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基于Partial New Causality的因果脑网络情绪识别
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作者 王斌 王忠民 张荣 《计算机应用与软件》 北大核心 2024年第2期158-163,共6页
为了研究情绪产生过程中脑区以及通道之间的因果作用,在部分格兰杰与新型因果关系的基础上,提出一种用于研究时间序列之间因果关系的部分新型因果关系(PNC)方法。在不同情绪下选取脑区内的8个通道,用PNC计算脑区内通道之间的因果连接关... 为了研究情绪产生过程中脑区以及通道之间的因果作用,在部分格兰杰与新型因果关系的基础上,提出一种用于研究时间序列之间因果关系的部分新型因果关系(PNC)方法。在不同情绪下选取脑区内的8个通道,用PNC计算脑区内通道之间的因果连接关系,根据连接关系构建因果网络;对因果网络中节点的信息流向和介数属性进行分析,将PNC因果网络和Granger因果网络节点之间的因果连接视为一种特征送入SVM中训练分类。实验结果表明,基于PNC因果网络和Granger因果网络的平均识别精度分别为76.4%和68.5%,PNC可用于计算时间序列之间的因果关系。 展开更多
关键词 部分新型因果关系 脑电 因果脑网络 脑区 网络属性分析 情绪识别
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Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS
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作者 Sumeng Wang Silu Chen +6 位作者 Huiqin Li Shuai Ben Tingyu Zhao Rui Zheng Meilin Wang Dongying Gu Lingxiang Liu 《The Journal of Biomedical Research》 CAS CSCD 2024年第1期37-50,共14页
The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant... The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant biomarkers involved in colorectal tumorigenesis is lacking.To address this gap,we conducted a study aiming to investigate this association and identify relevant biomarkers.We analyzed transcriptomic and proteomic profiles of 904 colorectal tumor tissues and 342 normal tissues to examine pathway enrichment,biological activity,and the immune microenvironment.Additionally,we evaluated genetic effects of single variants and genes on colorectal cancer susceptibility using data from genome-wide association studies(GWASs)involving both East Asian(7062 cases and 195745 controls)and European(24476 cases and 23073 controls)populations.We employed mediation analysis to infer the causal pathway,and applied multiplex immunofluorescence to visualize colocalized biomarkers in colorectal tumors and immune cells.Our findings revealed that both DNA replication activity and the flap structure-specific endonuclease 1(FEN1)gene were significantly enriched in colorectal tumor tissues,compared with normal tissues.Moreover,a genetic variant rs4246215 G>T in FEN1 was associated with a decreased risk of colorectal cancer(odds ratio=0.94,95%confidence interval:0.90–0.97,P_(meta)=4.70×10^(-9)).Importantly,we identified basophils and eosinophils that both exhibited a significantly decreased infiltration in colorectal tumors,and were regulated by rs4246215 through causal pathways involving both FEN1 and DNA replication.In conclusion,this trans-omics incorporating GWAS data provides insights into a plausible pathway connecting DNA replication and immunity,expanding biological knowledge of colorectal tumorigenesis and therapeutic targets. 展开更多
关键词 trans-omics DNA replication tumor immune microenvironment causal mediation colorectal tumorigenesis
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TCAS-PINN:Physics-informed neural networks with a novel temporal causality-based adaptive sampling method
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作者 郭嘉 王海峰 +1 位作者 古仕林 侯臣平 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期344-364,共21页
Physics-informed neural networks(PINNs)have become an attractive machine learning framework for obtaining solutions to partial differential equations(PDEs).PINNs embed initial,boundary,and PDE constraints into the los... Physics-informed neural networks(PINNs)have become an attractive machine learning framework for obtaining solutions to partial differential equations(PDEs).PINNs embed initial,boundary,and PDE constraints into the loss function.The performance of PINNs is generally affected by both training and sampling.Specifically,training methods focus on how to overcome the training difficulties caused by the special PDE residual loss of PINNs,and sampling methods are concerned with the location and distribution of the sampling points upon which evaluations of PDE residual loss are accomplished.However,a common problem among these original PINNs is that they omit special temporal information utilization during the training or sampling stages when dealing with an important PDE category,namely,time-dependent PDEs,where temporal information plays a key role in the algorithms used.There is one method,called Causal PINN,that considers temporal causality at the training level but not special temporal utilization at the sampling level.Incorporating temporal knowledge into sampling remains to be studied.To fill this gap,we propose a novel temporal causality-based adaptive sampling method that dynamically determines the sampling ratio according to both PDE residual and temporal causality.By designing a sampling ratio determined by both residual loss and temporal causality to control the number and location of sampled points in each temporal sub-domain,we provide a practical solution by incorporating temporal information into sampling.Numerical experiments of several nonlinear time-dependent PDEs,including the Cahn–Hilliard,Korteweg–de Vries,Allen–Cahn and wave equations,show that our proposed sampling method can improve the performance.We demonstrate that using such a relatively simple sampling method can improve prediction performance by up to two orders of magnitude compared with the results from other methods,especially when points are limited. 展开更多
