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Short term effect of Salvia miltiorrhiza in treating rat acetic acid chronic gastric ulcer and long term effect in preventing recurrence 被引量:8
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作者 Wang, GZ Ru, X +1 位作者 Ding, LH Li, HQ 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第2期77-78,共2页
AIM To study the short term effect of Danshen ( Salvia miltiorrhiza ) on acetic acid induced chronic gastric ulcer in rats and its long term effect in preventing recurrence. METHODS Rats with acetic acid indu... AIM To study the short term effect of Danshen ( Salvia miltiorrhiza ) on acetic acid induced chronic gastric ulcer in rats and its long term effect in preventing recurrence. METHODS Rats with acetic acid induced gastric ulcer were treated with Danshen and cimetidine for 30 days. Traditional gastric mucosal auto radiography and 3H TdR incorporation into gastric mucosa in vitro were employed to study the effects of Danshen in rat acetic acid induced chronic gastric ulcer, including ulcer index (UI), ulcer inhibitory rate (IR) and label rate (LR). RESULTS On the day 5, 30 and 126 of ulcer making, the UI in the Danshen group was obviously lower than that in the cimetidine group and the control group (42 3±3 9, 3 6±1 2, 4 4±2 3; 49 1±3 6, 5 9±1 4, 9 2±1 3; 61 0±3 8, 8 9±2 5, 12 4±2 4, respectively, P <0 01), the IR (%) in the Danshen group was obviously higher than that in the cimetidine group (31, 59, 64 8; 19, 33, 26, respectively), and the LR in the Danshen group was obviously higher than that in the cimetidine group and the control group (10 0±0 5, 16 2±0 8, 15 0±0 6; 9 0±0 5, 13 9±0 6, 10 8±0 7; 6 5±0 7, 10 1±0 5, 8 0±0 7, respectively, P <0 01). There was no obvious difference in UI in the Danshen group on day 30 as compared with that on day 126. CONCLUSION Danshen is effective in promoting ulcer healing and preventing recurrence. The mechanism of action is to strengthen the gastric mucosal barrier and to promote the gastric mucosal cell proliferation along the edge of the ulcer. 展开更多
关键词 DANSHEN disease models animal SALVIA miltiorrhiza stomach ulcer acetic acid cimitidine gastric MUCOSA RECURRENCE rats Wistar chronic diseases
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Gastrin,somatostatin,G and D cells of gastric ulcer in rats 被引量:14
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作者 Feng-Peng Sun Yu-Gang Song Wei Cheng Tong Zhao Yong-Li Yao,Department of Gastroenterology,Zhujiang Hospital,First Military Medical University,Guangzhou 510282,Guangdong Province,China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2002年第2期375-378,共4页
AIM: To investigate the relationship among gastrin, somatostatin, G and D cells in gastric ulcer and in its healing process in rats. METHODS: Fourty-nine Wistar rats were divided into 7 groups. The gastric ulcer model... AIM: To investigate the relationship among gastrin, somatostatin, G and D cells in gastric ulcer and in its healing process in rats. METHODS: Fourty-nine Wistar rats were divided into 7 groups. The gastric ulcer model was induced by acetic acid successfully. The gastrin and the somatostatin in rat plasma, gastric