Casein is a milk protein emerging as a potential nanosystem for applications in therapy and diagnosis.Casein consists of four major phosphoproteins with their homologous primary amino acid sequences into the following...Casein is a milk protein emerging as a potential nanosystem for applications in therapy and diagnosis.Casein consists of four major phosphoproteins with their homologous primary amino acid sequences into the following familiesαs1,αs2,β,andκ-casein.In the aqueous phase,casein forms micelles binding with colloidal calcium phosphate.Biocompatibility,high drug binding/encapsulation capability,potential to cross the blood-brain barrier,and targeted cellular uptake are a few of the properties of casein micelles,enabling their application in therapy.This review discusses various components,properties,and functions of casein phosphoproteins and casein micelles.Application-specific cross-linking mechanisms and different synthesis approaches are also discussed.This review extensively explores casein's structural and functional properties and its biomedical application:targeted drug delivery and tissue engineering.The potential applications of casein-based complexes for treating iron deficiency anaemia and casein-derived peptides for inhibition of neuronal cognitive disorders are also discussed in this review.展开更多
基金MoE IMPRINT(4291),ICMR(No.35/1/2020-GIA/Nano/BMS),DST-Inspire(DST/INSPIRE/04/2015/000377),DST-AMT(DST/TDT/AMT/2017/227),SERB-CRG(CRG/2020/005069)grants,Vasudha foundations,Hyderabad,IndiaAuthor SK acknowledges University Grants Commission(UGC),Govt.of India for UGC-JRF fellowship(18-340769)Author TA acknowledges DST,Govt.of India for Inspire fellowship(IF160291).
文摘Casein is a milk protein emerging as a potential nanosystem for applications in therapy and diagnosis.Casein consists of four major phosphoproteins with their homologous primary amino acid sequences into the following familiesαs1,αs2,β,andκ-casein.In the aqueous phase,casein forms micelles binding with colloidal calcium phosphate.Biocompatibility,high drug binding/encapsulation capability,potential to cross the blood-brain barrier,and targeted cellular uptake are a few of the properties of casein micelles,enabling their application in therapy.This review discusses various components,properties,and functions of casein phosphoproteins and casein micelles.Application-specific cross-linking mechanisms and different synthesis approaches are also discussed.This review extensively explores casein's structural and functional properties and its biomedical application:targeted drug delivery and tissue engineering.The potential applications of casein-based complexes for treating iron deficiency anaemia and casein-derived peptides for inhibition of neuronal cognitive disorders are also discussed in this review.
