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Brain repair for Parkinson's disease:is the answer in the matrix? 被引量:2
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作者 Niamh Moriarty Eilís Dowd 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第7期1187-1188,共2页
Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name,there is still an irrefutable need for a therapy that targets the underlying pathophys... Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name,there is still an irrefutable need for a therapy that targets the underlying pathophysiology of the disease and not solely its symptoms. 展开更多
关键词 brain repair for Parkinson’s disease:is the answer in the matrix
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Urokinase-type plasminogen activator promotes synaptic repair in the ischemic brain 被引量:5
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作者 ariel diaz manuel yepes 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第2期232-233,共2页
The central nervous system has a very high energy requirement. Accord- ingly, despite representing only 2% of the body's mass, the brain uses 20% of the total oxygen consumption. Importantly, because most of this ene... The central nervous system has a very high energy requirement. Accord- ingly, despite representing only 2% of the body's mass, the brain uses 20% of the total oxygen consumption. Importantly, because most of this energy is used to maintain synaptic activity, even a mild decrease in its supply to the brain has deleterious implications for synaptic function. 展开更多
关键词 Urokinase-type plasminogen activator promotes synaptic repair in the ischemic brain AR TSP OGD LRP
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Optimising repetitive transcranial magnetic stimulation for neural circuit repair following traumatic brain injury 被引量:1
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作者 Jennifer Rodger Rachel M.Sherrard 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第3期357-359,共3页
While it is well-known that neuronal activity promotes plasticity and connectivity, the success of activity-based neural rehabilitation programs remains extremely limited in human clinical experience because they cann... While it is well-known that neuronal activity promotes plasticity and connectivity, the success of activity-based neural rehabilitation programs remains extremely limited in human clinical experience because they cannot adequately control neuronal excitability and activity within the injured brain in order to induce repair. However, it is possible to non-invasively modulate brain plasticity using brain stimu- lation techniques such as repetitive transcranial (rTMS) and transcranial direct current stimulation (tDCS) techniques, which show promise for repairing injured neural circuits (Henrich-Noack et al., 2013; Lefaucher et al., 2014). Yet we are far from having full control of these techniques to repair the brain following neurotrauma and need more fundamen- tal research (Ellaway et al., 2014; Lefaucher et al., 2014). In this perspective we discuss the mechanisms by which rTMS may facilitate neurorehabilitation and propose experimental techniques with which magnetic stimulation may be investi- gated in order to optimise its treatment potential. 展开更多
