The complex and variable nature of traumatic spinal cord inju- ry （SCI） presents a unique challenge for translational research. SCI is not bound by any demographic nor is it limited to specific injury biomechanics.
Based on the working of Lighthill and Hunt et al., in the present paper the author has established the topological rules adapting to analysing the skin-friction lines and the section streamlines in cascades. These rul...Based on the working of Lighthill and Hunt et al., in the present paper the author has established the topological rules adapting to analysing the skin-friction lines and the section streamlines in cascades. These rules are (1) for a rotor cascade without shroud band, the total number of nodal points equals that the saddle points on the skin-friction line vector fields in eachpitch range; (2) for an annular or straight cascade with no-clearances at blade ends, the total number of saddle points is two more than that of nodal points on the skin-friction line fields in a pitch; (3) the total number of saddles in the secondary flow fields on cross-sections in cascade is one less than that of nodes; (4) in the section streamline vector fields on a meridian surface penetrating a flow passage, and on leading and trailing edge sections, the total number of nodes is equal to that of saddles; (5) on the streamline vector fields of a blade-to-blade surface, the total number of nodes is one less than that of saddles.展开更多
Molecular dynamics simulations of the displacement cascades in Fe 10%Cr systems are used to sinmlate the primary knocked-on atom events of the irradiation damage at temperatures 300, 600, and 750 K with primary knocke...Molecular dynamics simulations of the displacement cascades in Fe 10%Cr systems are used to sinmlate the primary knocked-on atom events of the irradiation damage at temperatures 300, 600, and 750 K with primary knockedon atom energies between 1 and 15 keV. The results indicate that the vacancies produced by the cascade are all in the central region of the displacement cascade. During the cascade, all recoil Fe and Cr atoms combine with each other to form Fe Cr or Fe Fe interstitial dumbbells as well as interstitial clusters. The number and the size of interstitial clusters increase with the energy of the primary knocked-on atom and the temperature. A few large clusters consist of a large number of lee interstitials with a few Cr atoms, the rest are lee Cr clusters with small and medium sizes. The interstitial dumbbells of Fe lee and Fe-Cr are in the （111）and （110） series directions, respectively.展开更多
Porphyromonas gingivalis, is the most prominent member of the bacteria flora associated with pathogenesis of periodontitis, a chronic inflammatory disease resulting in tooth loss. The extent of oral mucosal reaction t...Porphyromonas gingivalis, is the most prominent member of the bacteria flora associated with pathogenesis of periodontitis, a chronic inflammatory disease resulting in tooth loss. The extent of oral mucosal reaction to P. gingivalis invasion relays heavily on Toll-like receptors (TLRs) that recognize structurally common motifs of pathogens and initiate antibacterial responses. Among the virulence factors of P. gingivalis implicated in TLRs activation and triggering inflammatory responses leading to the development of periodontitis is the bacterium cell-wall lipopolysaccharide (LPS). The engagement by the LPS of oral mucosal TLR4 leads to initiation of signaling events characterized by the activation of mitogen-activated protein kinase (MAPK) and IκB-kinase complex (IKK) cascades, induction of phosphoinositide-specific phospholipase C (PLC)/protein kinase C (PKC)/PI3K pathway, up-regulation in TGF-α ectodomain shedding and EGFR transactivation, and the amplification of proinflammatory signals by spleen tyrosine kinase (Syk). These events, in turn, exert their control over transcription factors implicated in the induction of the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) genes that lead to up-regulation in the inflammatory mediators, PGE2 and NO. The systems involved in transcription factors activation, furthermore, remain under additional regulatory control through S-nitrosylation. Moreover, the LPS-induced TLR4 activation provides a docking site for Syk, the activation of which leads to amplification of the inflammatory signals by affecting transcription factors activation and their assembly to transcriptional complexes. Interestingly, the extent of oral mucosal inflammatory response to P. gingivalis remains under modulatory influence by two biologically active peptide hormones, leptin and ghrelin. Therefore, the presence of these multifunctional peptides in oral mucosa and saliva may be of significance in countering the destructive consequences of P. gingivalis—induced chronic mucosal inflammation that characterizes periodontitis.展开更多
This paper briefly describes the basic situation and features of Three Gorges Cascade, discusses the principle,functions, structure of the integrated automation system, and explains advanced techniques and principle a...This paper briefly describes the basic situation and features of Three Gorges Cascade, discusses the principle,functions, structure of the integrated automation system, and explains advanced techniques and principle and associated experiments of its monitoring and control展开更多
