Objective To gain insight on how exercise affects the outcomes of prostate cancer patients treated with androgen deprivation therapy,specifically cancer-related fatigue(CRF) and quality of life(QoL). Methods Systemati...Objective To gain insight on how exercise affects the outcomes of prostate cancer patients treated with androgen deprivation therapy,specifically cancer-related fatigue(CRF) and quality of life(QoL). Methods Systematic searches for randomized clinical trials(RCTs) evaluating the effects of exercise on CRF and QoL of prostate cancer patients receiving androgen deprivation therapy were carried out to identify the eligible studies from EMBASE,Pub Med and Cochrane library. Related data were extracted from eligible studies and then subjected to Reviewer Manage 5.3 for analysis. Standardized mean differences(SMD) and its 95% confidence interval(CI) were calculated. Results In all,10 RCTs involving 841 prostate cancer patients(448 of whom exercised and 393 did not) were included in this study. With respect to CRF,there was good consistency among different studies,and it was remarkably reduced in the exercise group(SMD=-0.32,95% CI:-0.45 to-0.18,P<0.00001,n=784). In regards to QoL,there was also good consistency among different studies,and it was also improved significantly in the exercise group(SMD=0.21,95% CI:0.08 to 0.34,P=0.002,n=841). Conclusion Exercise both reduced CRF and improved QoL in prostate cancer patients receiving androgen deprivation therapy.展开更多
Objective:To explore the effect of KAP intervention mode on resilience and cancer-related fatigue in patients with colorectal cancer undergoing chemotherapy.Methods:A prospective randomized trial was conducted.55 pati...Objective:To explore the effect of KAP intervention mode on resilience and cancer-related fatigue in patients with colorectal cancer undergoing chemotherapy.Methods:A prospective randomized trial was conducted.55 patients with colorectal cancer who received routine nursing from February 2018 to February 2019 were included in the control group,and 55 patients who received routine nursing+KAP intervention from March 2019 to March 2020 were included in the observation group.The scores of Resilience Scale and cancer-related fatigue scale(CFS)before and 6 months after intervention were compared between the two groups.Results:After 6 months of intervention,the score of resilience of the two groups was higher than that before intervention,and that of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05);The CFS score of the two groups was lower than that before intervention,and that of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion:KAP intervention model can improve the resilience of patients with colorectal cancer chemotherapy,reduce cancerrelated fatigue.展开更多
Crack growth rate curves are the fundamental material property for metal structures under fatigue loading. Although there are many crack growth rate curves available in the literature, few of them showed the capabilit...Crack growth rate curves are the fundamental material property for metal structures under fatigue loading. Although there are many crack growth rate curves available in the literature, few of them showed the capability to explain various special phenomena observed in tests. A modified constitutive relation recently proposed by McEvily and his co-workers showed very promising capability. This modified constitutive relation is further generalized by (1) introducing an unstable fracture condition; (2) defining a virtual strength to replace the yield stress; and (3) defining an overload and underload parameter. The performances of this general constitutive relation for fatigue crack growth is extensively studied and it is found that this general constitutive relation is able to explain various phenomena observed with particular strong capability on load sequence effect.展开更多
Cancer related fatigue(CRF)is one of the most common and painful reactions in cancer patients.Due to the negative effects of cancer itself and long-term treatment,patients often feel continuous burnout,fatigue and pow...Cancer related fatigue(CRF)is one of the most common and painful reactions in cancer patients.Due to the negative effects of cancer itself and long-term treatment,patients often feel continuous burnout,fatigue and powerlessness in both mental and physical aspects.Fatigue related to cancer and cancer treatment will affect the physical and mental health of cancer patients for a long time and continuously,and it is hard to be relieved through rest.Nowadays,most of the researches focus on the clinical manifestations of patients with cancer,such as pain,nausea and vomiting,weight loss and so on.The fatigue feeling of cancer patients is often one of the most easily overlooked pain symptoms in the treatment process.The influence of CRF on cancer patients may be one of the reasons for reducing the survival time of cancer patients.This paper aims to summarize and explore the pathogenesis of cancer-related fatigue,in order to analyze the related factors of cancer-related fatigue from multi-dimensional and multi-angle,and provide reference for its comprehensive treatment in clinic.展开更多