关键词 TMS Optimising repetitive transcranial magnetic stimulation for neural circuit repair following traumatic brain injury
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Repair and regeneration properties of Ginkgo biloba after ischemic brain injury 被引量:1
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作者 Aparna Raghavan Zahoor A.Shah 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第11期1104-1107,共4页
The irretrievable fate of neurons rhetoric for the first half of this dominated the neuroscience century, a position that was fiercely contested and recently debunked by extensive studies carried out in the field of n... The irretrievable fate of neurons rhetoric for the first half of this dominated the neuroscience century, a position that was fiercely contested and recently debunked by extensive studies carried out in the field of neuroregeneration research. The turning point came in the year 1928, when Ramon Y. Cajal's (Lobato, 2008) work suggested that the regenerative capacity of neurons, though limited, could exist beyond their physical be- ing and depended on the environment surrounding them. That the manipulation of the restrictive environment surrounding the neuron could aid the regenerative process was conclusively established by Aguayo and colleagues (Richardson et al., 1980). Since then, various strategies have been employed to target the different phases of regeneration which include: cell-replacement and augmenting endogenous neurogenesis, the use of trophic factors, reversal of the inhibitory cues, and induction of signal- ing pathways that stimulate axon growth and guidance (Horner and Gage. 2000). 展开更多
关键词 NSCs repair and regeneration properties of Ginkgo biloba after ischemic brain injury EGB
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脑出血去骨瓣减压术后择期行颅骨修补的效果
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作者 曾斌华 万辉 王新刚 《中国医学创新》 CAS 2024年第32期1-5,共5页
目的:探讨脑出血去骨瓣减压术后择期行颅骨修补的效果。方法:选取2021年1月—2023年6月南昌大学第四附属医院收治的86例行脑出血去骨瓣减压术并择期行颅骨修补的患者,按照修补时间实施分组处理,对照组43例在去骨瓣减压术后3~6个月实施... 目的:探讨脑出血去骨瓣减压术后择期行颅骨修补的效果。方法:选取2021年1月—2023年6月南昌大学第四附属医院收治的86例行脑出血去骨瓣减压术并择期行颅骨修补的患者,按照修补时间实施分组处理,对照组43例在去骨瓣减压术后3~6个月实施颅骨修补治疗,观察组43例在去骨瓣减压术后≥1个月且<3个月实施颅骨修补治疗。比较两组临床疗效、临床指标、并发症发生率、疼痛程度、颅脑指标、应激指标。结果:观察组总有效率高于对照组(P<0.05);观察组术后6个月NIHSS评分、mRS评分均低于对照组,GOS评分、MMSE评分均高于对照组(P<0.05);观察组并发症发生率低于对照组(P<0.05);观察组术后3、5、7 d头痛VAS评分均低于对照组(P<0.05);观察组术后24 h颅内压异常指数、脑灌注异常指数均低于对照组(P<0.05);观察组术后24 h皮质醇、IL-6、TNF-α均低于对照组(P<0.05)。结论:在脑出血去骨瓣减压术后≥1个月且<3个月实施颅骨修补治疗,可降低机体应激反应,同时改善颅脑指标及预后效果。 展开更多
关键词 脑出血 去骨瓣减压术 颅骨修补 颅脑指标 应激指标
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硬脑膜修复生物膜的大鼠原位脑植入局部神经毒性评价方法
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作者 邵安良 王小蕾 +2 位作者 张勇杰 陈亮 李静莉 《北京生物医学工程》 2024年第5期458-463,共6页
目的采用大鼠原位脑植入模型评价硬脑膜修复生物膜的局部神经毒性,旨在建立脑部原位植入局部神经毒性评价方法。方法选择硬脑膜修复生物膜为研究对象,以上市同类产品为对照品,经大鼠原位脑植入,获取包含颅骨、硬脑膜、植入材料及其周围... 目的采用大鼠原位脑植入模型评价硬脑膜修复生物膜的局部神经毒性,旨在建立脑部原位植入局部神经毒性评价方法。方法选择硬脑膜修复生物膜为研究对象,以上市同类产品为对照品,经大鼠原位脑植入,获取包含颅骨、硬脑膜、植入材料及其周围大脑组织的标本。采用苏木精-伊红(hematoxylin-eosin,HE)染色、Fluoro-Jade C(FJC)特殊染色与胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)免疫荧光考察植入物周围脑组织的局部组织学反应、神经元降解退行性变与星形胶质细胞增生来综合评价植入物的潜在神经毒性风险。结果植入4周、13周、26周后,与对照品相比,供试品的局部组织学反应均为无刺激反应;FJC染色单位面积阳性细胞数量不存在显著性差异(P>0.05),提示供试品的神经元降解程度与对照组相比不存在显著性差异;GFAP染色单位面积阳性细胞数量不存在显著性差异(P>0.05),提示供试品的星形胶质细胞增生程度与对照组相比不存在显著性差异。结论可以采用HE染色、FJC特殊染色与GFAP免疫荧光染色联合评价硬脑膜修复生物膜经大鼠原位脑植入后的局部神经毒性。 展开更多
