Hydrogen production by electrocatalytic water splitting promises a green and sustainable technology to address serious energy crisis and environmental pollution [1]. As well known, the process of electrocatalytic wate...Hydrogen production by electrocatalytic water splitting promises a green and sustainable technology to address serious energy crisis and environmental pollution [1]. As well known, the process of electrocatalytic water splitting is composed of two half reaction, i.e. oxygen evolution reaction (OER) at the anode and hydrogen evolution reaction (HER) at the cathode [2].展开更多
目的探讨杨桃根苯醌(benzoquinone of Averrhoa carambola L.root,BACR)对糖尿病小鼠的疗效及相关机制。方法小鼠尾静脉注射链脲佐菌素(STZ)建立糖尿病小鼠模型。测定小鼠空腹血糖(FBG),检测血清中甘油三酯(TG)、总胆固醇(TC)、高密度...目的探讨杨桃根苯醌(benzoquinone of Averrhoa carambola L.root,BACR)对糖尿病小鼠的疗效及相关机制。方法小鼠尾静脉注射链脲佐菌素(STZ)建立糖尿病小鼠模型。测定小鼠空腹血糖(FBG),检测血清中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、单核细胞趋化蛋白-1(MCP-1)、白介素-1β(IL-1β)水平,肝脏组织中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性;HE染色观察肝脏组织病理变化;免疫组化观察Toll样受体4(TLR4)、髓样分化因子(MyD88)、核转录因子-κB(NF-κB)表达差异。结果与模型组比较,BACR给药组血清中TC、TG、LDL-C、MCP-1、IL-1β及肝脏组织MDA明显降低,血清中HDL-C及肝脏中SOD、GSH-Px明显升高;HE结果显示,BACR改善肝脏组织病理情况;肝脏组织TLR4、MyD88、NF-κB蛋白表达明显减少。结论BACR对糖尿病小鼠有降糖降脂作用,其作用机制可能与抑制炎症因子释放,增强抗氧化能力有关。展开更多
基金financially supported by the Natural Science Foundation of Jiangxi Province of China (20192BAB213001)the Foundation of Jiangxi Educational Committee (GJJ180406)+2 种基金the Research Foundation for Advanced Talents of East China University of Technology (DHBK2018043)the National Natural Science Foundation of China (2187104721661001)。
文摘Hydrogen production by electrocatalytic water splitting promises a green and sustainable technology to address serious energy crisis and environmental pollution [1]. As well known, the process of electrocatalytic water splitting is composed of two half reaction, i.e. oxygen evolution reaction (OER) at the anode and hydrogen evolution reaction (HER) at the cathode [2].
文摘目的探讨杨桃根苯醌(benzoquinone of Averrhoa carambola L.root,BACR)对糖尿病小鼠的疗效及相关机制。方法小鼠尾静脉注射链脲佐菌素(STZ)建立糖尿病小鼠模型。测定小鼠空腹血糖(FBG),检测血清中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、单核细胞趋化蛋白-1(MCP-1)、白介素-1β(IL-1β)水平,肝脏组织中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性;HE染色观察肝脏组织病理变化;免疫组化观察Toll样受体4(TLR4)、髓样分化因子(MyD88)、核转录因子-κB(NF-κB)表达差异。结果与模型组比较,BACR给药组血清中TC、TG、LDL-C、MCP-1、IL-1β及肝脏组织MDA明显降低,血清中HDL-C及肝脏中SOD、GSH-Px明显升高;HE结果显示,BACR改善肝脏组织病理情况;肝脏组织TLR4、MyD88、NF-κB蛋白表达明显减少。结论BACR对糖尿病小鼠有降糖降脂作用,其作用机制可能与抑制炎症因子释放,增强抗氧化能力有关。
