Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control s...Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.展开更多
Boolean control network consists of a set of Boolean variables whose state is determined by other variables in the network. Boolean network is used for modeling complex system. In this paper, we have presented a model...Boolean control network consists of a set of Boolean variables whose state is determined by other variables in the network. Boolean network is used for modeling complex system. In this paper, we have presented a model of a context-aware system used in smart home based on Boolean control networks. This modeling describes the relationship between the context elements (person, time, location, and activity) and services (Morning Call, Sleeping, Guarding, Entertainment, and normal), which is effective to logical inference. We apply semi tensor matrix product to describe the dynamic of the system. This matrix form of expression is a convenient and reasonable way to design logic control system.展开更多
This paper gives an equivalent condition for the observability of Boolean control networks(BCNs) with time-variant delays in states under a mild assumption by using the graph-theoretic method under the framework of ...This paper gives an equivalent condition for the observability of Boolean control networks(BCNs) with time-variant delays in states under a mild assumption by using the graph-theoretic method under the framework of the semi-tensor product of matrices. First, the BCN under consideration is split into a finite number of subsystems with no time delays. Second, the observability of the BCN is verified by testing the observability of the so-called observability constructed path(a special subsystem without time delays) based on graph theory. These results extend the recent related results on the observability of BCNs. Examples are shown to illustrate the effectiveness of the results.展开更多
This paper focuses graph theory method for the problem of decomposition w.r.t. outputs for Boolean control networks(BCNs). First, by resorting to the semi-tensor product of matrices and the matrix expression of BCNs, ...This paper focuses graph theory method for the problem of decomposition w.r.t. outputs for Boolean control networks(BCNs). First, by resorting to the semi-tensor product of matrices and the matrix expression of BCNs, the definition of decomposition w.r.t. outputs is introduced. Second, by referring to the graphical structure of BCNs, a necessary and sufficient condition for the decomposition w.r.t. outputs is obtained based on graph theory method. Third, an effective algorithm to realize the maximum decomposition w.r.t. outputs is proposed. Finally, some examples are addressed to validate the theoretical results.展开更多
This paper investigates the Morgan's problem of Boolean control networks. Based on the matrix expression of logical functions, two key steps are proposed to solve the problem. First, the Boolean control network is co...This paper investigates the Morgan's problem of Boolean control networks. Based on the matrix expression of logical functions, two key steps are proposed to solve the problem. First, the Boolean control network is converted into an output- decomposed form by constructing a set of consistent outputfriendly subspaces, and a necessary and sufficient condition for the existence of the consistent output-friendly subspaces is obtained. Secondly, a type of state feedback controllers are designed to solve the Morgan's problem if it is solvable. By solving a set of matrix equations, a necessary and sufficient condition for converting an output-decomposed form to an input-output decomposed form is given, and by verifying the output controllability matrix, the solvability of Morgan's problem is obtained.展开更多
In this paper,observability is studied for periodically switched Boolean control networks(PSBCNs),which are managed with periodic switching signal and consist of some Boolean control networks.Firstly,via semi-tensor p...In this paper,observability is studied for periodically switched Boolean control networks(PSBCNs),which are managed with periodic switching signal and consist of some Boolean control networks.Firstly,via semi-tensor product of matrices,PSBCNs are expressed as algebraic forms.Secondly,a parallel system is constructed by combining two same PSBCNs,based on which,the observability problem of the original PSBCN can be transformed into the set reachability problem of this parallel system.Then,two necessary and sufficient conditions are obtained to detect reachability of parallel systems and observability of PSBCNs.In addition,the proposed conditions are extended to the case of state constraints.Finally,a practical example and a numerical example are provided to illustrate the results.展开更多
Observability is a fundamental property of a partially observed dynamical system,which means whether one can use an input sequence and the corresponding output sequence to determine the initial state.Observability pro...Observability is a fundamental property of a partially observed dynamical system,which means whether one can use an input sequence and the corresponding output sequence to determine the initial state.Observability provides bases for many related problems,such as state estimation,identification,disturbance decoupling,controller synthesis,etc.Until now,fundamental improvement has been obtained in observability of Boolean control networks(BCNs)mainly based on two methods-Edward F.Moore's partition and our observability graph or their equivalent representations found later based on the semitensor product(STP)of matrices(where the STP was proposed by Daizhan