fluid and antral tissue were measured by radioimmunoassay(RIA). G and D cells in antral mucosa were analyzed with polyclonal antibody of gastrin and somatostatin by immunohistochemical method and Quantimet 500 image analysis system. RESULTS: In gastric ulcer, the level of gastrin in plasma, gastric fluid, and antral tissue increased, that of somatostatin declined, and the disorder gradually recovered to the normal level in the healing process. Immunohistochemical technique of G and D cells in antral mucosa demonstrated that the number of G cells increased and that of D cells decreased, both areas of G and D cells declined, the ratio of number and area of G/D increased in gastric ulcer, and the disorder gradually recovered in the healing process. CONCLUSION: In gastric ulcer, the increased gastrin secreted by G cells, the declined somatostatin secreted by D cells, and the disordered G/D cell ratio can lead to gastrointestinal dysfunction. 展开更多
关键词 Animals Disease Models Animal gastric Mucosa Gastrin-Secreting Cells GASTRINS Male RATS Rats Wistar Research Support Non-U.S. Gov't SOMATOSTATIN Somatostatin-Secreting Cells stomach ulcer
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Traditional Chinese Medicine Nursing Protocols for Gastric ulcer(peptic ulcer)
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作者 Editorial Broad of Nursing of Integrated Traditional Chinese and Western Medicine 《中西医结合护理(中英文)》 2018年第5期1-3,共3页
Objective Gastric ulcer( peptic ulcer) is one of the most common digestive system diseases. This paper aimed to summarize the common syndromes of gastric ulcer( peptic ulcer),and to discuss related Traditional Chinese... Objective Gastric ulcer( peptic ulcer) is one of the most common digestive system diseases. This paper aimed to summarize the common syndromes of gastric ulcer( peptic ulcer),and to discuss related Traditional Chinese Medicine nursing interventions and health guidance. 展开更多
关键词 gastric ulcer NURSING of traditional Chinese medicine ANOREXIA stomach pain
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黄芪建中汤加味对脾胃虚寒型胃溃疡的影响
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作者 李少华 《中外医学研究》 2024年第13期120-123,共4页
目的:探讨黄芪建中汤加味对脾胃虚寒型胃溃疡的影响。方法:选取2022年6月—2023年8月淄博市中医医院收治的76例脾胃虚寒型胃溃疡患者。随机将其分为对照组和观察组,各38例。对照组给予常规治疗,观察组在对照组基础上给予黄芪建中汤加味... 目的:探讨黄芪建中汤加味对脾胃虚寒型胃溃疡的影响。方法:选取2022年6月—2023年8月淄博市中医医院收治的76例脾胃虚寒型胃溃疡患者。随机将其分为对照组和观察组,各38例。对照组给予常规治疗,观察组在对照组基础上给予黄芪建中汤加味治疗。比较两组治疗前后炎症因子、中医症候积分、氧化应激指标及临床疗效。结果:治疗后,两组白细胞介素-10(IL-10)、白细胞介素-6(IL-6)与肿瘤坏死因子-α(TNF-α)水平低于治疗前,观察组IL-6、IL-10、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组丙二醛(MDA)低于治疗前,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)高于治疗前,观察组MDA低于对照组,SOD及GSH-Px均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组胃脘疼痛、胸胁满闷、食欲不振、嗳气吞酸及倦怠乏力评分均低于治疗前,观察组胃脘疼痛、胸胁满闷、食欲不振、嗳气吞酸及倦怠乏力评分均低于对照组,差异有统计学意义(P<0.05)。观察组总有效率为94.74%,高于对照组的76.32%,差异有统计学意义(P<0.05)。结论:在西药治疗基础上联合黄芪建中汤加味可有效减轻脾胃虚寒型胃溃疡患者的炎症反应,改善其氧化应激反应,改善其病情,提高治疗效果。 展开更多
关键词 黄芪建中汤 脾胃虚寒型 胃溃疡 炎症因子 氧化应激 中医症候积分
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铋剂四联疗法联合针刺督脉背段压痛穴位治疗脾胃虚寒型Hp感染性胃溃疡疗效分析
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作者 王小沙 刘青塬 《中国烧伤创疡杂志》 2024年第2期152-156,共5页
