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Synthesis of water-soluble cystine C_(60) derivative with catalyst and its active oxygen radical scavenging ability 被引量:3
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作者 Zhen Hu Wen Chao Guan Xiang Ying Tang Li Zhen Huang Hong Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第1期51-54,共4页
A novel water-soluble cystine C60 derivative was synthesized in the presence of the catalyst, tetrabutylammonium hydroxide (TBAH). The product was characterized by FT-IR, UV, ^1H NMR, ^13C NMR, MS and elemental anal... A novel water-soluble cystine C60 derivative was synthesized in the presence of the catalyst, tetrabutylammonium hydroxide (TBAH). The product was characterized by FT-IR, UV, ^1H NMR, ^13C NMR, MS and elemental analysis. Furthermore, the scavenging ability to superoxygen anion radical O2^·- and hydroxyl radical ^·OH was studied by chemiluminescence. It was found that cystine C60 derivative showed an excellent efficiency in eliminating superoxygen anion radical and hydroxyl radical. The 50% inhibition concentration (IC50) for superoxygen anion radical and hydroxyl radical were 0.167 and 0.008 mg/mL, respectively. 展开更多
关键词 cystine c60 derivatives TBAH Superoxygen anion radical Hydroxyl radical cHEMILUMINEScENcE
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Theoretical Study on the Structures and Electronic Spectra of the Derivatives of C_(60)-P-2,4,6-Triphenyl Borazinc 被引量:3
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作者 JIANG Qi-Jun 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2005年第10期1140-1144,共5页
The structures and electronic spectra of the derivatives of C60-P-2,4,6-triphenyl borazinc have been studied by using AM 1 method. The calculated results indicate that this kind of compounds has a lower energy differe... The structures and electronic spectra of the derivatives of C60-P-2,4,6-triphenyl borazinc have been studied by using AM 1 method. The calculated results indicate that this kind of compounds has a lower energy difference between HOMO and LUMO. It is found that the electron cloud on unoccupied frontier orbital mainly comes from the contribution of C60, while that on occupied frontier orbital mainly concentrates on the side chain. A long-lived charge-separated state may occur in the objective compounds. 展开更多
关键词 derivatives of c60-P-2 4 6-triphenyl borazinc electronic spectra charge-separated state AM1
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Protective Effect of Reduced Glutathione C_(60) Derivative against Hydrogen Peroxide-induced Apoptosis in HEK 293T Cells 被引量:1
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作者 黄锦 周迟 +3 位作者 贺军 胡铮 官文超 刘胜洪 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2016年第3期356-363,共8页
Hydrogen peroxide(H_2O_2) and free radicals cause oxidative stress, which induces cellular injuries, metabolic dysfunction, and even cell death in various clinical abnormalities. Fullerene(C_(60)) is critical fo... Hydrogen peroxide(H_2O_2) and free radicals cause oxidative stress, which induces cellular injuries, metabolic dysfunction, and even cell death in various clinical abnormalities. Fullerene(C_(60)) is critical for scavenging oxygen free radicals originated from cell metabolism, and reduced glutathione(GSH) is another important endogenous antioxidant. In this study, a novel water-soluble reduced glutathione fullerene derivative(C_(60)-GSH) was successfully synthesized, and its beneficial roles in protecting against H_2O_2-induced oxidative stress and apoptosis in cultured HEK 293 T cells were investigated. Fourier Transform infrared spectroscopy and 1H nuclear magnetic resonance were used to confirm the chemical structure of C_(60)-GSH. Our results demonstrated that C_(60)-GSH prevented the reactive oxygen species(ROS)-mediated cell damage. Additionally, C_(60)-GSH pretreatment significantly attenuated H_2O_2-induced superoxide dismutase(SOD) consumption and malondialdehyde(MDA) elevation. Furthermore, C_(60)-GSH inhibited intracellular calcium mobilization, and subsequent cell apoptosis via bcl-2/bax-caspase-3 signaling pathway induced by H_2O_2 stimulation in HEK 293 T cells. Importantly, these protective effects of C_(60)-GSH were superior to those of GSH. In conclusion, these results suggested that C_(60)-GSH has potential to protect against H_2O_2-induced cell apoptosis by scavenging free radicals and maintaining intracellular calcium homeostasis without evident toxicity. 展开更多
关键词 reduced glutathione c60 derivative hydrogen peroxide oxidative stress apoptosis HEK 293T cells
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[2+2] Photocycloaddition of [60]Fullerene with Podophyllotoxin Derivative Containing Cyclohexadienone Group
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作者 QianRongLI LiQunLI ShaYANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第6期729-732,共4页
Photochemical [2+2] cycloaddition of C60 with podophyllotoxin derivative containing a cyclohexadienone group in o-dichlorobenzene afforded an isomeric mixture of adducts and a pure adduct of C60-fused podophyllotoxin ... Photochemical [2+2] cycloaddition of C60 with podophyllotoxin derivative containing a cyclohexadienone group in o-dichlorobenzene afforded an isomeric mixture of adducts and a pure adduct of C60-fused podophyllotoxin derivatives. The structures of the products were characterized by MS, NMR and IR spectra. 展开更多
关键词 Podophyllotoxin c60-fused podophyllotoxin derivative fullerene photocyclo- addition.
