Crises in the past have caused devastating,long-lasting impacts on the global economy.The after-effects always bring some dynamic and rigorous challenges for businesses and governments.Such challenges have always been...Crises in the past have caused devastating,long-lasting impacts on the global economy.The after-effects always bring some dynamic and rigorous challenges for businesses and governments.Such challenges have always been a point of discussion for scholars.The recent COVID-19 pandemic emaciated the global economy,leaving everyone mired in uncertainty,fear,and psychological impairments.One of the headwind features utilized by consumers during pandemic was panic buying(PB),which must be explored in various contexts for policymakers and practitioners.To address this gap,this study deployed a moderated mediation mechanism,integrating the health belief model(HBM)and competitive arousal theory(CAT)to excavate the notions underlying PB with the intrusion of evolved real-time psychological disorders:intolerance of uncertainty(IU)and cyberchondria(CYC).The study was conducted as a natural experiment in a South Asian developing economy using online surveys.It found that health beliefs—perceived severity(PSV)and perceived susceptibility(PSC)—positively impact perceived arousal(PA),which causes PB,and that PA has a sturdy mediator role.Moreover,in the relationship between health beliefs and arousal,the different psychological disorders were found to have significant moderating roles The study findings can help mitigate risk uncertainties and panic situations and thus contribute to consumers’wellbeing.展开更多
Since 2016,community group buying has grown significantly in China,largely driven by its efficient logistics,supply chains,low prices,and convenience.This model has been further popularized during the COVID-19 pandemi...Since 2016,community group buying has grown significantly in China,largely driven by its efficient logistics,supply chains,low prices,and convenience.This model has been further popularized during the COVID-19 pandemic due to its effectiveness in meeting daily needs while minimizing human-to-human contact.A key component of this business model is the“group leaders”-influential individuals within a community responsible for managing group buying activities,which include order collection,supplier liaison,and goods distribution.Their primary task is to form and sustain a reliable community group buying consortium,a task that demands excellent organizational and interpersonal skills.This paper examines this phenomenon using the lens of the differential mode of association,a theoretical model explaining interpersonal relationships in traditional Chinese society.The research indicates that group leaders,through regular interaction with consumers,are able to alter their social network position,increase their influence,understand consumer needs,provide satisfying services,and enhance trust,thereby transforming consumers into loyal group buying participants.This transformation not only brings stability to group buying activities but also reinforces the community influence of group leaders,thus fostering the growth of community group buying.展开更多
Online shopping in Cameroon is growing rapidly and gaining considerable ground.The phenomenon is relatively new as compared to the traditional brick-and-mortar store(serving customers face-to-face in a building rather...Online shopping in Cameroon is growing rapidly and gaining considerable ground.The phenomenon is relatively new as compared to the traditional brick-and-mortar store(serving customers face-to-face in a building rather than online).As the world faces digital transformations,businesses in Cameroon are seeking new ways to reach their customers and create favourable environments to effectively carryout online purchase.This study examines the factors that affect consumer online buying behaviour in Cameroon.Three theories guided this investigation:the Technology Acceptance Model(Davis,1989),Diffusion of Innovations Theory(Rogers,1995),and