Cheng),including necessary and sufficient conditions for different types of observability,extensions to probabilistic Boolean networks(PBNs)and singular BCNs,even to nondeterministic finite-transition systems(NFTSs);and the development(with the help of the STP of matrices)in related topics,such as com-putation of smallest invariant dual subspaces of BNs containing a set of Boolean functions,multiple-experiment observability verification/decomposition in BCNs,disturbance decoupling in BCNs,etc.This paper provides a thorough survey for these topics.The contents of the paper are guided by the above two methods.First,we show that Moore's partition-based method closely relates the following problems:computation of smallest invariant dual subspaces of BNs,multiple-experiment observ-ability verification/decomposition in BCNs,and disturbance decoupling in BCNs.However,this method does not apply to other types of observability or nondeterministic systems.Second,we show that based on our observability graph,four different types of observability have been verified in BCNs,verification results have also been extended to PBNs,singular BCNs,and NFTSs.In addition,Moore's partition also shows similarities between BCNs and linear time-invariant(LTI)control systems,e.g.,smallest invariant dual subspaces of BNs containing a set of Boolean functions in BCNs vs unobservable subspaces of LTI control systems,the forms of quotient systems based on observability decomposition in both types of systems.However,there are essential differences between the two types of systems,e.g.,"all plausible definitions of observability in LTI control systems turn out to be equivalent"(by Walter M.Wonham 1985),but there exist nonequivalent definitions of observability in BCNs;the quotient system based on observability decomposition always exists in an LTI control system,while a quotient system based on multiple-experiment observability decomposition does not always exist in a BCN.展开更多
In this paper,the problem of controllability of Boolean control networks(BCNs)with multiple time delays in both states and controls is investigated.First,the controllability problem of BCNs with multiple time delays i...In this paper,the problem of controllability of Boolean control networks(BCNs)with multiple time delays in both states and controls is investigated.First,the controllability problem of BCNs with multiple time delays in controls is considered.For this controllability problem,a controllability matrix is constructed by defining a new product of matrices,based on which a necessary and sufficient controllability condition is obtained.Then,the controllability of BCNs with multiple time delays in states is studied by giving a necessary and sufficient condition.Subsequently,based on these results,a controllability matrix for BCNs with multiple time delays in both states and controls is proposed that provides a concise controllability condition.Finally,two examples are given to illustrate the main results.展开更多
We aim to further study the global stability of Boolean control networks(BCNs)under aperiodic sampleddata control(ASDC).According to our previous work,it is known that a BCN under ASDC can be transformed into a switch...We aim to further study the global stability of Boolean control networks(BCNs)under aperiodic sampleddata control(ASDC).According to our previous work,it is known that a BCN under ASDC can be transformed into a switched Boolean network(SBN),and further global stability of the BCN under ASDC can be obtained by studying the global stability of the transformed SBN.Unfortunately,since the major idea of our previous work is to use stable subsystems to offset the state divergence caused by unstable subsystems,the SBN considered has at least one stable subsystem.The central thought in this paper is that switching behavior also has good stabilization;i.e.,the SBN can also be stable with appropriate switching laws designed,even if all subsystems are unstable.This is completely different from that in our previous work.Specifically,for this case,the dwell time(DT)should be limited within a pair of upper and lower bounds.By means of the discretized Lyapunov function and DT,a sufficient condition for global stability is obtained.Finally,the above results are demonstrated by a biological example.展开更多
Two types of cascading decomposition problems of Boolean control networks are investigated using a graph-theoretical method.A new graphic concept called nested perfect equal vertex partition(NPEVP)is proposed.Based on...Two types of cascading decomposition problems of Boolean control networks are investigated using a graph-theoretical method.A new graphic concept called nested perfect equal vertex partition(NPEVP)is proposed.Based on NPEVP,the necessary and sufficient graphic conditions for solvability of the cascading decomposition problems are obtained.Given the proposed graphic conditions,the logical coordinate transformations are constructively obtained to realize the corresponding cascading decomposition forms.Finally,two illustrative examples are provided to validate the results.展开更多
Single input single output system was studied. With proportion, differential, integral results of deviation between given input and output as controller input, the logic rules in control process was analyzed, these lo...Single input single output system was studied. With proportion, differential, integral results of deviation between given input and output as controller input, the logic rules in control process was analyzed, these logic rule with Pan-Boolean algebra was described, therefore a PID Pan-Boolean algebra control algorithm was obtained. The simulation results indicates that the new control algorithm is more effective compared to the traditional PID algorithm, having advantages such as more than 3 adjustable parameters of controllers, better result, and so on.展开更多
