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Gamma-ray Emission from the γ-ray-loud BL Lac Objects
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作者 Guang-ZhongXie Ben-ZhongDai +1 位作者 En-WeiLiang Zhao-HuaXie 《Chinese Journal of Astronomy and Astrophysics》 CSCD 北大核心 2001年第6期494-500,共7页
Using the HST observation data of BL Lac objects by Urry et al. and γ-ray observation data, we find that there is a correlation between Fγ and Fonuclei forγ-ray-loud BL Lac objects (correlation coefficients: 7γ=0.... Using the HST observation data of BL Lac objects by Urry et al. and γ-ray observation data, we find that there is a correlation between Fγ and Fonuclei forγ-ray-loud BL Lac objects (correlation coefficients: 7γ=0.63,p = 4.0 × 10-2), but no correlation between Fγ and Fohost, where Fonuclei and Fohost are the fluxes of nuclei and host galaxy in V-band. For 19γ-ray-loud BL Lac objects with observed spectral index in multi-wavebands, the spectral index correlations between any two bands are as follow: (1) there is a strong correlation between aγ and aK for 15 BL Lac objects(γ = 0.84,p = 3.11 × 10-4); (2) the correlation between aγ and ao for 12 BL Lac objects isγ = 0.82, p = 1.5 × 10-3; (3) there is no correlation between a7 and ax for 16 BL Lac objects. The results, together with characteristic double-humped shape of their SEDs, show that the synchrotron self-Compton mechanism might be a main mechanism for theγ-ray emission of the BL Lac objects. The electrons emitting JR and optical radiation via synchrotron are also responsible for upscattering these photons toγ-rays, and a variability in IR-optical regime should be accompanied by a change in theγ-rays. 展开更多
关键词 gamma rays - BL Lacertae objects: general
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A Study of the Energy Sources of Herbig-Haro Objects
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作者 Jing-Wen Yue-FangWu 《Chinese Journal of Astronomy and Astrophysics》 CSCD 北大核心 2002年第1期33-42,共10页
We make a statistical study of the energy sources of high-velocity phenomena, Herbig-Haro (HH) objects. IRAS counterparts of HH objects are identified. Their colors, brightness, geometric relation to the RH objects an... We make a statistical study of the energy sources of high-velocity phenomena, Herbig-Haro (HH) objects. IRAS counterparts of HH objects are identified. Their colors, brightness, geometric relation to the RH objects and SED are analysed. The sources are found to be concentrated in a band-shaped region in the IRAS color-color diagram. We suggest an explanation of thick surrounding material for this distribution. We propose a new method for identifying the energy sources based on color arid brightness. This method is applied to more than 200 HR objects whose energy sources are still unknown. Finally, a group of very young stellar object candidates which have similar properties to the RH energy sources is picked out. Their large-scale distribution is discussed. 展开更多
关键词 star: formation - ISM: Herbig-Haro objects - stars: pre-main- sequence
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Discovery of a variable broad absorption line in the BL Lac object PKS B0138-097 被引量:1
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作者 Shao-Hua Zhang Hui-Yuan Wang +2 位作者 Hong-Yan Zhou Ting-Gui Wang Peng Jiang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2011年第10期1163-1170,共8页
We report the discovery of a broad absorption line (BAL) of - 10^4 km s^-1 in width in the previously known BL Lac object PKS 0138-097, which we tentatively identified as an Mg II BAL. This is the first detection of... We report the discovery of a broad absorption line (BAL) of - 10^4 km s^-1 in width in the previously known BL Lac object PKS 0138-097, which we tentatively identified as an Mg II BAL. This is the first detection of a BAL, which is sometimes seen in powerful quasars with high accretion rates, in a BL Lac object. The BAL was clearly detected in its spectra spanning two epochs at a high luminosity state taken in the Sloan Digital Sky Survey (SDSS), while it disappeared in three SDSS spectra taken at a low luminosity state. The BAL and its variability pattern were also found in its historical multi-epoch spectra in the literature, but have been overlooked previously. In its high resolution radio maps, PKS 0138-097 shows a core plus a one- sided parsec-scale jet. The BAL variability can be interpreted as follows: The optical emission is dominated by the core in a high state and by the jet in a low state and the BAL material is located between the core and jet so that the BAL appears only when the core is shining. Our discovery suggests that outflows may also be produced in active galactic nuclei at a low accreting state. 展开更多
