾病的原因,对临床诊治具有一定的指导意义。 展开更多
关键词 骨显像 肾脏影像 单光子发射计算机断层扫描仪 肾小球滤过率
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全身骨显像与肿瘤标志物联合检测对NSCLC骨转移的诊断价值 被引量:22
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作者 柴华 韦琳琳 +5 位作者 杨志 李宁 廖光星 杨鸿宇 李党生 肖国有 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第12期628-632,共5页
目的:探讨全身骨显像和血清肿瘤标志物(CEA、CA125、CYFRA21-1)联合检测对非小细胞肺癌(non-small cell lung can-cer,NSCLC)患者骨转移诊断的临床应用价值。方法:回顾性分析广西医科大学附属肿瘤医院2014年1月至2016年6月185例首诊且... 目的:探讨全身骨显像和血清肿瘤标志物(CEA、CA125、CYFRA21-1)联合检测对非小细胞肺癌(non-small cell lung can-cer,NSCLC)患者骨转移诊断的临床应用价值。方法:回顾性分析广西医科大学附属肿瘤医院2014年1月至2016年6月185例首诊且经病理或细胞学检查确诊为NSCLC患者的全身骨显像及血清肿瘤标志物(CEA、CA125、CYFRA21-1)检测结果,计算单项检查与联合检查诊断骨转移效能。参照Soloway分级标准将NSCLC骨转移患者的全身骨显像结果进行分级。应用Spearman相关分析评价全身骨显像分级与血清肿瘤标志物水平的相关性。结果:185例NSCLC患者中78例发生骨转移,骨转移发生率为42.16%(78/185);全身骨显像诊断NSCLC骨转移的灵敏度、特异性分别为91.02%(71/78)、85.98%(92/107)。NSCLC骨转移组CEA、CA125及CYFRA21-1水平高于NSCLC无骨转移组,差异具有统计学意义(P<0.05);78例NSCLC骨转移患者中,EOD 0:8.98%(7/78),EOD 1:50.00%(39/78),EOD 2:21.79%(17/78),EOD 3:19.23%(15/78)。Spearman相关分析结果显示,全身骨显像分级与CEA、CA125及CYFRA21-1水平存在相关性(rs=0.579、0.274、0.327,均P<0.05)。全身骨显像与肿瘤标志物联合检测NSCLC骨转移诊断效能高于各项单项检测效能(AUC=0.922),灵敏度及特异性均提高(分别为92.30%、86.00%)。结论:全身骨显像对诊断NSCLC骨转移的诊断效能较高,适宜作为NSCLC骨转移的首选筛查方法,在临床中具有重要应用价值。全身骨显像联合CEA、CA125、CYFRA21-1检测比单项检测有助于提高NSCLC骨转移病灶检出率,临床实用性更强。 展开更多
关键词 全身骨显像 血清肿瘤标志物 非小细胞肺癌 骨转移
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风湿清方对CIA大鼠骨保护作用机制研究 被引量:18
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作者 姜泉 李德平 +10 位作者 曹炜 吴广均 唐晓颇 雷云 李家琇 康浩宸 高波 雷光 翟春红 翟华强 吴振宇 《中国中西医结合杂志》 CAS CSCD 北大核心 2013年第12期1648-1652,共5页
目的探讨风湿清方对胶原诱导的关节炎(collagen-induced arthritis,CIA)大鼠骨保护作用机制。方法试验分为空白组、模型组、西药组(MTX,1 mg/kg)和中药组(风湿清方,24 g生药/kg),除空白组外,其余各组大鼠CIA造模,西药组与中药组免疫后... 目的探讨风湿清方对胶原诱导的关节炎(collagen-induced arthritis,CIA)大鼠骨保护作用机制。方法试验分为空白组、模型组、西药组(MTX,1 mg/kg)和中药组(风湿清方,24 g生药/kg),除空白组外,其余各组大鼠CIA造模,西药组与中药组免疫后第14天开始给药,给药直至第56天。观察各组大鼠足趾体积(每周二、周五测量),检测干预3、6周时血清IL-17、RANKL、MIP-1α的表达水平及骨密度、核素骨显像,观察病理切片,评价清热活血方药对CIA大鼠骨破坏的干预情况。结果造模各组第10天起,双足体积开始增加,21天左右达到高峰,30天左右明显下降,其中两个给药组比模型组肿胀程度轻。与模型组同期比较,西药组干预3周后IL-17、RANKL降低(P<0.01,P<0.05),中药组干预3周后IL-17降低(P<0.05);两个给药组干预6周后RANKL均降低(P<0.01,P<0.05)。与模型组及西药组同期比较,中药组干预6周后整体BMD及踝关节BMD均升高(P<0.01,P<0.05).,中药组干预3周踝ROI/下颌骨升高、足趾ROI/下颌骨升高(P<0.05)。病理切片发现模型组关节腔隙明显增宽,滑膜组织增生严重,骨组织破坏,与模型组比较,两个给药组改善显著,软骨结构轮廓完整。结论风湿清方可以抑制骨密度下降,防止骨破坏,其机制可能通过骨免疫Th/RANKL系统,下调IL-17、RANKL、MIP-1α的表达水平,抑制破骨细胞的成熟和分化,促进成骨细胞活跃,从而抑制骨破坏。 展开更多
关键词 类风湿关节炎 风湿清方 骨免疫学 核素骨显像 骨密度
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