Uses and Gratifications Theory(Katz&Blumler,1974).The study focuses on students of the University of Buea who carry out online shopping.Purposive sampling is used,and data are collected from 365 respondents through a questionnaire with open and closed ended questions.Analysis of data is done with the use of the Statistical Package for Social Scientists(SPSS)Version 21 to determine the types of products consumers buy online;the degree to which consumer trust and satisfaction affect consumer loyalty;and the specific social,economic,and market factors that affect online buying behaviour.Findings indicate that:Consumers mostly buy fashion items(74.3%),electronics(44.7%),cosmetics(37.3%),and house equipment(34%)online.Consumers will repeat purchase from a marketer if they trust and are satisfied with the product and service quality(81.1%);hence,they will also encourage others to buy.If they are dissatisfied,they will not repeat purchase from the online store.Advertisement(76.1%),attractive pricing/discount(71.7%),product quality(71%),service quality(64.1%),convenience(72.3%),available income/money(49.6%),word of mouth recommendation(41.9%),and personal motivation(62.7%)constitute the major factors that affect consumer online buying behaviour.Results of the hypotheses testing show that:H1=Consumers buy more of fashion items online(X^(2)=9.950;df=16;p=0.869);H2=There is a significant relationship between trust and satisfaction and consumers online buying behaviour(X^(2)=270.765;df=16;p=0.000);and H3=Social,economic,and market factors significantly affect consumer online buying behaviour(X^(2)=106.328;df=16;p=0.000).The study recommends online marketers to develop their marketing strategies towards customer orientation and focus on the ease of use of their online shopping services.展开更多
目的了解肿瘤抗原肽的HLA限制性以及其诱导的T细胞能否杀伤肿瘤细胞,探索无关供者来源细胞用于过继性抗肿瘤T细胞治疗。方法使用16个肿瘤抗原肽诱导18名无关供者外周血单个核细胞(PBMC)分化为反应性T细胞,并分析HLA型别;利用NetMHC数据...目的了解肿瘤抗原肽的HLA限制性以及其诱导的T细胞能否杀伤肿瘤细胞,探索无关供者来源细胞用于过继性抗肿瘤T细胞治疗。方法使用16个肿瘤抗原肽诱导18名无关供者外周血单个核细胞(PBMC)分化为反应性T细胞,并分析HLA型别;利用NetMHC数据库预测肽和HLA分子亲和力;选择HLA-A2限制性的肿瘤抗原肽诱导第二组17名无关供者的PBMC进行杀瘤实验,反应性T细胞作为效应细胞,T2细胞及肿瘤抗原肽同源的肿瘤细胞作为靶细胞,测量LDH(乳酸脱氢酶)释放量或者RTCA(实时无标记细胞分析仪)检测效应细胞杀瘤效率,比较HLA-A2+和A2-T细胞杀瘤效率。结果筛出和HLA-A2具有高亲和力的肿瘤抗原肽LM7,可诱导5/11 HLA-A2+为反应性T细胞,其中HLA-A2+纯合子则为3/3,而HLA-A2-者则为2/7。LM7诱导反应性T细胞杀伤肿瘤百分比A2+组明显强于A2-组(60.72±11.28 vs 47.2±4.46,P=0.03)。结论本研究显示NetMHC预测对于纯合子样品更有帮助,肿瘤抗原肽LM7具有HLA-A2限制性,可诱导部分HLAA2+PBMC分化为反应性T细胞,可杀伤肿瘤,应对供者进行HLA筛选并分析其细胞功能,其诱导的反应性T细胞可作为过继性T细胞抗肿瘤治疗的细胞来源。展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.72272136 and 72172024)Humanities and Social Science Project from the Ministry of Education of China(20YJA630061).
文摘Crises in the past have caused devastating,long-lasting impacts on the global economy.The after-effects always bring some dynamic and rigorous challenges for businesses and governments.Such challenges have always been a point of discussion for scholars.The recent COVID-19 pandemic emaciated the global economy,leaving everyone mired in uncertainty,fear,and psychological impairments.One of the headwind features utilized by consumers during pandemic was panic buying(PB),which must be explored in various contexts for policymakers and practitioners.To address this gap,this study deployed a moderated mediation mechanism,integrating the health belief model(HBM)and competitive arousal theory(CAT)to excavate the notions underlying PB with the intrusion of evolved real-time psychological disorders:intolerance of uncertainty(IU)and cyberchondria(CYC).The study was conducted as a natural experiment in a South Asian developing economy using online surveys.It found that health beliefs—perceived severity(PSV)and perceived susceptibility(PSC)—positively impact perceived arousal(PA),which causes PB,and that PA has a sturdy mediator role.Moreover,in the relationship between health beliefs and arousal,the different psychological disorders were found to have significant moderating roles The study findings can help mitigate risk uncertainties and panic situations and thus contribute to consumers’wellbeing.