关键词 partial differential equation physics-informed neural networks residual-based adaptive sampling temporal causality
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Immune cell signatures and causal association with irritable bowel syndrome:A mendelian randomization study
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作者 Wei-Hao Chai Yan Ma +3 位作者 Jia-Jia Li Fei Guo Yi-Zhan Wu Jiang-Wei Liu 《World Journal of Clinical Cases》 SCIE 2024年第17期3094-3104,共11页
BACKGROUND The mucosal barrier's immune-brain interactions,pivotal for neural development and function,are increasingly recognized for their potential causal and therapeutic relevance to irritable bowel syndrome(I... BACKGROUND The mucosal barrier's immune-brain interactions,pivotal for neural development and function,are increasingly recognized for their potential causal and therapeutic relevance to irritable bowel syndrome(IBS).Prior studies linking immune inflammation with IBS have been inconsistent.To further elucidate this relationship,we conducted a Mendelian randomization(MR)analysis of 731 immune cell markers to dissect the influence of various immune phenotypes on IBS.Our goal was to deepen our understanding of the disrupted brain-gut axis in IBS and to identify novel therapeutic targets.AIM To leverage publicly available data to perform MR analysis on 731 immune cell markers and explore their impact on IBS.We aimed to uncover immunophenotypic associations with IBS that could inform future drug development and therapeutic strategies.METHODS We performed a comprehensive two-sample MR analysis to evaluate the causal relationship between immune cell markers and IBS.By utilizing genetic data from public databases,we examined the causal associations between 731 immune cell markers,encompassing median fluorescence intensity,relative cell abundance,absolute cell count,and morphological parameters,with IBS susceptibility.Sensitivity analyses were conducted to validate our findings and address potential heterogeneity and pleiotropy.RESULTS Bidirectional false discovery rate correction indicated no significant influence of IBS on immunophenotypes.However,our analysis revealed a causal impact of IBS on 30 out of 731 immune phenotypes(P<0.05).Nine immune phenotypes demonstrated a protective effect against IBS[inverse variance weighting(IVW)<0.05,odd ratio(OR)<1],while 21 others were associated with an increased risk of IBS onset(IVW≥0.05,OR≥1).CONCLUSION Our findings underscore a substantial genetic correlation between immune cell phenotypes and IBS,providing valuable insights into the pathophysiology of the condition.These results pave the way for the development of more precise biomarkers and targeted therapies for IBS.Furthermore,this research enriches our comprehension of immune cell roles in IBS pathogenesis,offering a foundation for more effective,personalized treatment approaches.These advancements hold promise for improving IBS patient quality of life and reducing the disease burden on individuals and their families. 展开更多
关键词 Irritable bowel syndrome Immunophenotypes causalITY Brain-gut axis Mendelian randomization Sensitivity analysis
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Causal role of immune cells in obstructive sleep apnea hypopnea syndrome:Mendelian randomization study
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作者 Huang-Hong Zhao Zhen Ma Dong-Sheng Guan 《World Journal of Clinical Cases》 SCIE 2024年第7期1227-1234,共8页
BACKGROUND Despite being one of the most prevalent sleep disorders,obstructive sleep apnea hypoventilation syndrome(OSAHS)has limited information on its immunologic foundation.The immunological underpinnings of certai... BACKGROUND Despite being one of the most prevalent sleep disorders,obstructive sleep apnea hypoventilation syndrome(OSAHS)has limited information on its immunologic foundation.The immunological underpinnings of certain major psychiatric diseases have been uncovered in recent years thanks to the extensive use of genome-wide association studies(GWAS)and genotyping techniques using highdensity genetic markers(e.g.,SNP or CNVs).But this tactic hasn't yet been applied to OSAHS.Using a Mendelian randomization analysis,we analyzed the causal link between immune cells and the illness in order to comprehend the immunological bases of OSAHS.AIM To investigate the immune cells'association with OSAHS via genetic methods,guiding future clinical research.METHODS A comprehensive two-sample mendelian randomization study was conducted to investigate the causal relationship between immune cell characteristics and OSAHS.Summary statistics for each immune cell feature were obtained from the GWAS catalog.Information on 731 immune cell properties,such as morphologic parameters,median fluorescence intensity,absolute cellular,and relative cellular,was compiled using publicly available genetic databases.The results'robustness,heterogeneity,and horizontal pleiotropy were confirmed using extensive sensitivity examination.RESULTS Following false discovery rate(FDR)correction,no statistically significant effect of OSAHS on immunophenotypes was observed.However,two lymphocyte subsets were found to have a significant association with the risk of OSAHS:Basophil%CD33dim HLA DR-CD66b-(OR=1.03,95%CI=1.01-1.03,P<0.001);CD38 on IgD+CD24-B cell(OR=1.04,95%CI=1.02-1.04,P=0.019).CONCLUSION This study shows a strong link between immune cells and OSAHS through a gene approach,thus offering direction for potential future medical research. 展开更多