In this paper, cascading failure is studied by coupled map lattice （CML） methods in preferential attachment community networks. It is found that external perturbation R is increasing with modularity Q growing by sim...In this paper, cascading failure is studied by coupled map lattice （CML） methods in preferential attachment community networks. It is found that external perturbation R is increasing with modularity Q growing by simulation. In particular, the large modularity Q can hold off the cascading failure dynamic process in community networks. Furthermore, different attack strategies also greatly affect the cascading failure dynamic process. It is particularly significant to control cascading failure process in real community networks.展开更多
This paper studies the cascading failure on random networks and scale-free networks by introducing the tolerance parameter of edge based on the coupled map lattices methods. The whole work focuses on investigating som...This paper studies the cascading failure on random networks and scale-free networks by introducing the tolerance parameter of edge based on the coupled map lattices methods. The whole work focuses on investigating some indices including the number of failed edges, dynamic edge tolerance capacity and the perturbation of edge. In general, it assumes that the perturbation is attributed to the normal distribution in adopted simulations. By investigating the effectiveness of edge tolerance in scale-free and random networks, it finds that the larger tolerance parameter λ can more efficiently delay the cascading failure process for scale-free networks than random networks. These results indicate that the cascading failure process can be effectively controlled by increasing the tolerance parameter λ. Moreover, the simulations also show that, larger variance of perturbation can easily trigger the cascading failures than the smaller one. This study may be useful for evaluating efficiency of whole traffic systems, and for alleviating cascading failure in such systems.展开更多
In a barotropic atmosphere, new Reynolds mean momentum equations including turbulent viscosity, dispersion, and instability are used not only to derive the KdV-Burgers-Kuramoto equation but also to analyze the physica...In a barotropic atmosphere, new Reynolds mean momentum equations including turbulent viscosity, dispersion, and instability are used not only to derive the KdV-Burgers-Kuramoto equation but also to analyze the physical mechanism of the cascades of energy and enstrophy. It shows that it is the effects of dispersion and instability that result in the inverse cascade. Then based on the conservation laws of the energy and enstrophy, a cascade model is put forward and the processes of the cascades are described.展开更多
The method in [1] has been extended to the case of rotational flow in this paper. A new method for dealing with the shock wave is presented. This method has the advantages of both the shock-fitting and the shock captu...The method in [1] has been extended to the case of rotational flow in this paper. A new method for dealing with the shock wave is presented. This method has the advantages of both the shock-fitting and the shock capturing methods. The direct problem and the mixed direct-inverse prob- lem of the rotational flow in a transonic plane cascade at both design and off design conditions are solved, and the results show that the present method has rapid convergence rate and high accuracy even for the flow with moderately strong shocks. The calculations have been carried out on the DPS-8 computer, and for the direct problem, only 50-80 iterations are needed, and 50-80 seconds of CPU time are required.展开更多
A new kind of multiobjective simulated annealing algorithm is proposed,in which the concept of non dominated character is introduced and a new multiobjective acceptance criterion is set up.The optimization example of...A new kind of multiobjective simulated annealing algorithm is proposed,in which the concept of non dominated character is introduced and a new multiobjective acceptance criterion is set up.The optimization example of a typical mathematical problem with two minimum objective functions indicates that all of the solutions contract to the set of the non dominated points,and the variation trend of the optimal solutions is verified to be identical with that obtained using Genetic Algor thms.The new developed algorithm is then applied to the multiobjective optimization design of turbine cascades,in which it is coupled with the aerodynamics computation of the cascade flow fields and performance and the calculated loss coefficient and work potential of the cascade are considered as the objective functions,thus setting up a technique to the engineering optimization design for the cascades.The optimization results,by the view of a group of optimal solutions,show that the algorithm is superior to the traditional technique of multiobjective optimization design and can be applied to more than two objective optimization cascade design problem or other engineering multiobjective optimization designs.展开更多
文摘The complex and variable nature of traumatic spinal cord inju- ry （SCI） presents a unique challenge for translational research. SCI is not bound by any demographic nor is it limited to specific injury biomechanics.