In this paper, we discuss how to transform the disordered phase into an ordered phase in random Boolean networks. To increase the effectiveness, a control scheme is proposed, which periodically freezes a fraction of t...In this paper, we discuss how to transform the disordered phase into an ordered phase in random Boolean networks. To increase the effectiveness, a control scheme is proposed, which periodically freezes a fraction of the network based on the average sensitivity of Boolean functions of the nodes. Theoretical analysis is carried out to estimate the expected critical value of the fraction, and shows that the critical value is reduced using this scheme compared to that of randomly freezing a fraction of the nodes. Finally, the simulation is given for illustrating the effectiveness of the proposed method.展开更多
This study is concerned with probabilistic Boolean control networks(PBCNs)with state feedback control.A novel definition of bisimilar PBCNs is proposed to lower computational complexity.To understand more on bisimulat...This study is concerned with probabilistic Boolean control networks(PBCNs)with state feedback control.A novel definition of bisimilar PBCNs is proposed to lower computational complexity.To understand more on bisimulation relations between PBCNs,we resort to a powerful matrix manipulation called semi-tensor product(STP).Because stabilization of networks is of critical importance,the propagation of stabilization with probability one between bisimilar PBCNs is then considered and proved to be attainable.Additionally,the transient periods(the maximum number of steps to implement stabilization)of two PBCNs are certified to be identical if these two networks are paired with a bisimulation relation.The results are then extended to the probabilistic Boolean networks.展开更多
Design of control strategies for gene regulatory networks is a challenging and important topic in systems biology. In this paper, the problem of finding both a minimum set of control nodes (control inputs) and a contr...Design of control strategies for gene regulatory networks is a challenging and important topic in systems biology. In this paper, the problem of finding both a minimum set of control nodes (control inputs) and a controller is studied. A control node corresponds to a gene that expression can be controlled. Here, a Boolean network is used as a model of gene regulatory networks, and control specifications on attractors, which represent cell types or states of cells, are imposed. It is important to design a gene regulatory network that has desired attractors and has no undesired attractors. Using a matrix-based representation of BNs, this problem can be rewritten as an integer linear programming problem. Finally, the proposed method is demonstrated by a numerical example on a WNT5A network, which is related to melanoma.展开更多
The nonlinear filter Boolean function of LILI-128 stream cipher generator is studied in this paper. First we measure the complexity of the stream ciphers sequence of LILI-128 stream cipher generator and obtain the sho...The nonlinear filter Boolean function of LILI-128 stream cipher generator is studied in this paper. First we measure the complexity of the stream ciphers sequence of LILI-128 stream cipher generator and obtain the shortest bit stream sequence reconstructed Boolean function of nonlinear filter in LILI-128 stream cipher generator. Then the least nonlinear Boolean function of generating stream cipher sequence is reconstructed by clusterig, nonlinear predictive and nonlinear synchronization from shortest bit stream sequence. We have verified the correctness of our reconstruction result by simulating the block diagram of Lili-128 keystream generator using our getting Boolean function and implement designers’ reference module of Lili-128 stream cipher public online, and two methods produce the same synchronous keystream sequence under same initial state, so that our research work proves that the nonlinear Boolean function of LILI-128 stream cipher generator is successfully broken.展开更多
In the post-genomic era, the construction and control of genetic regulatory networks using gene expression data is a hot research topic. Boolean networks (BNs) and its extension Probabilistic Boolean Networks (PBNs) h...In the post-genomic era, the construction and control of genetic regulatory networks using gene expression data is a hot research topic. Boolean networks (BNs) and its extension Probabilistic Boolean Networks (PBNs) have been served as an effective tool for this purpose. However, PBNs are difficult to be used in practice when the number of genes is large because of the huge computational cost. In this paper, we propose a simplified multivariate Markov model for approximating a PBN The new model can preserve the strength of PBNs, the ability to capture the inter-dependence of the genes in the network, qnd at the same time reduce the complexity of the network and therefore the computational cost. We then present an optimal control model with hard constraints for the purpose of control/intervention of a genetic regulatory network. Numerical experimental examples based on the yeast data are given to demonstrate the effectiveness of our proposed model and control policy.展开更多
基金supported by the National Natural Science Foundation of China (62273201,62173209,72134004,62303170)the Research Fund for the Taishan Scholar Project of Shandong Province of China (TSTP20221103)。
文摘Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.