关键词 Obstructive sleep apnea hypopnea syndrome IMMUNITY causal inference MR analysis Sensitivity
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Causal association between 25-hydroxyvitamin D status and cataract development:A two-sample Mendelian randomization study
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作者 Chun-Hui Wang Zhi-Kun Xin 《World Journal of Clinical Cases》 SCIE 2024年第16期2789-2795,共7页
BACKGROUND Vitamin deficiencies are linked to various eye diseases,and the influence of vitamin D on cataract formation has been noted in prior research.However,detailed investigations into the causal relationship bet... BACKGROUND Vitamin deficiencies are linked to various eye diseases,and the influence of vitamin D on cataract formation has been noted in prior research.However,detailed investigations into the causal relationship between 25-(OH)D status and cataract development remain scarce.AIM To explore a possible causal link between cataracts and vitamin D.METHODS In this study,we explored the causal link between 25-(OH)D levels and cataract development using Mendelian randomization.Our analytical approach included inverse-variance weighting(IVW),MR-Egger,weighted median,simple mode,and weighted mode methods.The primary analyses utilized IVW with random effects,supplemented by sensitivity and heterogeneity tests using both IVW and MR-Egger.MR-Egger was also applied for pleiotropy testing.Additionally,a leave-one-out analysis helped identify potentially impactful single-nucleotide polymorphisms.RESULTS The analysis revealed a positive association between 25-(OH)D levels and the risk of developing cataracts(OR=1.11,95%CI:1.00-1.22;P=0.032).The heterogeneity test revealed that our IVW analysis exhibited minimal heterogeneity(P>0.05),and the pleiotropy test findings confirmed the absence of pleiotropy within our IVW analysis(P>0.05).Furthermore,a search of the human genotype-phenotype association database failed to identify any potentially relevant risk-factor single nucleotide polymorphisms.CONCLUSION There is a potential causal link between 25-(OH)D levels and the development of cataracts,suggesting that greater 25-(OH)D levels may be a contributing risk factor for cataract formation.Further experimental research is required to confirm these findings. 展开更多
关键词 CATARACT 25-hydroxyvitamin D Mendelian randomization Single nucleotide polymorphism causal relationship
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基于差分Causal LSTM模型的气象图像短时预测研究
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作者 张晓晖 白文奇 +1 位作者 杨松楠 王晓娟 《西安理工大学学报》 北大核心 2023年第4期529-535,共7页
为解决气象图像序列在短时预测时预测精度低的问题,利用一种具有级联记忆单元的Causal LSTM,将图像梯度差分惩罚因子引入训练过程,来提高预测模型对短时序列动态和突变的建模能力,提出了差分Causal LSTM模型。研究首先通过循环神经网络... 为解决气象图像序列在短时预测时预测精度低的问题,利用一种具有级联记忆单元的Causal LSTM,将图像梯度差分惩罚因子引入训练过程,来提高预测模型对短时序列动态和突变的建模能力,提出了差分Causal LSTM模型。研究首先通过循环神经网络建立气象图像短时预测模型,然后分析了ConvLSTM模型对气象雷达回波图与卫星云图序列的预测效果,对于ConvLSTM模型预测气象图像存在严重模糊的问题,使用差分Causal LSTM模型进行优化,结果表明改进的模型能够有效改善模糊,提升预测结果的准确性。改进后的差分Causal LSTM模型在HKO-7数据集的测试样本中,关键成功指数(CSI)提高了0.019,在气象云图数据集中提高了0.078,模糊程度有所减弱。 展开更多
关键词 ConvLSTM causal LSTM 端到端模型 图像梯度差分损失
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Causal inference using regression-based statistical control: Confusion in Econometrics
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作者 Fan Chao Guang Yu 《Journal of Data and Information Science》 CSCD 2023年第1期21-28,共8页
Regression is a widely used econometric tool in research. In observational studies, based on a number of assumptions, regression-based statistical control methods attempt to analyze the causation between treatment and... Regression is a widely used econometric tool in research. In observational studies, based on a number of assumptions, regression-based statistical control methods attempt to analyze the causation between treatment and outcome by adding control variables. However, this approach may not produce reliable estimates of causal effects. In addition to the shortcomings of the method, this lack of confidence is mainly related to ambiguous formulations in econometrics, such as the definition of selection bias, selection of core control variables, and method of testing for robustness. Within the framework of the causal models, we clarify the assumption of causal inference using regression-based statistical controls, as described in econometrics, and discuss how to select core control variables to satisfy this assumption and conduct robustness tests for regression estimates. 展开更多
关键词 causal Inference Regression Observational Studies ECONOMETRICS causal Model