文摘Based on the working of Lighthill and Hunt et al., in the present paper the author has established the topological rules adapting to analysing the skin-friction lines and the section streamlines in cascades. These rules are (1) for a rotor cascade without shroud band, the total number of nodal points equals that the saddle points on the skin-friction line vector fields in eachpitch range; (2) for an annular or straight cascade with no-clearances at blade ends, the total number of saddle points is two more than that of nodal points on the skin-friction line fields in a pitch; (3) the total number of saddles in the secondary flow fields on cross-sections in cascade is one less than that of nodes; (4) in the section streamline vector fields on a meridian surface penetrating a flow passage, and on leading and trailing edge sections, the total number of nodes is equal to that of saddles; (5) on the streamline vector fields of a blade-to-blade surface, the total number of nodes is one less than that of saddles.
基金Project supported by the National Basic Research Program of China (Grant No. 2007CB209803)the Applied Basic Research Program of Hebei Province,China (Grant No. 10165401P)
文摘Molecular dynamics simulations of the displacement cascades in Fe 10%Cr systems are used to sinmlate the primary knocked-on atom events of the irradiation damage at temperatures 300, 600, and 750 K with primary knockedon atom energies between 1 and 15 keV. The results indicate that the vacancies produced by the cascade are all in the central region of the displacement cascade. During the cascade, all recoil Fe and Cr atoms combine with each other to form Fe Cr or Fe Fe interstitial dumbbells as well as interstitial clusters. The number and the size of interstitial clusters increase with the energy of the primary knocked-on atom and the temperature. A few large clusters consist of a large number of lee interstitials with a few Cr atoms, the rest are lee Cr clusters with small and medium sizes. The interstitial dumbbells of Fe lee and Fe-Cr are in the （111）and （110） series directions, respectively.
文摘Porphyromonas gingivalis, is the most prominent member of the bacteria flora associated with pathogenesis of periodontitis, a chronic inflammatory disease resulting in tooth loss. The extent of oral mucosal reaction to P. gingivalis invasion relays heavily on Toll-like receptors (TLRs) that recognize structurally common motifs of pathogens and initiate antibacterial responses. Among the virulence factors of P. gingivalis implicated in TLRs activation and triggering inflammatory responses leading to the development of periodontitis is the bacterium cell-wall lipopolysaccharide (LPS). The engagement by the LPS of oral mucosal TLR4 leads to initiation of signaling events characterized by the activation of mitogen-activated protein kinase (MAPK) and IκB-kinase complex (IKK) cascades, induction of phosphoinositide-specific phospholipase C (PLC)/protein kinase C (PKC)/PI3K pathway, up-regulation in TGF-α ectodomain shedding and EGFR transactivation, and the amplification of proinflammatory signals by spleen tyrosine kinase (Syk). These events, in turn, exert their control over transcription factors implicated in the induction of the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) genes that lead to up-regulation in the inflammatory mediators, PGE2 and NO. The systems involved in transcription factors activation, furthermore, remain under additional regulatory control through S-nitrosylation. Moreover, the LPS-induced TLR4 activation provides a docking site for Syk, the activation of which leads to amplification of the inflammatory signals by affecting transcription factors activation and their assembly to transcriptional complexes. Interestingly, the extent of oral mucosal inflammatory response to P. gingivalis remains under modulatory influence by two biologically active peptide hormones, leptin and ghrelin. Therefore, the presence of these multifunctional peptides in oral mucosa and saliva may be of significance in countering the destructive consequences of P. gingivalis—induced chronic mucosal inflammation that characterizes periodontitis.