关键词 硬脑膜修复生物膜 大鼠原位脑植入 局部神经毒性 苏木精-伊红染色 Fluoro-Jade C特殊染色 胶质纤维酸性蛋白免疫荧光染色
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Repair of glutamate-induced excitotoxic neuronal damage mediated by intracerebroventricular transplantation of neural stem cells in adult mice
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作者 马娟 于立坚 +4 位作者 马润娣 张永平 房娟芝 张霄瑜 于廷曦 《Neuroscience Bulletin》 SCIE CAS CSCD 2007年第4期209-214,共6页
Objective To investigate a possibility of repairing damaged brain by intracerebroventricular transplantation of neural stem cells (NSCs) in the adult mice subjected to glutamate-induced excitotoxic injury. Methods M... Objective To investigate a possibility of repairing damaged brain by intracerebroventricular transplantation of neural stem cells (NSCs) in the adult mice subjected to glutamate-induced excitotoxic injury. Methods Mouse NSCs were isolated from the brains of embryos at 15-day postcoitum (dpc). The expression of nestin, a special antigen for NSC, was detected by immunocytochemistry. Immunofluorescence staining was carried out to observe the survival and location of transplanted NSCs. The animals in the MSG+NSCs group received intracerebroventricular transplantation of NSCs (approximately 1.0×10^5 cells) separately on day 1 and day 10 after 10-d MSG exposure (4.0 g/kg per day). The mice in control and MSG groups received intracerebroventricular injection of Dulbecco's minimum essential medium (DMEM) instead of NSCs. On day 11 after the last NSC transplantation, the test of Y-maze discrimination learning was performed, and then the histopathology of the animal brains was studied to analyze the MSG-induced functional and morphological changes of brain and the effects of intracerebroventricular transplantation of NSCs on the brain repair. Results The isolated cells were Nestin-positive. The grafted NSCs in the host brain were region-specifically survived at 10-d post-transplantation. Intracerebroventricular transplantation of NSCs obviously facilitated the brain recovery from glutamate-induced behavioral disturbances and histopathological impairs in adult mice. Conclusion Intracerebroventricular transplantation of NSCs may be feasible in repairing diseased or damaged brain tissue. 展开更多
关键词 brain repair neural stem cells TRANSPLANTATION excitotoxic injury MICE
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功能性水凝胶在创伤性脑损伤组织修复中的作用
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作者 张彤 王妍 +2 位作者 杨春佳 岳庆鲲 吴庆田 《中国组织工程研究》 CAS 北大核心 2025年第28期6110-6117,共8页
背景:目前临床上传统的给药途径(口服或静脉注射)面临难以透过血脑屏障问题,对于开放性重度创伤性脑损伤的临床治疗结果往往低于预期。水凝胶是一类极为亲水的三维网络结构凝胶,在水中迅速溶胀并在此溶胀状态可以保持。目前有部分实验... 背景:目前临床上传统的给药途径(口服或静脉注射)面临难以透过血脑屏障问题,对于开放性重度创伤性脑损伤的临床治疗结果往往低于预期。水凝胶是一类极为亲水的三维网络结构凝胶,在水中迅速溶胀并在此溶胀状态可以保持。目前有部分实验应用可注射性功能水凝胶注射植入损伤部位以达到修复受损脑组织的目的,但这一治疗策略尚未应用于临床。目的:分析功能性水凝胶在创伤性脑损伤后组织修复中的作用,讨论水凝胶通过不同作用方式促进创伤性脑损伤后的神经组织再生,以期为创伤性脑损伤的临床治疗和基础研究提出新的思路。方法:以“hydrogels,functional hydrogel,composite hydrogels,traumatic brain injury,tissue repair,neural regeneration”“功能性水凝胶,创伤性脑损伤,组织修复,神经再生”为关键词在PubMed、Web of Science、中国知网和万方数据库检索2000年8月至2024年3月的相关文献。制定纳入和排除标准,通过阅读文献标题、摘要及全文内容进行筛选,最终纳入60篇相关文献进行综述。结果与结论:①基于分子设计的水凝胶可以模拟神经微结构,促进再生修复,模拟神经血管单元促进血管再生。②基于联合药物治疗原则的水凝胶可以递送内源性神经调控因子,包裹药物促进神经再生。③基于搭载干细胞恢复策略的水凝胶可以作为分子支架递送细胞治疗。④未来研究学者们还需进一步探索神经组织修复相关的功能性水凝胶,为创伤性脑损伤患者的治疗功能重建提供有效策略。 展开更多
