Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based c...Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,Indonesia.We assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic profile.Results:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 vaccines.From the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination status.The significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding Covid-19.Most participants had poor knowledge about the relationship between infertility and the Covid-19 vaccine.The general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.展开更多
The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the ...The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the electron beam from the Linac and increases its energy to the value required for the storage ring.The full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target values.These milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam commissioning.As measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,respectively.This paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.展开更多
Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-b...Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry.Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients.This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers,β-glucans.The literature data on their bioavailability,metabolic transformations,preclinical and human clinical research,and safety are discussed.Immunomodulatory mechanisms of polyphenol ingredients are also considered.These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity.Finally,we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.展开更多
Objective:To examine the pattern of COVID-19 infection and vaccination,and to explore pregnant women’s willingness and reluctance to accept a booster dose of the COVID-19 vaccine.Methods:This was a cross-sectional,de...Objective:To examine the pattern of COVID-19 infection and vaccination,and to explore pregnant women’s willingness and reluctance to accept a booster dose of the COVID-19 vaccine.Methods:This was a cross-sectional,descriptive study with a convenient sample size using a structured questionnaire among pregnant women attending the gynecology and obstetrics department at Acıbadem Mehmet Ali Aydinlar Hospital,Istanbul,Türkiye.The Health Belief Model scale was used to assess the intention and reluctance to accept a booster dose of the COVID-19 vaccine.Results:A total of 145 participants,with a mean age of(33.5±4.8)years,and a gestational age of(30.9±7.3)weeks,were enrolled in this study.88.8%Received full doses of the Pfizer-BioNTech vaccination.47.8%Participants suffered from vaccine adverse effects.Health Belief Model demonstrated a significant finding of perceived susceptibility(P<0.001),perceived severity of COVID-19 complications(P<0.001),and perceived benefits regarding a booster COVID-19 vaccination(P<0.001).Conclusions:Most pregnant women who received the COVID-19 immunization express a significant intention to receive a booster dose,regardless of the adverse effects experienced from the previous doses.However,a small percentage of the study sample express hesitancy about receiving the booster dose.展开更多
Background:We analysed data garnered during the ongoing Italian nationwide coronavirus disease 2019(COVID-19)vaccination campaign for comparing early COVID-19 monovalent vaccine efficacy in older persons who received ...Background:We analysed data garnered during the ongoing Italian nationwide coronavirus disease 2019(COVID-19)vaccination campaign for comparing early COVID-19 monovalent vaccine efficacy in older persons who received the primary vaccination cycle,the first vaccine booster,and the second vaccine booster.Methods:We conducted a retrospective analysis of early COVID-19 monovalent vaccine efficacy(i.e.,within 120 days)against COVID-19 related hospitalizations,intensive care unit(ICU)admissions and deaths in older persons(i.e.,aged≥80 years),by accessing official data of the COVID-19 national integrated surveillance program instituted by the Italian National Institute of Health.Vaccine efficacy was compared(odds ratio;OR)among cohorts receiving the primary vaccination cycle,the first vaccine booster,and the second vaccine booster.Results:A consistent decline could be seen in the rate of COVID-19 hospitalizations,ICU admissions and deaths with increasing number of monovalent immunizations.Within 120 days of administration,the first and second vaccine boosters had superior efficacy compared to the primary vaccination cycle,reducing the odds of all endpoints between 62%-71%and 69%-84%,respectively.A modestly superior early efficacy could also be noted for the second versus the first monovalent vaccine booster(ORs of all endpoints further reduced by 18%-48%).Conclusion:Since an increasing number of immunizations is associated with a lower risk of unfavourable COVID-19 outcomes,vaccine boosters may be useful for limiting the clinical burden of this infectious disease in elderly populations.展开更多
The analysis of natural vibration characteristics has become one of important steps of the manufacture and dynamic design in the aerospace industry. This paper presents a new scenario called virtual cutting in the con...The analysis of natural vibration characteristics has become one of important steps of the manufacture and dynamic design in the aerospace industry. This paper presents a new scenario called virtual cutting in the context of the transfer matrix method of linear multibody systems closed- loop topology for computing the free vibration characteristics of elastically coupled flexible launch vehicle boosters. In this approach, the coupled system is idealized as a triple-beam system-like structure coupled by linear translational springs, where a non-uniform free-free Euler-Bemoulli beam is used. A large thrust-to-weight ratio leads to large axial accelera- tions that result in an axial inertia load distribution from nose to tail. Consequently, it causes the development of significant compressive forces along the length of the launch vehicle. Therefore, it is important to take into account this effect in the transverse vibration model. This scenario does not need the global dynamics equations of a system, and it has high computational efficiency and low memory requirements. The validity of the presented scenario is achieved through com- parison to other approaches published in the literature.展开更多