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Shared genetics and bidirectional causal relationships between type 2 diabetes and attention-deficit/hyperactivity disorder 被引量:1
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作者 Ancha Baranova Vikas Chandhoke +1 位作者 Hongbao Cao Fuquan Zhang 《General Psychiatry》 CSCD 2023年第2期106-113,共8页
Background Type 2 diabetes(T2D)is a chronic metabolic disorder with high comorbidity with mental disorders.The genetic links between attention-deficit/hyperactivity disorder(ADHD)and T2D have yet to be elucidated.Aims... Background Type 2 diabetes(T2D)is a chronic metabolic disorder with high comorbidity with mental disorders.The genetic links between attention-deficit/hyperactivity disorder(ADHD)and T2D have yet to be elucidated.Aims We aim to assess shared genetics and potential associations between ADHD and T2D.Methods We performed genetic correlation,two-sample Mendelian randomisation and polygenic overlap analyses between ADHD and T2D.The genome-wide association study(GWAS)summary results of T2D(80154 cases and 853816 controls),ADHD2019(20183 cases and 35191 controls from the 2019 GWAS ADHD dataset)and ADHD2022(38691 cases and 275986 controls from the 2022 GWAS ADHD dataset)were used for the analyses.The T2D dataset was obtained from the DIAGRAM Consortium.The ADHD datasets were obtained from the Psychiatric Genomics Consortium.We compared genome-wide association signals to reveal shared genetic variation between T2D and ADHD using the larger ADHD2022 dataset.Moreover,molecular pathways were constructed based on large-scale literature data to understand the connection between ADHD and T2D.Results T2D has positive genetic correlations with ADHD2019(rg=0.33)and ADHD2022(rg=0.31).Genetic liability to ADHD2019 was associated with an increased risk for T2D(odds ratio(OR):1.30,p<0.001),while genetic liability to ADHD2022 had a suggestive causal effect on T2D(OR:1.30,p=0.086).Genetic liability to T2D was associated with a higher risk for ADHD2019(OR:1.05,p=0.001)and ADHD2022(OR:1.03,p<0.001).The polygenic overlap analysis showed that most causal variants of T2D are shared with ADHD2022.T2D and ADHD2022 have three overlapping loci.Molecular pathway analysis suggests that ADHD and T2D could promote the risk of each other through inflammatory pathways.Conclusions Our study demonstrates substantial shared genetics and bidirectional causal associations between ADHD and T2D. 展开更多
关键词 diabetes OVERLAP causal
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Evaluating the causal relationship between human blood metabolites and gastroesophageal reflux disease 被引量:1
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作者 Jia-Yan Hu Mi Lv +3 位作者 Kun-Li Zhang Xi-Yun Qiao Yu-Xi Wang Feng-Yun Wang 《World Journal of Gastrointestinal Oncology》 SCIE 2023年第12期2169-2184,共16页
BACKGROUND Gastroesophageal reflux disease(GERD)affects approximately 13% of the global population.However,the pathogenesis of GERD has not been fully elucidated.The development of metabolomics as a branch of systems ... BACKGROUND Gastroesophageal reflux disease(GERD)affects approximately 13% of the global population.However,the pathogenesis of GERD has not been fully elucidated.The development of metabolomics as a branch of systems biology in recent years has opened up new avenues for the investigation of disease processes.As a powerful statistical tool,Mendelian randomization(MR)is widely used to explore the causal relationship between exposure and outcome.AIM To analyze of the relationship between 486 blood metabolites and GERD.METHODS Two-sample MR analysis was used to assess the causal relationship between blood metabolites and GERD.A genome-wide association study(GWAS)of 486 metabolites was the exposure,and two different GWAS datasets of GERD were used as endpoints for the base analysis and replication and meta-analysis.Bonferroni correction is used to determine causal correlation features(P<1.03×10^(-4)).The results were subjected to sensitivity analysis to assess heterogeneity and pleiotropy.Using the MR Steiger filtration method to detect whether there is a reverse causal relationship between metabolites and GERD.In addition,metabolic pathway analysis was conducted using the online database based MetaboAnalyst 5.0 software.RESULTS In MR analysis,four blood metabolites are negatively correlated with GERD:Levulinate(4-oxovalerate),stearate(18:0),adrenate(22:4n6)and p-acetamidophenylglucuronide.However,we also found a positive correlation between four blood metabolites and GERD:Kynurenine,1-linoleoylglycerophosphoethanolamine,butyrylcarnitine and guanosine.And bonferroni correction showed that butyrylcarnitine(odd ratio 1.10,95% confidence interval:1.05-1.16,P=7.71×10^(-5))was the most reliable causal metabolite.In addition,one significant pathways,the"glycerophospholipid metabolism"pathway,can be involved in the pathogenesis of GERD.CONCLUSION Our study found through the integration of genomics and metabolomics that butyrylcarnitine may be a potential biomarker for GERD,which will help further elucidate the pathogenesis of GERD and better guide its treatment.At the same time,this also contributes to early screening and prevention of GERD.However,the results of this study require further confirmation from both basic and clinical real-world studies. 展开更多