关键词 GALAXIES active -- galaxies absorption lines -- BL Lacertae objects individual (PKS 0138-097)
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Properties of BL Lac Objects with Redshift ≤ 0.2 被引量:1
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作者 Ben-ZhongDai Guang-ZhongXie 《Chinese Journal of Astronomy and Astrophysics》 CSCD 北大核心 2002年第1期8-16,共9页
We present a large sample which includes 82 BL Lac objects with red- shifts below 0.2 from recent literature. We find strong correlations in both flux and luminosity between the radio (5 GHz) and optical bands (5500 A... We present a large sample which includes 82 BL Lac objects with red- shifts below 0.2 from recent literature. We find strong correlations in both flux and luminosity between the radio (5 GHz) and optical bands (5500 A). The correlations in other bands are very weak. Five TeV BL Lacs and two suspect sources are found to have similar properties as high- frequency- peaked BL Lacs (HBLs). Our results suggest that both the radio and optical emissions are from the same radiation mech- anism in the SSC model. The TeV BL Lac candidates should be HBLs or HBL-like objects with small redshifts. 展开更多
关键词 galaxies: active - BL Lacertae objects: general -gamma-ray: observations - radiation mechanisms: non-thermal
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The BL Lac Object PKS 0537-441: A Lens or Being Lensed?
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作者 Jochen Heidt Klaus Jger +3 位作者 Kari Nilsson Ulrich Hopp Josef W. Fried Eckhard Sutorius 《天文研究与技术》 CSCD 北大核心 2003年第S1期117-120,共4页
We present and discuss deep high resolution images taken with the ESO NTT as well as spectra taken with the ESO VLT in the field of the BL Lac object PKS 0537 441. We could neither detect the host galaxy nor a galaxy ... We present and discuss deep high resolution images taken with the ESO NTT as well as spectra taken with the ESO VLT in the field of the BL Lac object PKS 0537 441. We could neither detect the host galaxy nor a galaxy along the line of sight to the BL Lac as claimed from previous observations. We found 4 nearby companion galaxies which could be a splitted and magnified image of a distant background galaxy. Our VLT spectra, however, rule out this possibility. All 4 companions have similar redshifts as the BL Lac and may (at least in part) trigger the enormous activity in this source. PKS 0537 441 might be located in a galaxy cluster as rich as Abell 1. Alternatively, the BL Lac could also be located in the outskirts of a galaxy cluster or even be projected on a large scale structure as indicated by spectra of 30 galaxies in the field. Either lensing hypothesis (lens or being lensed) is considerably weakened by our observations. 展开更多
关键词 PKS A Lens or Being Lensed The BL Lac object PKS 0537-441
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MODS: A Novel Metaheuristic of Deterministic Swapping for the Multi-Objective Optimization of Combinatorials Problems
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作者 Elias David Nifio Ruiz Carlos Julio Ardila Hemandez +2 位作者 Daladier Jabba Molinares Agustin Barrios Sarmiento Yezid Donoso Meisel 《Computer Technology and Application》 2011年第4期280-292,共13页
This paper states a new metaheuristic based on Deterministic Finite Automata (DFA) for the multi - objective optimization of combinatorial problems. First, a new DFA named Multi - Objective Deterministic Finite Auto... This paper states a new metaheuristic based on Deterministic Finite Automata (DFA) for the multi - objective optimization of combinatorial problems. First, a new DFA named Multi - Objective Deterministic Finite Automata (MDFA) is defined. MDFA allows the representation of the feasible solutions space of combinatorial problems. Second, it is defined and implemented a metaheuritic based on MDFA theory. It is named Metaheuristic of Deterministic Swapping (MODS). MODS is a local search strategy that works using a MDFA. Due to this, MODS never take into account unfeasible solutions. Hence, it is not necessary to verify the problem constraints for a new solution found. Lastly, MODS is tested using well know instances of the Bi-Objective Traveling Salesman Problem (TSP) from TSPLIB. Its results were compared with eight Ant Colony inspired algorithms and two Genetic algorithms taken from the specialized literature. The comparison was made using metrics such as Spacing, Generational Distance, Inverse Generational Distance and No-Dominated Generation Vectors. In every case, the MODS results on the metrics were always better and in some of those cases, the superiority was 100%. 展开更多
关键词 METAHEURISTIC deterministic finite automata combinatorial problem multi - objective optimization metrics.