文摘Since 2016,community group buying has grown significantly in China,largely driven by its efficient logistics,supply chains,low prices,and convenience.This model has been further popularized during the COVID-19 pandemic due to its effectiveness in meeting daily needs while minimizing human-to-human contact.A key component of this business model is the“group leaders”-influential individuals within a community responsible for managing group buying activities,which include order collection,supplier liaison,and goods distribution.Their primary task is to form and sustain a reliable community group buying consortium,a task that demands excellent organizational and interpersonal skills.This paper examines this phenomenon using the lens of the differential mode of association,a theoretical model explaining interpersonal relationships in traditional Chinese society.The research indicates that group leaders,through regular interaction with consumers,are able to alter their social network position,increase their influence,understand consumer needs,provide satisfying services,and enhance trust,thereby transforming consumers into loyal group buying participants.This transformation not only brings stability to group buying activities but also reinforces the community influence of group leaders,thus fostering the growth of community group buying.
文摘Online shopping in Cameroon is growing rapidly and gaining considerable ground.The phenomenon is relatively new as compared to the traditional brick-and-mortar store(serving customers face-to-face in a building rather than online).As the world faces digital transformations,businesses in Cameroon are seeking new ways to reach their customers and create favourable environments to effectively carryout online purchase.This study examines the factors that affect consumer online buying behaviour in Cameroon.Three theories guided this investigation:the Technology Acceptance Model(Davis,1989),Diffusion of Innovations Theory(Rogers,1995),and Uses and Gratifications Theory(Katz&Blumler,1974).The study focuses on students of the University of Buea who carry out online shopping.Purposive sampling is used,and data are collected from 365 respondents through a questionnaire with open and closed ended questions.Analysis of data is done with the use of the Statistical Package for Social Scientists(SPSS)Version 21 to determine the types of products consumers buy online;the degree to which consumer trust and satisfaction affect consumer loyalty;and the specific social,economic,and market factors that affect online buying behaviour.Findings indicate that:Consumers mostly buy fashion items(74.3%),electronics(44.7%),cosmetics(37.3%),and house equipment(34%)online.Consumers will repeat purchase from a marketer if they trust and are satisfied with the product and service quality(81.1%);hence,they will also encourage others to buy.If they are dissatisfied,they will not repeat purchase from the online store.Advertisement(76.1%),attractive pricing/discount(71.7%),product quality(71%),service quality(64.1%),convenience(72.3%),available income/money(49.6%),word of mouth recommendation(41.9%),and personal motivation(62.7%)constitute the major factors that affect consumer online buying behaviour.Results of the hypotheses testing show that:H1=Consumers buy more of fashion items online(X^(2)=9.950;df=16;p=0.869);H2=There is a significant relationship between trust and satisfaction and consumers online buying behaviour(X^(2)=270.765;df=16;p=0.000);and H3=Social,economic,and market factors significantly affect consumer online buying behaviour(X^(2)=106.328;df=16;p=0.000).The study recommends online marketers to develop their marketing strategies towards customer orientation and focus on the ease of use of their online shopping services.
文摘目的了解肿瘤抗原肽的HLA限制性以及其诱导的T细胞能否杀伤肿瘤细胞,探索无关供者来源细胞用于过继性抗肿瘤T细胞治疗。方法使用16个肿瘤抗原肽诱导18名无关供者外周血单个核细胞(PBMC)分化为反应性T细胞,并分析HLA型别;利用NetMHC数据库预测肽和HLA分子亲和力;选择HLA-A2限制性的肿瘤抗原肽诱导第二组17名无关供者的PBMC进行杀瘤实验,反应性T细胞作为效应细胞,T2细胞及肿瘤抗原肽同源的肿瘤细胞作为靶细胞,测量LDH(乳酸脱氢酶)释放量或者RTCA(实时无标记细胞分析仪)检测效应细胞杀瘤效率,比较HLA-A2+和A2-T细胞杀瘤效率。结果筛出和HLA-A2具有高亲和力的肿瘤抗原肽LM7,可诱导5/11 HLA-A2+为反应性T细胞,其中HLA-A2+纯合子则为3/3,而HLA-A2-者则为2/7。LM7诱导反应性T细胞杀伤肿瘤百分比A2+组明显强于A2-组(60.72±11.28 vs 47.2±4.46,P=0.03)。结论本研究显示NetMHC预测对于纯合子样品更有帮助,肿瘤抗原肽LM7具有HLA-A2限制性,可诱导部分HLAA2+PBMC分化为反应性T细胞,可杀伤肿瘤,应对供者进行HLA筛选并分析其细胞功能,其诱导的反应性T细胞可作为过继性T细胞抗肿瘤治疗的细胞来源。