关键词 功能性水凝胶 创伤性脑损伤 组织修复 神经再生 药物递送 干细胞搭载 工程化水凝胶
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重型颅脑创伤去骨瓣减压术后4~8周与12周修复颅骨改善转归作用比较
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作者 姜涛 柏建兵 +2 位作者 于泓 王阳 张明 《脑与神经疾病杂志》 CAS 2024年第8期523-528,F0003,共7页
目的比较重型颅脑创伤去骨瓣减压术后4~8 w与12 w修复颅骨对预后转归的改善作用。方法选取2022年1月至2023年1月三二〇一医院收治的重型颅脑创伤102例患者,分为对照组、观察组,每组51例,两组均行去骨瓣减压治疗,观察组于去骨瓣减压后4~8... 目的比较重型颅脑创伤去骨瓣减压术后4~8 w与12 w修复颅骨对预后转归的改善作用。方法选取2022年1月至2023年1月三二〇一医院收治的重型颅脑创伤102例患者,分为对照组、观察组,每组51例,两组均行去骨瓣减压治疗,观察组于去骨瓣减压后4~8w修复颅骨,对照组于去骨瓣减压后12w行颅骨修复。于颅骨修复术前、术后3d、术后1w比较两组脑氧代谢[颈内静脉血氧含量(CjvO_(2))、血氧饱和度(SjvO_(2))、脑氧摄取率(O_(2)ER)]、缺损侧与缺损对侧大脑中动脉(MCA)血流速、神经元特异性烯醇化酶(NSE)、S100蛋白B(S100B)水平变化,于颅骨修复术前、术后3个月、术后6个月评价患者神经功能、认知功能、生活质量,于颅骨修复后6个月评价患者垂体功能状态及预后转归情况。结果术后3d、1w观察组CjvO_(2)、SjvO_(2)、缺损侧与缺损对侧MCA血流速高于对照组,O_(2)ER、NSE、S100B水平低于对照组(P<0.05)。术后3个月、6个月观察组神经功能评分低于对照组,认知功能、生活质量评分高于对照组(P<0.05)。观察组垂体功能减退发生率低于对照组(P>0.05)。观察组预后优良率高于对照组(P<0.05)。结论重型颅脑创伤去骨瓣减压术后4~8 w修复颅脑更有助于改善脑氧代谢、脑动力学,减少神经功能及认知功能风险,促进患者预后转归。 展开更多
关键词 重型颅脑创伤 去骨瓣减压术 颅骨修复 预后转归
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X-射线修复交叉互补蛋白5在脑胶质瘤中的表达及临床意义
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作者 王怡 马宏宁 +4 位作者 刘超奇 董育清 丁娟 王志军 赵薇 《宁夏医科大学学报》 2024年第3期230-235,共6页
目的分析X-射线修复交叉互补蛋白5(XRCC5)在脑胶质瘤(brain glioma,BG)中的表达水平及其与临床病理特征和预后的关系。方法利用癌症基因图谱(TCGA)数据库的RNA测序数据分析XRCC5在636例BG[468例低分级脑胶质瘤(LGG),168例多形性胶质母... 目的分析X-射线修复交叉互补蛋白5(XRCC5)在脑胶质瘤(brain glioma,BG)中的表达水平及其与临床病理特征和预后的关系。方法利用癌症基因图谱(TCGA)数据库的RNA测序数据分析XRCC5在636例BG[468例低分级脑胶质瘤(LGG),168例多形性胶质母细胞瘤(GBM)]与正常脑组织的表达差异,比较XRCC5表达水平与年龄、性别、病理分级、生存期以及肿瘤增殖相关抗原67(MKI67)表达水平的相关性。对BG组织芯片(47例LGG、75例GBM及3例正常脑组织)进行XRCC5免疫组化染色,进一步验证XRCC5表达水平与BG病理分级的关系。结果TCGA分析结果显示,XRCC5在BG组织中的表达水平高于正常脑组织(P<0.001),在GBM组的表达水平高于LGG组(P<0.001);XRCC5表达水平与BG病理分级呈正相关(P<0.001),与MKI67表达水平呈正相关(P<0.001);XRCC5高表达组生存期长于低表达组(P<0.001);不同性别、不同年龄段XRCC5表达水平差异均无统计学意义(P均>0.05);XRCC5的免疫组化染色结果显示,肿瘤组织中XRCC5表达水平高于正常人脑组织(P<0.05)。结论XRCC5在BG组织中升高,且与恶性肿瘤的生物标记物MKI67呈正相关。XRCC5表达越高,患者的预后越好,生存期越长。 展开更多
关键词 脑胶质瘤 TCGA数据库 X-射线修复交叉互补蛋白5 肿瘤增殖相关抗原67 生存期分析
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格隆溴铵对老年患者腹腔镜腹股沟疝修补术的术后认知功能障碍的影响
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作者 冯闰 冯艳坤 +2 位作者 陈培培 张力 陈治军 《中国内镜杂志》 2024年第10期9-15,共7页
目的探讨格隆溴铵术前用药对老年患者腹腔镜腹股沟疝修补术的术后认知功能障碍(POCD)的影响。方法选取择期行喉罩全身麻醉腹腔镜腹股沟疝修补手术的老年患者74例,随机分为对照组(C组,25例)、低剂量格隆溴铵组(0.2 mg,L组,24例)和中剂量... 目的探讨格隆溴铵术前用药对老年患者腹腔镜腹股沟疝修补术的术后认知功能障碍(POCD)的影响。方法选取择期行喉罩全身麻醉腹腔镜腹股沟疝修补手术的老年患者74例,随机分为对照组(C组,25例)、低剂量格隆溴铵组(0.2 mg,L组,24例)和中剂量格隆溴铵组(0.4 mg,M组,25例)。于术前1 d和手术后3 d分别采集患者血液样本,采用ELISA法检测血清炎症因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]和脑功能相关因子[5-羟色胺(5-HT)和脑源性神经营养因子(BDNF)]含量,分析术前和术后血清5-HT、炎症因子和BDNF的变化。使用蒙特利尔认知评估量表(MoCA)对术前1 d和手术后3 d患者的认知功能进行评估,并分析手术前后患者认知功能的变化。记录置入喉罩前或拔除喉罩后气道分泌物评分、心律失常、口干和排尿困难的发生情况。结果3组患者POCD发生率比较,差异无统计学意义(P>0.05);术后3 d,L组血清5-HT和BDNF水平明显高于C组,L组血清BDNF水平明显高于M组,差异均有统计学意义(P<0.05);术后3 d,C组血清IL-1β、IL-6和TNF-α水平较术前1 d明显升高,差异均有统计学意义(P<0.05),M组血清IL-6和TNF-α水平较术前1 d明显升高,差异均有统计学意义(P<0.05),L组血清IL-1β、IL-6和TNF-α水平与术前1 d比较,差异均无统计学意义(P>0.05),3组患者术后3 d血清IL-1β、IL-6和TNF-α水平组间比较,差异均无统计学意义(P>0.05);与C组比较,L组和M组术后气道分泌物明显减少,差异均有统计学意义(P<0.05),但L组与M组比较,差异无统计学意义(P>0.05);M组不良反应发生率(口干和排尿困难)较L组和C组明显增加,差异均有统计学意义(P<0.05)。结论低剂量(0.2 mg)格隆溴铵更适合作为老年患者腹腔镜腹股沟疝修补术的术前用药,增加剂量可能增加POCD和不良反应的风险。 展开更多