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A synchrotron self-Compton scenario for the very high energy γ-ray emission of the intermediate BL Lacertae object W Comae
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作者 Jin Zhang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2009年第7期777-782,共6页
W Comae has significant variability in multi-wavelengthes, from radio to gamma-ray bands. A bright outburst in optical and X-ray bands was observed in 1998, and most recently, a strong TeV flare was detected by VERITA... W Comae has significant variability in multi-wavelengthes, from radio to gamma-ray bands. A bright outburst in optical and X-ray bands was observed in 1998, and most recently, a strong TeV flare was detected by VERITAS in 2008. It is the first TeV intermediate-frequency-peaked BL Lacertae source. I find that both the broadband spectral energy distributions (SEDs) which were quasi-simultaneously obtained during the TeV flare and during the optical/X-ray outburst are well fit by using a single-zone synchrotron + synchrotron-self-Compton model. The satisfactory fitting requires a large beaming factor, i.e., δ- 25 and δ- 20 for the TeV flare and the optical/X-ray outburst, respectively, suggesting that both the optical/X-ray outburst and the TeV flare are from a relativistic jet. The size of the emission region of the TeV flare is three times larger than that of the optical/X-ray outburst, and the strength of the magnetic field for the TeV flare is - 14 times smaller than that of the X-ray/optical outburst, likely indicating that the region of the TeV flare is more distant from the core than that of the X-ray/optical outburst. The inverse Compton component of the TeV flare peaks around 1.3 GeV, but it is around 20 MeV for the X-ray/optical outburst, lower than that for the TeV flare by two orders of magnitude. The model predicts that the optical/X-ray outburst might be accompanied by a strong MeV/GeV emission, but the TeV flare may be not associated with the X-ray/optical outburst. The GeV emission is critical for characterizing the SEDs of the optical/X-ray outburst and the TeV flare. The predicted GeV flux is above the sensitivity of Fermi/LAT, and it could be verified with the observations by Fermi/LAT in the near future. 展开更多
关键词 BL Lacertae objects individual: W Comae - gamma-rays observations - gamma-rays theory - radiation mechanisms non-thermal
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RE Production Base Will Be Built in Baotou During 2006-2010
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《China Rare Earth Information》 2005年第11期3-3,共1页
关键词 2010 RE Production Base Will Be built in Baotou During 2006-2010 BE
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Observation of Complex Organic Molecules Containing Peptide-like Bonds Toward Hot Core G358.93-0.03 MM1
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作者 Arijit Manna Sabyasachi Pal 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第7期181-189,共9页
In star formation regions,the complex organic molecules(COMs)that contain peptide bonds(-NH-C(=O)-)play a major role in the metabolic process because-NH-C(=O)-is connected to amino acids(R-CHNH_2-COOH).Over the past f... In star formation regions,the complex organic molecules(COMs)that contain peptide bonds(-NH-C(=O)-)play a major role in the metabolic process because-NH-C(=O)-is connected to amino acids(R-CHNH_2-COOH).Over the past few decades,many COMs containing peptide-like bonds have been detected in hot molecular cores(HMCs),hot corinos,and cold molecular clouds,however,their prebiotic chemistry is poorly understood.We present the first detection of the rotational