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Recent applications and chiral separation development based on stationary phases in open tubular capillary electrochromatography(2019–2022) 被引量:1
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作者 Xinyu Li Qianjie Ma +2 位作者 Xiangtai Zheng Qin Chen Xiaodong Sun 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2023年第4期323-339,共17页
Capillary electrochromatography(CEC)plays a significant role in chiral separation via the double separation principle,partition coefficient difference between the two phases,and electroosmotic flow-driven separation.G... Capillary electrochromatography(CEC)plays a significant role in chiral separation via the double separation principle,partition coefficient difference between the two phases,and electroosmotic flow-driven separation.Given the distinct properties of the inner wall stationary phase(SP),the separation ability of each SP differs from one another.Particularly,it provides large room for promising applications of open tubular capillary electrochromatography(OT-CEC).We divided the OT-CEC SPs developed over the past four years into six types:ionic liquids,nanoparticle materials,microporous materials,biomaterials,non-nanopolymers,and others,to mainly introduce their characteristics in chiral drug separation.There also added a few classic SPs that occurred within ten years as supplements to enrich the features of each SP.Additionally,we discuss their applications in metabolomics,food,cosmetics,environment,and biology as analytes in addition to chiral drugs.OT-CEC plays an increasingly significant role in chiral separation and may promote the development of capillary electrophoresis(CE)combined with other instruments in recent years,such as CE with mass spectrometry(CE/MS)and CE with ultraviolet light detector(CE/UV). 展开更多
关键词 capillary electrochromatography Open tubular capillary Chiral separation Stationary phase capillary electrophoresis with mass spectrometry(CE/MS)
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Recent advances of capillary electrophoresis-mass spectrometry instrumentation and methodology 被引量:5
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作者 You Jiang Mu-Yi He +4 位作者 Wen-Jing Zhang Pan Luo Dan Guo Xiang Fang Wei Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2017年第8期1640-1652,共13页
Capillary electrophoresis-mass spectrometry(CE-MS) is a powerful separation and analytical technique in the field of analytical chemistry. This review provides an update of instrumentation developments in the method... Capillary electrophoresis-mass spectrometry(CE-MS) is a powerful separation and analytical technique in the field of analytical chemistry. This review provides an update of instrumentation developments in the methodology of CE-MS systems. A selection of relevant articles covers the literatures published from Jan. 2013 to Feb. 2017. Special attentions were paid to the sample injection and ionization processes.Applications of these CE-MS systems were also introduced through representative examples. General conclusions and perspectives were given at the last. 展开更多
关键词 capillary electrophoresis mass spectrometry Instrumentation and methodology developments Interfaces Bio-analytical chemistry
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Potential of capillary electrophoresis mass spectrometry for the characterization and monitoring of amine-derivatized naphthenic acids from oil sands process-affected water 被引量:2
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作者 Matthew S.MacLennan Cai Tie +4 位作者 Kevin Kovalchik Kerry M.Peru Xinxiang Zhang John V.Headley David D.Y.Chen 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2016年第11期203-212,共10页
Capillary electrophoresis coupled to mass spectrometry(CE–MS) was used for the analysis of naphthenic acid fraction compounds(NAFCs) of oil sands process-affected water(OSPW). A standard mixture of amine-deriva... Capillary electrophoresis coupled to mass spectrometry(CE–MS) was used for the analysis of naphthenic acid fraction compounds(NAFCs) of oil sands process-affected water(OSPW). A standard mixture of amine-derivatized naphthenic acids is injected directly onto the CE column and analyzed by CE–MS in less than 15 min. Time of flight MS analysis(TOFMS), optimized for high molecular weight ions, showed NAFCs between 250 and 800 m/z. With a quadrupole mass analyzer, only low-molecular weight NAFCs(between 100 and 450 m/z) are visible under our experimental conditions. Derivatization of NAFCs consisted of two-step amidation reactions mediated by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(EDC), or mediated by a mixture of EDC and N-hydroxysuccinimide, in dimethyl sulfoxide, dichloromethane or ethyl acetate. The optimum background electrolyte composition was determined to be 30%(V/V) methanol in water and 2%(V/V) formic acid. NAFCs extracted from OSPW in the Athabasca oil sands region were used to demonstrate the feasibility of CE–MS for the analysis of NAFCs in environmental samples, showing that the labeled naphthenic acids are in the mass range of 350 to 1500 m/z. 展开更多
关键词 capillary electrophoresis mass spectrometry Electrospray ionization Carbodiimide Oil sands process-affected water Naphthenic acids
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