肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9(sex determining ...肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9(sex determining region Y box-9)除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。展开更多
930588 Types of anticellular structure antiserain scleroderma patients.NI Zumei(倪祖梅),etal.Cellbiol Instit,CAMS,Shanghai,200031.Natl Med J China 1993;73(5):270-272.The sera of 338 scleroderma patients were cy-tologi...930588 Types of anticellular structure antiserain scleroderma patients.NI Zumei(倪祖梅),etal.Cellbiol Instit,CAMS,Shanghai,200031.Natl Med J China 1993;73(5):270-272.The sera of 338 scleroderma patients were cy-tologically examined with indirect immunofluo-rescence method.The sera were classified ac-cording to their anti-cellular structure anti-body.Among these sera,six main types of cellu-lar structure antiserum were found:antikineto-chore,antinucleolus,antichromatin,anti-展开更多
文摘肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9(sex determining region Y box-9)除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。
文摘930588 Types of anticellular structure antiserain scleroderma patients.NI Zumei(倪祖梅),etal.Cellbiol Instit,CAMS,Shanghai,200031.Natl Med J China 1993;73(5):270-272.The sera of 338 scleroderma patients were cy-tologically examined with indirect immunofluo-rescence method.The sera were classified ac-cording to their anti-cellular structure anti-body.Among these sera,six main types of cellu-lar structure antiserum were found:antikineto-chore,antinucleolus,antichromatin,anti-