emission lines of formamide(NH_2CHO)and isocyanic acid(HNCO),which contain peptide-like bonds toward the chemically rich HMC G358.93-0.03 MM1,using high-resolution and high-sensitivity Atacama Large Millimeter/submillimeter Array bands 6 and 7.We estimate that the column densities of NH_2CHO and HNCO toward G358.93-0.03 MM1 are(2.80±0.29)×10~(15)cm~(-2)and(1.80±0.42)×10~(16)cm~(-2)with excitation temperatures of 165±21 K and 170±32 K,respectively.The fractional abundances of NH_2CHO and HNCO toward G358.93-0.03 MM1 are(9.03±1.44)×10~(-10)and(5.80±2.09)×10^(-9).We compare the estimated abundances of NH_2CHO and HNCO with the existing threephase warm-up chemical model abundance values and notice that the observed and modeled abundances are very close.We conclude that NH_2CHO is produced by the reaction of NH_2and H_2CO in the gas phase toward G358.93-0.03 MM1.Likewise,HNCO is produced on the surface of grains by the reaction of NH and CO toward G358.93-0.03 MM1.We also find that NH_2CHO and HNCO are chemically linked toward G358.93-0.03 MM1. 展开更多
关键词 ISM individual objects(G358.93-0.03)-ISM abundances-ISM kinematics and dynamics-stars formation-astrochemistry
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Study of Complex Nitrogen and Oxygen-bearing Molecules toward the High-mass Protostar IRAS 18089–1732
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作者 Arijit Manna Sabyasachi Pal +1 位作者 Tapas Baug Sougata Mondal 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第6期81-93,共13页
The observation of oxygen(O)-and nitrogen(N)-bearing molecules gives an idea about the complex prebiotic chemistry in the interstellar medium.Recent millimeter and submillimeter wavelength observations have shown the ... The observation of oxygen(O)-and nitrogen(N)-bearing molecules gives an idea about the complex prebiotic chemistry in the interstellar medium.Recent millimeter and submillimeter wavelength observations have shown the presence of complex O-and N-bearing molecules in the star formation regions.So,the investigation of those molecules is crucial to understanding the chemical complexity in the star-forming regions.In this article,we present the identification of the rotational emission lines of N-bearing molecules ethyl cyanide(C_(2)H_(5)CN)and cyanoacetylene(HC_(3)N),and O-bearing molecule methyl formate(CH_(3)OCHO)toward high-mass protostar IRAS18089–1732 using the Atacama Compact Array.We also detected the emission lines of both the N-and O-bearing molecule formamide(NH_(2)CHO)in the envelope of IRAS 18089–1732.We have detected the v=0 and 1 state rotational emission lines of CH_(3)OCHO.We also detected the two vibrationally excited states of HC_(3)N(v7=1 and v7=2).The estimated fractional abundances of C_(2)H_(5)CN,HC_(3)N(v7=1),HC_(3)N(v7=2),and NH_(2)CHO toward IRAS 18089–1732 are(1.40±0.5)×10^(-10),(7.5±0.7)×10^(-11),(3.1±0.4)×10^(-11),and(6.25±0.82)×10^(-11)respectively.Similarly,the estimated fractional abundances of CH_(3)OCHO(v=0)and CH_(3)OCHO(v=1)are(1.90±0.9)×10^(-9)and(8.90±0.8)×10^(-10),respectively.We also created the integrated emission maps of the detected molecules,and the observed molecules may have originated from the extended envelope of the protostar.We show that C_(2)H_(5)CNand HC_(3)N are most probably formed via the subsequential hydrogenation of the CH_(2)CHCNand the reaction between C_(2)H_(2)and CN on the grain surface of IRAS 18089–1732.We found that NH_(2)CHO is probably produced due to the reaction between NH_(2)and H_(2)CO in the gas phase.Similarly,CH_(3)OCHO is possibly created via the reaction between radical CH_(3)O and radical HCO on the grain surface of IRAS 18089–1732. 展开更多