关键词 Blood metabolites Gastroesophageal reflux disease Mendelian randomization causalITY PATHOGENESIS Biomarkers Metabolic pathway
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Local-to-Global Causal Reasoning for Cross-Document Relation Extraction
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作者 Haoran Wu Xiuyi Chen +3 位作者 Zefa Hu Jing Shi Shuang Xu Bo Xu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第7期1608-1621,共14页
Cross-document relation extraction(RE),as an extension of information extraction,requires integrating information from multiple documents retrieved from open domains with a large number of irrelevant or confusing nois... Cross-document relation extraction(RE),as an extension of information extraction,requires integrating information from multiple documents retrieved from open domains with a large number of irrelevant or confusing noisy texts.Previous studies focus on the attention mechanism to construct the connection between different text features through semantic similarity.However,similarity-based methods cannot distinguish valid information from highly similar retrieved documents well.How to design an effective algorithm to implement aggregated reasoning in confusing information with similar features still remains an open issue.To address this problem,we design a novel local-toglobal causal reasoning(LGCR)network for cross-document RE,which enables efficient distinguishing,filtering and global reasoning on complex information from a causal perspective.Specifically,we propose a local causal estimation algorithm to estimate the causal effect,which is the first trial to use the causal reasoning independent of feature similarity to distinguish between confusing and valid information in cross-document RE.Furthermore,based on the causal effect,we propose a causality guided global reasoning algorithm to filter the confusing information and achieve global reasoning.Experimental results under the closed and the open settings of the large-scale dataset Cod RED demonstrate our LGCR network significantly outperforms the state-ofthe-art methods and validate the effectiveness of causal reasoning in confusing information processing. 展开更多
关键词 causal reasoning cross document graph reasoning relation extraction(RE)
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Causal associations between inflammatory bowel disease and anxiety:A bidirectional Mendelian randomization study
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作者 Ying He Chun-Lan Chen +1 位作者 Jian He Si-De Liu 《World Journal of Gastroenterology》 SCIE CAS 2023年第44期5872-5881,共10页
BACKGROUND Anxiety is common in patients with inflammatory bowel disease(IBD),including those with ulcerative colitis(UC)and Crohn’s disease(CD);however,the causal relationship between IBD and anxiety remains unknown... BACKGROUND Anxiety is common in patients with inflammatory bowel disease(IBD),including those with ulcerative colitis(UC)and Crohn’s disease(CD);however,the causal relationship between IBD and anxiety remains unknown.AIM To investigate the causal relationship between IBD and anxiety by using bidirectional Mendelian randomization analysis.METHODS Single nucleotide polymorphisms retrieved from genome-wide association studies(GWAS)of the European population were identified as genetic instrument variants.GWAS statistics for individuals with UC(6968 patients and 20464 controls;adults)and CD(5956 patients and 14927 controls;adults)were obtained from the International IBD Genetics Consortium.GWAS statistics for individuals with anxiety were obtained from the Psychiatric Genomics Consortium(2565 patients and 14745 controls;adults)and FinnGen project(20992 patients and 197800 controls;adults),respectively.Inverse-variance weighted was applied to assess the causal relationship,and the results were strengthened by heterogeneity,pleiotropy and leave-one-out analyses.RESULTS Genetic susceptibility to UC was associated with an increased risk of anxiety[odds ratio:1.071(95%confidence interval:1.009-1.135),P=0.023],while genetic susceptibility to CD was not associated with anxiety.Genetic susceptibility to anxiety was not associated with UC or CD.No heterogeneity or pleiotropy was observed,and the leave-one-out analysis excluded the potential influence of a particular variant.CONCLUSION This study revealed that genetic susceptibility to UC was significantly associated with anxiety and highlighted the importance of early screening for anxiety in patients with UC. 展开更多
关键词 Inflammatory bowel disease ANXIETY causal effect Mendelian randomization Genome-wide association studies
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Exploring the asymmetric effect of COVID‑19 pandemic news on the cryptocurrency market:evidence from nonlinear autoregressive distributed lag approach and frequency domain causality
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作者 Ştefan Cristian Gherghina Liliana Nicoleta Simionescu 《Financial Innovation》 2023年第1期692-749,共58页