关键词 格隆溴铵 腹腔镜腹股沟疝修补术 炎症因子 脑源性神经营养因子(BDNF) 术后认知功能障碍(POCD) 全身麻醉 术前用药
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小胶质细胞在卒中中的作用
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作者 Anna M Planas 唐颖馨(编译) 《神经损伤与功能重建》 2024年第2期F0003-F0003,共1页
小胶质细胞在缺血后的炎症反应和受损组织的清除中扮演关键角色,它们对缺血引起的干扰反应迅速,致力于恢复失去的稳态。然而,被修改的环境,包括离子失衡、关键的神经元-小胶质细胞相互作用的中断、去极化传播以及来自坏死神经元的危险... 小胶质细胞在缺血后的炎症反应和受损组织的清除中扮演关键角色,它们对缺血引起的干扰反应迅速,致力于恢复失去的稳态。然而,被修改的环境,包括离子失衡、关键的神经元-小胶质细胞相互作用的中断、去极化传播以及来自坏死神经元的危险信号的产生,诱导了小胶质细胞的形态和表型转变。这导致它们表现为促炎表型并增加吞噬活动。从缺血后的第3天开始,巨噬细胞渗透到坏死组织核心,而小胶质细胞则在病灶周边聚集。此外,炎症促使代谢转向有利于糖酵解、戊糖磷酸途径和脂质合成。这些转变与吞噬脂质的摄入相结合,促进了脂滴生成、合成代谢,并使小胶质细胞增殖。增殖的小胶质细胞释放营养因子,有助于神经保护和修复。然而,一些小胶质细胞持续积累脂质,并转变为功能失调且可能有害的泡沫细胞。研究还表明,有些小胶质细胞要么清除凋亡细胞能力的受损,要么消除突触、活神经元或内皮细胞。然而,阐明被吞噬细胞的生存能力、局部环境特征、组织损伤程度和时间序列将是至关重要的。缺血为小胶质细胞提供了丰富多样的、依赖于区域和损伤的刺激,随着时间演变导致出现不同的小胶质细胞表型,包括表现为促炎性或功能失调特征的细胞,以及显示出促进修复功能的细胞。准确分析小胶质细胞表型,以及更精确地了解相关的缺血后组织条件,是对卒中进行针对性干预的必要步骤。 展开更多
关键词 脑缺血 危险信号 异质性 炎症 脂质 吞噬作用 修复
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早期颅骨修补术在脑外伤治疗中的临床疗效研究
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作者 黄普鑫 张鲁林 +2 位作者 韩伟 王文波 崔延芳 《科技与健康》 2024年第9期41-44,共4页
探讨在脑外伤治疗中早期颅骨修补术的临床效果。选取2017年10月—2021年10月兰州市西固区人民医院收治的56例脑外伤患者为研究对象,采用随机数字表法将其分成对照组(n=28,脑外伤手术后3个月后进行颅骨修补术)与研究组(n=28,脑外伤手术后... 探讨在脑外伤治疗中早期颅骨修补术的临床效果。选取2017年10月—2021年10月兰州市西固区人民医院收治的56例脑外伤患者为研究对象,采用随机数字表法将其分成对照组(n=28,脑外伤手术后3个月后进行颅骨修补术)与研究组(n=28,脑外伤手术后3个月内进行早期颅骨修补术),对比两组患者治疗效果。结果显示,研究组痊愈患者数量多于对照组,重度残疾患者数量少于对照组(P<0.05);治疗后,研究组患者NIHSS评分低于对照组,MMSE评分高于对照组(P<0.05);治疗后,研究组患者健侧与患侧大脑中动脉平均血流速度均大于对照组(P<0.05);研究组患者并发症总发生率低于对照组(P<0.05)。研究发现,早期颅骨修补术在脑外伤治疗中的临床疗效明显,可降低患者残疾率,改善患者神经功能缺损情况,并发症发生率较低,值得临床推广应用。 展开更多
关键词 脑外伤 早期颅骨修补术 动脉平均血流速 神经功能 并发症
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Combined cell-based therapy strategies for the treatment of Parkinson's disease:focus on mesenchymal stromal cells 被引量:3
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作者 Jannette Rodríguez-Pallares María García-Garrote +1 位作者 Juan A.Parga JoséLuis Labandeira-García 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第3期478-484,共7页
Parkinson’s disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra.Levodopa is an effective and well-tolerated dopamin... Parkinson’s disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra.Levodopa is an effective and well-tolerated dopamine replacement agent.However,levodopa provides only symptomatic improvements,without affecting the underlying pathology,and is associated with side effects after long-term use.Cell-based replacement is a promising strategy that offers the possibility to replace lost neurons in Parkinson’s disease treatment.Clinical studies of transplantation of human fetal ventral mesencephalic tissue have provided evidence that the grafted dopaminergic neurons can reinnervate the striatum,release dopamine,integrate into the host neural circuits,and improve motor functions.One of the limiting factors for cell therapy in Parkinson’s disease is the low survival rate of grafted dopaminergic cells.Different factors could cause cell death of dopaminergic neurons after grafting such as mechanical trauma,growth factor deprivation,hypoxia,and neuroinflammation.Neurotrophic factors play an essential role in the survival of grafted cells.However,direct,timely,and controllable delivery of neurotrophic factors into the