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Theoretical Study on Two C_(16)H_(12)O_4 Isomers of Derivatives of Pagodane
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作者 LIU Feng-Ling DU Ai-Ming WANG Su-Jing 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2006年第2期180-186,共7页
Two C16H12O4 isomers of derivatives of pagodane were firstly reported and studied by using DFT method. Geometries, energies, and vibrational frequencies have been calculated for the two C16H12O4 isomers with pagodane-... Two C16H12O4 isomers of derivatives of pagodane were firstly reported and studied by using DFT method. Geometries, energies, and vibrational frequencies have been calculated for the two C16H12O4 isomers with pagodane-like structures at the B3LYP/6-31G^** level of theory. Symmetries of isomer 1 and 2 are D2h and D2d, respectively. Heats of formation for the two C16H12O4 isomers have been estimated in this paper. According to the heats of formation, the two C16H12O4 isomers are more stable than pagodane. Heats of formation as well as the vibrational analysis indicate that the two C16H12O4 isomers enjoy sufficient stability to allow for the experimental preparation. 展开更多
关键词 two c16H12O4 isomers of derivatives of pagodane B3LYP/6-31G^** vibrational frequency heat of formation
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Evaluation of Epidermal Growth Factor-Incorporating Skin Care Product in Culture Experiment Using Human Fibroblasts 被引量:1
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作者 Akiko Yamamoto Haruka Ohno Yoshimitsu Kuroyanagi 《Open Journal of Regenerative Medicine》 2016年第2期44-54,共11页
This study aimed to investigate the potential of a skin care product composed of hyaluronic acid (HA) and collagen (Col) sponge containing epidermal growth factor (EGF), vitamin C derivative (VC), glucosylceramide (GC... This study aimed to investigate the potential of a skin care product composed of hyaluronic acid (HA) and collagen (Col) sponge containing epidermal growth factor (EGF), vitamin C derivative (VC), glucosylceramide (GC), poly(γ-glutamic acid) (PGA), and argentine (Arg). High-molecular weight HA aqueous solution, hydrolyzed low-molecular weight HA aqueous solution, and heat- denatured Col aqueous solution were mixed, into which each aqueous solution containing EGF, VC, GC, PGA, or Arg were added, followed by freeze-drying to obtain a spongy EGF-incorporating skin care product (EGF-skin care product). In order to evaluate the first efficacy of EGF, fibroblast proliferation was assessed after 6 days of cultivation in the conditioned medium prepared by dissolving EGF-skin care product in a conventional culture medium. The fibroblast densities increased more effectively in conditioned medium with EGF than in control medium without EGF. In order to evaluate the second efficacy of EGF, the amount of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) produced by fibroblasts were assessed in a wound surface model. A fibroblast-incorporating Col gel sheet (cultured dermal substitute: CDS) was elevated to the air- medium interface, onto which a spongy sheet of EGF-skin care product was placed and cultured for 7 days. The condition covered with or without EGF-skin care product is divided into (+) EGF or (-) EGF, respectively. Fibroblasts in the CDS released 3.7 times more VEGF and 25 times more HGF in (+) EGF compared with (-) EGF. In another experiment, an aqueous solution of EGF-skin care product was added onto CDS and cultured for 7 days. Aqueous solutions were prepared and stored at 4°C or 37°C for a different period of 1 day, 2 weeks, and 4 weeks, respectively. Fibroblasts in CDS under different condition released similar amount of VEGF and HGF. This result indicated that the efficacy of EGF was maintained even after preservation at 37°C for 4 weeks. These findings suggest that EGF-skin care product can be used on damaged skin surface by placing its spongy sheet or its solution. 展开更多
关键词 Skin care Product Hyaluronic Acid cOLLAGEN Epidermal Growth Factor Vitamin c derivative
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C_(60)衍生物的MALDI-TOFMS分析 被引量:1