关键词 ISM:individual objects(IRA 18089-1732)(except) ISM:abundances ISM:kinematics and dynamics stars:formation ASTROCHEMISTRY
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水平地震下土-桩-结构相互作用简化分析方法 被引量:24
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作者 肖晓春 迟世春 林皋 《哈尔滨工业大学学报》 EI CAS CSCD 北大核心 2003年第5期561-564,共4页
基于Penzien提出的集中质量法 ,将上部结构和桩基离散为剪切型质点串 ,以弹簧和阻尼器模拟周围土体 ,建立土 -桩 -结构动力相互作用的分析模型 ,给出相互作用参数的确定方法 ,并考虑土体的动力非线性和材料阻尼特性 ,通过等价线性迭代... 基于Penzien提出的集中质量法 ,将上部结构和桩基离散为剪切型质点串 ,以弹簧和阻尼器模拟周围土体 ,建立土 -桩 -结构动力相互作用的分析模型 ,给出相互作用参数的确定方法 ,并考虑土体的动力非线性和材料阻尼特性 ,通过等价线性迭代逼近土体的非线性动态响应 .运用此模型对某 180m混凝土烟囱按桩基础和刚性基础两种方案进行自振特性和地震时程反应对比分析 ,得到两种基础形式结构的位移、剪力、弯矩的分布形式基本一致 ,但考虑桩 -土 -上部结构相互作用的桩基础使结构体系的周期延长 ,变形增大 ,剪力和弯矩相应减小 .桩 -土 -上部结构相互作用增加了结构的柔性 。 展开更多
关键词 水平地震 --结构相互作用 等价体系 自由场 阻尼 地震响应 时程分析 桩基础
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桥梁结构push-over方法抗震性能研究 被引量:21
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作者 柳春光 林皋 《大连理工大学学报》 EI CAS CSCD 北大核心 2005年第3期395-400,共6页
从解决桥梁结构实际问题出发,根据桥梁结构的震害规律和特点,考虑桥梁结构的位移延性、耗能特性等方面因素,通过具体桥梁算例比较了非线性静力push-over分析方法与动力时程分析方法建立的桥梁结构能力曲线,从而说明了push-over方法在桥... 从解决桥梁结构实际问题出发,根据桥梁结构的震害规律和特点,考虑桥梁结构的位移延性、耗能特性等方面因素,通过具体桥梁算例比较了非线性静力push-over分析方法与动力时程分析方法建立的桥梁结构能力曲线,从而说明了push-over方法在桥梁结构抗震性能评价中的可行性;另外,基于我国《公路工程抗震设计规范》(JTJ004—89)给出的弹性反应谱建立了地震需求谱;最后,利用push-over方法分析了具体桥梁结构的地震破坏状态,给出了桥梁结构在不同地震烈度条件下和不同超越概率加速度峰值条件下的破损状态.研究结果对实际工程中抗震性能决策有一定借鉴意义. 展开更多
关键词 桥梁结构 push—over方法 地震需求谱 抗震性能 非线性静力 位移延性
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基于改进加权D-S信息融合的结构多损伤位置识别 被引量:8
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作者 郭惠勇 张陵 周进雄 《工程力学》 EI CSCD 北大核心 2005年第1期235-240,共6页
将信息融合技术中的D-S证据融合理论应用于结构的多损伤定位问题,为了解决证据融合理论中的不同证据应具有不同的重要性的问题,提出了一种新的加权证据调整的方法。这种方法利用加权平均值和优先权的证据分布形态对证据进行了加权调整,... 将信息融合技术中的D-S证据融合理论应用于结构的多损伤定位问题,为了解决证据融合理论中的不同证据应具有不同的重要性的问题,提出了一种新的加权证据调整的方法。这种方法利用加权平均值和优先权的证据分布形态对证据进行了加权调整,调整后的证据保证了加权平均值不变以及优先权证据分布形态的稳定。仿真结果表明,采用了证据融合方法的多损伤定位,可以产生比单一信息源更精确、更完全的估计和判决,而基于改进加权证据融合技术具有更好的对多损伤定位的识别,优于基本D-S证据组合方法以及其它加权证据组合方法。 展开更多
关键词 损伤识别 信息融合 证据理论 合成规则 加权调整
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基于单极化TerraSAR-X影像提取建筑区研究 被引量:6
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作者 蒋丹丹 卢刚 陈成 《地理与地理信息科学》 CSCD 北大核心 2016年第1期60-65,F0003,共7页
基于多时相单极化TerraSAR-X影像,提取后向散射系数特征影像、变差函数纹理特征影像、干涉特征影像,并对其波段组合,在基于eCognition软件多尺度分割的基础上,选择训练样本对象,充分挖掘样本对象的光谱、纹理特征信息,通过建立特征分离... 基于多时相单极化TerraSAR-X影像,提取后向散射系数特征影像、变差函数纹理特征影像、干涉特征影像,并对其波段组合,在基于eCognition软件多尺度分割的基础上,选择训练样本对象,充分挖掘样本对象的光谱、纹理特征信息,通过建立特征分离性指标,降低特征维数,最后应用面向对象的分类方法实现了建筑区的自动提取,提取精度达93.50%。这一研究表明特征组合影像具有较大的分割优势,特征的优化选择在减少特征冗余的同时维持了较高的信息提取精度,且弥补了eCognition软件纹理特征计算慢的不足。 展开更多
关键词 TerraSAR-X影像 建筑区提取 影像分割 降低特征维数 面向对象分类
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地基-结构系统地震响应的突变模型分析 被引量:1
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作者 房营光 曹洪 《岩土力学》 EI CAS CSCD 北大核心 2003年第5期729-732,共4页
由拉格朗日方程导出地基-结构系统地震响应分析的动力方程,利用突变模型分析了系统对地震响应的复杂过程,并分析了振幅响应的跳跃现象和“路径”效应等非线性动力特性,得出了有意义的结论。分析结果对地基-结构系统的参数设计有一定的... 由拉格朗日方程导出地基-结构系统地震响应分析的动力方程,利用突变模型分析了系统对地震响应的复杂过程,并分析了振幅响应的跳跃现象和“路径”效应等非线性动力特性,得出了有意义的结论。分析结果对地基-结构系统的参数设计有一定的参考价值。 展开更多
关键词 地基-结构系统 地震响应 突变分析 跳跃
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Optical quasi-periodic oscillation and color behavior of blazar PKS 2155–304 被引量:5
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作者 Bing-Kai Zhang Xiao-Yun Zhao +1 位作者 Chun-Xiao Wang Ben-Zhong Dai 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第8期933-941,共9页