brain faces important limitations.Different types of cells secrete neurotrophic factors constitutively and co-transplantation of these cells with dopaminergic neurons represents a feasible strategy to increase neuronal survival.In this review,we provide a general overview of the pioneering studies on cell transplantation developed in patients and animal models of Parkinson’s disease,with a focus on neurotrophic factor-secreting cells,with a particular interest in mesenchymal stromal cells;that co-implanted with dopaminergic neurons would serve as a strategy to increase cell survival and improve graft outcomes. 展开更多
关键词 brain repair cell replacement co-grafts dopaminergic neurons fetal ventral mesencephalic tissue mesenchymal stem cells neural grafting neural transplantation NEUROBLASTS neurotrophic factors
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Repair of abnormal perfusion foci in idiopathic epilepsy patients under long-term antiepileptic treatment 被引量:7
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作者 Weimin Wang Siyu Zhao Yaqing Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第2期155-160,共6页
Epileptic seizure control and the disappearance of epileptJform discharge are not indicative of the absence of abnormal perfusion foci. Perfusion abnormalities are a major cause of epileptic discharge, and the existen... Epileptic seizure control and the disappearance of epileptJform discharge are not indicative of the absence of abnormal perfusion foci. Perfusion abnormalities are a major cause of epileptic discharge, and the existence of abnormal perfusion loci implies possible relapse. Very little is known about perfusion abnormality repair in epilepsy. The present study selected 43 cases of idiopathic epilepsy under antiepileptic drug control for an average of 24 months. Comparisons between interictal single-photon emission CT (SPECT) images and long-term electroencephalogram (EEG) pre- and post-treatment showed that cases of normal SPECT increased by 48% (12/25) following treatment, with a total number of 15 reduced loci (,36%, 15/41 ). Perfusion foci, Le., region of interest, were altered following treatment. These changes included: normal to abnormal in 3 cases (7%, 3/43; 2 hyperperfusion and 1 hypoperfusion); abnormal to normal in 14 cases (32%, 14/43; 10 pre-treatment hypopeffusion and 4 hyperperfusion); abnormal to abnormal in 7 cases (16%, 7/43; hyperperfusion to hypoperfusion in 5 cases, hypoperfusion to hyperpeffusion in 2 cases). Long-term EEG revealed in an increase in the number of normal cases by 20 (40%, 20/39), and there were 25 fewer cases with epileptiform discharges (66%, 25/38). These findings demonstrate that long-term control of anti-epileptic drugs partially repaired cerebral perfusion abnormalities and reduced epileptiform discharges in idiopathic epilepsy. 展开更多
关键词 abnormal perfusion focus brain damage idiopathic epilepsy neural regeneration region of interest repair single-photon emission computed tomography
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Electroacupuncture at Baihui (DU20) acupoint upregulates mRNA expression of NeuroD molecules in the brains of newborn rats suffering in utero fetal distress