In this study, a new unified creep constitutive relation and a mod- ified energy-based fatigue model have been established respectively to describe the creep flow and predict the fatigue life of Sn-Pb solders. It is f...In this study, a new unified creep constitutive relation and a mod- ified energy-based fatigue model have been established respectively to describe the creep flow and predict the fatigue life of Sn-Pb solders. It is found that the relation successfully elucidates the creep mechanism related to current constitutive relations. The model can be used to describe the temperature and frequency dependent low cycle fatigue behavior of the solder. The relation and the model are further employed in part Ⅱ to develop the numerical simulation approach for the long-term reliability assessment of the plastic ball grid array (BGA) assembly.展开更多
Fatigue is usually the cause for the cracks identified at bridge elements in service. With an increase in the introduction of corrugated steel web girders in recent highway bridge construction, the understanding of th...Fatigue is usually the cause for the cracks identified at bridge elements in service. With an increase in the introduction of corrugated steel web girders in recent highway bridge construction, the understanding of the fatigue behaviour of welded details in such structures becomes an important issue for the design. The typical welded details were represented as welded joints assembled by longitudinal corrugated plates. All the experiments were performed under fatigue loading using a servo-control testing machine. The test results from the failure mode observation with the aid of infrared thermo-graph technology show that the failure manner of these welded joints is comparable to that of the corrugated steel web beams reported previously. It is indicated from the stiffness degradation analysis that the welded joints with larger corrugation angle have higher stiffness and greater stiffness degradation in the notable stiffness degradation range. It is shown from the test S-N relations based on the free regression and forced regression analyses that there is a good linear dependence between lg(N) and lg(ΔS). It is also demonstrated that the proposed fracture mechanics analytical model is able to give a prediction slightly lower but on the safe side for the mean stresses at 2 million cycles of the test welded joints.展开更多
A so-called 'local probabilistic Paris relation method' was presented for measuring the random thresholds of long fatigue crack propagation. A check was made to the conventional method, in which the thresholds...A so-called 'local probabilistic Paris relation method' was presented for measuring the random thresholds of long fatigue crack propagation. A check was made to the conventional method, in which the thresholds were measured statistically and directly by the test data. It was revealed that this method was not reasonable because the test data have seldom a unified level of crack growth rates. Differently,in the presented method the Paris-Erdogan equation was applied to model the local test data around the thresholds. Local probabilistic relations with both the survival probability and the confidence were established on a lognormal distribution of the stress density factors. And then, the probabilistic thresholds were derived from the probabilistic factors with a given critical level of growth rate. An analysis on the test data of LZ50 axle steel for the Chinese railway vehicles verifies that the present method is feasible and available.展开更多
Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on ...Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.展开更多
in reliability design of fatigue under random loading, the influence of loading se-quence must be considered. In order to avoid the uneertain hypothesis in the Miner's rule, ie. thatthe sum of damage equals one re...in reliability design of fatigue under random loading, the influence of loading se-quence must be considered. In order to avoid the uneertain hypothesis in the Miner's rule, ie. thatthe sum of damage equals one represents failure, this paper proposes the probabilistic relativeMine's rule. This paper also presents a new method for calculating reliability, ie. the syntheticmethod of Miner's rule and interference model. This model considers not only the influence ofstress concentration, dimension and surface, but also the influence of stress amplitude and se-quence.展开更多