文摘This paper briefly describes the basic situation and features of Three Gorges Cascade, discusses the principle,functions, structure of the integrated automation system, and explains advanced techniques and principle and associated experiments of its monitoring and control
基金supported by National Basic Research Program of China (Grant No 2006CB705500)Changjiang Scholars and Innovative Research Team in University (Grant No IRT0605)the National Natural Science Foundation of China (Grant No 70631001)
文摘In this paper, cascading failure is studied by coupled map lattice （CML） methods in preferential attachment community networks. It is found that external perturbation R is increasing with modularity Q growing by simulation. In particular, the large modularity Q can hold off the cascading failure dynamic process in community networks. Furthermore, different attack strategies also greatly affect the cascading failure dynamic process. It is particularly significant to control cascading failure process in real community networks.
基金supported by National Basic Research Program of China (Grant No 2006CB705500)Chang-Jiang Scholars and Innovative Research Team in University of China (Grant No IRT0605)the National Natural Science Foundation of China (Grant No70631001)
文摘This paper studies the cascading failure on random networks and scale-free networks by introducing the tolerance parameter of edge based on the coupled map lattices methods. The whole work focuses on investigating some indices including the number of failed edges, dynamic edge tolerance capacity and the perturbation of edge. In general, it assumes that the perturbation is attributed to the normal distribution in adopted simulations. By investigating the effectiveness of edge tolerance in scale-free and random networks, it finds that the larger tolerance parameter λ can more efficiently delay the cascading failure process for scale-free networks than random networks. These results indicate that the cascading failure process can be effectively controlled by increasing the tolerance parameter λ. Moreover, the simulations also show that, larger variance of perturbation can easily trigger the cascading failures than the smaller one. This study may be useful for evaluating efficiency of whole traffic systems, and for alleviating cascading failure in such systems.
基金supported by the National Natural Science Foundation of China under Grant No.40175016the Research Fund for the Doctoral Programs of Higher Education under Grant No.2000000156.
文摘In a barotropic atmosphere, new Reynolds mean momentum equations including turbulent viscosity, dispersion, and instability are used not only to derive the KdV-Burgers-Kuramoto equation but also to analyze the physical mechanism of the cascades of energy and enstrophy. It shows that it is the effects of dispersion and instability that result in the inverse cascade. Then based on the conservation laws of the energy and enstrophy, a cascade model is put forward and the processes of the cascades are described.
文摘The method in [1] has been extended to the case of rotational flow in this paper. A new method for dealing with the shock wave is presented. This method has the advantages of both the shock-fitting and the shock capturing methods. The direct problem and the mixed direct-inverse prob- lem of the rotational flow in a transonic plane cascade at both design and off design conditions are solved, and the results show that the present method has rapid convergence rate and high accuracy even for the flow with moderately strong shocks. The calculations have been carried out on the DPS-8 computer, and for the direct problem, only 50-80 iterations are needed, and 50-80 seconds of CPU time are required.
文摘A new kind of multiobjective simulated annealing algorithm is proposed,in which the concept of non dominated character is introduced and a new multiobjective acceptance criterion is set up.The optimization example of a typical mathematical problem with two minimum objective functions indicates that all of the solutions contract to the set of the non dominated points,and the variation trend of the optimal solutions is verified to be identical with that obtained using Genetic Algor thms.The new developed algorithm is then applied to the multiobjective optimization design of turbine cascades,in which it is coupled with the aerodynamics computation of the cascade flow fields and performance and the calculated loss coefficient and work potential of the cascade are considered as the objective functions,thus setting up a technique to the engineering optimization design for the cascades.The optimization results,by the view of a group of optimal solutions,show that the algorithm is superior to the traditional technique of multiobjective optimization design and can be applied to more than two objective optimization cascade design problem or other engineering multiobjective optimization designs.
