RFLPs for XbaI, BelI and BglI sites of human FⅧwere informative for 48%, 41% and 15% of females studied, respectively. BglI RFLP is different from that reported by Chan et al, a fact suggests Yangtze River region pop...RFLPs for XbaI, BelI and BglI sites of human FⅧwere informative for 48%, 41% and 15% of females studied, respectively. BglI RFLP is different from that reported by Chan et al, a fact suggests Yangtze River region population of China would be at variance with the Southern Chinese population in certain RFLP distribution. TaqI allelic system Ⅰin the DXS52 region also shows the same variance among them, but heterozygous rate 0f 71% for system Ⅰ(alleles 1 to 8) and 49% for system Ⅱ(αand βalleles) were very similar. Using the Bell/XbaI RFLPs, accurate information could be obtained from this study for 56% of women who were at risk for hemophilia A (HA) carriership. The carrier of the remaining 44% could be determined by utilizing the TaqI RFLP. In addition, we report a new intergenie polymorphism (9%) at DXS115 as a marker for detection of heterozygotes in families at risk for HA. The advantage of using the XbaI/KpnI RFLP is that both the intragemie RFLP and the new intergenie RFLP can be evaluated on the same blot at the same time.展开更多
Objective The study is to identify the carrier rate of common deafness mutation in Chinese pregnant women via detecting deafness gene mutations with gene chip. Methods The pregnant women in obstetric clinic without he...Objective The study is to identify the carrier rate of common deafness mutation in Chinese pregnant women via detecting deafness gene mutations with gene chip. Methods The pregnant women in obstetric clinic without hearing impairment and hearing disorders family history were selected. The informed consent was signed. Peripheral blood was taken to extract genom- ic DNA. Application of genetic deafness gene chip for detecting 9 mutational hot spot of the most common 4 Chinese deafness genes, namely GJB2 （35delG, 176del16bp, 235delC, 299delAT）, GJB3 （C538T） ,SLC26A4 （ IVS72A〉G, A2168G） and mito- chondrial DNA 12S rRNA （A1555G, C1494T） . Further genetic testing were provided to the spouses and newborns of the screened carriers. Results Peripheral blood of 430 pregnant women were detected, detection of deafness gene mutation carri- ers in 24 cases（4.2%）, including 13 cases of the GJB2 heterozygous mutation, 3 cases of SLC26A4 heterozygous mutation, 1 cases of GJB3 heterozygous mutation, and 1 case of mitochondrial 12S rRNA mutation. 18 spouses and 17 newborns took further genetic tests, and 6 newborns inherited the mutation from their mother. Conclusion The common deafness genes muta- tion has a high carrier rate in pregnant women group, 235delC and IVS7-2A〉G heterozygous mutations are common.展开更多
Coexistence and interoperability between 20 MHz and 40 MHz device and modes of op-erations are stressed in standard IEEE 802.11n system.It is mandate to report the both sub-channels states to Medium Access Control(MAC...Coexistence and interoperability between 20 MHz and 40 MHz device and modes of op-erations are stressed in standard IEEE 802.11n system.It is mandate to report the both sub-channels states to Medium Access Control(MAC) at receiver,since for 40 MHz device,it should serve not only 20 MHz but also 40 MHz signals receiving.Both energy detection and carrier sense are employed to detect channel state.In the case of 20/40 M mode,the power difference between the two sub-channels is also detected in order to report the channel state accurately.The simulation results demonstrate that the performance of the proposed methods are much better than the methods which just employ energy detection.Besides,the simulation results show that the proposed methods ensure that the channel sensing is not a roadblock of IEEE 802.11n system design.展开更多
The carrier synchronization algorithm of the autonomous radio for deep space is studied.When the signal modulation is unknown,this paper improves the existing universal carrier synchronization loop for multiple modula...The carrier synchronization algorithm of the autonomous radio for deep space is studied.When the signal modulation is unknown,this paper improves the existing universal carrier synchronization loop for multiple modulations,expands the frequency tracking range of the loop,proposes a Tong detection-based M-ary Phase Shift Keying(M-PSK)signal locking detection algorithm to rapidly and effectively determine whether the current phase discrimination mode matches the modulation mode,so as to independently choose whether to switch the phase discrimination mode.Through theoretical analysis and comparison,it is described that the total detection probability of the algorithm proposed in this paper is significantly higher than the probability of single lock detection.Simulation results show that the algorithm has high detection probabiUty and low computational complexity at a low signal to noise ratio.展开更多