目的分析铋剂四联疗法联合针刺督脉背段压痛穴位治疗脾胃虚寒型幽门螺杆菌(Hp)感染性胃溃疡的临床疗效。方法选取2020年1月至2021年12月河南科技大学第一附属医院收治的80例脾胃虚寒型Hp感染性胃溃疡患者作为研究对象,按照不同治疗方法... 目的分析铋剂四联疗法联合针刺督脉背段压痛穴位治疗脾胃虚寒型幽门螺杆菌(Hp)感染性胃溃疡的临床疗效。方法选取2020年1月至2021年12月河南科技大学第一附属医院收治的80例脾胃虚寒型Hp感染性胃溃疡患者作为研究对象,按照不同治疗方法将其分为联合组(40例)与对照组(40例),联合组患者采用铋剂四联疗法联合针刺督脉背段压痛穴位治疗,对照组患者单纯采用铋剂四联疗法治疗,对比观察两组患者中医症候评分、溃疡长径、血清胃泌素(GAS)水平、Hp转阴率及临床疗效。结果治疗14 d后,联合组患者胃脘疼痛、食后腹胀、嗳气泛酸、恶心反胃评分以及血清GAS水平均明显低于对照组(t=6.910、6.318、7.140、9.345、8.819,P均<0.001),溃疡长径明显短于对照组(t=18.860,P<0.001);联合组患者Hp转阴率为87.5%,明显高于对照组患者的Hp转阴率67.5%(χ^(2)=4.588,P=0.032);联合组患者中显效26例、有效11例、无效3例,明显优于对照组患者的显效19例、有效10例、无效11例(Z=-1.997,P=0.046)。结论铋剂四联疗法联合针刺督脉背段压痛穴位治疗脾胃虚寒型Hp感染性胃溃疡,可明显降低GAS水平,提高Hp转阴率,改善患者脾胃虚寒症状,促进溃疡愈合。 展开更多
关键词 针刺 督脉背段 压痛穴位 铋剂四联疗法 Hp感染 胃溃疡 脾胃虚寒
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黄芪建中汤治疗脾胃虚寒型胃溃疡效果观察
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作者 张予 《中国药业》 CAS 2024年第S01期302-304,共3页
目的探讨黄芪建中汤治疗脾胃虚寒型胃溃疡的临床效果。方法选取医院2020年5月至2023年5月收治的脾胃虚寒型胃溃疡患者96例,随机分为对照组和观察组,各48例。对照组予常规西医治疗,观察组予黄芪建中汤治疗。结果观察组总有效率为93.75%,... 目的探讨黄芪建中汤治疗脾胃虚寒型胃溃疡的临床效果。方法选取医院2020年5月至2023年5月收治的脾胃虚寒型胃溃疡患者96例,随机分为对照组和观察组,各48例。对照组予常规西医治疗,观察组予黄芪建中汤治疗。结果观察组总有效率为93.75%,显著高于对照组的79.17%(P<0.05)。观察组胃消化功能指标生长抑素、胃动素水平均显著高于对照组,胃泌素、血管活性肠肽水平均显著低于对照组(P<0.05)。观察组不良反应发生率为4.17%,显著低于对照组的25.00%(P<0.05)。结论应用黄芪建中汤治疗脾胃虚寒型胃溃疡,能改善患者的临床症状,有利于其胃功能恢复。 展开更多
关键词 脾胃虚寒型 胃溃疡 黄芪建中汤 胃消化功能 临床疗效
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沉香温胃丸对低温环境下胃溃疡的防治作用
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作者 周琳梅 《中国医药指南》 2024年第30期137-140,共4页
目的 研究低温环境下胃溃疡防治中沉香温胃丸的应用价值。方法 于2023年4月至2024年3月选取大鼠进行动物实验,选取36只大鼠,根据管理方法分组,均匀分设6组,包括空白组、胃溃疡模型组(造模组)、奥美拉唑用药组(西药组)、低剂量中药组、... 目的 研究低温环境下胃溃疡防治中沉香温胃丸的应用价值。方法 于2023年4月至2024年3月选取大鼠进行动物实验,选取36只大鼠,根据管理方法分组,均匀分设6组,包括空白组、胃溃疡模型组(造模组)、奥美拉唑用药组(西药组)、低剂量中药组、中剂量中药组、高剂量中药组,其中中药3组均为沉香温胃丸用药,比较各组胃溃疡指数、血清白细胞介素6(IL-6)指标、胃黏膜蛋白浓度血清丙二醛(MDA)指标。结果 胃溃疡指数比较,造模组最高,用药4组较低,空白组最低(P <0.05)。血清IL-6指标比较,造模组IL-6指标较高(P <0.05),用药4组、空白组IL-6指标无统计学意义(P> 0.05)。蛋白浓度比较,造模组MDA指标较高,其次为用药4组,空白组最低(P <0.05),用药4组MDA指标无统计学意义(P> 0.05)。结论 沉香温胃丸可缓解大鼠胃溃疡病情,减轻局部炎性反应,改善胃溃疡指数,促进胃黏膜修复,疗效与西药奥美拉唑相近,应用价值较高。 展开更多
关键词 低温环境下胃溃疡 应激性溃疡 沉香温胃丸 药物实验 大鼠
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基于King达标理论风险管理对胃溃疡合并胃出血患者的并发症及生活质量影响
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作者 苏晓鹏 《中国医药指南》 2024年第16期26-29,共4页
目的 探讨基于King达标理论风险管理对胃溃疡合并胃出血患者的并发症及生活质量的影响。方法 选取2022年4月至2023年4月我院收治的80例胃溃疡合并胃出血患者,按随机数字表法将患者分为对照组、研究组,各40例,研究组采用基于King达标理... 目的 探讨基于King达标理论风险管理对胃溃疡合并胃出血患者的并发症及生活质量的影响。方法 选取2022年4月至2023年4月我院收治的80例胃溃疡合并胃出血患者,按随机数字表法将患者分为对照组、研究组,各40例,研究组采用基于King达标理论风险管理,对照组予以常规护理。对比两组患者护理前后焦虑自评量表(SAS)、抑郁自评量表(SDS)评分改善情况及并发症发生率。结果 护理后,研究组胃溃疡合并胃出血患者SAS、SDS等不良心理评分低于对照组(P <0.05),生活质量评分高于对照组(P <0.05),研究组并发症发生率低于对照组(P <0.05)。结论 基于King达标理论风险管理能有效降低胃溃疡合并胃出血患者的并发症发生率,提高生活质量,改善患者不良心理。 展开更多
关键词 胃溃疡 胃出血 基于King达标理论 风险管理 并发症 生活质量
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胃康灵联合替普瑞酮治疗肝气犯胃型胃溃疡疗效分析
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作者 翟张凯 刘茜茜 《中国烧伤创疡杂志》 2024年第1期70-73,共4页