This paper explores the asymmetric effect of COVID-19 pandemic news,as measured by the coronavirus indices(Panic,Hype,Fake News,Sentiment,Infodemic,and Media Coverage),on the cryptocurrency market.Using daily data fro... This paper explores the asymmetric effect of COVID-19 pandemic news,as measured by the coronavirus indices(Panic,Hype,Fake News,Sentiment,Infodemic,and Media Coverage),on the cryptocurrency market.Using daily data from January 2020 to September 2021 and the exponential generalized autoregressive conditional heter-oskedasticity model,the results revealed that both adverse and optimistic news had the same effect on Bitcoin returns,indicating fear of missing out behavior does not prevail.Furthermore,when the nonlinear autoregressive distributed lag model is esti-mated,both positive and negative shocks in pandemic indices promote Bitcoin’s daily changes;thus,Bitcoin is resistant to the SARS-CoV-2 pandemic crisis and may serve as a hedge during market turmoil.The analysis of frequency domain causality supports a unidirectional causality running from the Coronavirus Fake News Index and Sentiment Index to Bitcoin returns,whereas daily fluctuations in the Bitcoin price Granger affect the Coronavirus Panic Index and the Hype Index.These findings may have significant policy implications for investors and governments because they highlight the impor-tance of news during turbulent times.The empirical results indicate that pandemic news could significantly influence Bitcoin’s price. 展开更多
关键词 COVID-19 Bitcoin NARDL EGARCH Frequency domain causality
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Performance of Bayesian Propensity Score Adjustment for Estimating Causal Effects in Small Clinical Trials
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作者 Airi Takagi Takuhiro Yamaguchi 《Open Journal of Statistics》 2023年第1期1-15,共15页
Propensity score (PS) adjustment can control confounding effects and reduce bias when estimating treatment effects in non-randomized trials or observational studies. PS methods are becoming increasingly used to estima... Propensity score (PS) adjustment can control confounding effects and reduce bias when estimating treatment effects in non-randomized trials or observational studies. PS methods are becoming increasingly used to estimate causal effects, including when the sample size is small compared to the number of confounders. With numerous confounders, quasi-complete separation can easily occur in logistic regression used for estimating the PS, but this has not been addressed. We focused on a Bayesian PS method to address the limitations of quasi-complete separation faced by small trials. Bayesian methods are useful because they estimate the PS and causal effects simultaneously while considering the uncertainty of the PS by modelling it as a latent variable. In this study, we conducted simulations to evaluate the performance of Bayesian simultaneous PS estimation by considering the specification of prior distributions for model comparison. We propose a method to improve predictive performance with discrete outcomes in small trials. We found that the specification of prior distributions assigned to logistic regression coefficients was more important in the second step than in the first step, even when there was a quasi-complete separation in the first step. Assigning Cauchy (0, 2.5) to coefficients improved the predictive performance for estimating causal effects and improving the balancing properties of the confounder. 展开更多
关键词 Bayesian Estimation causal Inference Propensity Score Quasi-Complete Separation Prior Distribution
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Causal Circular Narrative and Time-Space Construction of the Movie Little Big Woman
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作者 ZHAO Zhi-qing 《Journal of Literature and Art Studies》 2023年第2期122-128,共7页
Chinese film Little Big Woman takes the father’s funeral as the main line to tell the story of family affection and real-life emotional entanglements.In the narrative with multiple clues,we go back to find the hidden... Chinese film Little Big Woman takes the father’s funeral as the main line to tell the story of family affection and real-life emotional entanglements.In the narrative with multiple clues,we go back to find the hidden reasons,and the gradually clear reflection of the past is related to the real situation of the characters.Causal cycle narrative is not only a narrative strategy,but also a narrative logic with deep Chinese traditional cultural and philosophical connotations. 展开更多
关键词 Little Big Woman causalITY temporal and spatial processing narrative thread
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Studying History Education of High School in Taiwan by Causal Layered Analysis
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作者 Huai Liu 《Journal of Literature and Art Studies》 2023年第11期906-920,共15页