通过分析《理虚元鉴》一书中对“虚劳六因”和“治虚三本二统论”理论的阐述,得出肺癌癌因性疲乏(cancer related fatigue,CRF)的病因病机可从“火”立论,总结为肺中伏火、火衰毒蕴、水火不济和血虚痰火四种。临证遵其“阴虚统于肺、阳...通过分析《理虚元鉴》一书中对“虚劳六因”和“治虚三本二统论”理论的阐述,得出肺癌癌因性疲乏(cancer related fatigue,CRF)的病因病机可从“火”立论,总结为肺中伏火、火衰毒蕴、水火不济和血虚痰火四种。临证遵其“阴虚统于肺、阳虚统于脾”之旨,重视使用清金保肺、培土温中法,调治过程中当秉持“勿犯中州之土”“勿损至高之气”及“期年为限”的观点,为临床辨证论治肺癌CRF提供借鉴。展开更多
文摘Objective To gain insight on how exercise affects the outcomes of prostate cancer patients treated with androgen deprivation therapy,specifically cancer-related fatigue(CRF) and quality of life(QoL). Methods Systematic searches for randomized clinical trials(RCTs) evaluating the effects of exercise on CRF and QoL of prostate cancer patients receiving androgen deprivation therapy were carried out to identify the eligible studies from EMBASE,Pub Med and Cochrane library. Related data were extracted from eligible studies and then subjected to Reviewer Manage 5.3 for analysis. Standardized mean differences(SMD) and its 95% confidence interval(CI) were calculated. Results In all,10 RCTs involving 841 prostate cancer patients(448 of whom exercised and 393 did not) were included in this study. With respect to CRF,there was good consistency among different studies,and it was remarkably reduced in the exercise group(SMD=-0.32,95% CI:-0.45 to-0.18,P<0.00001,n=784). In regards to QoL,there was also good consistency among different studies,and it was also improved significantly in the exercise group(SMD=0.21,95% CI:0.08 to 0.34,P=0.002,n=841). Conclusion Exercise both reduced CRF and improved QoL in prostate cancer patients receiving androgen deprivation therapy.
文摘Objective:To explore the effect of KAP intervention mode on resilience and cancer-related fatigue in patients with colorectal cancer undergoing chemotherapy.Methods:A prospective randomized trial was conducted.55 patients with colorectal cancer who received routine nursing from February 2018 to February 2019 were included in the control group,and 55 patients who received routine nursing+KAP intervention from March 2019 to March 2020 were included in the observation group.The scores of Resilience Scale and cancer-related fatigue scale(CFS)before and 6 months after intervention were compared between the two groups.Results:After 6 months of intervention,the score of resilience of the two groups was higher than that before intervention,and that of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05);The CFS score of the two groups was lower than that before intervention,and that of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion:KAP intervention model can improve the resilience of patients with colorectal cancer chemotherapy,reduce cancerrelated fatigue.
文摘Crack growth rate curves are the fundamental material property for metal structures under fatigue loading. Although there are many crack growth rate curves available in the literature, few of them showed the capability to explain various special phenomena observed in tests. A modified constitutive relation recently proposed by McEvily and his co-workers showed very promising capability. This modified constitutive relation is further generalized by (1) introducing an unstable fracture condition; (2) defining a virtual strength to replace the yield stress; and (3) defining an overload and underload parameter. The performances of this general constitutive relation for fatigue crack growth is extensively studied and it is found that this general constitutive relation is able to explain various phenomena observed with particular strong capability on load sequence effect.
文摘Cancer related fatigue(CRF)is one of the most common and painful reactions in cancer patients.Due to the negative effects of cancer itself and long-term treatment,patients often feel continuous burnout,fatigue and powerlessness in both mental and physical aspects.Fatigue related to cancer and cancer treatment will affect the physical and mental health of cancer patients for a long time and continuously,and it is hard to be relieved through rest.Nowadays,most of the researches focus on the clinical manifestations of patients with cancer,such as pain,nausea and vomiting,weight loss and so on.The fatigue feeling of cancer patients is often one of the most easily overlooked pain symptoms in the treatment process.The influence of CRF on cancer patients may be one of the reasons for reducing the survival time of cancer patients.This paper aims to summarize and explore the pathogenesis of cancer-related fatigue,in order to analyze the related factors of cancer-related fatigue from multi-dimensional and multi-angle,and provide reference for its comprehensive treatment in clinic.
