Generation of Synthetic Transcriptome Data with Defined Statistical Properties for the Development and Testing of New Analysis Methods

We have previously developed a combined signal/variance distribution model that accounts for the particular statistical properties of datasets generated on the Applied Biosystems AB1700 transcriptome system. Here we show that this model can be efficiently used to generate synthetic datasets with statistical properties virtually identical to those of the actual data by aid of the JAVA application ace.map creator 1.0 that we have developed. The fundamentally different structure of AB1700 transcriptome profiles requires re-evaluation, adaptation, or even redevelopment of many of the standard microarray analysis methods in order to avoid misinterpretation of the data on the one hand, and to draw full benefit from their increased specificity and sensitivity on the other hand. Our composite data model and the ace.map creator 1.0 application thereby not only present proof of the correctness of our parameter estimation, but also provide a tool for the generation of synthetic test data that will be useful for further development and testing of analysis methods.

A review of research on public transport priority based on CiteSpace

The prioritization of public transit as an essential means of promoting sustainable urban development has a significant role in improving the quality of public transportation services,reducing traffic congestion,and enhancing air quality.To improve the implementation of public transit prioritization policies,this study conducted a comprehensive review of relevant literature on public transit prioritization from two major citation databases(Web of Science and China National Knowledge Infrastructure)from 2003 to 2021.Utilizing the visualization analysis software CiteSpace,this study analyzed knowledge visualization from five aspects:research sources,research institutions,knowledge foundation,knowledge frontier,and research hotspots,and summarized the research history and implementation effectiveness of public transit prioritization policies.The study concludes that existing research has some deficiencies in terms of urban diversity,comprehensive evaluation system,holistic perspective,interdisciplinary collaboration,and consideration of economic and environmental impacts.Future research should focus on development directions such as intelligence,sustainability,interdisciplinary collaboration,and integration of multi-modal transportation.The findings of this study can provide valuable references for the implementation of public transportation prioritization policies and future research.