目的探讨胃康灵联合替普瑞酮治疗肝气犯胃型胃溃疡的临床疗效。方法选取2021年4月至2022年4月黄河三门峡医院收治的98例肝气犯胃型胃溃疡患者作为研究对象,按照不同治疗方法将其分为观察组(48例)与对照组(50例),观察组患者采用胃康灵联... 目的探讨胃康灵联合替普瑞酮治疗肝气犯胃型胃溃疡的临床疗效。方法选取2021年4月至2022年4月黄河三门峡医院收治的98例肝气犯胃型胃溃疡患者作为研究对象,按照不同治疗方法将其分为观察组(48例)与对照组(50例),观察组患者采用胃康灵联合替普瑞酮治疗,对照组患者单纯采用替普瑞酮治疗,对比观察两组患者血清胃肠激素与炎症因子水平以及临床疗效。结果治疗8周后,观察组患者血清胃泌素(GAS)、胃动素(MOT)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)水平均明显低于对照组(t=8845、2683、5194、3377,P<0001、P=0009、P<0001、P=0001);观察组患者中无效6例、有效4例、显效14例、痊愈24例,明显优于对照组患者的无效15例、有效8例、显效10例、痊愈17例(Z=-2314,P=0021)。结论与单纯应用替普瑞酮相比,胃康灵联合替普瑞酮更能明显改善肝气犯胃型胃溃疡患者胃肠激素以及炎症因子水平,疗效更显著,临床应用价值更高。 展开更多
关键词 肝气犯胃证 胃溃疡 胃康灵 替普瑞酮 胃肠激素 炎症因子
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黄芪建中汤联合西药“三联法”治疗脾胃虚寒型胃溃疡的临床效果观察
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作者 陈琳 《中国社区医师》 2024年第6期95-97,共3页
目的:观察黄芪建中汤联合西药“三联法”治疗脾胃虚寒型胃溃疡的临床效果。方法:选取2021年10月—2022年10月宣城中医院收治的80例脾胃虚寒型胃溃疡患者作为研究对象,采用随机数字表法分为对照组与观察组,各40例。对照组给予常规西药“... 目的:观察黄芪建中汤联合西药“三联法”治疗脾胃虚寒型胃溃疡的临床效果。方法:选取2021年10月—2022年10月宣城中医院收治的80例脾胃虚寒型胃溃疡患者作为研究对象,采用随机数字表法分为对照组与观察组,各40例。对照组给予常规西药“三联法”治疗,观察组在对照组基础上给予黄芪建中汤治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.034)。治疗前,两组纳差、腹痛、乏力、便溏、嗳气评分比较,差异无统计学意义(P>0.05);治疗后,两组纳差、腹痛、乏力、便溏、嗳气评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组复发率低于对照组,幽门螺杆菌(Hp)清除率高于对照组,差异有统计学意义(P<0.05)。结论:黄芪建中汤联合西药“三联法”治疗脾胃虚寒型胃溃疡的临床效果显著,可改善患者的临床症状,修复胃黏膜,提高Hp清除率,降低复发率。 展开更多
关键词 黄芪建中汤 胃溃疡 脾胃虚寒型
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温中补益方加减治疗胃溃疡脾胃虚寒证的效果
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作者 孙博 赵亚培 肖高健 《河南医学研究》 CAS 2024年第16期3034-3037,共4页
目的观察温中补益方治疗胃溃疡脾胃虚寒证的效果。方法采用前瞻性随机对照研究,选择2022年1—12月平煤神马集团总医院收治的胃溃疡脾胃虚寒证患者作为研究对象,采用随机数字表法分组,对照组(35例)接受标准西药治疗,观察组(35例)在对照... 目的观察温中补益方治疗胃溃疡脾胃虚寒证的效果。方法采用前瞻性随机对照研究,选择2022年1—12月平煤神马集团总医院收治的胃溃疡脾胃虚寒证患者作为研究对象,采用随机数字表法分组,对照组(35例)接受标准西药治疗,观察组(35例)在对照组基础上增加温中补益方治疗。比较患者临床疗效、中医证候积分、胃肠激素水平以及治疗期间不良反应发生情况。结果观察组总有效率(94.29%)高于对照组(74.29%)(P<0.05)。经过治疗,两组患者中医证候积分降低,观察组更低(P<0.05);两组患者胃泌素水平降低,胃动素水平升高,观察组胃泌素水平更低,胃动素水平更高(P<0.05)。观察组不良反应发生率(14.29%)与对照组(28.57%)比较,差异无统计学意义(P>0.05)。结论温中补益方在胃溃疡脾胃虚寒证患者中的治疗效果显著,可以更好改善患者临床症状和胃肠激素水平。 展开更多
关键词 胃溃疡 脾胃虚寒证 温中补益方 胃肠激素
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荆花胃康胶丸联合胶体酒石酸铋胶囊对胃溃疡患者肠道菌群及溃疡愈合的影响
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作者 张莉莉 王方方 +1 位作者 王艳晖 张飞娟 《黑龙江医药科学》 2024年第3期184-186,共3页
目的:研究荆花胃康胶丸联合胶体酒石酸铋胶囊对胃溃疡患者肠道菌群及溃疡愈合的影响。方法:选取平顶山市第一人民医院消化内科收治的117例胃溃疡患者为研究对象,随机分为对照组和研究组,对照组采用胶体酒石酸铋胶囊治疗,研究组采用荆花... 目的:研究荆花胃康胶丸联合胶体酒石酸铋胶囊对胃溃疡患者肠道菌群及溃疡愈合的影响。方法:选取平顶山市第一人民医院消化内科收治的117例胃溃疡患者为研究对象,随机分为对照组和研究组,对照组采用胶体酒石酸铋胶囊治疗,研究组采用荆花胃康胶丸联合胶体酒石酸铋胶囊治疗,连续用药4周后,比较两组患者肠道菌群变化、溃疡愈合情况及不良反应发生情况。结果:治疗前研究组患者胃肠道双歧杆菌(6.62±0.61)lgCFU/g、乳酸菌(6.92±0.72)lgCFU/g、肠球菌(11.13±1.11)lgCFU/g、葡萄球菌(6.68±0.52)lgCFU/g、大肠杆菌(10.68±1.08)lgCFU/g,对照组患者胃肠道双歧杆菌(6.58±0.60)lgCFU/g、乳酸菌(6.95±0.67)lgCFU/g、肠球菌(11.08±1.17)lgCFU/g、葡萄球菌(6.70±0.53)lgCFU/g、大肠杆菌(10.57±1.11)lgCFU/g,两组患者肠道菌群无统计学差异(P>0.05);治疗后研究组患者胃肠道双歧杆菌(10.67±0.71a)lgCFU/g、乳酸菌(10.12±0.87)lgCFU/g、肠球菌(6.87±0.91)lgCFU/g、葡萄球菌(3.17±0.33)lgCFU/g、大肠杆菌(7.21±0.23)lgCFU/g,对照组患者胃肠道双歧杆菌(8.35±0.63)lgCFU/g、乳酸菌(8.83±1.12)lgCFU/g、肠球菌(8.21±0.73)lgCFU/g、葡萄球菌(4.86±0.51)lgCFU/g、大肠杆菌(8.84±0.46)lgCFU/g,两组患者双歧杆菌、乳酸菌数目明显增多,且研究组增长数目高于对照组,肠球菌、葡萄球菌、大肠杆菌数目下降,研究组下降数目多于对照组(P<0.05)。研究组溃疡愈合总有效率98.28%高于对照组81.35%,不良反应发生率5.17%低于对照组20.34%(P<0.05)。结论:荆花胃康胶丸联合胶体酒石酸铋胶囊能有效调节胃溃疡患者肠道菌群,促进溃疡愈合,且不良反应发生率较低。 展开更多
关键词 荆花胃康胶丸 胶体酒石酸铋胶囊 胃溃疡 肠道菌群
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疏肝和胃方联合四联疗法治疗肝胃气滞型胃溃疡临床观察
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作者 刘生玲 《中国中医药现代远程教育》 2024年第15期146-149,共4页