文摘Boolean control network consists of a set of Boolean variables whose state is determined by other variables in the network. Boolean network is used for modeling complex system. In this paper, we have presented a model of a context-aware system used in smart home based on Boolean control networks. This modeling describes the relationship between the context elements (person, time, location, and activity) and services (Morning Call, Sleeping, Guarding, Entertainment, and normal), which is effective to logical inference. We apply semi tensor matrix product to describe the dynamic of the system. This matrix form of expression is a convenient and reasonable way to design logic control system.
基金supported by the National Natural Science Foundation of China under Grant Nos.61603109and 51209051the Natural Science Foundation of Heilongjiang Province of China under Grant No.LC2016023+1 种基金the Fundamental Research Funds for the Central Universities under Grant Nos.HEUCFM170406 and HEUCFM170112the State Key Laboratory of Ocean Engineering(Shanghai Jiao Tong University)under Grant No.1415
文摘This paper gives an equivalent condition for the observability of Boolean control networks(BCNs) with time-variant delays in states under a mild assumption by using the graph-theoretic method under the framework of the semi-tensor product of matrices. First, the BCN under consideration is split into a finite number of subsystems with no time delays. Second, the observability of the BCN is verified by testing the observability of the so-called observability constructed path(a special subsystem without time delays) based on graph theory. These results extend the recent related results on the observability of BCNs. Examples are shown to illustrate the effectiveness of the results.
基金supported in part by the National Natural Science Foundation of China under Grant Nos.61673012,11271194a Project on the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘This paper focuses graph theory method for the problem of decomposition w.r.t. outputs for Boolean control networks(BCNs). First, by resorting to the semi-tensor product of matrices and the matrix expression of BCNs, the definition of decomposition w.r.t. outputs is introduced. Second, by referring to the graphical structure of BCNs, a necessary and sufficient condition for the decomposition w.r.t. outputs is obtained based on graph theory method. Third, an effective algorithm to realize the maximum decomposition w.r.t. outputs is proposed. Finally, some examples are addressed to validate the theoretical results.
文摘This paper investigates the Morgan's problem of Boolean control networks. Based on the matrix expression of logical functions, two key steps are proposed to solve the problem. First, the Boolean control network is converted into an output- decomposed form by constructing a set of consistent outputfriendly subspaces, and a necessary and sufficient condition for the existence of the consistent output-friendly subspaces is obtained. Secondly, a type of state feedback controllers are designed to solve the Morgan's problem if it is solvable. By solving a set of matrix equations, a necessary and sufficient condition for converting an output-decomposed form to an input-output decomposed form is given, and by verifying the output controllability matrix, the solvability of Morgan's problem is obtained.
基金supported by the National Natural Science Foundation of China under Grant Nos.12101366, 62103176 and 72134004the Natural Science Foundation of Shandong Province under Grant Nos. ZR2020QF117 and ZR2019BF023
文摘In this paper,observability is studied for periodically switched Boolean control networks(PSBCNs),which are managed with periodic switching signal and consist of some Boolean control networks.Firstly,via semi-tensor product of matrices,PSBCNs are expressed as algebraic forms.Secondly,a parallel system is constructed by combining two same PSBCNs,based on which,the observability problem of the original PSBCN can be transformed into the set reachability problem of this parallel system.Then,two necessary and sufficient conditions are obtained to detect reachability of parallel systems and observability of PSBCNs.In addition,the proposed conditions are extended to the case of state constraints.Finally,a practical example and a numerical example are provided to illustrate the results.