After the 21st century,high school history learning will focus on teachers promoting the twelve-year state education.In recent years,in line with the changes in the new 108-year social curriculum,supporting strategies... After the 21st century,high school history learning will focus on teachers promoting the twelve-year state education.In recent years,in line with the changes in the new 108-year social curriculum,supporting strategies have been proposed:such as literacy orientation,inquiry and practice,learning process archives,and the structural direction of the controversial Chinese history into East Asian history.Historical learning has indeed had a great impact on the people’s national spiritual education and the development of historical consciousness in Taiwan’s education policy.This is the reason Taiwan’s Ministry of Education strives to improve students’historical literacy and connotation application abilities.When developing a learning policy,both external and internal learning factors need to be considered.The external aspect deals with the reasons for learning:Is learning for the purpose of using or accumulating historical wisdom in daily life to learn from the past and the present,on the other hand,to test the content of the course and the degree of absorption;or is it specifically for exams or other enlightenment purposes.The internal aspect involves those most affected by the policy:students and teachers.After studying and observing high school history learning policies for decades,some alternative future visions for history learning were found in the method of reflection on future research-the conclusion is that history is interestingly revitalized,and the preferred future is thematic history.According to the famous futurology scholar Sohail Inayatuallah’s proposal:the causal layering model.It helps understand how Taiwan’s historical policies operate.And how teachers and students on the front line respond to changes and take future actions.The key is to change the future:in the process of building an alternative future,whether the internal and external mix has changed or whether you want to try new things and expand your horizons.In fact,the difficulty of teaching lies in students’cooperation and conscious learning.Therefore,in the analysis of learning through alternative futures,is it possible to distinguish between internal and external situations and methods such as:1.Internal:Is education centered on teachers?Or is it student-centered?2.External:Does the Ministry of Education prioritize testing,or encourage teachers to adopt interactive communication and integrate education into the curriculum?Therefore,what is the function and inspiration of studying high school history and life?If thematic history teaching is used:teachers can use thematic learning methods to help students focus on causal relationships,the causes of turning points,or the evolution process of the beginning and end of events.This is more advantageous for testing based on the application topic,and it is easy to test how much understanding and understanding of history?Has an activating effect.By studying history in high school,using the“CLA(Causal layered analysis)”method of future studies,you can enter the stage of worldview exploration with the goal of improving professional depth and emotional level,and use it in your own understanding and utilization of history.Based on research,some insights into the prospects and thinking of learning history in high schools are provided:1.Facing the impact of declining birthrate,Taiwan needs a macro perspective to improve its future competitiveness and look forward to a new perspective on world history,using futuristic cause-and-effect level analysis to combine world changes with daily life applications.2.The study of history in high schools should go into a systematic construction:understand its cause-and-effect relationships and global trends,so teachers play a professional and future role in controlling the use of new information and technology.3.In the future,humans may develop more“intelligent”needs.As a reference from history or to explore the preferred path for the future,there will also be a greater need to innovate and meet challenges.4.Studying high school history has entered the professional field.Through self-exploration,it can be transformed into life affairs and establish the concept and value of lifelong learning.5.In studying the“history of high school learning”,have new prospects for the future of education.Through professional knowledge such as“trend theory and causal hierarchy analysis”of futurology,pursue new horizons and visions,making future education full of hope and possibility. 展开更多
关键词 learn history CLA(causal layered analysis) learning process alternative future exploration and implementation transformation breakthrough intelligence future satisfaction
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Causal Inference 被引量:8
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作者 Kun Kuang Lian Li +7 位作者 Zhi Geng Lei Xu Kun Zhang Beishui Liao Huaxin Huang Peng Ding Wang Miao Zhichao Jiang 《Engineering》 SCIE EI 2020年第3期253-263,共11页