目的探讨肝胃气滞型胃溃疡(GU)患者应用疏肝和胃方联合四联疗法的效果。方法采用随机数字表法将2020年1月—2022年3月萍乡市第二人民医院收治的60例GU患者分为两组,每组30例。对照组予以四联疗法,观察组在对照组的基础上加用自拟疏肝和... 目的探讨肝胃气滞型胃溃疡(GU)患者应用疏肝和胃方联合四联疗法的效果。方法采用随机数字表法将2020年1月—2022年3月萍乡市第二人民医院收治的60例GU患者分为两组,每组30例。对照组予以四联疗法,观察组在对照组的基础上加用自拟疏肝和胃方,两组均连续治疗4周。比较两组临床疗效、中医证候积分、炎症因子水平、胃肠激素水平、幽门螺杆菌(Hp)转阴率及不良反应。结果治疗后,观察组生长抑素(SS)水平及Hp转阴率较对照组高,各项中医证候积分及肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、胃泌素(GAS)水平较对照组低,差异均有统计学意义(P<0.05)。观察组临床总有效率93.33%(28/30)高于对照组的73.33%(22/30)(P<0.05)。两组均未见明显不良反应。结论疏肝理气联合四联疗法、和胃止痛法治疗肝胃气滞型GU患者可增强临床效果、减轻炎症反应、改善胃肠功能,且安全性好,值得推广。 展开更多
关键词 胃脘痛 胃溃疡 肝胃气滞证 疏肝理气法 和胃止痛法 四联疗法 中西医结合疗法
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四君子汤加减联合艾灸疗法治疗胃溃疡脾胃气虚证的临床效果
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作者 朱精琪 《反射疗法与康复医学》 2024年第1期57-60,共4页
目的分析胃溃疡(GU)脾胃气虚证患者采用四君子汤加减联合艾灸疗法治疗的效果.方法选取2020年1月—2023年1月曹县人民医院收治的82例GU脾胃气虚证患者为研究对象,按随机数字表法将其分为对照组及观察组.对照组(n=41)采用艾灸疗法治疗,在... 目的分析胃溃疡(GU)脾胃气虚证患者采用四君子汤加减联合艾灸疗法治疗的效果.方法选取2020年1月—2023年1月曹县人民医院收治的82例GU脾胃气虚证患者为研究对象,按随机数字表法将其分为对照组及观察组.对照组(n=41)采用艾灸疗法治疗,在此基础上,观察组(n=41)采用四君子汤加减治疗.比较两组患者的中医证候积分、症状消失时间、血清炎症因子水平及溃疡愈合率.结果治疗后,观察组的中医证候积分为(16.43±3.48)分,低于对照组(19.76±3.31)分,差异有统计学意义(P﹤0.05).观察组的餐后饱腹感、早饱、上腹痛、嗳气消失时间分别为(1.46±0.25)d、(1.67±0.43)d、(2.05±0.62)d、(2.45±0.83)d,均短于对照组的(1.88±0.43)d、(1.96±0.48)d、(3.63±0.73)d、(3.66±0.91)d,组间差异有统计学意义(P﹤0.05).治疗后,观察组的白细胞介素-6、肿瘤坏死因子-α、转化生长因子-β1水平分别为(106.33±23.16)ng/mL、(51.64±6.67)pg/mL、(1.02±0.15)pg/mL,均低于对照组的(154.56±35.67)ng/mL、(63.54±7.35)pg/mL、(1.57±0.67)pg/mL,组间差异有统计学意义(P﹤0.05).观察组的溃疡总愈合率为90.24%,高于对照组的70.73%,差异有统计学意义(P﹤0.05).结论GU脾胃气虚证患者采用四君子加减与艾灸疗法治疗的效果显著,可快速缓解症状,减轻机体炎症反应,提升溃疡总愈合率,值得推广. 展开更多
关键词 胃溃疡 脾胃气虚证 四君子汤加减 艾灸疗法 中医证候积分 炎症因子
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Experimental study on mechanism and protection of stress ulcer produced by explosive noise 被引量:13
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作者 LIU Guo Shi 1, HUANG Yu Xin 1, LI Shuan Wei 2, PAN Bo Rong 3, WANG Xin 1, SUN Da Yong 1 and WANG Qing Li 1 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第6期64-68,共5页
AIM To establish an experimental model of stress ulcer produced by explosive noise, and to probe into its mechanism and protection. METHODS The country standard Wistar white rats were randomly divided into control ... AIM To establish an experimental model of stress ulcer produced by explosive noise, and to probe into its mechanism and protection. METHODS The country standard Wistar white rats were randomly divided into control group ( n =8), which were neither stimulated nor protected, and stimulating group (divided into subgroups A, B and C, including 8 rats each which were decapitated to draw blood for test immediately, 12 hours and 24 hours after stimulation) and prevention group (divided into subgroups A, B and C, having 8 rats each, subgroup A was given cimetidine, B anisodamine and C both drugs). Firing noises of submachine guns were used as inflicting factor. The rats were fasted for 24 hours and stimulated by firing noise for 12 hours. The change of ulcer index, gastric mucosal and related serum hormones were observed. RESULTS Stress ulcer was significant in the stimulating group, and its ulcer index (8 6±0 6) was remarkably higher than that