文摘Observability is a fundamental property of a partially observed dynamical system,which means whether one can use an input sequence and the corresponding output sequence to determine the initial state.Observability provides bases for many related problems,such as state estimation,identification,disturbance decoupling,controller synthesis,etc.Until now,fundamental improvement has been obtained in observability of Boolean control networks(BCNs)mainly based on two methods-Edward F.Moore's partition and our observability graph or their equivalent representations found later based on the semitensor product(STP)of matrices(where the STP was proposed by Daizhan Cheng),including necessary and sufficient conditions for different types of observability,extensions to probabilistic Boolean networks(PBNs)and singular BCNs,even to nondeterministic finite-transition systems(NFTSs);and the development(with the help of the STP of matrices)in related topics,such as com-putation of smallest invariant dual subspaces of BNs containing a set of Boolean functions,multiple-experiment observability verification/decomposition in BCNs,disturbance decoupling in BCNs,etc.This paper provides a thorough survey for these topics.The contents of the paper are guided by the above two methods.First,we show that Moore's partition-based method closely relates the following problems:computation of smallest invariant dual subspaces of BNs,multiple-experiment observ-ability verification/decomposition in BCNs,and disturbance decoupling in BCNs.However,this method does not apply to other types of observability or nondeterministic systems.Second,we show that based on our observability graph,four different types of observability have been verified in BCNs,verification results have also been extended to PBNs,singular BCNs,and NFTSs.In addition,Moore's partition also shows similarities between BCNs and linear time-invariant(LTI)control systems,e.g.,smallest invariant dual subspaces of BNs containing a set of Boolean functions in BCNs vs unobservable subspaces of LTI control systems,the forms of quotient systems based on observability decomposition in both types of systems.However,there are essential differences between the two types of systems,e.g.,"all plausible definitions of observability in LTI control systems turn out to be equivalent"(by Walter M.Wonham 1985),but there exist nonequivalent definitions of observability in BCNs;the quotient system based on observability decomposition always exists in an LTI control system,while a quotient system based on multiple-experiment observability decomposition does not always exist in a BCN.
基金supported by the Natural Science Foundation of Chongqing,China(No.CSTB2022NSCQ-MSX2869)the Science and Technology Research Program of Chongqing Municipal Education Commission,China(No.KJQN202200524)+1 种基金the Research Project of National Center for Applied Mathematics in Chongqing,China(No.ncamc2022-msxm05)the Program of Chongqing Normal University,China(No.21XLB045)。
文摘In this paper,the problem of controllability of Boolean control networks(BCNs)with multiple time delays in both states and controls is investigated.First,the controllability problem of BCNs with multiple time delays in controls is considered.For this controllability problem,a controllability matrix is constructed by defining a new product of matrices,based on which a necessary and sufficient controllability condition is obtained.Then,the controllability of BCNs with multiple time delays in states is studied by giving a necessary and sufficient condition.Subsequently,based on these results,a controllability matrix for BCNs with multiple time delays in both states and controls is proposed that provides a concise controllability condition.Finally,two examples are given to illustrate the main results.
基金Project supported by the Natural Science Foundation of Jiangsu Province,China(No.BK20170019)the Fundamental Research Funds for the Central Universities+2 种基金the National Natural Science Foundation of China(Nos.61973078,61573102,and 11671158)Hong Kong RGC GRF,China(No.17301519)IMR and RAE Research Fund from Faculty of Science,HKU,China。
文摘We aim to further study the global stability of Boolean control networks(BCNs)under aperiodic sampleddata control(ASDC).According to our previous work,it is known that a BCN under ASDC can be transformed into a switched Boolean network(SBN),and further global stability of the BCN under ASDC can be obtained by studying the global stability of the transformed SBN.Unfortunately,since the major idea of our previous work is to use stable subsystems to offset the state divergence caused by unstable subsystems,the SBN considered has at least one stable subsystem.The central thought in this paper is that switching behavior also has good stabilization;i.e.,the SBN can also be stable with appropriate switching laws designed,even if all subsystems are unstable.This is completely different from that in our previous work.Specifically,for this case,the dwell time(DT)should be limited within a pair of upper and lower bounds.By means of the discretized Lyapunov function and DT,a sufficient condition for global stability is obtained.Finally,the above results are demonstrated by a biological example.
基金Project supported by the National Natural Science Foundation of China(No.61673012)。
文摘Two types of cascading decomposition problems of Boolean control networks are investigated using a graph-theoretical method.A new graphic concept called nested perfect equal vertex partition(NPEVP)is proposed.Based on NPEVP,the necessary and sufficient graphic conditions for solvability of the cascading decomposition problems are obtained.Given the proposed graphic conditions,the logical coordinate transformations are constructively obtained to realize the corresponding cascading decomposition forms.Finally,two illustrative examples are provided to validate the results.