Causal inference is a powerful modeling tool for explanatory analysis,which might enable current machine learning to become explainable.How to marry causal inference with machine learning to develop explainable artifi... Causal inference is a powerful modeling tool for explanatory analysis,which might enable current machine learning to become explainable.How to marry causal inference with machine learning to develop explainable artificial intelligence(XAI)algorithms is one of key steps toward to the artificial intelligence 2.0.With the aim of bringing knowledge of causal inference to scholars of machine learning and artificial intelligence,we invited researchers working on causal inference to write this survey from different aspects of causal inference.This survey includes the following sections:“Estimating average treatment effect:A brief review and beyond”from Dr.Kun Kuang,“Attribution problems in counterfactual inference”from Prof.Lian Li,“The Yule–Simpson paradox and the surrogate paradox”from Prof.Zhi Geng,“Causal potential theory”from Prof.Lei Xu,“Discovering causal information from observational data”from Prof.Kun Zhang,“Formal argumentation in causal reasoning and explanation”from Profs.Beishui Liao and Huaxin Huang,“Causal inference with complex experiments”from Prof.Peng Ding,“Instrumental variables and negative controls for observational studies”from Prof.Wang Miao,and“Causal inference with interference”from Dr.Zhichao Jiang. 展开更多
关键词 causal inference Instructive variables Negative control causal reasoning and explanation causal discovery Counterfactual inference Treatment effect estimation
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含causal算子分数阶非线性微分方程的拟线性方法 被引量:1
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作者 王培光 李志芳 《河北大学学报(自然科学版)》 CAS 北大核心 2012年第1期1-6,共6页
采用拟线性化方法讨论了含causal算子的分数阶非线性微分方程初值问题,通过构造2个单调迭代序列,证明了它们一致且平方收敛于给出问题的解.
关键词 拟线性方法 causal算子 分数阶微分方程 平方收敛
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Causality Diagram-based Scheduling Approach for Blast Furnace Gas System 被引量:6
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作者 Feng Jin Jun Zhao +1 位作者 Chunyang Sheng Wei Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2018年第2期587-594,共8页
Rational use of blast furnace gas(BFG) in steel industry can raise economic profit, save fossil energy resources and alleviate the environment pollution. In this paper, a causality diagram is established to describe t... Rational use of blast furnace gas(BFG) in steel industry can raise economic profit, save fossil energy resources and alleviate the environment pollution. In this paper, a causality diagram is established to describe the causal relationships among the decision objective and the variables of the scheduling process for the industrial system, based on which the total scheduling amount of the BFG system can be computed by using a causal fuzzy C-means(CFCM) clustering algorithm. In this algorithm,not only the distances among the historical samples but also the effects of different solutions on the gas tank level are considered.The scheduling solution can be determined based on the proposed causal probability of the causality diagram calculated by the total amount and the conditions of the adjustable units. The causal probability quantifies the impact of different allocation schemes of the total scheduling amount on the BFG system. An evaluation method is then proposed to evaluate the effectiveness of the scheduling solutions. The experiments by using the practical data coming from a steel plant in China indicate that the proposed approach can effectively improve the scheduling accuracy and reduce the gas diffusion. 展开更多
关键词 Blast furnace gas system causal fuzzy C-means(CFCM) clustering causality diagram SCHEDULING
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Exploring the Big Data Using a Rigorous and Quantitative Causality Analysis 被引量:2
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作者 X. San Liang 《Journal of Computer and Communications》 2016年第5期53-59,共7页
Causal analysis is a powerful tool to unravel the data complexity and hence provide clues to achieving, say, better platform design, efficient interoperability and service management, etc. Data science will surely ben... Causal analysis is a powerful tool to unravel the data complexity and hence provide clues to achieving, say, better platform design, efficient interoperability and service management, etc. Data science will surely benefit from the advancement in this field. Here we introduce into this community a recent finding in physics on causality and the subsequent rigorous and quantitative causality analysis. The resulting formula is concise in form, involving only the common statistics namely sample covariance. A corollary is that causation implies correlation, but not vice versa, resolving the long-standing philosophical debate over correlation versus causation. The applicability to big data analysis is validated with time series purportedly generated with hidden processes. As a demonstration, a preliminary application to the gross domestic product (GDP) data of United States, China, and Japan reveals some subtle USA-China-Japan relations in certain periods.   展开更多
关键词 causalITY Big Data Information Flow Time Series causal Network
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