The interaction between amino acid drugs, aminobutyric acid, carbocisteine and levodopa, with chloranil was studied spectrophotometrically. The conditions were investigated and optimized. The interaction obeyed Beer＇...The interaction between amino acid drugs, aminobutyric acid, carbocisteine and levodopa, with chloranil was studied spectrophotometrically. The conditions were investigated and optimized. The interaction obeyed Beer＇s law over the range of 0.2-8.7, 1.2-20 and 2-26.4 μg/mL for aminobutyric acid, carbocisteine and levodopa, respectively. The validity was compared with that by the official methods^1,3,5 and the recovery studies of standard addition method, the result is satisfactory. The proposed method has been successfully applied to the determination of the above drugs in tablets.展开更多
Carbocisteine,also known as carbocysteine,is a mucolytic that reduces the viscosity of sputum and thus can be used to help relieve symptoms of chronic obstructive pulmonary disorder and bronchiectasis by allowing the ...Carbocisteine,also known as carbocysteine,is a mucolytic that reduces the viscosity of sputum and thus can be used to help relieve symptoms of chronic obstructive pulmonary disorder and bronchiectasis by allowing the sufferer to expel sputum more easily.A total of three new metal complexes of carbocysteine,HCcy with the metal ions Sr(Ⅱ),Ba(Ⅱ),and Pb(Ⅱ)have been successfully prepared in alkaline medium in situ H_(2)O/CH_(3)OH(50/50 w/w).The complexes obtained are characterized quantitatively and qualitatively by using micro elemental analysis,FTIR spectroscopy,UV-Vis spectroscopy,X-ray powder diffraction spectroscopy,^(1)H-NMR,and conductivity measurements.From the spectral study,all the synthesized Ccy complexes obtained as monomeric structure and the metals center moieties are six-coordinated except lead(Ⅱ)complex which existed as a four-coordinated respectively,suggesting formulas[Sr(Ccy)(H_(2)O)_(2)],[Ba(Ccy)(H_(2)O)_(2)]and[Pb(Ccy)]in neutral form.Beside,regarding both Sr(Ⅱ)and Ba(Ⅱ)complexes,the aquo groups are existed inside the coordination sphere.The infrared assignments reveal that HCcy ligand act as a bidentate ligand with the metal ions through oxygens of the deprotonated carboxylic COOH group.The 1H-NMR spectrum of the[Ba(Ccy)(H_(2)O)_(2)]complex has an absent of the proton of-COOH groups upon the deprotonated of carboxylic group.展开更多
Background Previous studies have suggested that nomogram can simplize complicated calculations of several varibles. A simple nomogram was constructed to estimate absorption rate coefficient (k a) by using the peak t...Background Previous studies have suggested that nomogram can simplize complicated calculations of several varibles. A simple nomogram was constructed to estimate absorption rate coefficient (k a) by using the peak time (t peak ) and the elimination rate coefficient (k e) of drugs administered orally Methods The nomogram was based on the plasma concentration-time (C-T) curve equation and the function relation between t peak , k a and k e A mathematical analysis was presented for the construction of single chart nomogram To check the degree of accuracy of the developed nomogram, we used it to analyze retrospective profiles of 46 drugs and compared the k a values obtained graphically and those calculated by numerically solving the descriptive equation In addition, we measured the carbocisteine concentration of 18 healthy volunteers by HPLC with fluorescence detection To analyze performance error, the measured carbocisteine concentrations were compared with predicted concentrations by the k a obtained from the nomograms along with the other pharmacokinetic parameters Results The estimated of k a values from nomograms were in very close proximity with the numerical values The performance error was as follows: median performance error (MDPE) and median absolute performance error (MDAPE) were 1 32% and 18 15%, respectively Conclusions The developed nomogram is accurate and reliable The size of performance error meets the demand of clinical pharmacokinetics Therefore, the nomograms can offer another convenient and easy method for rational individualized dosage regimens展开更多
文摘The interaction between amino acid drugs, aminobutyric acid, carbocisteine and levodopa, with chloranil was studied spectrophotometrically. The conditions were investigated and optimized. The interaction obeyed Beer＇s law over the range of 0.2-8.7, 1.2-20 and 2-26.4 μg/mL for aminobutyric acid, carbocisteine and levodopa, respectively. The validity was compared with that by the official methods^1,3,5 and the recovery studies of standard addition method, the result is satisfactory. The proposed method has been successfully applied to the determination of the above drugs in tablets.
基金Taif University Researches Supporting Project number(TURSP-2020/15),Taif University,Taif,Saudi Arabia。
文摘Carbocisteine,also known as carbocysteine,is a mucolytic that reduces the viscosity of sputum and thus can be used to help relieve symptoms of chronic obstructive pulmonary disorder and bronchiectasis by allowing the sufferer to expel sputum more easily.A total of three new metal complexes of carbocysteine,HCcy with the metal ions Sr(Ⅱ),Ba(Ⅱ),and Pb(Ⅱ)have been successfully prepared in alkaline medium in situ H_(2)O/CH_(3)OH(50/50 w/w).The complexes obtained are characterized quantitatively and qualitatively by using micro elemental analysis,FTIR spectroscopy,UV-Vis spectroscopy,X-ray powder diffraction spectroscopy,^(1)H-NMR,and conductivity measurements.From the spectral study,all the synthesized Ccy complexes obtained as monomeric structure and the metals center moieties are six-coordinated except lead(Ⅱ)complex which existed as a four-coordinated respectively,suggesting formulas[Sr(Ccy)(H_(2)O)_(2)],[Ba(Ccy)(H_(2)O)_(2)]and[Pb(Ccy)]in neutral form.Beside,regarding both Sr(Ⅱ)and Ba(Ⅱ)complexes,the aquo groups are existed inside the coordination sphere.The infrared assignments reveal that HCcy ligand act as a bidentate ligand with the metal ions through oxygens of the deprotonated carboxylic COOH group.The 1H-NMR spectrum of the[Ba(Ccy)(H_(2)O)_(2)]complex has an absent of the proton of-COOH groups upon the deprotonated of carboxylic group.
文摘Background Previous studies have suggested that nomogram can simplize complicated calculations of several varibles. A simple nomogram was constructed to estimate absorption rate coefficient (k a) by using the peak time (t peak ) and the elimination rate coefficient (k e) of drugs administered orally Methods The nomogram was based on the plasma concentration-time (C-T) curve equation and the function relation between t peak , k a and k e A mathematical analysis was presented for the construction of single chart nomogram To check the degree of accuracy of the developed nomogram, we used it to analyze retrospective profiles of 46 drugs and compared the k a values obtained graphically and those calculated by numerically solving the descriptive equation In addition, we measured the carbocisteine concentration of 18 healthy volunteers by HPLC with fluorescence detection To analyze performance error, the measured carbocisteine concentrations were compared with predicted concentrations by the k a obtained from the nomograms along with the other pharmacokinetic parameters Results The estimated of k a values from nomograms were in very close proximity with the numerical values The performance error was as follows: median performance error (MDPE) and median absolute performance error (MDAPE) were 1 32% and 18 15%, respectively Conclusions The developed nomogram is accurate and reliable The size of performance error meets the demand of clinical pharmacokinetics Therefore, the nomograms can offer another convenient and easy method for rational individualized dosage regimens