in both the control group and prevention group (0 3±0 1, P <0 01). Its serum gastrin (Gas ng/L , 294±163 vs 63±40, P <0 01) and endothelin (ET ng/L , 181±57 vs 135±42, P <0 01) were apparently higher than those in the control group, and its serum nitric oxide (NO) level was conspicuously lower than that in the control group ( ng/L , 0 2±0 1 vs 0 8±0 5, P <0 05), while the serum gastrin level ( ng/L , 556±225) in prevention group was distinctly higher than that in both the control ( P <0 01) and stimulating group ( P <0 05). There were no significant differences in the changes of ET and NO between the control and the stimulating groups. CONCLUSION Stress ulcer model of rats can be successfully established by the stimulation of explosive noise. Gas, ET and NO are related to the formation of stress ulcer, and play an important role in its mechanism. Hepatic function affected by noise is observed in this experiment. 展开更多
关键词 stomach ulcer/etiology stomach ulcer/prevention and control gastric mucosa/pathology noise/adverse effects STRESS ulcer
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Protection of gastric mucosa from ethanol induced injury by recombinant epidermal growth factor in rats 被引量:6
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作者 XU Chun Di 1, GAN Ren Bao 2, CHEN Shun Nian 1, JIANG Shi Hu 1 and XU Jia Yu 1 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第5期74-75,共2页
AIM To determine whether recombinant human epidermal growth factor (rhEGF) can protect gastric mucosa against ethanol induced injury in rats. METHOD Fifty four SD rats weighing 200g - 500g each were divided ... AIM To determine whether recombinant human epidermal growth factor (rhEGF) can protect gastric mucosa against ethanol induced injury in rats. METHOD Fifty four SD rats weighing 200g - 500g each were divided into six groups after fasting for 24 hours. Three groups received different doses of oral rhEGF (30, 60 and 120μg·kg -1 ·d -1 ), one group was given cimetidine, one subcutaneous rhEGF (rhEGFⅣ) and one received saline as control. RESULTS Acute gastric dilatation developed in the control and cimetidine groups and bloody gastric juice was found in the control group. The ulcer index was 58 in control group, 53 in rhEGFⅠ, 46 in rhEGFⅡ ( P <0 01) , 11 in rhEGFⅢ ( P <0 01) , 19 in rhEGFⅣ ( P <0 01) , and 39 in cimetidine group ( P <0 05) . CONCLUSION rhEGF protected gastric mucosa against ethanol induced damage. The effect was dose dependent with blood levels of epidermal growth factor (EGF) at a dosage range of 60μg·kg -1 ·d -1 -120μg·kg -1 ·d -1 . It was more effective by injection than via oral route at the same dosage. 展开更多
关键词 stomach ulcer gastric MUCOSA EPIDERMAL GROWTH FACTOR urogastrone
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Management of Helicobacter pylori infection after gastric surgery 被引量:5
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作者 Yang-Sheng Lin Ming-Jen Chen +3 位作者 Shou-Chuan Shih Ming-Joug Bair Ching-Ju Fang Horng-Yuan Wang 《World Journal of Gastroenterology》 SCIE CAS 2014年第18期5274-5282,共9页