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作者 Lu Chen Yan Liu +3 位作者 Qiao-mei Lin Lan Xue Wei Wang Jian-wen Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第4期604-609,共6页
Neuro D plays a key regulatory effect on differentiation of neural stem cells into mature neurons in the brain.Thus,we assumed that electroacupuncture at Baihui(DU20) acupoint in newborn rats exposed to in utero fet... Neuro D plays a key regulatory effect on differentiation of neural stem cells into mature neurons in the brain.Thus,we assumed that electroacupuncture at Baihui(DU20) acupoint in newborn rats exposed to in utero fetal distress would influence expression of Neuro D.Electroacupuncture at Baihui was performed for 20 minutes on 3-day-old(Day 3) newborn Sprague-Dawley rats exposed to in utero fetal distress;electroacupuncture parameters consisted of sparse and dense waves at a frequency of 2–10 Hz.Real-time fluorescent quantitative PCR results demonstrated that m RNA expression of Neuro D,a molecule that indicates Neuro D,increased with prolonged time in brains of newborn rats,and peaked on Day 22.The level of m RNA expression was similar between Day 16 and Day 35.These findings suggest that electro acupuncture at Baihui acupoint could effectively increase m RNA expression of molecules involved in Neuro D in the brains of newborn rats exposed to in utero fetal distress. 展开更多
关键词 nerve regeneration brain injury in utero fetal distress hypoxic-ischemic brain injury electroacupuncture real-time fluorescent quantitative PCR Neuro D nerve repair Baihui(DU20) acupoint non-acupoint neural regeneration
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脑脊液途径给药神经修复治疗的中国专家共识(2022版) 被引量:2
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作者 广东省医师协会神经修复专业医师分会 北京医师协会神经修复学专家委员会 +15 位作者 脑脊液途径给药神经修复治疗全国协作组 陈琳 张志强 郭俭 何超 黄方杰 黄红云 焦红亮 刘晶 唐洲平 王闻雅 王莹 向光红 杨波 张萍 赵建华 《中国组织工程研究》 CAS 北大核心 2023年第17期2780-2788,共9页
背景:目前神经修复药物的开发和给药方式仍然具有挑战性,加上神经系统受到血脑屏障和血脑脊液屏障的高度保护,限制了大多数药物的临床治疗效果。通过脑脊液途径直接给药至神经系统是重要的临床治疗策略,但目前缺少统一的临床应用标准。... 背景:目前神经修复药物的开发和给药方式仍然具有挑战性,加上神经系统受到血脑屏障和血脑脊液屏障的高度保护,限制了大多数药物的临床治疗效果。通过脑脊液途径直接给药至神经系统是重要的临床治疗策略,但目前缺少统一的临床应用标准。目的:对目前脑脊液途径给药的现状以及临床应用的适应证、具体方法和注意事项等进行说明,以期推广应用并提高临床疗效。方法:通过组织全国多个学科的有关专家研讨编写并最终完成该专家共识。结果与结论:脑脊液途径给药进行神经修复治疗具有较广泛的临床适应证和应用前景,但应用过程中仍需注意脑脊液途径给药的安全性、效率、给药复合配方组合、最大耐受剂量和充分的知情同意等。 展开更多
关键词 脑脊液途径 神经修复 血脑屏障 神经营养 神经系统疾病
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Expression of hypoxia-inducible factor 1 alpha and oligodendrocyte lineage gene-1 in cultured brain slices after oxygen-glucose deprivation 被引量:1
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作者 Hong Cui Weijuan Han +1 位作者 Lijun Yang Yanzhong Chang 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第4期328-337,共10页
Oligodendrocyte lineage gene-1 expressed in oligodendrocytes may trigger the repair of neuronal myelin impairment, and play a crucial role in myelin repair. Hypoxia-inducible factor la, a transcription factor, is of g... Oligodendrocyte lineage gene-1 expressed in oligodendrocytes may trigger the repair of neuronal myelin impairment, and play a crucial role in myelin repair. Hypoxia-inducible factor la, a transcription factor, is of great significance in premature infants with hypoxic-ischemic brain damage There is little evidence of direct regulatory effects of hypoxia-inducible factor le on oligodendrocyte lineage gene-l. In