PKS 2155-304 is a well studied BL Lac object in the southern sky. The historical optical data during different periods have been collected and compiled. Light curves spanning 35 yr have been constructed. The R-band li... PKS 2155-304 is a well studied BL Lac object in the southern sky. The historical optical data during different periods have been collected and compiled. Light curves spanning 35 yr have been constructed. The R-band light curve has been ana- lyzed by means of three methods: the epoch folding method, the Jurkevich method and the discrete correlation function method. It is derived that there is an evident periodic component of 317 d (i.e. 0.87 yr) superposed on a long-term trend with large- amplitude variation in the light curve. The variability of this source is accompanied by a slight color variation, and the brightness and color index are correlated with each other. On a long-term time scale, PKS 2155-304 exhibits a tendency of bluer-when- brighter, which means the spectrum becomes flatter when the source brightens. 展开更多
关键词 BL Lacertae objects general -- BL Lacertae objects individual (PKS 2155-304) -- galaxies active -- method statistical
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Multi-features Based Approach for Moving Shadow Detection 被引量:4
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作者 周宁 周曼丽 +1 位作者 许毅平 方宝红 《Journal of Donghua University(English Edition)》 EI CAS 2004年第6期76-80,共5页
In the video-based surveillance application, moving shadows can affect the correct localization and detection of moving objects. This paper aims to present a method for shadow detection and suppression used for moving... In the video-based surveillance application, moving shadows can affect the correct localization and detection of moving objects. This paper aims to present a method for shadow detection and suppression used for moving visual object detection. The major novelty of the shadow suppression is the integration of several features including photometric invariant color feature, motion edge feature, and spatial feature etc. By modifying process for false shadow detected, the averaging detection rate of moving object reaches above 90% in the test of Hall-Monitor sequence. 展开更多
关键词 MOVING SHADOW detection MULTI - features MOVING object DETECTION
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A Possible 456-Day Optical Period of OQ 530 被引量:2
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作者 Yi Liu Juan Li Jun-Hui Fan 《Chinese Journal of Astronomy and Astrophysics》 CSCD 2007年第3期380-388,共9页
The post-1994 observations of the blazar OQ 530 in optical BVRI bands, and radio observations at 22 GHz and 37 GHz were collected. The date compensated discrete Fourier transform (DCDFr) and CLEANest methods were us... The post-1994 observations of the blazar OQ 530 in optical BVRI bands, and radio observations at 22 GHz and 37 GHz were collected. The date compensated discrete Fourier transform (DCDFr) and CLEANest methods were used to search for possible periodicities. Two possible periods of 456±100 days and 258±29 days were found in the optical bands. The existence of possible correlations between the optical and radio emissions was investigated by means of discrete correlation function (DCF) analysis, and no significant correlation was found. Some possible mechanisms for the periodic variability are discussed. 展开更多
关键词 GALAXIES active - BL Lacertae objects general - BL Lacertae objects indi-vidual OQ 530
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Optogenetics-induced activation of glutamate receptors improves memory function in mice with Alzheimer’s disease 被引量:6
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作者 Ke-Wei Wang Xiao-Lin Ye +2 位作者 Ting Huang Xi-Fei Yang Liang-Yu Zou 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第12期2147-2155,共9页
