Epigenetics refers to how chromatin-associated factors and reversible chromatin modifications maintain DNA-based programs by regulating the chromatin structure(Strahl and Allis,2000).In recent years,genome sequencing ...Epigenetics refers to how chromatin-associated factors and reversible chromatin modifications maintain DNA-based programs by regulating the chromatin structure(Strahl and Allis,2000).In recent years,genome sequencing studies of cancer have shown that genes encoding epigenetic factors are commonly mutated in cancer(Garraway and Lander,2013).Dys regulated,or mutant.展开更多
基金supported by the National Natural Science Foundation of China(81672771 and 81871867 to C.X.)the Ministry of Science and Technology of the People’s Republic of China(2017YFA0504102 to D.P.)+1 种基金Tianjin Municipal Special Program of Talents Development for Excellent Youth ScholarsThe Chair of this National Key Research and Development Project(2017YFA0504102)is Duanqing Pei,and the corresponding author of this artical,Chenghao Xuan,is one of the members of the project.
文摘Epigenetics refers to how chromatin-associated factors and reversible chromatin modifications maintain DNA-based programs by regulating the chromatin structure(Strahl and Allis,2000).In recent years,genome sequencing studies of cancer have shown that genes encoding epigenetic factors are commonly mutated in cancer(Garraway and Lander,2013).Dys regulated,or mutant.
文摘触脑脊液神经元（cerebrospinal fluid-contacting neurons,CSF-cNs）是一种分布于脑室、中央管、脑室周器及脑实质等处与脑脊液接触的特殊神经元。根据分布位置不同可将CSF-cNs分为室管膜上、室管膜下和远位CSF-cNs三类,不同部位的CSF-cNs分泌不同的神经递质。以往研究CSF-cNs多采用脑室注射辣根过氧化物酶标记的霍乱毒素B亚单位（cholera toxin subunit B labeled with horseradish peroxidase,CB-HRP）进行逆行追踪.