基金The project supported by the National Natural Science Foundation of China (59705008)
文摘In this study, a new unified creep constitutive relation and a mod- ified energy-based fatigue model have been established respectively to describe the creep flow and predict the fatigue life of Sn-Pb solders. It is found that the relation successfully elucidates the creep mechanism related to current constitutive relations. The model can be used to describe the temperature and frequency dependent low cycle fatigue behavior of the solder. The relation and the model are further employed in part Ⅱ to develop the numerical simulation approach for the long-term reliability assessment of the plastic ball grid array (BGA) assembly.
基金Projects(51308363,11327801)supported by the National Natural Science Foundation of ChinaProject(2013-1792-9-4)supported by the Scientific Research Foundation for the Returned Overseas Chinese ScholarsProject(YJ201307)supported by the Start-up Research Fund for Introduced Talents of Sichuan University,China
文摘Fatigue is usually the cause for the cracks identified at bridge elements in service. With an increase in the introduction of corrugated steel web girders in recent highway bridge construction, the understanding of the fatigue behaviour of welded details in such structures becomes an important issue for the design. The typical welded details were represented as welded joints assembled by longitudinal corrugated plates. All the experiments were performed under fatigue loading using a servo-control testing machine. The test results from the failure mode observation with the aid of infrared thermo-graph technology show that the failure manner of these welded joints is comparable to that of the corrugated steel web beams reported previously. It is indicated from the stiffness degradation analysis that the welded joints with larger corrugation angle have higher stiffness and greater stiffness degradation in the notable stiffness degradation range. It is shown from the test S-N relations based on the free regression and forced regression analyses that there is a good linear dependence between lg(N) and lg(ΔS). It is also demonstrated that the proposed fracture mechanics analytical model is able to give a prediction slightly lower but on the safe side for the mean stresses at 2 million cycles of the test welded joints.
基金Project supported by the National Natural Science Foundation of China (Nos. 50375130 and 50323003)the Special Foundation for the Authors of National Excellent Doctoral Disserta tions (No. 200234)the Outstanding Young Teachers Program of State Education Ministry (No. 2101)
文摘A so-called 'local probabilistic Paris relation method' was presented for measuring the random thresholds of long fatigue crack propagation. A check was made to the conventional method, in which the thresholds were measured statistically and directly by the test data. It was revealed that this method was not reasonable because the test data have seldom a unified level of crack growth rates. Differently,in the presented method the Paris-Erdogan equation was applied to model the local test data around the thresholds. Local probabilistic relations with both the survival probability and the confidence were established on a lognormal distribution of the stress density factors. And then, the probabilistic thresholds were derived from the probabilistic factors with a given critical level of growth rate. An analysis on the test data of LZ50 axle steel for the Chinese railway vehicles verifies that the present method is feasible and available.
文摘Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.
文摘in reliability design of fatigue under random loading, the influence of loading se-quence must be considered. In order to avoid the uneertain hypothesis in the Miner's rule, ie. thatthe sum of damage equals one represents failure, this paper proposes the probabilistic relativeMine's rule. This paper also presents a new method for calculating reliability, ie. the syntheticmethod of Miner's rule and interference model. This model considers not only the influence ofstress concentration, dimension and surface, but also the influence of stress amplitude and se-quence.
文摘通过分析《理虚元鉴》一书中对“虚劳六因”和“治虚三本二统论”理论的阐述,得出肺癌癌因性疲乏(cancer related fatigue,CRF)的病因病机可从“火”立论,总结为肺中伏火、火衰毒蕴、水火不济和血虚痰火四种。临证遵其“阴虚统于肺、阳虚统于脾”之旨,重视使用清金保肺、培土温中法,调治过程中当秉持“勿犯中州之土”“勿损至高之气”及“期年为限”的观点,为临床辨证论治肺癌CRF提供借鉴。