Optogenetics is a combination of optics and genetics technology that can be used to activate or inhibit specific cells in tissues. It has been used to treat Parkinson’s disease, epilepsy and neurological diseases, bu... Optogenetics is a combination of optics and genetics technology that can be used to activate or inhibit specific cells in tissues. It has been used to treat Parkinson’s disease, epilepsy and neurological diseases, but rarely Alzheimer’s disease. Adeno-associated virus carrying the CaMK promoter driving the optogenetic channelrhodopsin-2 (CHR2) gene (or without the CHR2 gene, as control) was injected into the bilateral dentate gyri, followed by repeated intrahippocampal injections of soluble low-molecular-weight amyloid-β1–42 peptide (Aβ1–42). Subsequently, the region was stimulated with a 473 nm laser (1–3 ms, 10 Hz, 5 minutes). The novel object recognition test was conducted to test memory function in mice. Immunohistochemical staining was performed to analyze the numbers of NeuN and synapsin Ia/b-positive cells in the hippocampus. Western blot assay was carried out to analyze the expression levels of glial fibrillary acidic protein, NeuN, synapsin Ia/b, metabotropic glutamate receptor-1a (mGluR-1a), mGluR-5, N-methyl-D-aspartate receptor subunit NR1, glutamate receptor 2, interleukin-1β, interleukin-6 and interleukin-10. Optogenetic stimulation improved working and short-term memory in mice with Alzheimer’s disease. This neuroprotective effect was associated with increased expression of NR1, glutamate receptor 2 and mGluR-5 in the hippocampus, and decreased expression of glial fibrillary acidic protein and interleukin-6. Our results show that optogenetics can be used to regulate the neuronal-glial network to ameliorate memory functions in mice with Alzheimer’s disease. The study was approved by the Animal Resources Committee of Jinan University, China (approval No. LL-KT-2011134) on February 28, 2011. 展开更多
关键词 nerve REGENERATION Alzheimer's disease amyloid-β1-42 DENTATE GYRUS channelrhodopsin-2 GLUTAMATE receptors memory neuroinflammation novel object recognition immunohistochemistry western blot assay neural REGENERATION
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The intrinsic γ-ray emissions of Fermi blazars 被引量:1
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作者 Chao Lin Jun-Hui Fan Hu-Bing Xiao 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2017年第7期25-38,共14页
The beaming effect is important for understanding the observational properties of blazars.In this work, we collect 91 Fermi blazars with available radio Doppler factors. γ-ray Doppler factors are estimated and compar... The beaming effect is important for understanding the observational properties of blazars.In this work, we collect 91 Fermi blazars with available radio Doppler factors. γ-ray Doppler factors are estimated and compared with radio Doppler factors for some sources. The intrinsic(de-beamed)γ-ray flux density(fγin), intrinsic γ-ray luminosity(Lγin) and intrinsic synchrotron peak frequency(VPin)are calculated. Then we study the correlations between finγand redshift and find that they follow the theoretical relation: log f =-2.0 log z + const. When the subclasses are considered, we find that stationary jets are perhaps dominant in low synchrotron peaked blazars. Sixty-three Fermi blazars with both available short variability time scales(?T) and Doppler factors are also collected. We find that the intrinsic relationship between Lγin and ?Tinobeys the Elliot & Shapiro and Abramowicz & Nobili relations. Strong positive correlation between fγinand VPinis found, suggesting that synchrotron emissions are highly correlated with γ-ray emissions. 展开更多
关键词 GALAXIES active - BL Lacertae objects general - gamma-rays GALAXIES
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