this study, brain slices of Sprague-Dawley rats were cultured and subjected to oxygen-glucose deprivation. Then, slices were transfected with hypoxia-inducible factor la or oligodendrocyte lineage gene-1. The expression levels of hypoxia-inducible factor la and oligodendrocyte lineage gene-1 were significantly up-regulated in rat brains prior to transfection, as detected by immunohistochemical staining. Eight hours after transfection of slices with hypoxia-inducible factor la, oligodendrocyte lineage gene-1 expression was upregulated, and reached a peak 24 hours after transfection. Oligodendrocyte lineage gene-1 transfection induced no significant differences in hypoxia-inducible factor la levels in rat brain tissues with oxygen-glucose deprivation. These experimental findings indicate that hypoxia-inducible factor la can regulate oligodendrocyte lineage gene-1 expression in hypoxic brain tissue, thus repairing the neural impairment. 展开更多
关键词 neural regeneration brain injury biological factors hypoxia-inducible factor la oligodendrocyte lineage gene-1 oxygen-glucose deprivation brain slice culture immunohistochemistry OLIGODENDROCYTE myelin repair premature delivery rat grants-supported paper photographs-containing paper neuroregeneration
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不同时期颅骨缺损修补术对脑外伤开颅术后并发脑积水患者预后的改善分析 被引量:1
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作者 赵晖 《系统医学》 2023年第11期150-154,共5页
目的 临床分析不同时期颅骨缺损修补术对脑外伤开颅术后并发脑积水患者预后的改善效果。方法选择2021年9月-2022年9月淄博市中心医院神经外科收治的70例脑外伤开颅术后颅骨缺损并发脑积水患者,通过随机数表法分为研究组35例、对照组35例... 目的 临床分析不同时期颅骨缺损修补术对脑外伤开颅术后并发脑积水患者预后的改善效果。方法选择2021年9月-2022年9月淄博市中心医院神经外科收治的70例脑外伤开颅术后颅骨缺损并发脑积水患者,通过随机数表法分为研究组35例、对照组35例,对照组于术后3~6个月行颅骨缺损修补术,研究组于术后3个月为行颅骨缺损修补术,对比两组的治疗疗效。结果 研究组疗效优于对照组,差异有统计学意义(P<0.05)。术前,两组颅内压水平比较,差异无统计学意义(P>0.05)。术后,两组颅内压水平均下降,且研究组低于对照组,差异有统计学意义(P<0.05)。术前,两组美国国立卫生院神经功能缺损评分(National Institutes of Health Stroke Scale, NIHSS)比较,差异无统计学意义(P>0.05);术后,两组NIHSS评分均较术前低,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率低于对照组(2.86%vs 25.71%),差异有统计学意义(χ^(2)=7.467,P=0.017)。结论 针对颅骨缺损,在术后3个月内早期进行颅骨缺损修补术,可加速其神经损伤的修复,提高疗效,并具有较好的安全性,是一项值得深入探讨的课题。 展开更多
关键词 不同时期 颅骨缺损修补术 脑外伤开颅术后并发脑积水
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深低温停循环和顺行脑灌注在新生儿主动脉缩窄矫治术中的应用效果对比
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作者 黄晶晶 陈家蓉 +3 位作者 张赋 农明滩 李纯培 陆燕燕 《广西医学》 CAS 2023年第23期2825-2830,2841,共7页
目的 比较深低温停循环(DHCA)和顺行脑灌注(ACP)两种灌注方法在新生儿主动脉缩窄矫治术中的有效性和安全性。方法 纳入40例合并有血流动力学异常的心内畸形的主动脉缩窄新生儿作为研究对象,将其随机分为DHCA组(n=20)和ACP组(n=20),分别... 目的 比较深低温停循环(DHCA)和顺行脑灌注(ACP)两种灌注方法在新生儿主动脉缩窄矫治术中的有效性和安全性。方法 纳入40例合并有血流动力学异常的心内畸形的主动脉缩窄新生儿作为研究对象,将其随机分为DHCA组(n=20)和ACP组(n=20),分别应用DHCA和ACP技术进行主动脉缩窄矫治术。比较两组患儿围术期(术前、术后第1天、术后第2天)的血清肌酐水平,以及术后急性肾损伤(AKI)和其他术后并发症的发生情况,对比两组的停循环或者脑灌注时间、主动脉阻断时间、体外循环持续时间、停循环期或脑灌注期间脑组织和肾脏组织血氧饱和度、术后AKI少尿期放置腹膜透析时间、术后呼吸机使用时间、心脏ICU(CICU)停留时间及总住院时间。结果 术后住院期间复查超声心动图提示40例患儿心内畸形矫治满意,且无死亡病例。两组患儿血清肌酐水平有随时间延长而升高的趋势,而ACP组术后第1天及第2天的血肌酐水平低于DHCA组(P<0.05)。所有患儿术后均出现AKI,但未发生神经系统损伤和不可逆性肾功能衰竭,两组其他术后并发症总发生率差异无统计学意义(P>0.05)。两组停循环或者脑灌注时间差异无统计学意义(P>0.05),而ACP组脑组织及肾脏组织血氧饱和度优于DHCA组,主动脉阻断时间、体外循环总时间、呼吸机使用时间、CICU停留时间、术后AKI少尿期放置腹膜透析时间及总住院时间短于DHCA组(P<0.05)。结论 对于合并有血流动力学异常的心内畸形的主动脉缩窄新生儿,相对于DHCA,ACP应用于主动脉缩窄矫治术可发挥更优的脑部和肾脏保护作用,可能更加安全、有效。 展开更多
关键词 主动脉缩窄 心内畸形 深低温停循环 顺行脑灌注 矫治术 灌注策略 脑保护作用 急性肾损伤 新生儿
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