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作者 邓慧敏 周丽华 +1 位作者 邓芹英 赵善楷 《分析测试学报》 CAS CSCD 北大核心 2004年第z1期134-135,共2页
  C60衍生物在超导、非线性光学、催化、材料和生物活性等方面有巨大的潜在应用价值.C60衍生物大多为固体,蒸汽压较低,采用需要加热才能够使样品气化电离的质谱或"硬"电离质谱方法进行测定,易造成C60衍生物分解并释放出配体...   C60衍生物在超导、非线性光学、催化、材料和生物活性等方面有巨大的潜在应用价值.C60衍生物大多为固体,蒸汽压较低,采用需要加热才能够使样品气化电离的质谱或"硬"电离质谱方法进行测定,易造成C60衍生物分解并释放出配体.…… 展开更多
关键词 c60 derivatives Matrix-assisted laser desorption/ionization mass spectrometiy 4-Tert-butyl-4’-ni-trostilbene(TBNS) matrix
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Studies on the Electronic Structures of the C_60, C_60H_60 and C_60F_60
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作者 Wang Zhizhong, Shen Erzhong and Wang Liqun (Institute of Theoretical Chemistry, Jilin University, Changchun) 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1991年第4期227-230,共4页
The present paper represents the electronic structures of the cluster C60 and its derivatives C60H60 and C60F60 with FOOT-type of structure. On the basis of the total energies and molecular orbital energies from CNDO/... The present paper represents the electronic structures of the cluster C60 and its derivatives C60H60 and C60F60 with FOOT-type of structure. On the basis of the total energies and molecular orbital energies from CNDO/2 calculations the clusters' stabilities, electronic configurations and charge distributions are discussed. The calculation results and discussion are very beneficial to understanding physical and chemical properties of the cluster C60 and its derivatives. 展开更多
关键词 cluster c60 and its derivatives Electronic structures cNDO/2
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The synthesis and fluorescence of a methoxy-phenyl substituted C_60-pyrrolidine derivative
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作者 ZHOU, De-Jian GAN, Liang-Bing LUO, Chu-Ping HUANG, Chun-HuiYAO, Guang-QingState Key Laboratory of Rare Earth Materials Chemistry and Applications, Peking University,Beijing 100871, China 《Chinese Journal of Chemistry》 SCIE CAS CSCD 1997年第1期35-41,共7页
A new 4-methoxyphenyl substituted C60-pyrrolidine derivative, C60(C10H13NO) (1), was prepared and its room-temperature fluorescence was studied. Its fluorescence intensity is three times stronger than that of C60. Its... A new 4-methoxyphenyl substituted C60-pyrrolidine derivative, C60(C10H13NO) (1), was prepared and its room-temperature fluorescence was studied. Its fluorescence intensity is three times stronger than that of C60. Its singlet energy was estimated to be 25 kJ/mol lower than that of C60. The fluorescence lifetime was determined to be 2.1+0.3 ns by using the frequency domain method. The fluorescence quenching by concentration and aromatic electron donor: N, N-dimethyl aniline (DMA) was investigated. Data show that its fluorescence could not be quenched by DMA. 展开更多
关键词 c60-pyrrolidine derivative FLUOREScENcE fluorescence quenching
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Oxygen-promoted Pd/C-catalyzed Suzuki–Miyaura reaction of potassium aryltrifluoroborates 被引量:2
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作者 Chun Liu Chao Liu +2 位作者 Xin-Min Li Zhan-Ming Gao Zi-Lin Jin 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第5期631-634,共4页
A simple and highly efficient protocol has been developed for the Pd/C-catalyzed ligand-free Suzuki- Miyaura reaction of potassium aryltrifluoroborates. In this catalytic system, the results demonstrate that oxygen pl... A simple and highly efficient protocol has been developed for the Pd/C-catalyzed ligand-free Suzuki- Miyaura reaction of potassium aryltrifluoroborates. In this catalytic system, the results demonstrate that oxygen plays a positive role in the cross-coupling reaction. In addition, this catalytic system could be successfully applied to synthesize biaryl compounds containing a carbazole moiety and the catalyst was recycled seven times without significant loss of catalytic activitv. 展开更多
关键词 Pd/c Oxygen-promoting effect Suzuki-Miyaura reaction Potassium aryltrifluoroborates carbazole derivatives
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