The objective of this study was to investigate the effects of natural capsicum extract(NCE,containing 2%natural capsaicin,the rest is carrier)replacing chlortetracycline(CTC)on performance,digestive enzyme activities,...The objective of this study was to investigate the effects of natural capsicum extract(NCE,containing 2%natural capsaicin,the rest is carrier)replacing chlortetracycline(CTC)on performance,digestive enzyme activities,antioxidant capacity,inflammatory cytokines,and gut health in weaned pigs.A total of 108 weaned pigs(Duroc×[Landrace×Yorkshire],initial body weight-8.68±1.34 kg;weaned on d 28)were randomly allotted into 3 treatments with 6 replicate pens per treatment(3 barrows and 3 gilts per pen).The treatments include a corn-soybean meal basal diet as a control group(CON),a CTC group(basal diet+CTC at 75 mg/kg),and a NCE group(basal diet--NEC at 80 mg/kg).Compared with CON and CTC,NCE had increased(P<0.05)average daily gain in phase 2(d 15 to 28)and overall(d 1 to 28),and higher(P<0.05)apparent total tract digestibility of gross energy,dry matter,crude protein,and organic matter in phase 1(d 1 to 14).These pigs also had increased(P<0.05)pancrelipase activity in pancreas,α-amylase,lipase and protease activities in the jejunal mucosa,and lipase activity in the ileal mucosa on d 28.Moreover,NCE had increased(P<0.05)the contents of growth hormone,β-endorphin,5-hydroxytryptamine,total antioxidant capacity,total superoxide dismutase,catalase,and IL-10,as well as decreased(P<0.05)contents of malondialdehyde,tumor nuclear factor-a,interferon-y,and interleukin-6 in serum on d 28 compared with CON and CTC.NCE showed higher(P<0.05)propionic acid,butyric acid and total volatile fatty acids(VFA)contents,and increased(P<0.05)relative abundance of Faecalibacterium in colon,as well as higher(P<0.05)propionic acid and total volatile fatty acids in cecum on d 28 compared with CON.In conclusion,NCE replacing CTC could enhance performance via improving digestive enzyme activities,antioxidant capacity,anti-inflammatory function,gut VFA composition and microbiota community in weaned pigs,and it could be used as a potential target for the development of feed additives.展开更多
基金the Beijing Municipal Natural Science Foundation(6202019)National Natural Science Foundation of China(31772612).
文摘The objective of this study was to investigate the effects of natural capsicum extract(NCE,containing 2%natural capsaicin,the rest is carrier)replacing chlortetracycline(CTC)on performance,digestive enzyme activities,antioxidant capacity,inflammatory cytokines,and gut health in weaned pigs.A total of 108 weaned pigs(Duroc×[Landrace×Yorkshire],initial body weight-8.68±1.34 kg;weaned on d 28)were randomly allotted into 3 treatments with 6 replicate pens per treatment(3 barrows and 3 gilts per pen).The treatments include a corn-soybean meal basal diet as a control group(CON),a CTC group(basal diet+CTC at 75 mg/kg),and a NCE group(basal diet--NEC at 80 mg/kg).Compared with CON and CTC,NCE had increased(P<0.05)average daily gain in phase 2(d 15 to 28)and overall(d 1 to 28),and higher(P<0.05)apparent total tract digestibility of gross energy,dry matter,crude protein,and organic matter in phase 1(d 1 to 14).These pigs also had increased(P<0.05)pancrelipase activity in pancreas,α-amylase,lipase and protease activities in the jejunal mucosa,and lipase activity in the ileal mucosa on d 28.Moreover,NCE had increased(P<0.05)the contents of growth hormone,β-endorphin,5-hydroxytryptamine,total antioxidant capacity,total superoxide dismutase,catalase,and IL-10,as well as decreased(P<0.05)contents of malondialdehyde,tumor nuclear factor-a,interferon-y,and interleukin-6 in serum on d 28 compared with CON and CTC.NCE showed higher(P<0.05)propionic acid,butyric acid and total volatile fatty acids(VFA)contents,and increased(P<0.05)relative abundance of Faecalibacterium in colon,as well as higher(P<0.05)propionic acid and total volatile fatty acids in cecum on d 28 compared with CON.In conclusion,NCE replacing CTC could enhance performance via improving digestive enzyme activities,antioxidant capacity,anti-inflammatory function,gut VFA composition and microbiota community in weaned pigs,and it could be used as a potential target for the development of feed additives.