文摘RFLPs for XbaI, BelI and BglI sites of human FⅧwere informative for 48%, 41% and 15% of females studied, respectively. BglI RFLP is different from that reported by Chan et al, a fact suggests Yangtze River region population of China would be at variance with the Southern Chinese population in certain RFLP distribution. TaqI allelic system Ⅰin the DXS52 region also shows the same variance among them, but heterozygous rate 0f 71% for system Ⅰ(alleles 1 to 8) and 49% for system Ⅱ(αand βalleles) were very similar. Using the Bell/XbaI RFLPs, accurate information could be obtained from this study for 56% of women who were at risk for hemophilia A (HA) carriership. The carrier of the remaining 44% could be determined by utilizing the TaqI RFLP. In addition, we report a new intergenie polymorphism (9%) at DXS115 as a marker for detection of heterozygotes in families at risk for HA. The advantage of using the XbaI/KpnI RFLP is that both the intragemie RFLP and the new intergenie RFLP can be evaluated on the same blot at the same time.
文摘Objective The study is to identify the carrier rate of common deafness mutation in Chinese pregnant women via detecting deafness gene mutations with gene chip. Methods The pregnant women in obstetric clinic without hearing impairment and hearing disorders family history were selected. The informed consent was signed. Peripheral blood was taken to extract genom- ic DNA. Application of genetic deafness gene chip for detecting 9 mutational hot spot of the most common 4 Chinese deafness genes, namely GJB2 （35delG, 176del16bp, 235delC, 299delAT）, GJB3 （C538T） ,SLC26A4 （ IVS72A〉G, A2168G） and mito- chondrial DNA 12S rRNA （A1555G, C1494T） . Further genetic testing were provided to the spouses and newborns of the screened carriers. Results Peripheral blood of 430 pregnant women were detected, detection of deafness gene mutation carri- ers in 24 cases（4.2%）, including 13 cases of the GJB2 heterozygous mutation, 3 cases of SLC26A4 heterozygous mutation, 1 cases of GJB3 heterozygous mutation, and 1 case of mitochondrial 12S rRNA mutation. 18 spouses and 17 newborns took further genetic tests, and 6 newborns inherited the mutation from their mother. Conclusion The common deafness genes muta- tion has a high carrier rate in pregnant women group, 235delC and IVS7-2A〉G heterozygous mutations are common.
文摘Coexistence and interoperability between 20 MHz and 40 MHz device and modes of op-erations are stressed in standard IEEE 802.11n system.It is mandate to report the both sub-channels states to Medium Access Control(MAC) at receiver,since for 40 MHz device,it should serve not only 20 MHz but also 40 MHz signals receiving.Both energy detection and carrier sense are employed to detect channel state.In the case of 20/40 M mode,the power difference between the two sub-channels is also detected in order to report the channel state accurately.The simulation results demonstrate that the performance of the proposed methods are much better than the methods which just employ energy detection.Besides,the simulation results show that the proposed methods ensure that the channel sensing is not a roadblock of IEEE 802.11n system design.
基金Supported by Program for New Century Excellent Talents in University(NCET-12-0030)National Natural Science Foundation of China(91438116)
文摘The carrier synchronization algorithm of the autonomous radio for deep space is studied.When the signal modulation is unknown,this paper improves the existing universal carrier synchronization loop for multiple modulations,expands the frequency tracking range of the loop,proposes a Tong detection-based M-ary Phase Shift Keying(M-PSK)signal locking detection algorithm to rapidly and effectively determine whether the current phase discrimination mode matches the modulation mode,so as to independently choose whether to switch the phase discrimination mode.Through theoretical analysis and comparison,it is described that the total detection probability of the algorithm proposed in this paper is significantly higher than the probability of single lock detection.Simulation results show that the algorithm has high detection probabiUty and low computational complexity at a low signal to noise ratio.