The Maastricht IV/Florence Consensus Report and the Second Asia-Pacific Consensus Guidelines strongly recommend eradication of Helicobacter pylori(H.pylori)in patients with previous gastric neoplasia who have undergon... The Maastricht IV/Florence Consensus Report and the Second Asia-Pacific Consensus Guidelines strongly recommend eradication of Helicobacter pylori(H.pylori)in patients with previous gastric neoplasia who have undergone gastric surgery.However,the guidelines do not mention optimal timing,eradication regimens,diagnostic tools,and follow-up strategies for patients undergoing gastrectomy and do not indicate if eradication of H.pylori reduces the risk of marginal ulcer or stump cancer in the residual stomach after gastrectomy.The purpose of this review is to provide an update which may help physicians to properly manage H.pylori infection in patients who have undergone gastric surgery.This review focuses on(1)the microenvironment change in the stomach after gastrectomy;(2)the phenomenon of spontaneous clearance of H.pylori after gastrectomy;(3)the effects of H.pylori on gastric atrophy and intestinal metaplasia after gastrectomy;(4)incidence and clinical features of ulcers developing after gastrectomy;(5)does eradication of H.pylori reduce the risk of gastric stump cancer in the residual stomach?(6)does eradication of H.pylori reduce the risk of secondary metachronous gastric cancer in the residual stomach?and(7)optimal timing and regimens for H.pylori eradication,diagnostic tools and follow-up strategies for patients undergoing gastrectomy. 展开更多
关键词 Helicobacter pylori GASTRECTOMY gastric stump Treatment outcome stomach neoplasms stomach ulcer Atrophic gastritis METAPLASIA
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Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up 被引量:12
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作者 Sang Kil Lee Yong Chan Lee +6 位作者 Jae Bock Chung Chae Yoon Chon Young Myoung Moon Jin Kyung Kang In-Suh Park Chang Ok Suh Woo Ik Yang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第2期223-226,共4页
AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities. METHODS:A total of 55 pati... AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities. METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed. RESULTS:Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori (Hpylori) regimen only.The duration to reach complete remission was 12 months (85 percentile,2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases. CONCLUSION:Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloriinfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication. 展开更多
关键词 ADULT Aged Endoscopy Digestive System Follow-Up Studies gastric Mucosa Helicobacter Infections Helicobacter pylori Humans Lymphoma Mucosa-Associated Lymphoid Tissue Middle Aged Pyloric Antrum Remission Induction Retrospective Studies stomach ulcer
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Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa 被引量:14
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作者 Xi-Zhong Shen Marcel W.L. Koo Chi-Hin Cho Department of Gastroenterology,Zhongshan Hospital,Fudan University,136 Yixueyuan Road,Shanghai 200032,ChinaDepartment of Pharmacology.Faculty of Medicine,University of Hong Kong,5 Sassoon Road,Pokfulam,Hong Kong,ChinaSupported by .Dr.Marcel W.L.Koo,Department of Pharmacology,FacuLty of Medicine,the University of Hong Kong,5 Sassoon Road,Hong Kong,China.Wlkoo@hkusua.hku.hk 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第4期496-499,共4页