基金Project (J51801) supported by Shanghai Education Commission Key DisciplineProject(08ZY79)supported by Shanghai Education Commission Research FundProject(DZ207004)supported by Shanghai Second Polytechnic University Fund
文摘Single input single output system was studied. With proportion, differential, integral results of deviation between given input and output as controller input, the logic rules in control process was analyzed, these logic rule with Pan-Boolean algebra was described, therefore a PID Pan-Boolean algebra control algorithm was obtained. The simulation results indicates that the new control algorithm is more effective compared to the traditional PID algorithm, having advantages such as more than 3 adjustable parameters of controllers, better result, and so on.
基金supported in part by the National Natural Science Foundation of China (Grant Nos. 60874018,60736022,and 60821091)
文摘In this paper, we discuss how to transform the disordered phase into an ordered phase in random Boolean networks. To increase the effectiveness, a control scheme is proposed, which periodically freezes a fraction of the network based on the average sensitivity of Boolean functions of the nodes. Theoretical analysis is carried out to estimate the expected critical value of the fraction, and shows that the critical value is reduced using this scheme compared to that of randomly freezing a fraction of the nodes. Finally, the simulation is given for illustrating the effectiveness of the proposed method.
基金Project supported by the National Natural Science Foundation of China(Nos.61603268 and 61773319)the Fundamental Research Funds for the Central Universities,China(No.JBK190502)。
文摘This study is concerned with probabilistic Boolean control networks(PBCNs)with state feedback control.A novel definition of bisimilar PBCNs is proposed to lower computational complexity.To understand more on bisimulation relations between PBCNs,we resort to a powerful matrix manipulation called semi-tensor product(STP).Because stabilization of networks is of critical importance,the propagation of stabilization with probability one between bisimilar PBCNs is then considered and proved to be attainable.Additionally,the transient periods(the maximum number of steps to implement stabilization)of two PBCNs are certified to be identical if these two networks are paired with a bisimulation relation.The results are then extended to the probabilistic Boolean networks.
文摘Design of control strategies for gene regulatory networks is a challenging and important topic in systems biology. In this paper, the problem of finding both a minimum set of control nodes (control inputs) and a controller is studied. A control node corresponds to a gene that expression can be controlled. Here, a Boolean network is used as a model of gene regulatory networks, and control specifications on attractors, which represent cell types or states of cells, are imposed. It is important to design a gene regulatory network that has desired attractors and has no undesired attractors. Using a matrix-based representation of BNs, this problem can be rewritten as an integer linear programming problem. Finally, the proposed method is demonstrated by a numerical example on a WNT5A network, which is related to melanoma.
文摘The nonlinear filter Boolean function of LILI-128 stream cipher generator is studied in this paper. First we measure the complexity of the stream ciphers sequence of LILI-128 stream cipher generator and obtain the shortest bit stream sequence reconstructed Boolean function of nonlinear filter in LILI-128 stream cipher generator. Then the least nonlinear Boolean function of generating stream cipher sequence is reconstructed by clusterig, nonlinear predictive and nonlinear synchronization from shortest bit stream sequence. We have verified the correctness of our reconstruction result by simulating the block diagram of Lili-128 keystream generator using our getting Boolean function and implement designers’ reference module of Lili-128 stream cipher public online, and two methods produce the same synchronous keystream sequence under same initial state, so that our research work proves that the nonlinear Boolean function of LILI-128 stream cipher generator is successfully broken.
文摘In the post-genomic era, the construction and control of genetic regulatory networks using gene expression data is a hot research topic. Boolean networks (BNs) and its extension Probabilistic Boolean Networks (PBNs) have been served as an effective tool for this purpose. However, PBNs are difficult to be used in practice when the number of genes is large because of the huge computational cost. In this paper, we propose a simplified multivariate Markov model for approximating a PBN The new model can preserve the strength of PBNs, the ability to capture the inter-dependence of the genes in the network, qnd at the same time reduce the complexity of the network and therefore the computational cost. We then present an optimal control model with hard constraints for the purpose of control/intervention of a genetic regulatory network. Numerical experimental examples based on the yeast data are given to demonstrate the effectiveness of our proposed model and control policy.
基金supported by the National Natural Science Fouudation of China(Nos61203050,61143002,61104065)the Natural Science Foundation of Educational Commission of Henan Province(Nos2011B110002,12B 110002)