The most common booster is called input pressure reduced （IPR） booster. However, this type of booster has its own shortages, such as its small output flow, when the boosting ratio is higher, the shortage becomes mor...The most common booster is called input pressure reduced （IPR） booster. However, this type of booster has its own shortages, such as its small output flow, when the boosting ratio is higher, the shortage becomes more distinct. Recent research on pneumatic boosters mainly focused on the factors that influence the characteristics of the boosters, some new kinds of pneumatic booster structures were designed, but the efficiency and output flow of these boosters are still not improved sufficiently. In order to improve the output flow of the pneumatic booster, a new kind of booster, expansion energy used （EEU） booster, is proposed. Non-linear differential equations of the pneumatic booster are set up. By using the software MATLAB/Simulink for simulation, the motion characteristics of the pistons, the characteristics of the output flow of the boosters are obtained for analysis of a principle. The principle, which is used to elevate the output flow of the two kinds of boosters, is that the average pressure of the air in the driving chambers of the EEU booster is higher than that of the IPR booster. The simulation and experimental research of the output flow characteristics are done. The simulation and experimental results are in a good accordance. And the simulation and experimental results show that when the air source pressure and the output pressure are set at 0.6 MPa and 0.8 MPa, respectively, with the increase of the terminal pressure of the air in the driving chamber, the output flow of the IPR booster ascends stably. As the terminal pressure of the air in the driving chamber goes up, the output flow of the EEU booster rises, and later it almost remains constant. In addition, with the same terminal pressure, the output flow of the EEU booster is greater than that of the IPR booster, and the difference decreases when the terminal pressure grows. At last, the output pressure is set at 0.8 MPa, under the optimum work state of the EEU booster, the output flow of the two kinds of boosters all declines with the rise of the boosting ratio. Furthermore, the output flow of the EEU booster is higher than that of IPR booster by 95 L/min approximately. The proposed research lays the foundation for optimistic of the EEU booster.展开更多
In order to design a low-cost pneumatic force servo system with large output forces,a scheme of a booster cylinder controlled by high speed solenoid valves is proposed.A nonlinear model of the system is established,in...In order to design a low-cost pneumatic force servo system with large output forces,a scheme of a booster cylinder controlled by high speed solenoid valves is proposed.A nonlinear model of the system is established,in which the hysteresis of high speed solenoid valve is considered.In order to deal with parameter uncertainty and disturbances of noise and friction,a feed-forward control method based on a disturbance observer is proposed.A practical pneumatic force servo system is used to testify the feasibility of the proposed controller.The experimental results show that pneumatic force servo system based on the proposed controller has high force tracking accuracy and quick response.展开更多
文摘Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,Indonesia.We assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic profile.Results:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 vaccines.From the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination status.The significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding Covid-19.Most participants had poor knowledge about the relationship between infertility and the Covid-19 vaccine.The general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.
基金This work was supported by the National Natural Science Foundation of China(No.12005239).
文摘The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the electron beam from the Linac and increases its energy to the value required for the storage ring.The full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target values.These milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam commissioning.As measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,respectively.This paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.
基金supported by the Science Fund of the Republic of Serbia,#Grant No:7748088。
文摘Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry.Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients.This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers,β-glucans.The literature data on their bioavailability,metabolic transformations,preclinical and human clinical research,and safety are discussed.Immunomodulatory mechanisms of polyphenol ingredients are also considered.These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity.Finally,we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.
文摘Objective:To examine the pattern of COVID-19 infection and vaccination,and to explore pregnant women’s willingness and reluctance to accept a booster dose of the COVID-19 vaccine.Methods:This was a cross-sectional,descriptive study with a convenient sample size using a structured questionnaire among pregnant women attending the gynecology and obstetrics department at Acıbadem Mehmet Ali Aydinlar Hospital,Istanbul,Türkiye.The Health Belief Model scale was used to assess the intention and reluctance to accept a booster dose of the COVID-19 vaccine.Results:A total of 145 participants,with a mean age of(33.5±4.8)years,and a gestational age of(30.9±7.3)weeks,were enrolled in this study.88.8%Received full doses of the Pfizer-BioNTech vaccination.47.8%Participants suffered from vaccine adverse effects.Health Belief Model demonstrated a significant finding of perceived susceptibility(P<0.001),perceived severity of COVID-19 complications(P<0.001),and perceived benefits regarding a booster COVID-19 vaccination(P<0.001).Conclusions:Most pregnant women who received the COVID-19 immunization express a significant intention to receive a booster dose,regardless of the adverse effects experienced from the previous doses.However,a small percentage of the study sample express hesitancy about receiving the booster dose.