AIM: To investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense. METHODS: Rats for sleep disruption were placed... AIM: To investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense. METHODS: Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7d sleep deprivation. RT-PCR, immunohistochemistry and Western blotting were used to determine the expression of heat shock protein 70. Ethanol (500mL.L(-1), i.g.) was used to induce gastric mucosa damage. RESULTS: RT-PCR, Western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500mL.L(-1) ethanol challenge, the ulcer area found in the rats with 7d sleep deprivation (19.15 +/- 4.2)mm(2) was significantly lower (P【0.01) than the corresponding control (53.7 +/- 8.1) mm(2). CONCLUSION: Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection. 展开更多
关键词 Animals Central Nervous System Depressants Ethanol gastric Mucosa Gene Expression HSP70 Heat-Shock Proteins IMMUNOHISTOCHEMISTRY Male RNA Messenger RATS Rats Sprague-Dawley Research Support Non-U.S. Gov't Sleep Deprivation stomach ulcer control
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GC/MS-based differential metabolic profiling of human peptic ulcer disease to study Helicobacter pylori-induced metabolic perturbations 被引量:2
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作者 GAGANJOT GUPTA DEEPAK BANSAL +5 位作者 ANSHULA SHARMA TAWSEEF AHMAD ATUL SACHDEV AJAZ AHMAD HAMED A.EL-SEREHY BALJINDER KAUR 《BIOCELL》 SCIE 2021年第5期1299-1311,共13页
Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism ... Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H.pylori-induced pathogenicity.The rationale of the study is to explore the underlying distinct metabolic mechanisms of H.pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry.GC/MS-based analytical method was used to compare metabolic profiles of healthy controls(N=20)and peptic ulcer patients(N=45).Acquired metabolomic data were analyzed by constructing a diagnostic model using principal component analysis and a non-parametric two-tailed paired Wilcoxon analysis to identify disease-specific metabolic biomarkers.A total of 75 low-molecular-weight endogenous metabolites were detected during comparative metabolomic analysis of PUD vs.healthy gut tissues,among which 16 metabolites are being proposed to be diagnostic markers of Human PUD.Perturbations related to amino acids,carbohydrates,fatty acids,organic acids,and sterol metabolism were significantly revealed during this differential metabolomic profiling.Results convincingly suggest that metabolic profiles can contribute immensely in early diagnosis of the disease and understanding molecular mechanisms of disease progression for predicting novel drug targets for prophylactic and anaphylactic measures. 展开更多
关键词 Peptic ulcer disease gastric cancer Helicobacter pylori Metabolic profiling PERTURBATIONS stomach ulcers
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