文摘Background:We analysed data garnered during the ongoing Italian nationwide coronavirus disease 2019(COVID-19)vaccination campaign for comparing early COVID-19 monovalent vaccine efficacy in older persons who received the primary vaccination cycle,the first vaccine booster,and the second vaccine booster.Methods:We conducted a retrospective analysis of early COVID-19 monovalent vaccine efficacy(i.e.,within 120 days)against COVID-19 related hospitalizations,intensive care unit(ICU)admissions and deaths in older persons(i.e.,aged≥80 years),by accessing official data of the COVID-19 national integrated surveillance program instituted by the Italian National Institute of Health.Vaccine efficacy was compared(odds ratio;OR)among cohorts receiving the primary vaccination cycle,the first vaccine booster,and the second vaccine booster.Results:A consistent decline could be seen in the rate of COVID-19 hospitalizations,ICU admissions and deaths with increasing number of monovalent immunizations.Within 120 days of administration,the first and second vaccine boosters had superior efficacy compared to the primary vaccination cycle,reducing the odds of all endpoints between 62%-71%and 69%-84%,respectively.A modestly superior early efficacy could also be noted for the second versus the first monovalent vaccine booster(ORs of all endpoints further reduced by 18%-48%).Conclusion:Since an increasing number of immunizations is associated with a lower risk of unfavourable COVID-19 outcomes,vaccine boosters may be useful for limiting the clinical burden of this infectious disease in elderly populations.
基金supported by the Research Fund for the Doctoral Program of Higher Education of China(Grants 20113219110025,20133219110037)the National Natural Science Foundation of China(Grants 11102089,61304137)the Program for New Century Excellent Talents in University(NCET-10-0075)
文摘The analysis of natural vibration characteristics has become one of important steps of the manufacture and dynamic design in the aerospace industry. This paper presents a new scenario called virtual cutting in the context of the transfer matrix method of linear multibody systems closed- loop topology for computing the free vibration characteristics of elastically coupled flexible launch vehicle boosters. In this approach, the coupled system is idealized as a triple-beam system-like structure coupled by linear translational springs, where a non-uniform free-free Euler-Bemoulli beam is used. A large thrust-to-weight ratio leads to large axial accelera- tions that result in an axial inertia load distribution from nose to tail. Consequently, it causes the development of significant compressive forces along the length of the launch vehicle. Therefore, it is important to take into account this effect in the transverse vibration model. This scenario does not need the global dynamics equations of a system, and it has high computational efficiency and low memory requirements. The validity of the presented scenario is achieved through com- parison to other approaches published in the literature.
文摘The most common booster is called input pressure reduced （IPR） booster. However, this type of booster has its own shortages, such as its small output flow, when the boosting ratio is higher, the shortage becomes more distinct. Recent research on pneumatic boosters mainly focused on the factors that influence the characteristics of the boosters, some new kinds of pneumatic booster structures were designed, but the efficiency and output flow of these boosters are still not improved sufficiently. In order to improve the output flow of the pneumatic booster, a new kind of booster, expansion energy used （EEU） booster, is proposed. Non-linear differential equations of the pneumatic booster are set up. By using the software MATLAB/Simulink for simulation, the motion characteristics of the pistons, the characteristics of the output flow of the boosters are obtained for analysis of a principle. The principle, which is used to elevate the output flow of the two kinds of boosters, is that the average pressure of the air in the driving chambers of the EEU booster is higher than that of the IPR booster. The simulation and experimental research of the output flow characteristics are done. The simulation and experimental results are in a good accordance. And the simulation and experimental results show that when the air source pressure and the output pressure are set at 0.6 MPa and 0.8 MPa, respectively, with the increase of the terminal pressure of the air in the driving chamber, the output flow of the IPR booster ascends stably. As the terminal pressure of the air in the driving chamber goes up, the output flow of the EEU booster rises, and later it almost remains constant. In addition, with the same terminal pressure, the output flow of the EEU booster is greater than that of the IPR booster, and the difference decreases when the terminal pressure grows. At last, the output pressure is set at 0.8 MPa, under the optimum work state of the EEU booster, the output flow of the two kinds of boosters all declines with the rise of the boosting ratio. Furthermore, the output flow of the EEU booster is higher than that of IPR booster by 95 L/min approximately. The proposed research lays the foundation for optimistic of the EEU booster.
基金Supported by the National Natural Science Foundation of China(51375045)the State Key Laboratory Program of Fluid Power and Mechatronic Systems of China(GZKF-201214)
文摘In order to design a low-cost pneumatic force servo system with large output forces,a scheme of a booster cylinder controlled by high speed solenoid valves is proposed.A nonlinear model of the system is established,in which the hysteresis of high speed solenoid valve is considered.In order to deal with parameter uncertainty and disturbances of noise and friction,a feed-forward control method based on a disturbance observer is proposed.A practical pneumatic force servo system is used to testify the feasibility of the proposed controller.The experimental results show that pneumatic force servo system based on the proposed controller has high force tracking accuracy and quick response.
